Incidental Mutation 'R7098:Vmn2r102'
| ID |
550672 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r102
|
| Ensembl Gene |
ENSMUSG00000095961 |
| Gene Name |
vomeronasal 2, receptor 102 |
| Synonyms |
EG224572 |
| MMRRC Submission |
045190-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7098 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
19880661-19915010 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 19914670 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Histidine to Leucine
at position 745
(H745L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126559
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000171741]
|
| AlphaFold |
L7N279 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000171741
AA Change: H745L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000126559
Gene: ENSMUSG00000095961
AA Change: H745L
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
82 |
448 |
5.2e-38 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
1.1e-21 |
PFAM |
|
Pfam:7tm_3
|
595 |
830 |
1.8e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
100% (78/78) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A430033K04Rik |
T |
A |
5: 138,644,784 (GRCm39) |
M223K |
probably benign |
Het |
| Abce1 |
T |
C |
8: 80,412,678 (GRCm39) |
T550A |
probably benign |
Het |
| Acoxl |
C |
T |
2: 127,696,835 (GRCm39) |
Q28* |
probably null |
Het |
| Adam8 |
T |
C |
7: 139,559,412 (GRCm39) |
K820R |
possibly damaging |
Het |
| Adamts3 |
G |
T |
5: 90,009,354 (GRCm39) |
A103D |
probably damaging |
Het |
| Apba2 |
T |
A |
7: 64,386,696 (GRCm39) |
V441D |
probably damaging |
Het |
| Arap2 |
A |
G |
5: 62,833,293 (GRCm39) |
|
probably null |
Het |
| Arhgef10l |
T |
A |
4: 140,308,222 (GRCm39) |
M44L |
probably benign |
Het |
| Asb4 |
T |
C |
6: 5,398,499 (GRCm39) |
C155R |
probably damaging |
Het |
| Bpifb6 |
A |
T |
2: 153,748,810 (GRCm39) |
K269* |
probably null |
Het |
| Cc2d2a |
A |
T |
5: 43,840,481 (GRCm39) |
T161S |
probably benign |
Het |
| Ccdc15 |
T |
A |
9: 37,255,256 (GRCm39) |
Q98L |
probably damaging |
Het |
| Col19a1 |
A |
G |
1: 24,565,555 (GRCm39) |
S259P |
unknown |
Het |
| Col5a2 |
A |
T |
1: 45,419,227 (GRCm39) |
D1284E |
possibly damaging |
Het |
| Cyp2c70 |
T |
C |
19: 40,168,931 (GRCm39) |
T119A |
probably benign |
Het |
| Dennd6b |
C |
T |
15: 89,072,890 (GRCm39) |
C188Y |
probably damaging |
Het |
| Dhx8 |
T |
A |
11: 101,628,594 (GRCm39) |
|
probably null |
Het |
| Dhx9 |
T |
C |
1: 153,340,768 (GRCm39) |
K624R |
probably benign |
Het |
| Dpys |
C |
T |
15: 39,656,727 (GRCm39) |
V447M |
probably damaging |
Het |
| E130308A19Rik |
T |
C |
4: 59,753,004 (GRCm39) |
S706P |
possibly damaging |
Het |
| Esrrb |
A |
G |
12: 86,517,189 (GRCm39) |
D107G |
probably benign |
Het |
| Frmd4a |
T |
C |
2: 4,577,244 (GRCm39) |
S367P |
probably damaging |
Het |
| Garin2 |
G |
A |
12: 78,766,408 (GRCm39) |
|
probably null |
Het |
| Gdi1 |
G |
A |
X: 73,350,461 (GRCm39) |
R55H |
probably benign |
Het |
| Gm136 |
T |
C |
4: 34,746,628 (GRCm39) |
I128V |
probably benign |
Het |
| Gm6525 |
T |
A |
3: 84,082,309 (GRCm39) |
C77S |
possibly damaging |
Het |
| Grid2ip |
T |
C |
5: 143,343,346 (GRCm39) |
F14S |
probably damaging |
Het |
| Hdhd3 |
C |
T |
4: 62,418,152 (GRCm39) |
R8H |
probably damaging |
Het |
| Kdelr1 |
C |
A |
7: 45,523,480 (GRCm39) |
A69D |
possibly damaging |
Het |
| Krtap16-3 |
T |
A |
16: 88,759,560 (GRCm39) |
Y51F |
unknown |
Het |
| Lrrc40 |
T |
A |
