Incidental Mutation 'R7097:Ces1g'
ID 550563
Institutional Source Beutler Lab
Gene Symbol Ces1g
Ensembl Gene ENSMUSG00000057074
Gene Name carboxylesterase 1G
Synonyms Ses-1, Ces-1, Ces1
MMRRC Submission 045189-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R7097 (G1)
Quality Score 225.009
Status Validated
Chromosome 8
Chromosomal Location 94028997-94063837 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 94043665 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Cysteine at position 425 (G425C)
Ref Sequence ENSEMBL: ENSMUSP00000037555 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044602]
AlphaFold Q8VCC2
Predicted Effect possibly damaging
Transcript: ENSMUST00000044602
AA Change: G425C

PolyPhen 2 Score 0.894 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000037555
Gene: ENSMUSG00000057074
AA Change: G425C

DomainStartEndE-ValueType
Pfam:COesterase 1 545 3.6e-168 PFAM
Pfam:Abhydrolase_3 136 295 5.7e-11 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 99% (75/76)
MGI Phenotype FUNCTION: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This enzyme is the major liver enzyme and functions in liver drug clearance. The expression and activity of this gene is age-related but independent of growth hormone level. This gene is clustered with Ces7 and Ces3 on chromosome 8. [provided by RefSeq, Jun 2010]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik A G 17: 9,224,052 (GRCm39) N435S probably damaging Het
Aip A T 19: 4,165,381 (GRCm39) V195E probably benign Het
Amer3 A T 1: 34,627,869 (GRCm39) I703F probably benign Het
Amfr T C 8: 94,738,637 (GRCm39) E7G probably benign Het
Angel1 A G 12: 86,773,158 (GRCm39) S4P probably damaging Het
Atp2c1 A G 9: 105,341,850 (GRCm39) I146T probably damaging Het
Atp6v0e A G 17: 26,914,390 (GRCm39) T72A probably benign Het
Bahcc1 T C 11: 120,163,472 (GRCm39) V590A possibly damaging Het
Bcl6 A G 16: 23,791,364 (GRCm39) V330A possibly damaging Het
Bcl6 T C 16: 23,791,652 (GRCm39) D234G probably damaging Het
Btaf1 C T 19: 36,926,502 (GRCm39) T58I probably damaging Het
Ccdc175 A T 12: 72,175,183 (GRCm39) probably null Het
Cdca4 C A 12: 112,785,189 (GRCm39) V180L probably benign Het
Chl1 T C 6: 103,683,409 (GRCm39) L745P probably damaging Het
Clec4g T A 8: 3,769,518 (GRCm39) T42S possibly damaging Het
Ctsg A C 14: 56,337,489 (GRCm39) I238S probably damaging Het
Cyb5rl A T 4: 106,944,513 (GRCm39) E41V unknown Het
Dcdc2a A G 13: 25,291,681 (GRCm39) E222G probably benign Het
Dnaaf1 G T 8: 120,323,538 (GRCm39) G509V possibly damaging Het
Dnah5 A G 15: 28,453,410 (GRCm39) I4394V probably benign Het
Dot1l T G 10: 80,626,560 (GRCm39) S1260R probably damaging Het
Dst T G 1: 34,208,341 (GRCm39) I1089S probably damaging Het
Efcab3 A T 11: 104,899,787 (GRCm39) I4350F possibly damaging Het
Eps8l3 A G 3: 107,791,801 (GRCm39) probably null Het
Fam135b A G 15: 71,493,917 (GRCm39) V4A possibly damaging Het
Fnip2 T C 3: 79,388,313 (GRCm39) E806G probably benign Het
Fryl T A 5: 73,231,251 (GRCm39) I1609F probably benign Het
Gdi1 G A X: 73,350,461 (GRCm39) R55H probably benign Het
Gsn A T 2: 35,185,061 (GRCm39) K339* probably null Het
