Mutagenetix > Incidental Mutation

Incidental Mutation 'R7116:Or11g25'

551795

Institutional Source

Beutler Lab

Gene Symbol

Or11g25

Ensembl Gene

ENSMUSG00000095765

Gene Name

olfactory receptor family 11 subfamily G member 25

Synonyms

MOR106-15, MOR106-10, Olfr741, GA_x6K02T2PMLR-6197851-6198786

MMRRC Submission

045207-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.093) question?

Stock #

R7116 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

50710514-50723852 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 50723025 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 37 (I37F)

Ref Sequence

ENSEMBL: ENSMUSP00000145848 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071932] [ENSMUST00000205518] [ENSMUST00000213903]

AlphaFold

L7N1Y5

Predicted Effect

probably benign
Transcript: ENSMUST00000071932
AA Change: I37F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000071824
Gene: ENSMUSG00000095765
AA Change: I37F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	1.2e-55	PFAM
Pfam:7tm_1	45	294	2.4e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000205518
AA Change: I37F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

Predicted Effect

probably benign
Transcript: ENSMUST00000213903
AA Change: I37F

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn1	A	G	12: 80,251,751 (GRCm39)	S109P	probably damaging	Het
Afg3l1	T	G	8: 124,216,601 (GRCm39)	L280R	probably damaging	Het
Akap13	T	A	7: 75,369,943 (GRCm39)	S129T	probably benign	Het
Ankrd11	A	G	8: 123,622,869 (GRCm39)	S328P	probably damaging	Het
Aox3	A	T	1: 58,192,689 (GRCm39)	E554D	probably benign	Het
Bcl11a	T	C	11: 24,113,839 (GRCm39)	V394A	probably damaging	Het
Cass4	A	G	2: 172,269,889 (GRCm39)	Y657C	unknown	Het
Ccdc88a	C	T	11: 29,454,051 (GRCm39)	A1738V	probably benign	Het
Cfap74	T	C	4: 155,539,518 (GRCm39)	F948L	unknown	Het
Chgb	A	T	2: 132,623,237 (GRCm39)		probably benign	Het
Coro1c	C	T	5: 113,990,267 (GRCm39)	W138*	probably null	Het
Dgkb	A	G	12: 38,031,989 (GRCm39)	Q17R	probably benign	Het
Esco2	A	G	14: 66,064,006 (GRCm39)	Y393H	probably damaging	Het
Eya3	T	A	4: 132,422,110 (GRCm39)	D228E	probably benign	Het
Fat2	T	C	11: 55,173,162 (GRCm39)	D2517G	probably damaging	Het
Fry	T	A	5: 150,319,334 (GRCm39)		probably null	Het
Gal3st2b	A	T	1: 93,868,498 (GRCm39)	Q243L	possibly damaging	Het
Gimap9	C	T	6: 48,654,989 (GRCm39)	A192V	probably benign	Het
Glg1	T	A	8: 111,905,589 (GRCm39)	Q564L	probably benign	Het
H2-Aa	A	T	17: 34,502,601 (GRCm39)	Y188*	probably null	Het
Hira	T	C	16: 18,730,864 (GRCm39)	Y188H	probably damaging	Het
Ighv8-8	C	T	12: 115,257,814 (GRCm39)	D76N	probably benign	Het
Irf6	T	C	1: 192,849,905 (GRCm39)	F276L	probably damaging	Het
Itpr1	T	C	6: 108,458,229 (GRCm39)	C2000R	probably damaging	Het
Jakmip3	T	C	7: 138,621,979 (GRCm39)	V293A	possibly damaging	Het
Kcnh7	A	G	2: 62,707,614 (GRCm39)	V132A	probably benign	Het
Kcnj1	A	G	9: 32,308,277 (GRCm39)	T234A	possibly damaging	Het
Kpna3	T	A	14: 61,605,635 (GRCm39)	N470I	probably benign	Het
Lamb2	T	C	9: 108,364,522 (GRCm39)	F1121L	probably damaging	Het
Lingo1	T	C	9: 56,527,911 (GRCm39)	D232G	probably benign	Het
Lpxn	T	A	19: 12,788,622 (GRCm39)	N70K	probably benign	Het
Ltbp4	T	A	7: 27,004,852 (GRCm39)	H1657L	probably damaging	Het
Luzp2	C	A	7: 54,915,078 (GRCm39)	F334L	possibly damaging	Het
Mgat5b	A	T	11: 116,835,785 (GRCm39)	S142C	possibly damaging	Het
Mroh7	G	A	4: 106,568,517 (GRCm39)	T396I	probably benign	Het
Muc5b	T	C	7: 141,417,487 (GRCm39)	S3478P	probably benign	Het
Nfatc2	A	T	2: 168,349,269 (GRCm39)	M626K	probably benign	Het
Nlrp14	A	G	7: 106,782,255 (GRCm39)	D484G	possibly damaging	Het
Npc1	T	C	18: 12,344,601 (GRCm39)	Y423C	probably damaging	Het
Nrsn1	A	G	13: 25,437,388 (GRCm39)	I180T	probably damaging	Het
Or51a8	T	A	7: 102,549,842 (GRCm39)	N89K	probably benign	Het
Osbpl6	A	T	2: 76,426,225 (GRCm39)	I935F	probably benign	Het
Otog	T	C	7: 45,947,689 (GRCm39)	F96L	probably damaging	Het
Pde1b	T	C	15: 103,436,745 (GRCm39)	L534P	possibly damaging	Het
Pdzd8	C	T	19: 59,288,125 (GRCm39)	E1092K	probably damaging	Het
Pfkl	T	C	10: 77,837,249 (GRCm39)	H108R	probably benign	Het
Pkhd1l1	G	A	15: 44,421,372 (GRCm39)	V3047I	probably benign	Het
Plag1	A	T	4: 3,904,812 (GRCm39)	C126*	probably null	Het
Pphln1	T	A	15: 93,353,406 (GRCm39)	S229T	probably benign	Het
Pramel5	C	T	4: 144,000,451 (GRCm39)	D42N	possibly damaging	Het
Psd3	A	G	8: 68,166,390 (GRCm39)	V915A	probably benign	Het
Ptdss1	T	A	13: 67,093,391 (GRCm39)	I77N	probably benign	Het
Rsbn1	T	A	3: 103,821,892 (GRCm39)	C3*	probably null	Het
Shank1	C	T	7: 43,976,585 (GRCm39)	A561V	unknown	Het
Stip1	C	T	19: 6,999,178 (GRCm39)	G467S	possibly damaging	Het
Sv2c	A	T	13: 96,113,152 (GRCm39)	V599E	probably damaging	Het
Vmn2r37	T	C	7: 9,220,898 (GRCm39)	T322A	probably benign	Het
Vmn2r60	T	A	7: 41,786,487 (GRCm39)	M430K	probably benign	Het
Wipf3	T	A	6: 54,458,904 (GRCm39)		probably null	Het

