Incidental Mutation 'R7100:Gstcd'
ID 550753
Institutional Source Beutler Lab
Gene Symbol Gstcd
Ensembl Gene ENSMUSG00000028018
Gene Name glutathione S-transferase, C-terminal domain containing
Synonyms 4933434L15Rik
MMRRC Submission 045192-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7100 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 132687513-132797794 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 132790704 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 21 (T21K)
Ref Sequence ENSEMBL: ENSMUSP00000029651 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029651] [ENSMUST00000080583]
AlphaFold Q5RL51
Predicted Effect probably benign
Transcript: ENSMUST00000029651
AA Change: T21K

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000029651
Gene: ENSMUSG00000028018
AA Change: T21K

DomainStartEndE-ValueType
low complexity region 52 62 N/A INTRINSIC
low complexity region 168 181 N/A INTRINSIC
low complexity region 195 205 N/A INTRINSIC
low complexity region 208 229 N/A INTRINSIC
Pfam:GidB 417 515 9e-9 PFAM
Pfam:Methyltransf_32 424 548 1.1e-15 PFAM
Pfam:MTS 430 508 5.3e-6 PFAM
Pfam:Methyltransf_31 440 571 2.6e-11 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000080583
AA Change: T21K

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000079421
Gene: ENSMUSG00000028018
AA Change: T21K

DomainStartEndE-ValueType
low complexity region 52 62 N/A INTRINSIC
low complexity region 168 181 N/A INTRINSIC
low complexity region 195 205 N/A INTRINSIC
low complexity region 208 229 N/A INTRINSIC
Pfam:GidB 418 516 1.5e-8 PFAM
Pfam:Methyltransf_32 424 548 1.1e-15 PFAM
Pfam:Methyltransf_31 440 569 2.5e-11 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actl10 A G 2: 154,394,315 (GRCm39) E89G probably damaging Het
Adgrv1 A T 13: 81,419,016 (GRCm39) V5993E probably damaging Het
Amdhd1 T C 10: 93,372,936 (GRCm39) probably null Het
Amph T C 13: 19,334,011 (GRCm39) *691Q probably null Het
Ankrd55 A G 13: 112,492,644 (GRCm39) K272E probably benign Het
Arhgef10l C T 4: 140,244,126 (GRCm39) V838I possibly damaging Het
Arl2 C A 19: 6,184,774 (GRCm39) V160F probably benign Het
Catsperb T C 12: 101,412,297 (GRCm39) V128A possibly damaging Het
Cdk11b T A 4: 155,710,050 (GRCm39) L17H probably damaging Het
Cpsf1 A T 15: 76,480,314 (GRCm39) N1391K possibly damaging Het
Cpxm2 C T 7: 131,656,544 (GRCm39) A573T probably benign Het
Cspg4b T A 13: 113,455,501 (GRCm39) F516I Het
Daxx T C 17: 34,130,416 (GRCm39) S144P probably damaging Het
Dpp3 T C 19: 4,968,069 (GRCm39) D303G probably damaging Het
Fam181a T A 12: 103,282,132 (GRCm39) N12K probably damaging Het
Flg2 A T 3: 93,111,018 (GRCm39) R1015S unknown Het
Fstl5 A G 3: 76,443,600 (GRCm39) H315R probably benign Het
Fut4 A G 9: 14,662,689 (GRCm39) S202P probably damaging Het
Gm5114 T C 7: 39,057,708 (GRCm39) D637G possibly damaging Het
Heca C T 10: 17,791,121 (GRCm39) V312M probably benign Het
Herpud1 A G 8: 95,117,475 (GRCm39) R144G probably damaging Het
Hycc2 T A 1: 58,573,653 (GRCm39) T384S possibly damaging Het
Ino80 A G 2: 119,204,994 (GRCm39) S1511P possibly damaging Het
Irf2bp2 T C 8: 127,318,472 (GRCm39) T365A probably benign Het
Klk1 G A 7: 43,878,848 (GRCm39) G214E probably damaging Het
Lama3 A T 18: 12,715,701 (GRCm39) N1719I possibly damaging Het
Lmna A G 3: 88,392,297 (GRCm39) I365T probably damaging Het
Lrp8 C A 4: 107,659,647 (GRCm39) A13E possibly damaging Het
Ly75 A G 2: 60,136,778 (GRCm39) L1483P probably benign Het
Maco1 T C 4: 134,533,971 (GRCm39) D550G probably damaging Het
Mid1 A G X: 168,768,073 (GRCm39) D407G probably benign Het
Mpl G T 4: 118,314,607 (GRCm39) A21E Het
Mus81 C T 19: 5,534,239 (GRCm39) G360S probably damaging Het
Nmt2 T A 2: 3,313,950 (GRCm39) S250T probably benign Het
Nr1d1 C A 11: 98,662,160 (GRCm39) R158L probably damaging Het
Pcgf6 G A 19: 47,039,153 (GRCm39) P36S unknown Het
Pcnx2 G A 8: 126,485,853 (GRCm39) A1915V probably benign Het
Peak1 A G 9: 56,166,677 (GRCm39) V417A probably damaging Het
Phf20l1 A G 15: 66,476,689 (GRCm39) N262S probably benign Het
Plaat5 T A 19: 7,616,923 (GRCm39) F313I unknown Het
Ppp2r5d A G 17: 46,996,608 (GRCm39) V355A probably benign Het
Rasa3 T C 8: 13,636,897 (GRCm39) T395A probably benign Het
Rims1 T A 1: 22,416,697 (GRCm39) I432F probably benign Het
Rnf123 C T 9: 107,933,838 (GRCm39) C1080Y probably damaging Het
Serpina3g T C 12: 104,204,570 (GRCm39) probably benign Het
Shank2 T A 7: 143,964,901 (GRCm39) D836E possibly damaging Het
Slc24a5 A C 2: 124,922,591 (GRCm39) S118R probably damaging Het
Smg1 G T 7: 117,783,743 (GRCm39) H1048N unknown Het
Specc1l T G 10: 75,081,329 (GRCm39) S242A probably benign Het
Tagap1 A T 17: 7,224,111 (GRCm39) L195Q possibly damaging Het
Trpc3 C A 3: 36,704,216 (GRCm39) E580D probably benign Het
Ttn A T 2: 76,541,166 (GRCm39) V33940E probably benign Het
Upp2 G T 2: 58,681,817 (GRCm39) R318L probably benign Het
Vezt T A 10: 93,832,795 (GRCm39) E205D probably benign Het
Vmn1r177 A G 7: 23,565,535 (GRCm39) F114L probably benign Het
Vmn2r53 C A 7: 12,315,513 (GRCm39) E769* probably null Het
Vnn3 T C 10: 23,741,840 (GRCm39) Y382H probably damaging Het
Other mutations in Gstcd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01540:Gstcd APN 3 132,692,175 (GRCm39) missense probably damaging 0.96
IGL01800:Gstcd APN 3 132,790,335 (GRCm39) critical splice donor site probably null
IGL02434:Gstcd APN 3 132,701,963 (GRCm39) splice site probably benign
IGL02720:Gstcd APN 3 132,777,722 (GRCm39) missense probably benign 0.00
R0367:Gstcd UTSW 3 132,692,138 (GRCm39) splice site probably benign
R0378:Gstcd UTSW 3 132,692,169 (GRCm39) missense probably damaging 1.00
R0382:Gstcd UTSW 3 132,692,169 (GRCm39) missense probably damaging 1.00
R0465:Gstcd UTSW 3 132,688,905 (GRCm39) missense probably benign 0.04
R1295:Gstcd UTSW 3 132,711,389 (GRCm39) missense probably damaging 1.00
R1861:Gstcd UTSW 3 132,688,868 (GRCm39) missense probably damaging 1.00
R2056:Gstcd UTSW 3 132,787,814 (GRCm39) missense probably benign 0.00
R2331:Gstcd UTSW 3 132,704,641 (GRCm39) missense probably damaging 0.98
R2513:Gstcd UTSW 3 132,788,082 (GRCm39) missense possibly damaging 0.87
R2513:Gstcd UTSW 3 132,788,081 (GRCm39) missense possibly damaging 0.59
R3547:Gstcd UTSW 3 132,790,599 (GRCm39) missense possibly damaging 0.86
R4022:Gstcd UTSW 3 132,787,829 (GRCm39) missense probably damaging 1.00
R4713:Gstcd UTSW 3 132,688,860 (GRCm39) missense probably damaging 1.00
R4877:Gstcd UTSW 3 132,711,314 (GRCm39) splice site probably benign
R5152:Gstcd UTSW 3 132,790,717 (GRCm39) missense possibly damaging 0.95
R5165:Gstcd UTSW 3 132,790,440 (GRCm39) missense probably damaging 0.99
R6106:Gstcd UTSW 3 132,704,675 (GRCm39) missense probably benign 0.02
R6177:Gstcd UTSW 3 132,787,834 (GRCm39) missense probably damaging 1.00
R7264:Gstcd UTSW 3 132,790,540 (GRCm39) missense probably benign 0.00
R7785:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R7786:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R7972:Gstcd UTSW 3 132,777,894 (GRCm39) missense probably benign 0.10
R7975:Gstcd UTSW 3 132,777,863 (GRCm39) missense probably damaging 1.00
R8029:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R8036:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R8088:Gstcd UTSW 3 132,787,868 (GRCm39) missense probably damaging 0.99
R8716:Gstcd UTSW 3 132,688,950 (GRCm39) missense probably damaging 1.00
R8722:Gstcd UTSW 3 132,777,822 (GRCm39) nonsense probably null
R9276:Gstcd UTSW 3 132,777,665 (GRCm39) missense probably damaging 1.00
R9575:Gstcd UTSW 3 132,704,708 (GRCm39) missense probably damaging 1.00
R9789:Gstcd UTSW 3 132,790,357 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCGCCTGCTTTGAAATAACCTG -3'
(R):5'- AGCCATTGTTCAGCCTAGAAG -3'

Sequencing Primer
(F):5'- CAGTGAGGACTAAGCAAAC -3'
(R):5'- GCTTGAAGGCCTATAACC -3'
Posted On 2019-05-15