3: 157,747,276 (GRCm39) |
N129K |
probably benign |
Het |
| Man1b1 |
T |
A |
2: 25,228,196 (GRCm39) |
D155E |
probably damaging |
Het |
| Mcm5 |
T |
C |
8: 75,847,529 (GRCm39) |
V442A |
probably damaging |
Het |
| Mfsd14a |
C |
T |
3: 116,435,361 (GRCm39) |
A235T |
probably benign |
Het |
| Mmp1a |
C |
A |
9: 7,475,938 (GRCm39) |
T401K |
probably benign |
Het |
| Mpig6b |
C |
T |
17: 35,283,320 (GRCm39) |
R196Q |
unknown |
Het |
| Mroh1 |
C |
T |
15: 76,292,657 (GRCm39) |
Q262* |
probably null |
Het |
| Msh3 |
A |
T |
13: 92,410,619 (GRCm39) |
D656E |
possibly damaging |
Het |
| Muc4 |
A |
T |
16: 32,577,465 (GRCm39) |
T252S |
|
Het |
| Myh15 |
C |
T |
16: 48,997,420 (GRCm39) |
A1746V |
possibly damaging |
Het |
| Myh8 |
C |
A |
11: 67,169,879 (GRCm39) |
T66K |
probably benign |
Het |
| Nemf |
A |
T |
12: 69,359,241 (GRCm39) |
Y999N |
probably damaging |
Het |
| Neurod1 |
T |
C |
2: 79,285,029 (GRCm39) |
N118S |
probably damaging |
Het |
| Nlrp1b |
T |
A |
11: 71,109,100 (GRCm39) |
I134L |
possibly damaging |
Het |
| Nsun7 |
A |
T |
5: 66,418,326 (GRCm39) |
I19F |
probably damaging |
Het |
| Ofcc1 |
A |
G |
13: 40,157,442 (GRCm39) |
|
probably null |
Het |
| P2rx7 |
A |
G |
5: 122,811,856 (GRCm39) |
E389G |
probably damaging |
Het |
| Pam |
C |
T |
1: 97,826,072 (GRCm39) |
R194H |
probably benign |
Het |
| Pcnt |
A |
G |
10: 76,220,673 (GRCm39) |
S2052P |
probably benign |
Het |
| Pfkfb4 |
T |
A |
9: 108,828,222 (GRCm39) |
Y86N |
probably benign |
Het |
| Plcd3 |
T |
A |
11: 102,968,689 (GRCm39) |
D334V |
probably damaging |
Het |
| Ppard |
T |
C |
17: 28,517,787 (GRCm39) |
V285A |
possibly damaging |
Het |
| Prune2 |
A |
G |
19: 17,097,966 (GRCm39) |
S1157G |
probably benign |
Het |
| Psg21 |
A |
T |
7: 18,386,470 (GRCm39) |
L172H |
probably damaging |
Het |
| Psme4 |
C |
A |
11: 30,800,661 (GRCm39) |
T1417K |
probably damaging |
Het |
| Ptprc |
T |
C |
1: 138,027,423 (GRCm39) |
D336G |
probably benign |
Het |
| Ralgapa1 |
A |
T |
12: 55,837,095 (GRCm39) |
|
probably null |
Het |
| Rap1gap |
C |
A |
4: 137,443,393 (GRCm39) |
|
probably null |
Het |
| Scap |
T |
C |
9: 110,201,310 (GRCm39) |
S100P |
possibly damaging |
Het |
| Scpep1 |
T |
C |
11: 88,820,011 (GRCm39) |
I426V |
possibly damaging |
Het |
| Sdk1 |
T |
C |
5: 142,082,625 (GRCm39) |
I1341T |
probably damaging |
Het |
| Sfmbt2 |
T |
A |
2: 10,584,000 (GRCm39) |
Y786N |
probably benign |
Het |
| Sh3tc1 |
A |
T |
5: 35,859,358 (GRCm39) |
|
probably null |
Het |
| Slc5a5 |
T |
A |
8: 71,341,182 (GRCm39) |
I386F |
probably damaging |
Het |
| Smarca4 |
T |
G |
9: 21,546,116 (GRCm39) |
M98R |
probably benign |
Het |
| St18 |
G |
A |
1: 6,898,066 (GRCm39) |
D623N |
probably damaging |
Het |
| Sult2a1 |
A |
T |
7: 13,549,978 (GRCm39) |
|
probably null |
Het |
| Tgfb2 |
C |
T |
1: 186,362,834 (GRCm39) |
R330H |
probably damaging |
Het |
| Thoc3 |
A |
G |
13: 54,614,119 (GRCm39) |
I168T |
probably damaging |
Het |
| Tmem126a |
C |
T |
7: 90,100,062 (GRCm39) |
M160I |
possibly damaging |
Het |
| Tmem200b |
C |
T |
4: 131,649,704 (GRCm39) |
P208L |
probably benign |
Het |
| Tnrc6c |
T |
C |
11: 117,604,952 (GRCm39) |
V29A |
probably benign |
Het |
| Tsc1 |
C |
T |
2: 28,565,744 (GRCm39) |
S465F |
probably benign |
Het |
| Ttll5 |
A |
G |
12: 85,964,447 (GRCm39) |
|
probably null |
Het |
| Unc13d |
G |
T |
11: 115,954,552 (GRCm39) |
L1019I |
probably damaging |
Het |
| Wars2 |
T |
G |
3: 99,123,957 (GRCm39) |
S273A |
probably damaging |
Het |
| Xrcc6 |
C |
