Incidental Mutation 'R0595:Tas2r138'
ID 55057
Institutional Source Beutler Lab
Gene Symbol Tas2r138
Ensembl Gene ENSMUSG00000058250
Gene Name taste receptor, type 2, member 138
Synonyms T2R138, mt2r31, Tas2r38
MMRRC Submission 038785-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0595 (G1)
Quality Score 200
Status Validated
Chromosome 6
Chromosomal Location 40589249-40590244 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 40589799 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 149 (L149P)
Ref Sequence ENSEMBL: ENSMUSP00000075876 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076565]
AlphaFold Q7TQA6
Predicted Effect probably damaging
Transcript: ENSMUST00000076565
AA Change: L149P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000075876
Gene: ENSMUSG00000058250
AA Change: L149P

DomainStartEndE-ValueType
Pfam:TAS2R 11 315 3.8e-64 PFAM
Meta Mutation Damage Score 0.8294 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.8%
  • 10x: 97.3%
  • 20x: 94.5%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a T A 5: 8,790,417 (GRCm39) D1093E probably damaging Het
Aldh2 G T 5: 121,711,563 (GRCm39) A276D probably damaging Het
Aldh2 C T 5: 121,711,564 (GRCm39) A276T probably damaging Het
Aldh7a1 C T 18: 56,679,965 (GRCm39) probably benign Het
Ano1 C T 7: 144,143,890 (GRCm39) R964H possibly damaging Het
Apob G A 12: 8,058,369 (GRCm39) V2251I probably benign Het
Atp6v1e1 A G 6: 120,778,091 (GRCm39) V148A probably benign Het
Bbs9 T A 9: 22,408,111 (GRCm39) H73Q probably benign Het
Brca1 A G 11: 101,415,713 (GRCm39) V807A probably benign Het
Cacna1b C T 2: 24,540,001 (GRCm39) probably benign Het
Cadps2 A T 6: 23,321,703 (GRCm39) probably null Het
Cep152 T C 2: 125,436,983 (GRCm39) Q519R probably damaging Het
Cep295 A C 9: 15,243,487 (GRCm39) Y1608* probably null Het
Cfap54 T C 10: 92,720,598 (GRCm39) I2619V unknown Het
Dnajb9 A G 12: 44,255,067 (GRCm39) V7A probably benign Het
Ep400 T C 5: 110,851,408 (GRCm39) K1358R unknown Het
Fbxw7 C A 3: 84,884,674 (GRCm39) probably null Het
Fsip2 T C 2: 82,777,296 (GRCm39) Y108H probably damaging Het
Ggt6 T A 11: 72,328,493 (GRCm39) L331Q probably damaging Het
Ifitm1 T A 7: 140,548,242 (GRCm39) I25N possibly damaging Het
Krt75 C T 15: 101,476,789 (GRCm39) E367K probably damaging Het
Lifr A G 15: 7,206,950 (GRCm39) Y487C probably damaging Het
Map3k6 G T 4: 132,968,574 (GRCm39) G59W probably damaging Het
Mme A G 3: 63,235,602 (GRCm39) T129A probably benign Het
Mmp10 G A 9: 7,508,199 (GRCm39) E442K probably benign Het
Myh13 T C 11: 67,235,672 (GRCm39) S646P probably benign Het
Nbea A T 3: 55,535,917 (GRCm39) I2889N probably benign Het
Nlrp4d T A 7: 10,114,972 (GRCm39) K581N probably benign Het
Nr3c2 C T 8: 77,636,233 (GRCm39) P445S possibly damaging Het
Or5p63 A T 7: 107,810,868 (GRCm39) N289K probably damaging Het
Pck1 T A 2: 172,998,822 (GRCm39) V360E probably damaging Het
Plekha7 T C 7: 115,744,203 (GRCm39) D766G probably damaging Het
Prag1 A G 8: 36,614,156 (GRCm39) N1236S probably damaging Het
Prkdc A C 16: 15,625,952 (GRCm39) Q3326P probably damaging Het
Prrc2b T C 2: 32,073,189 (GRCm39) M57T probably damaging Het
Rb1 A T 14: 73,511,120 (GRCm39) F330I probably damaging Het
Rufy4 A G 1: 74,180,089 (GRCm39) E448G possibly damaging Het
Scn10a T A 9: 119,495,129 (GRCm39) M371L probably benign Het
Sgta T C 10: 80,884,742 (GRCm39) D189G probably damaging Het
Spata31d1b A G 13: 59,864,091 (GRCm39) H413R probably benign Het
Stau2 T C 1: 16,510,674 (GRCm39) T95A probably damaging Het
Supt4a C T 11: 87,633,982 (GRCm39) probably null Het
Tanc2 A G 11: 105,605,003 (GRCm39) probably null Het
Tap2 T A 17: 34,431,328 (GRCm39) V422D probably damaging Het
Tex15 T C 8: 34,062,645 (GRCm39) S692P probably damaging Het
Tgm2 C T 2: 157,984,962 (GRCm39) R48H probably damaging Het
Ticrr T A 7: 79,345,311 (GRCm39) F1725L possibly damaging Het
Tnpo2 T A 8: 85,778,670 (GRCm39) C672* probably null Het
Xkr9 A G 1: 13,771,008 (GRCm39) I175V probably benign Het
Zfp428 T A 7: 24,214,803 (GRCm39) S140T probably benign Het
Other mutations in Tas2r138
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00550:Tas2r138 APN 6 40,589,520 (GRCm39) missense probably benign 0.07
IGL01468:Tas2r138 APN 6 40,589,410 (GRCm39) missense probably benign 0.22
IGL02626:Tas2r138 APN 6 40,589,649 (GRCm39) missense possibly damaging 0.61
IGL03008:Tas2r138 APN 6 40,590,116 (GRCm39) missense probably damaging 1.00
R2845:Tas2r138 UTSW 6 40,589,701 (GRCm39) missense probably benign 0.09
R2975:Tas2r138 UTSW 6 40,590,198 (GRCm39) missense probably benign 0.00
R4202:Tas2r138 UTSW 6 40,589,410 (GRCm39) missense possibly damaging 0.95
R4923:Tas2r138 UTSW 6 40,589,820 (GRCm39) missense possibly damaging 0.82
R5526:Tas2r138 UTSW 6 40,589,914 (GRCm39) missense probably benign 0.00
R6647:Tas2r138 UTSW 6 40,589,733 (GRCm39) missense possibly damaging 0.91
R6869:Tas2r138 UTSW 6 40,589,355 (GRCm39) missense probably damaging 1.00
R8781:Tas2r138 UTSW 6 40,589,850 (GRCm39) missense probably benign 0.00
R8786:Tas2r138 UTSW 6 40,589,611 (GRCm39) missense probably damaging 1.00
R9200:Tas2r138 UTSW 6 40,589,494 (GRCm39) missense probably damaging 1.00
R9258:Tas2r138 UTSW 6 40,590,129 (GRCm39) missense probably damaging 1.00
R9475:Tas2r138 UTSW 6 40,589,392 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GGACAAGCTGCCATCATCCCTATAC -3'
(R):5'- TGCTTCCAGCAGATGAAAGACCC -3'

Sequencing Primer
(F):5'- TTGTGCCATAGCATCAGTAAGG -3'
(R):5'- GATGAAAGACCCACTGAGCC -3'
Posted On 2013-07-11