Incidental Mutation 'R7096:Trak2'
ID 550463
Institutional Source Beutler Lab
Gene Symbol Trak2
Ensembl Gene ENSMUSG00000026028
Gene Name trafficking protein, kinesin binding 2
Synonyms 2900022D04Rik, GRIF-1, CALS-C, OIP98, GRIF1, Als2cr3, 4733401O11Rik
MMRRC Submission 045188-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7096 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 58939608-59012589 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 58942749 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Histidine at position 886 (N886H)
Ref Sequence ENSEMBL: ENSMUSP00000027186 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027186] [ENSMUST00000174120]
AlphaFold Q6P9N8
Predicted Effect probably damaging
Transcript: ENSMUST00000027186
AA Change: N886H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027186
Gene: ENSMUSG00000026028
AA Change: N886H

DomainStartEndE-ValueType
Pfam:HAP1_N 48 353 2.5e-135 PFAM
Pfam:Milton 426 565 3e-26 PFAM
low complexity region 663 673 N/A INTRINSIC
low complexity region 693 714 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000174120
SMART Domains Protein: ENSMUSP00000134253
Gene: ENSMUSG00000026028

DomainStartEndE-ValueType
Pfam:HAP1_N 47 354 1.3e-129 PFAM
Pfam:Milton 411 565 1.1e-41 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 97% (68/70)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abhd18 T G 3: 40,888,305 (GRCm39) M383R probably damaging Het
Acd T A 8: 106,425,121 (GRCm39) E366V possibly damaging Het
Acvr2b T A 9: 119,257,255 (GRCm39) probably null Het
Alg10b C T 15: 90,111,564 (GRCm39) T136I probably benign Het
Ankrd42 T A 7: 92,241,040 (GRCm39) K440* probably null Het
Apc T A 18: 34,449,010 (GRCm39) S1969T probably damaging Het
Arhgef25 T C 10: 127,019,897 (GRCm39) Y447C probably damaging Het
AW146154 G A 7: 41,130,867 (GRCm39) A83V probably benign Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Barhl1 T G 2: 28,799,726 (GRCm39) I300L probably benign Het
Brd1 C A 15: 88,598,138 (GRCm39) R536L probably damaging Het
Brms1 T A 19: 5,096,708 (GRCm39) I130N probably damaging Het
Ccdc68 A G 18: 70,073,241 (GRCm39) H63R probably damaging Het
Ccl28 A G 13: 120,112,429 (GRCm39) I74V probably benign Het
Cd300ld T A 11: 114,878,321 (GRCm39) I64F possibly damaging Het
Cdkl2 G A 5: 92,181,043 (GRCm39) Q199* probably null Het
Cdkn2c C T 4: 109,518,555 (GRCm39) R133Q probably benign Het
Coq2 A G 5: 100,811,586 (GRCm39) probably benign Het
Coq6 T C 12: 84,408,595 (GRCm39) probably null Het
Csmd2 C T 4: 128,356,519 (GRCm39) S1608L Het
Cyp11b2 T A 15: 74,727,837 (GRCm39) R82W probably damaging Het
Cyp2d10 T C 15: 82,289,462 (GRCm39) T217A probably benign Het
Dclk2 C T 3: 86,700,566 (GRCm39) R638H probably damaging Het
Dnah7a T C 1: 53,522,599 (GRCm39) I2880V possibly damaging Het
Dync1h1 C A 12: 110,623,512 (GRCm39) T3595K probably damaging Het