A |
15: 81,919,955 (GRCm39) |
S498* |
probably null |
Het |
| Ybx1 |
A |
T |
4: 119,140,050 (GRCm39) |
N92K |
possibly damaging |
Het |
|
| Other mutations in Vmn2r102 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Vmn2r102
|
APN |
17 |
19,899,154 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00974:Vmn2r102
|
APN |
17 |
19,897,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL00978:Vmn2r102
|
APN |
17 |
19,899,185 (GRCm39) |
splice site |
probably null |
|
|
IGL01589:Vmn2r102
|
APN |
17 |
19,899,066 (GRCm39) |
missense |
probably benign |
|
|
IGL01738:Vmn2r102
|
APN |
17 |
19,898,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01994:Vmn2r102
|
APN |
17 |
19,880,731 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02066:Vmn2r102
|
APN |
17 |
19,914,191 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02525:Vmn2r102
|
APN |
17 |
19,901,447 (GRCm39) |
missense |
probably benign |
|
|
IGL02589:Vmn2r102
|
APN |
17 |
19,901,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02814:Vmn2r102
|
APN |
17 |
19,898,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03028:Vmn2r102
|
APN |
17 |
19,914,328 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL03162:Vmn2r102
|
APN |
17 |
19,914,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4431001:Vmn2r102
|
UTSW |
17 |
19,896,958 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R0042:Vmn2r102
|
UTSW |
17 |
19,880,851 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0131:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0132:Vmn2r102
|
UTSW |
17 |
19,899,025 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0268:Vmn2r102
|
UTSW |
17 |
19,898,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0441:Vmn2r102
|
UTSW |
17 |
19,914,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0583:Vmn2r102
|
UTSW |
17 |
19,897,043 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0600:Vmn2r102
|
UTSW |
17 |
19,898,277 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0606:Vmn2r102
|
UTSW |
17 |
19,899,106 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0674:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0709:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0879:Vmn2r102
|
UTSW |
17 |
19,914,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1349:Vmn2r102
|
UTSW |
17 |
19,880,887 (GRCm39) |
splice site |
probably benign |
|
|
R1473:Vmn2r102
|
UTSW |
17 |
19,914,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1630:Vmn2r102
|
UTSW |
17 |
19,899,032 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1727:Vmn2r102
|
UTSW |
17 |
19,897,770 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1759:Vmn2r102
|
UTSW |
17 |
19,914,755 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1809:Vmn2r102
|
UTSW |
17 |
19,897,881 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2013:Vmn2r102
|
UTSW |
17 |
19,897,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R2086:Vmn2r102
|
UTSW |
17 |
19,896,949 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2241:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Vmn2r102
|
UTSW |
17 |
19,914,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3814:Vmn2r102
|
UTSW |
17 |
19,899,093 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3827:Vmn2r102
|
UTSW |
17 |
19,914,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4159:Vmn2r102
|
UTSW |
17 |
19,898,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4505:Vmn2r102
|
UTSW |
17 |
