Incidental Mutation 'R7133:Ctnnd2'
ID |
552856 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Ctnnd2
|
Ensembl Gene |
ENSMUSG00000022240 |
Gene Name |
catenin delta 2 |
Synonyms |
Nprap, Catnd2, neurojugin, catenin (cadherin associated protein), delta 2 |
MMRRC Submission |
045218-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R7133 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
15 |
Chromosomal Location |
30172739-31029487 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 30480995 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glycine
at position 81
(E81G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000080427
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000081728]
[ENSMUST00000226116]
[ENSMUST00000226119]
[ENSMUST00000228282]
|
AlphaFold |
no structure available at present |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000081728
AA Change: E81G
PolyPhen 2
Score 0.471 (Sensitivity: 0.89; Specificity: 0.90)
|
SMART Domains |
Protein: ENSMUSP00000080427 Gene: ENSMUSG00000022240 AA Change: E81G
Domain | Start | End | E-Value | Type |
coiled coil region
|
50 |
84 |
N/A |
INTRINSIC |
low complexity region
|
87 |
97 |
N/A |
INTRINSIC |
low complexity region
|
148 |
159 |
N/A |
INTRINSIC |
low complexity region
|
216 |
230 |
N/A |
INTRINSIC |
low complexity region
|
238 |
257 |
N/A |
INTRINSIC |
ARM
|
577 |
617 |
1.85e-8 |
SMART |
ARM
|
621 |
662 |
1.15e-9 |
SMART |
ARM
|
663 |
720 |
1.51e1 |
SMART |
ARM
|
722 |
769 |
2.74e1 |
SMART |
ARM
|
830 |
871 |
4.88e0 |
SMART |
ARM
|
902 |
942 |
2.76e-7 |
SMART |
low complexity region
|
964 |
973 |
N/A |
INTRINSIC |
ARM
|
995 |
1039 |
5.64e-4 |
SMART |
low complexity region
|
1086 |
1099 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000226116
AA Change: E81G
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226119
AA Change: E81G
PolyPhen 2
Score 0.606 (Sensitivity: 0.87; Specificity: 0.91)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000228282
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
Validation Efficiency |
98% (91/93) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] PHENOTYPE: Mice homozygous for a reporter allele exhibit abnormal conditioning, spatial learning and coordination behaviors and abnormal long term potentiation. [provided by MGI curators]
|
Allele List at MGI |
All alleles(1) : Targeted(1)
|
Other mutations in this stock |
Total: 91 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2610008E11Rik |
T |
A |
10: 78,902,473 (GRCm39) |
K614N |
probably benign |
Het |
2610008E11Rik |
T |
G |
10: 78,902,474 (GRCm39) |
K614T |
probably benign |
Het |
Ahsa1 |
T |
A |
12: 87,317,116 (GRCm39) |
S120R |
probably benign |
Het |
Anapc16 |
G |
A |
10: 59,832,302 (GRCm39) |
T37I |
possibly damaging |
Het |
Arid2 |
C |
A |
15: 96,276,756 (GRCm39) |
P1606H |
probably damaging |
Het |
Ash1l |
TATCTCCTTTTCCAAAAA |