Ecscr T A 18: 35,848,478 (GRCm39) E183V probably damaging Het
Elovl6 A G 3: 129,398,755 (GRCm39) N52S probably benign Het
Eps8l1 G T 7: 4,477,190 (GRCm39) A455S probably benign Het
Gpat2 A G 2: 127,270,209 (GRCm39) N74S probably benign Het
Gstk1 C A 6: 42,226,407 (GRCm39) T172K probably damaging Het
Gtf3c1 T C 7: 125,295,731 (GRCm39) probably null Het
Gucy2c T C 6: 136,705,339 (GRCm39) D532G probably benign Het
Hoxc12 T A 15: 102,845,473 (GRCm39) N62K possibly damaging Het
Hsdl1 C A 8: 120,293,064 (GRCm39) A124S possibly damaging Het
Il11 T C 7: 4,778,995 (GRCm39) Y45C probably damaging Het
Lcat C T 8: 106,666,309 (GRCm39) M404I possibly damaging Het
Ldhb A G 6: 142,447,099 (GRCm39) F72L probably benign Het
Map10 T C 8: 126,398,662 (GRCm39) L685P probably damaging Het
Me2 A G 18: 73,927,961 (GRCm39) V174A probably benign Het
Med13l C A 5: 118,859,991 (GRCm39) Q328K possibly damaging Het
Mta2 A T 19: 8,925,139 (GRCm39) I336F probably damaging Het
Mterf1a A T 5: 3,941,769 (GRCm39) I33N probably damaging Het
Myo15b T A 11: 115,782,324 (GRCm39) probably null Het
Myof C A 19: 37,924,648 (GRCm39) G1215V probably damaging Het
Nlgn2 G A 11: 69,716,516 (GRCm39) T675M probably damaging Het
Or1e26 T A 11: 73,480,463 (GRCm39) M34L probably benign Het
Or5p61 C A 7: 107,758,848 (GRCm39) M77I probably benign Het
Or6c38 T C 10: 128,929,715 (GRCm39) I43V probably damaging Het
Padi3 T C 4: 140,527,435 (GRCm39) D122G probably damaging Het
Pcnx3 G A 19: 5,722,643 (GRCm39) R1350C probably damaging Het
Pdzrn4 C A 15: 92,295,384 (GRCm39) Q197K probably benign Het
Pitpnm2 C T 5: 124,267,324 (GRCm39) G639S possibly damaging Het
Piwil4 T A 9: 14,648,112 (GRCm39) K156* probably null Het
Pkmyt1 T A 17: 23,953,087 (GRCm39) H214Q probably damaging Het
Pnpt1 G A 11: 29,104,867 (GRCm39) R597Q probably benign Het
Poteg C A 8: 27,963,595 (GRCm39) A344E probably benign Het
Rad21l A G 2: 151,509,840 (GRCm39) M87T probably benign Het
Ranbp17 T C 11: 33,424,896 (GRCm39) I487V probably benign Het
Rap1gap2 C A 11: 74,283,057 (GRCm39) R681L probably damaging Het
Rimbp2 C A 5: 128,851,333 (GRCm39) R871L probably damaging Het
Rnf135 T C 11: 80,080,051 (GRCm39) V114A probably benign Het
Skic2 T A 17: 35,060,446 (GRCm39) H849L probably benign Het
Snai2 A G 16: 14,525,028 (GRCm39) H178R possibly damaging Het
Stip1 C T 19: 6,999,178 (GRCm39) G467S possibly damaging Het
Taar1 A T 10: 23,796,809 (GRCm39) E169V possibly damaging Het
Tdrd12 G T 7: 35,187,014 (GRCm39) D625E Het
Tlr6 A G 5: 65,111,119 (GRCm39) V596A probably benign Het
Tsga10 T A 1: 37,879,695 (GRCm39) D32V probably damaging Het
Vmn1r214 A G 13: 23,219,196 (GRCm39) D230G probably damaging Het
Vmn2r108 A G 17: 20,682,762 (GRCm39) L814S probably damaging Het
Zbbx T C 3: 74,989,044 (GRCm39) D353G probably benign Het
Other mutations in Trak2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01410:Trak2 APN 1 58,962,766 (GRCm39) missense probably damaging 1.00