19,880,845 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4515:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4517:Vmn2r102
|
UTSW |
17 |
19,901,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4535:Vmn2r102
|
UTSW |
17 |
19,914,975 (GRCm39) |
missense |
probably benign |
|
|
R4662:Vmn2r102
|
UTSW |
17 |
19,901,424 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4708:Vmn2r102
|
UTSW |
17 |
19,914,576 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4734:Vmn2r102
|
UTSW |
17 |
19,897,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4834:Vmn2r102
|
UTSW |
17 |
19,898,203 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4927:Vmn2r102
|
UTSW |
17 |
19,880,661 (GRCm39) |
start codon destroyed |
probably benign |
0.00 |
|
R5077:Vmn2r102
|
UTSW |
17 |
19,897,834 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5181:Vmn2r102
|
UTSW |
17 |
19,897,003 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5277:Vmn2r102
|
UTSW |
17 |
19,914,393 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5418:Vmn2r102
|
UTSW |
17 |
19,914,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5810:Vmn2r102
|
UTSW |
17 |
19,897,804 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5864:Vmn2r102
|
UTSW |
17 |
19,914,943 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R6168:Vmn2r102
|
UTSW |
17 |
19,914,402 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6266:Vmn2r102
|
UTSW |
17 |
19,899,007 (GRCm39) |
missense |
probably benign |
|
|
R6432:Vmn2r102
|
UTSW |
17 |
19,901,483 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R6487:Vmn2r102
|
UTSW |
17 |
19,898,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6597:Vmn2r102
|
UTSW |
17 |
19,914,450 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6797:Vmn2r102
|
UTSW |
17 |
19,880,694 (GRCm39) |
nonsense |
probably null |
|
|
R7009:Vmn2r102
|
UTSW |
17 |
19,914,456 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7134:Vmn2r102
|
UTSW |
17 |
19,897,749 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7463:Vmn2r102
|
UTSW |
17 |
19,896,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7511:Vmn2r102
|
UTSW |
17 |
19,901,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7512:Vmn2r102
|
UTSW |
17 |
19,914,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7556:Vmn2r102
|
UTSW |
17 |
19,898,093 (GRCm39) |
missense |
probably benign |
|
|
R8126:Vmn2r102
|
UTSW |
17 |
19,880,712 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8385:Vmn2r102
|
UTSW |
17 |
19,914,088 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8410:Vmn2r102
|
UTSW |
17 |
19,898,196 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9045:Vmn2r102
|
UTSW |
17 |
19,880,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9267:Vmn2r102
|
UTSW |
17 |
19,896,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Vmn2r102
|
UTSW |
17 |
19,897,558 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9363:Vmn2r102
|
UTSW |
17 |
19,897,614 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9524:Vmn2r102
|
UTSW |
17 |
19,897,564 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9747:Vmn2r102
|
UTSW |
17 |
19,898,129 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Vmn2r102
|
UTSW |
17 |
19,914,305 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCTATTACTGTGGTCCTTGCC -3'
(R):5'- CTTCCCTTTAGTGCTGTGGTAGAC -3'
Sequencing Primer
(F):5'- GCCTTTAAGGTCAGTTTTCCAG -3'
(R):5'- CAGGAAGAAAGGTAACCCAGACAC -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation