Incidental Mutation 'R7109:Or4d10'
ID 551424
Institutional Source Beutler Lab
Gene Symbol Or4d10
Ensembl Gene ENSMUSG00000067526
Gene Name olfactory receptor family 4 subfamily D member 10
Synonyms MOR239-7, GA_x6K02T2RE5P-2433425-2432490, Olfr1425
MMRRC Submission 045201-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R7109 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 12051059-12051994 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 12051576 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 140 (I140T)
Ref Sequence ENSEMBL: ENSMUSP00000151154 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087828] [ENSMUST00000214918]
AlphaFold K7N659
Predicted Effect probably benign
Transcript: ENSMUST00000087828
AA Change: I141T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000085130
Gene: ENSMUSG00000067526
AA Change: I141T

DomainStartEndE-ValueType
Pfam:7tm_4 30 303 9.3e-48 PFAM
Pfam:7tm_1 40 286 8.8e-22 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214918
AA Change: I140T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T G 2: 151,315,673 (GRCm39) K2Q probably damaging Het
Abtb2 T C 2: 103,545,860 (GRCm39) Y903H probably benign Het
Adamtsl3 C T 7: 82,261,069 (GRCm39) P29S Het
Alcam T A 16: 52,097,192 (GRCm39) T355S probably damaging Het
Anapc1 A G 2: 128,516,522 (GRCm39) V404A probably benign Het
Bst2 A G 8: 71,989,926 (GRCm39) F49S possibly damaging Het
C1qtnf9 G C 14: 61,017,019 (GRCm39) W183S probably benign Het
Camsap3 A G 8: 3,648,087 (GRCm39) I132V possibly damaging Het
Cchcr1 T A 17: 35,828,838 (GRCm39) probably null Het
Cenpk A G 13: 104,367,256 (GRCm39) K31E probably benign Het
Cfap221 T C 1: 119,853,301 (GRCm39) K798E possibly damaging Het
Copb2 T A 9: 98,463,333 (GRCm39) probably null Het
Dennd1a T A 2: 37,938,804 (GRCm39) Y102F probably damaging Het
Eif2ak4 C T 2: 118,235,532 (GRCm39) P88S probably damaging Het
Epha6 C A 16: 59,503,031 (GRCm39) V959F probably damaging Het
Fam193a C A 5: 34,623,165 (GRCm39) T1251K possibly damaging Het
Herc1 A T 9: 66,389,171 (GRCm39) Q3896L probably benign Het
Ikbip C A 10: 90,919,090 (GRCm39) D34E probably benign Het
Insr A G 8: 3,308,481 (GRCm39) V185A probably benign Het
Jakmip1 C T 5: 37,332,109 (GRCm39) Q930* probably null Het
Klc1 A G 12: 111,743,299 (GRCm39) I209V probably benign Het
Lrrk2 T A 15: 91,648,985 (GRCm39) L1660M probably damaging Het
Mbd3l1 G T 9: 18,396,210 (GRCm39) D112Y possibly damaging Het
Mrps2 T A 2: 28,358,258 (GRCm39) V16E probably benign Het
Ncoa1 G A 12: 4,372,978 (GRCm39) T141I possibly damaging Het
Ndst2 G T 14: 20,779,911 (GRCm39) R110S probably damaging Het
Nlrp2 A G 7: 5,331,616 (GRCm39) V260A probably damaging Het
Or51a6 A T 7: 102,604,460 (GRCm39) V116E probably damaging Het
Or5p1 A G 7: 107,916,959 (GRCm39) N286S probably damaging Het
Or7g16 A T 9: 18,726,904 (GRCm39) S229T probably benign Het
Pah T C 10: 87,406,148 (GRCm39) V262A probably damaging Het