Other mutations in Or11g25

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01773:Or11g25	APN	14	50,723,230 (GRCm39)	missense	probably damaging	0.98
IGL01796:Or11g25	APN	14	50,722,998 (GRCm39)	missense	probably benign	0.28
IGL01916:Or11g25	APN	14	50,722,950 (GRCm39)	missense	probably benign	0.01
IGL02686:Or11g25	APN	14	50,723,426 (GRCm39)	missense	probably benign	0.01
IGL02874:Or11g25	APN	14	50,723,686 (GRCm39)	missense	possibly damaging	0.57
IGL02898:Or11g25	APN	14	50,723,643 (GRCm39)	missense	probably damaging	1.00
PIT4515001:Or11g25	UTSW	14	50,723,536 (GRCm39)	missense	probably benign	0.03
R0085:Or11g25	UTSW	14	50,723,791 (GRCm39)	missense	probably benign	0.16
R1777:Or11g25	UTSW	14	50,723,757 (GRCm39)	missense	probably benign	0.08
R1850:Or11g25	UTSW	14	50,723,055 (GRCm39)	missense	probably benign
R2270:Or11g25	UTSW	14	50,723,494 (GRCm39)	missense	probably damaging	1.00
R2338:Or11g25	UTSW	14	50,723,097 (GRCm39)	missense	possibly damaging	0.47
R2971:Or11g25	UTSW	14	50,723,065 (GRCm39)	missense	probably damaging	0.99
R4594:Or11g25	UTSW	14	50,723,619 (GRCm39)	missense	probably benign	0.00
R5383:Or11g25	UTSW	14	50,723,509 (GRCm39)	nonsense	probably null
R5708:Or11g25	UTSW	14	50,723,452 (GRCm39)	missense	probably damaging	1.00
R6038:Or11g25	UTSW	14	50,723,677 (GRCm39)	missense	probably damaging	1.00
R6038:Or11g25	UTSW	14	50,723,677 (GRCm39)	missense	probably damaging	1.00
R7702:Or11g25	UTSW	14	50,723,751 (GRCm39)	missense	possibly damaging	0.79
R8169:Or11g25	UTSW	14	50,723,692 (GRCm39)	missense	probably benign	0.13
R9040:Or11g25	UTSW	14	50,722,995 (GRCm39)	missense	probably benign	0.00
R9139:Or11g25	UTSW	14	50,723,707 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- TCCAGTGGTCAGAAAACTTCCTAG -3'
(R):5'- GTGTCTGAAAGGAAGTTGGCC -3'

Sequencing Primer
(F):5'- GATGAGGAAACTACTCTGTGTCC -3'
(R):5'- GGAAGTTGGCCAACATGTTG -3'

Posted On

2019-05-15