Hecw2 T A 1: 53,904,283 (GRCm39) Y1155F possibly damaging Het
Kif20b T A 19: 34,951,892 (GRCm39) N1723K probably damaging Het
Kif2b T C 11: 91,467,650 (GRCm39) D211G probably benign Het
Lhfpl4 C T 6: 113,153,632 (GRCm39) V140I probably benign Het
Med16 C T 10: 79,739,177 (GRCm39) G203D probably damaging Het
Mrgpra3 T A 7: 47,239,389 (GRCm39) Y179F probably benign Het
Muc6 AGGCGCAGAAACCCTGGC AGGC 7: 141,214,363 (GRCm39) probably null Het
Myo18b A G 5: 113,022,271 (GRCm39) S374P unknown Het
Myoz1 A G 14: 20,699,477 (GRCm39) I287T possibly damaging Het
Ncoa6 T C 2: 155,279,983 (GRCm39) D11G probably benign Het
Nlrp9c A G 7: 26,085,046 (GRCm39) Y178H probably damaging Het
Nmur1 T C 1: 86,315,230 (GRCm39) T212A probably damaging Het
Oacyl A G 18: 65,853,323 (GRCm39) D143G probably benign Het
Obox5 A G 7: 15,492,732 (GRCm39) Y229C probably damaging Het
Or10d1c A T 9: 38,893,914 (GRCm39) M142K probably benign Het
Or1j12 A G 2: 36,342,702 (GRCm39) Y35C probably damaging Het
Or1j18 G T 2: 36,624,436 (GRCm39) M34I probably benign Het
Or1x2 C A 11: 50,918,428 (GRCm39) L200I probably benign Het
Or8c13 A T 9: 38,091,632 (GRCm39) C162* probably null Het
Pcdhb17 A C 18: 37,619,566 (GRCm39) N452T probably benign Het
Pear1 T G 3: 87,658,752 (GRCm39) H901P probably benign Het
Peds1 C G 2: 167,503,398 (GRCm39) A7P probably benign Het
Pi16 A G 17: 29,545,313 (GRCm39) Y192C probably damaging Het
Pip5k1b T G 19: 24,335,424 (GRCm39) E362D probably damaging Het
Pla2g5 T C 4: 138,531,830 (GRCm39) D58G probably damaging Het
Pole T A 5: 110,472,968 (GRCm39) probably null Het
Prdm16 G T 4: 154,429,925 (GRCm39) T348K probably damaging Het
Prkdc T A 16: 15,507,207 (GRCm39) F896I probably damaging Het
Prmt7 T C 8: 106,961,732 (GRCm39) F215S unknown Het
Prss23 T A 7: 89,159,392 (GRCm39) T226S probably damaging Het
Ptpn14 G A 1: 189,595,595 (GRCm39) W739* probably null Het
Rfx5 G T 3: 94,863,850 (GRCm39) G135C probably damaging Het
Scmh1 A G 4: 120,382,252 (GRCm39) H573R probably benign Het
Serpina5 G T 12: 104,068,554 (GRCm39) probably null Het
Sh3rf2 G A 18: 42,237,227 (GRCm39) probably null Het
Slc38a2 T C 15: 96,591,182 (GRCm39) M229V probably damaging Het
Slc6a17 C G 3: 107,400,464 (GRCm39) G222R probably damaging Het
Sp110 C T 1: 85,507,406 (GRCm39) G367D possibly damaging Het
Srcap C A 7: 127,138,213 (GRCm39) L1128M probably damaging Het
Tpra1 T A 6: 88,885,276 (GRCm39) I76N probably damaging Het
Trav6-4 A T 14: 53,692,049 (GRCm39) Y52F probably benign Het
Trp63 C A 16: 25,639,227 (GRCm39) H138Q probably damaging Het
Trub2 A G 2: 29,669,838 (GRCm39) V177A possibly damaging Het
Ugt2a2 T C 5: 87,608,255 (GRCm39) D528G possibly damaging Het
Wnk2 C A 13: 49,256,314 (GRCm39) R269L possibly damaging Het
Zc3h12c T A 9: 52,027,226 (GRCm39) Q731L possibly damaging Het
Other mutations in Ces1g
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00841:Ces1g APN 8 94,029,615 (GRCm39) missense possibly damaging 0.61
IGL00971:Ces1g APN 8 94,029,660 (GRCm39) missense probably damaging 1.00
IGL01583:Ces1g APN 8 94,033,587 (GRCm39) missense probably damaging 1.00
IGL02993:Ces1g APN 8 94,043,707 (GRCm39) missense probably benign 0.00
IGL03386:Ces1g APN 8 94,052,440 (GRCm39) missense probably benign 0.00
R0359:Ces1g UTSW 8 94,055,163 (GRCm39) splice site probably benign
R0373:Ces1g UTSW 8 94,057,821 (GRCm39) missense probably benign 0.06
R0499:Ces1g UTSW 8 94,060,317 (GRCm39) missense probably benign 0.01
R0689:Ces1g UTSW 8 94,055,035 (GRCm39) missense probably damaging 1.00
R1756:Ces1g UTSW 8 94,033,582 (GRCm39) missense probably benign 0.03
R3052:Ces1g UTSW 8 94,061,676 (GRCm39) missense possibly damaging 0.50
R3150:Ces1g UTSW 8 94,052,444 (GRCm39) missense probably benign 0.45
R3899:Ces1g UTSW 8 94,029,678 (GRCm39) missense probably damaging 1.00
R3966:Ces1g UTSW 8 94,055,139 (GRCm39) missense possibly damaging 0.50
R4134:Ces1g UTSW 8 94,046,500 (GRCm39) missense probably benign 0.00
R4198:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.11
R4332:Ces1g UTSW 8 94,046,446 (GRCm39) missense probably benign 0.01
R4719:Ces1g UTSW 8 94,043,718 (GRCm39) missense possibly damaging 0.59
R4841:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4842:Ces1g UTSW 8 94,060,323 (GRCm39) missense probably benign 0.01
R4843:Ces1g UTSW 8 94,057,893 (GRCm39) missense probably damaging 1.00
R5344:Ces1g UTSW 8 94,063,821 (GRCm39) start gained probably benign
R5405:Ces1g UTSW 8 94,032,496 (GRCm39) missense probably benign 0.29
R5425:Ces1g UTSW 8 94,052,428 (GRCm39) missense probably benign 0.20
R5884:Ces1g UTSW 8 94,033,558 (GRCm39) missense probably benign 0.24
R6022:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R6183:Ces1g UTSW 8 94,057,867 (GRCm39) missense possibly damaging 0.48
R6197:Ces1g UTSW 8 94,063,764 (GRCm39) missense probably benign 0.01
R6307:Ces1g UTSW 8 94,057,820 (GRCm39) missense possibly damaging 0.60
R6688:Ces1g UTSW 8 94,033,600 (GRCm39) missense possibly damaging 0.92
R6863:Ces1g UTSW 8 94,043,647 (GRCm39) missense possibly damaging 0.92
R7122:Ces1g UTSW 8 94,043,665 (GRCm39) missense possibly damaging 0.89
R7180:Ces1g UTSW 8 94,029,576 (GRCm39) missense probably benign 0.04
R7202:Ces1g UTSW 8 94,029,595 (GRCm39) missense probably benign 0.01
R7361:Ces1g UTSW 8 94,060,307 (GRCm39) missense not run
R7537:Ces1g UTSW 8 94,046,455 (GRCm39) missense probably benign 0.01
R7621:Ces1g UTSW 8 94,055,094 (GRCm39) missense probably damaging 1.00
R8200:Ces1g UTSW 8 94,055,085 (GRCm39) missense probably damaging 1.00
R8895:Ces1g UTSW 8 94,046,512 (GRCm39) missense possibly damaging 0.83
R9248:Ces1g UTSW 8 94,060,319 (GRCm39) missense possibly damaging 0.62
R9290:Ces1g UTSW 8 94,029,545 (GRCm39) missense probably benign 0.07
R9324:Ces1g UTSW 8 94,055,118 (GRCm39) missense probably damaging 1.00
R9361:Ces1g UTSW 8 94,061,646 (GRCm39) critical splice donor site probably null
R9565:Ces1g UTSW 8 94,061,792 (GRCm39) missense probably benign 0.06
R9615:Ces1g UTSW 8 94,061,807 (GRCm39) missense probably damaging 1.00
Z1176:Ces1g UTSW 8 94,052,439 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- ACCTCCTAGATGAACTTGCATGTG -3'
(R):5'- TCTGGAAAAGCTCCCTTTGC -3'

Sequencing Primer
(F):5'- CTCATAGACACTTACTGGTAGAAGC -3'
(R):5'- CCTTTGCAATACGTAAGGTGGCTAC -3'
Posted On 2019-05-15