Pcnt T G 10: 76,205,738 (GRCm39) E2538A probably damaging Het
Pdxk T A 10: 78,282,810 (GRCm39) I162F probably damaging Het
Plod2 T C 9: 92,455,650 (GRCm39) F110L probably damaging Het
Pm20d2 A T 4: 33,187,186 (GRCm39) L154Q probably damaging Het
Podxl2 C T 6: 88,820,566 (GRCm39) V445I possibly damaging Het
Ppp1r3a A T 6: 14,719,235 (GRCm39) W560R probably benign Het
Rasal3 A G 17: 32,611,683 (GRCm39) S815P probably damaging Het
Rdm1 A G 11: 101,524,654 (GRCm39) K196E probably damaging Het
Rsf1 CG CGACGGCGGGG 7: 97,229,115 (GRCm39) probably benign Het
Scn1a T C 2: 66,181,286 (GRCm39) D79G possibly damaging Het
Slc22a21 A G 11: 53,870,329 (GRCm39) Y119H possibly damaging Het
Stip1 C T 19: 6,999,178 (GRCm39) G467S possibly damaging Het
Synrg C A 11: 83,930,498 (GRCm39) A1280E possibly damaging Het
Szt2 A G 4: 118,232,676 (GRCm39) C2396R unknown Het
Trappc3 A G 4: 126,167,726 (GRCm39) N95S probably benign Het
Tulp4 C T 17: 6,282,055 (GRCm39) H695Y probably damaging Het
Ush2a T A 1: 188,113,681 (GRCm39) D633E probably benign Het
Wasl G A 6: 24,633,186 (GRCm39) P151S probably benign Het
Wwp2 A G 8: 108,209,988 (GRCm39) N122S probably benign Het
Zfp51 A G 17: 21,683,831 (GRCm39) R149G possibly damaging Het
Zfp764 A G 7: 127,003,887 (GRCm39) S415P possibly damaging Het
Other mutations in Or4d10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01936:Or4d10 APN 19 12,051,421 (GRCm39) missense probably benign 0.00
IGL02508:Or4d10 APN 19 12,051,251 (GRCm39) missense possibly damaging 0.90
IGL03183:Or4d10 APN 19 12,051,392 (GRCm39) missense probably damaging 0.98
R1164:Or4d10 UTSW 19 12,051,605 (GRCm39) nonsense probably null
R1866:Or4d10 UTSW 19 12,051,183 (GRCm39) missense probably benign 0.03
R3745:Or4d10 UTSW 19 12,051,744 (GRCm39) missense probably damaging 1.00
R4364:Or4d10 UTSW 19 12,051,861 (GRCm39) missense probably benign 0.13
R4888:Or4d10 UTSW 19 12,051,679 (GRCm39) missense probably damaging 1.00
R4962:Or4d10 UTSW 19 12,051,639 (GRCm39) missense probably damaging 1.00
R5954:Or4d10 UTSW 19 12,051,447 (GRCm39) missense possibly damaging 0.96
R6383:Or4d10 UTSW 19 12,051,727 (GRCm39) missense probably damaging 1.00
R6409:Or4d10 UTSW 19 12,052,111 (GRCm39) start gained probably benign
R6417:Or4d10 UTSW 19 12,051,324 (GRCm39) missense probably benign 0.18
R6420:Or4d10 UTSW 19 12,051,324 (GRCm39) missense probably benign 0.18
R7446:Or4d10 UTSW 19 12,051,061 (GRCm39) makesense probably null
R7505:Or4d10 UTSW 19 12,051,969 (GRCm39) missense possibly damaging 0.88
R9689:Or4d10 UTSW 19 12,051,567 (GRCm39) missense possibly damaging 0.90
Z1176:Or4d10 UTSW 19 12,051,274 (GRCm39) missense probably damaging 1.00
Z1176:Or4d10 UTSW 19 12,051,204 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GACCATGTAGGACACCAGTAAC -3'
(R):5'- TGGTGGACCTTCTCTCAGAC -3'

Sequencing Primer
(F):5'- CCATAGTGTGGTGAGCATTCC -3'
(R):5'- GTGGACCTTCTCTCAGACAGAAAG -3'
Posted On 2019-05-15