Incidental Mutation 'R0597:Il16'
ID 55123
Institutional Source Beutler Lab
Gene Symbol Il16
Ensembl Gene ENSMUSG00000001741
Gene Name interleukin 16
Synonyms
MMRRC Submission 038786-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.255) question?
Stock # R0597 (G1)
Quality Score 207
Status Validated
Chromosome 7
Chromosomal Location 83292033-83394934 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to T at 83327183 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000118516 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001792] [ENSMUST00000153560]
AlphaFold O54824
Predicted Effect probably benign
Transcript: ENSMUST00000001792
SMART Domains Protein: ENSMUSP00000001792
Gene: ENSMUSG00000001741

DomainStartEndE-ValueType
low complexity region 76 92 N/A INTRINSIC
low complexity region 99 115 N/A INTRINSIC
PDZ 222 300 6.5e-23 SMART
PDZ 361 438 3.89e-12 SMART
low complexity region 507 526 N/A INTRINSIC
low complexity region 556 577 N/A INTRINSIC
low complexity region 589 602 N/A INTRINSIC
low complexity region 647 680 N/A INTRINSIC
low complexity region 776 787 N/A INTRINSIC
low complexity region 825 839 N/A INTRINSIC
low complexity region 978 989 N/A INTRINSIC
PDZ 1115 1192 3.6e-16 SMART
low complexity region 1201 1216 N/A INTRINSIC
PDZ 1234 1310 4.11e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000153560
SMART Domains Protein: ENSMUSP00000118516
Gene: ENSMUSG00000001741

DomainStartEndE-ValueType
low complexity region 76 92 N/A INTRINSIC
low complexity region 99 115 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.6%
  • 3x: 99.0%
  • 10x: 97.4%
  • 20x: 94.1%
Validation Efficiency 97% (71/73)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a knock-out allele display a transient but consistent increase of thymidine incorporation in anti-CD3-stimulated CD4+ T cells, but fail to show a hyperproliferative T cell phenotype using BrdU labeling. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy10 T C 1: 165,352,631 (GRCm39) probably null Het
Anxa11 T C 14: 25,874,652 (GRCm39) I221T probably damaging Het
Arhgap33 C G 7: 30,225,871 (GRCm39) R565P probably damaging Het
Bmpr2 T C 1: 59,880,584 (GRCm39) probably benign Het
Btn2a2 T A 13: 23,670,580 (GRCm39) H51L probably benign Het
Casz1 T C 4: 149,028,851 (GRCm39) S1099P probably benign Het
Cnot4 A G 6: 35,028,438 (GRCm39) S393P possibly damaging Het
Cntnap5a T C 1: 116,112,191 (GRCm39) probably benign Het
Cobl T C 11: 12,204,699 (GRCm39) T586A probably benign Het
Crocc T C 4: 140,747,224 (GRCm39) K1528R probably benign Het
Crocc A G 4: 140,744,382 (GRCm39) L1838P probably benign Het
Dact2 A G 17: 14,417,303 (GRCm39) V299A probably benign Het
Dapk1 C A 13: 60,909,198 (GRCm39) N1270K probably benign Het
Ddx41 T C 13: 55,680,819 (GRCm39) Y375C probably damaging Het
Dock5 T A 14: 68,022,383 (GRCm39) probably null Het
Dyrk4 T G 6: 126,863,612 (GRCm39) probably null Het
Eno1b T C 18: 48,180,806 (GRCm39) I328T probably benign Het
Fam210b A G 2: 172,187,773 (GRCm39) probably benign Het
Fbxl13 A G 5: 21,819,712 (GRCm39) I229T probably benign Het
Fbxo39 A G 11: 72,207,747 (GRCm39) D33G probably damaging Het
Fbxw11 A G 11: 32,670,496 (GRCm39) E120G probably damaging Het
Fbxw2 A T 2: 34,701,032 (GRCm39) L261Q probably damaging Het
Gm5800 A C 14: 51,953,461 (GRCm39) N51K probably benign Het
Gm6899 A G 11: 26,543,768 (GRCm39) probably benign Het
Gpx8 T C 13: 113,182,035 (GRCm39) T133A possibly damaging Het
Grin3a C T 4: 49,665,351 (GRCm39) V1095M probably damaging Het
Grip2 T C 6: 91,773,178 (GRCm39) probably benign Het
Hacd4 A G 4: 88,355,757 (GRCm39) F43L probably damaging Het
Hif1a T G 12: 73,989,049 (GRCm39) S645R probably benign Het
Hipk3 A G 2: 104,263,982 (GRCm39) S839P possibly damaging Het
Idi2l C A 13: 8,990,802 (GRCm39) probably benign Het
Il3ra T A 14: 14,351,166 (GRCm38) probably null Het
Il5ra A G 6: 106,721,296 (GRCm39) M1T probably null Het
Klra2 G A 6: 131,197,148 (GRCm39) R251C probably benign Het
Lamc2 C T 1: 153,009,367 (GRCm39) V813M probably benign Het
Lbr A G 1: 181,659,778 (GRCm39) V139A probably benign Het
Lrp5 T C 19: 3,650,777 (GRCm39) D1219G possibly damaging Het
Map3k6 C T 4: 132,972,863 (GRCm39) P341S possibly damaging Het
Mcts2 A G 2: 152,529,609 (GRCm39) E140G probably benign Het
Med1 T C 11: 98,060,264 (GRCm39) M222V probably benign Het
Mef2a G T 7: 66,884,896 (GRCm39) S406* probably null Het
Muc19 A T 15: 91,784,696 (GRCm39) noncoding transcript Het
Nr1h2 A G 7: 44,201,684 (GRCm39) probably benign Het
Or13j1 A T 4: 43,706,592 (GRCm39) probably null Het
Or2w6 C A 13: 21,843,316 (GRCm39) R59L probably damaging Het
Or56a42-ps1 A G 7: 104,777,425 (GRCm39) V73A possibly damaging Het
Or5ac23 A T 16: 59,149,123 (GRCm39) F250I probably damaging Het
P4hb G A 11: 120,459,070 (GRCm39) T141I possibly damaging Het
Polr3a A G 14: 24,534,202 (GRCm39) V101A probably benign Het
Pou4f2 A G 8: 79,161,869 (GRCm39) S245P probably benign Het
Pramel26 G T 4: 143,539,222 (GRCm39) N90K probably damaging Het
Rnpep A G 1: 135,200,157 (GRCm39) V266A probably damaging Het
Scly G A 1: 91,237,555 (GRCm39) G206R probably damaging Het
Sec14l3 A T 11: 4,024,814 (GRCm39) K254N probably damaging Het
Sgpp1 A T 12: 75,781,874 (GRCm39) I155N probably damaging Het
Slc22a14 A G 9: 119,001,190 (GRCm39) L468P probably damaging Het
Slc22a27 A G 19: 7,843,249 (GRCm39) F377L probably benign Het
Slc44a3 T C 3: 121,253,719 (GRCm39) I625V probably benign Het
Slc47a2 A T 11: 61,200,802 (GRCm39) I373N probably damaging Het
Slfn10-ps A T 11: 82,926,479 (GRCm39) noncoding transcript Het
Smarcd1 T A 15: 99,608,975 (GRCm39) I383N probably damaging Het
Sort1 A G 3: 108,246,226 (GRCm39) D401G probably damaging Het
Sprr2a3 G T 3: 92,195,897 (GRCm39) M1I probably null Het
Sycp2 A C 2: 177,998,373 (GRCm39) V1049G possibly damaging Het
Tecrl T A 5: 83,502,775 (GRCm39) K10* probably null Het
Tnpo3 A T 6: 29,578,564 (GRCm39) C303* probably null Het
Vmn2r23 A G 6: 123,706,680 (GRCm39) I503M probably benign Het
Zbtb8os T A 4: 129,240,670 (GRCm39) I164N probably damaging Het
Zfp292 T C 4: 34,807,399 (GRCm39) N1882D probably benign Het
Zfp91 T C 19: 12,747,459 (GRCm39) I555V possibly damaging Het
Other mutations in Il16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00427:Il16 APN 7 83,301,666 (GRCm39) missense probably benign 0.02
IGL01743:Il16 APN 7 83,301,507 (GRCm39) missense probably benign 0.00
IGL01770:Il16 APN 7 83,322,234 (GRCm39) splice site probably benign
IGL02025:Il16 APN 7 83,302,056 (GRCm39) missense probably damaging 1.00
IGL02317:Il16 APN 7 83,316,097 (GRCm39) missense probably damaging 1.00
IGL02412:Il16 APN 7 83,301,899 (GRCm39) missense probably benign 0.03
IGL02550:Il16 APN 7 83,323,704 (GRCm39) missense possibly damaging 0.90
IGL02568:Il16 APN 7 83,310,484 (GRCm39) missense probably damaging 1.00
IGL02578:Il16 APN 7 83,327,194 (GRCm39) critical splice donor site probably null
IGL02815:Il16 APN 7 83,300,249 (GRCm39) missense probably damaging 0.98