IGL01982:Trak2 APN 1 58,965,814 (GRCm39) missense possibly damaging 0.94
IGL02154:Trak2 APN 1 58,947,888 (GRCm39) missense probably damaging 1.00
IGL02399:Trak2 APN 1 58,949,204 (GRCm39) missense probably benign 0.00
IGL02732:Trak2 APN 1 58,949,222 (GRCm39) missense probably benign 0.19
IGL02734:Trak2 APN 1 58,949,222 (GRCm39) missense probably benign 0.19
IGL03147:Trak2 UTSW 1 58,949,222 (GRCm39) missense probably benign 0.19
P0041:Trak2 UTSW 1 58,949,123 (GRCm39) missense probably damaging 1.00
R0079:Trak2 UTSW 1 58,965,883 (GRCm39) missense probably damaging 1.00
R0791:Trak2 UTSW 1 58,942,820 (GRCm39) missense probably benign
R0792:Trak2 UTSW 1 58,942,820 (GRCm39) missense probably benign
R1099:Trak2 UTSW 1 58,961,000 (GRCm39) missense probably benign 0.05
R1899:Trak2 UTSW 1 58,985,495 (GRCm39) start codon destroyed probably null 0.98
R1903:Trak2 UTSW 1 58,958,014 (GRCm39) splice site probably null
R2292:Trak2 UTSW 1 58,974,916 (GRCm39) missense probably damaging 0.99
R2312:Trak2 UTSW 1 58,974,941 (GRCm39) missense probably damaging 1.00
R3720:Trak2 UTSW 1 58,985,404 (GRCm39) critical splice donor site probably null
R4966:Trak2 UTSW 1 58,958,480 (GRCm39) missense probably damaging 1.00
R5088:Trak2 UTSW 1 58,974,967 (GRCm39) missense probably benign 0.06
R5730:Trak2 UTSW 1 58,960,966 (GRCm39) missense probably damaging 1.00
R5840:Trak2 UTSW 1 58,958,432 (GRCm39) missense probably damaging 1.00
R5981:Trak2 UTSW 1 58,947,849 (GRCm39) missense probably benign 0.01
R6000:Trak2 UTSW 1 58,950,971 (GRCm39) missense possibly damaging 0.71
R6053:Trak2 UTSW 1 58,943,228 (GRCm39) missense possibly damaging 0.62
R6894:Trak2 UTSW 1 58,950,892 (GRCm39) missense probably damaging 1.00
R6916:Trak2 UTSW 1 58,949,184 (GRCm39) missense probably benign 0.06
R7544:Trak2 UTSW 1 58,960,227 (GRCm39) splice site probably null
R7847:Trak2 UTSW 1 58,974,977 (GRCm39) missense possibly damaging 0.88
R7889:Trak2 UTSW 1 58,957,983 (GRCm39) missense probably damaging 1.00
R8039:Trak2 UTSW 1 58,985,447 (GRCm39) missense probably benign 0.16
R8313:Trak2 UTSW 1 58,960,306 (GRCm39) nonsense probably null
R8728:Trak2 UTSW 1 58,974,934 (GRCm39) missense probably benign 0.01
R8930:Trak2 UTSW 1 58,974,967 (GRCm39) missense probably benign
R8932:Trak2 UTSW 1 58,974,967 (GRCm39) missense probably benign
R9263:Trak2 UTSW 1 58,985,481 (GRCm39) missense probably benign 0.01
R9291:Trak2 UTSW 1 58,943,058 (GRCm39) missense probably damaging 1.00
R9404:Trak2 UTSW 1 58,960,296 (GRCm39) missense possibly damaging 0.53
R9670:Trak2 UTSW 1 58,985,463 (GRCm39) nonsense probably null
X0067:Trak2 UTSW 1 58,947,691 (GRCm39) missense probably benign 0.18
Predicted Primers PCR Primer
(F):5'- TCTCTCAAGTTAGGCCGGTC -3'
(R):5'- TTCCTGCAAGAAATGTATGGCTTG -3'

Sequencing Primer
(F):5'- AAGTTAGGCCGGTCTCCACTC -3'
(R):5'- CTCCTGATGTTGGACAGCTGAAG -3'
Posted On 2019-05-15