IGL03157:Il16 APN 7 83,371,611 (GRCm39) missense probably damaging 1.00
IGL03161:Il16 APN 7 83,371,707 (GRCm39) missense probably damaging 1.00
IGL03188:Il16 APN 7 83,337,371 (GRCm39) missense probably benign 0.00
IGL03213:Il16 APN 7 83,295,708 (GRCm39) missense probably damaging 1.00
IGL03274:Il16 APN 7 83,310,442 (GRCm39) missense probably damaging 1.00
R0201:Il16 UTSW 7 83,371,516 (GRCm39) missense probably damaging 0.99
R0309:Il16 UTSW 7 83,371,762 (GRCm39) missense probably damaging 1.00
R0942:Il16 UTSW 7 83,312,349 (GRCm39) missense probably benign 0.01
R1018:Il16 UTSW 7 83,323,746 (GRCm39) missense probably damaging 1.00
R1434:Il16 UTSW 7 83,304,520 (GRCm39) missense probably benign
R1715:Il16 UTSW 7 83,297,936 (GRCm39) missense probably benign 0.01
R2179:Il16 UTSW 7 83,337,287 (GRCm39) splice site probably null
R2520:Il16 UTSW 7 83,301,202 (GRCm39) missense probably benign 0.03
R3425:Il16 UTSW 7 83,293,248 (GRCm39) missense probably damaging 1.00
R3761:Il16 UTSW 7 83,300,093 (GRCm39) missense possibly damaging 0.96
R3943:Il16 UTSW 7 83,301,223 (GRCm39) missense probably damaging 0.97
R4470:Il16 UTSW 7 83,300,046 (GRCm39) intron probably benign
R4530:Il16 UTSW 7 83,330,518 (GRCm39) intron probably benign
R4583:Il16 UTSW 7 83,332,107 (GRCm39) missense probably damaging 1.00
R4777:Il16 UTSW 7 83,300,104 (GRCm39) missense probably benign 0.14
R4874:Il16 UTSW 7 83,310,153 (GRCm39) missense possibly damaging 0.56
R4876:Il16 UTSW 7 83,322,302 (GRCm39) missense probably benign
R5677:Il16 UTSW 7 83,323,761 (GRCm39) missense probably damaging 1.00
R5686:Il16 UTSW 7 83,297,936 (GRCm39) missense probably benign 0.36
R5920:Il16 UTSW 7 83,301,552 (GRCm39) missense probably benign 0.03
R6115:Il16 UTSW 7 83,301,775 (GRCm39) nonsense probably null
R6459:Il16 UTSW 7 83,371,536 (GRCm39) missense probably damaging 1.00
R6459:Il16 UTSW 7 83,371,529 (GRCm39) missense probably damaging 1.00
R6601:Il16 UTSW 7 83,371,677 (GRCm39) missense probably damaging 1.00
R6616:Il16 UTSW 7 83,295,684 (GRCm39) missense probably benign 0.37
R6642:Il16 UTSW 7 83,337,335 (GRCm39) missense probably benign 0.03
R6721:Il16 UTSW 7 83,312,270 (GRCm39) critical splice donor site probably null
R7009:Il16 UTSW 7 83,295,596 (GRCm39) missense probably benign
R7144:Il16 UTSW 7 83,295,659 (GRCm39) missense probably damaging 0.97
R7346:Il16 UTSW 7 83,293,249 (GRCm39) missense probably damaging 1.00
R7403:Il16 UTSW 7 83,319,343 (GRCm39) missense probably damaging 1.00
R7499:Il16 UTSW 7 83,323,702 (GRCm39) missense probably damaging 0.99
R7814:Il16 UTSW 7 83,319,348 (GRCm39) missense possibly damaging 0.46
R7941:Il16 UTSW 7 83,332,037 (GRCm39) missense probably damaging 0.98
R8098:Il16 UTSW 7 83,295,767 (GRCm39) missense probably damaging 1.00
R8317:Il16 UTSW 7 83,304,538 (GRCm39) missense probably benign
R8437:Il16 UTSW 7 83,301,351 (GRCm39) missense probably damaging 1.00
R9094:Il16 UTSW 7 83,301,559 (GRCm39) missense probably benign
R9267:Il16 UTSW 7 83,371,757 (GRCm39) missense probably benign 0.01
R9445:Il16 UTSW 7 83,337,380 (GRCm39) nonsense probably null
R9595:Il16 UTSW 7 83,322,273 (GRCm39) nonsense probably null
R9651:Il16 UTSW 7 83,332,064 (GRCm39) missense probably damaging 0.96
Z1176:Il16 UTSW 7 83,302,035 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TCCCAGAAATTGAACAGGGGCAC -3'
(R):5'- CAAGCTGCCCATGAACTACTCTTCC -3'

Sequencing Primer
(F):5'- GGCTGACAACAGCACCTG -3'
(R):5'- TAAGCTCTGAAACTCTGGGAC -3'
Posted On 2013-07-11