TA |
3: 88,890,764 (GRCm39) |
|
probably null |
Het |
Asic1 |
T |
A |
15: 99,569,968 (GRCm39) |
N96K |
probably damaging |
Het |
Asph |
A |
T |
4: 9,484,575 (GRCm39) |
D582E |
probably benign |
Het |
Astn1 |
A |
G |
1: 158,400,557 (GRCm39) |
D528G |
probably damaging |
Het |
Atp9b |
A |
G |
18: 80,952,871 (GRCm39) |
V164A |
|
Het |
Cbx6 |
C |
T |
15: 79,712,866 (GRCm39) |
G187D |
possibly damaging |
Het |
Cct7 |
A |
G |
6: 85,443,627 (GRCm39) |
T332A |
probably benign |
Het |
Clca4a |
A |
T |
3: 144,667,651 (GRCm39) |
L440* |
probably null |
Het |
Crybg2 |
A |
T |
4: 133,792,754 (GRCm39) |
I130F |
probably benign |
Het |
Crybg3 |
T |
C |
16: 59,357,167 (GRCm39) |
E798G |
probably damaging |
Het |
Cwc22 |
C |
T |
2: 77,759,822 (GRCm39) |
R75H |
possibly damaging |
Het |
Cym |
T |
G |
3: 107,121,530 (GRCm39) |
D254A |
probably damaging |
Het |
Dcaf11 |
T |
A |
14: 55,806,383 (GRCm39) |
|
probably null |
Het |
Dctn1 |
A |
T |
6: 83,157,026 (GRCm39) |
|
probably null |
Het |
Dennd5a |
C |
T |
7: 109,495,449 (GRCm39) |
|
probably null |
Het |
Dmpk |
T |
A |
7: 18,821,232 (GRCm39) |
C217S |
probably damaging |
Het |
Dnah1 |
C |
A |
14: 31,008,033 (GRCm39) |
V2125L |
probably benign |
Het |
Exoc4 |
G |
A |
6: 33,415,408 (GRCm39) |
A427T |
probably benign |
Het |
Farp2 |
G |
T |
1: 93,548,956 (GRCm39) |
V1021F |
probably damaging |
Het |
Flg2 |
T |
C |
3: 93,127,069 (GRCm39) |
S1994P |
unknown |
Het |
Fmnl1 |
T |
C |
11: 103,072,610 (GRCm39) |
|
probably null |
Het |
Frem2 |
T |
A |
3: 53,479,760 (GRCm39) |
I1978F |
possibly damaging |
Het |
Gan |
T |
A |
8: 117,913,969 (GRCm39) |
C122* |
probably null |
Het |
Gpr25 |
T |
A |
1: 136,188,559 (GRCm39) |
Y18F |
probably damaging |
Het |
Hoxa7 |
C |
T |
6: 52,192,720 (GRCm39) |
E223K |
probably benign |
Het |
Hypk |
A |
G |
2: 121,283,961 (GRCm39) |
|
probably null |
Het |
Ibsp |
A |
T |
5: 104,450,172 (GRCm39) |
K27* |
probably null |
Het |
Ighv6-5 |
T |
A |
12: 114,380,395 (GRCm39) |
T41S |
probably benign |
Het |
Ighv9-4 |
T |
C |
12: 114,263,757 (GRCm39) |
M59V |
probably benign |
Het |
Il17rb |
T |
C |
14: 29,718,828 (GRCm39) |
D418G |
probably damaging |
Het |
Ints5 |
T |
A |
19: 8,872,923 (GRCm39) |
V294E |
probably damaging |
Het |
Irx6 |
G |
A |
8: 93,405,041 (GRCm39) |
C303Y |
probably damaging |
Het |
Itih3 |
T |
A |
14: 30,639,655 (GRCm39) |
I389F |
probably damaging |
Het |
Lama1 |
C |
T |
17: 68,089,141 (GRCm39) |
T1604I |
|
Het |
Lama3 |
C |
A |
18: 12,672,843 (GRCm39) |
Q873K |
probably benign |
Het |
Lhx1 |
T |
G |
11: 84,410,746 (GRCm39) |
S284R |
probably benign |
Het |
Lrba |
T |
A |
3: 86,302,238 (GRCm39) |
|
probably null |
Het |
Lrg1 |
C |
T |
17: 56,427,592 (GRCm39) |
G127R |
possibly damaging |
Het |
Macir |
G |
A |
1: 97,573,645 (GRCm39) |
P140L |
probably benign |
Het |
Mapre1 |
T |
A |
2: 153,606,883 (GRCm39) |
L205H |
probably benign |
Het |
Meltf |
A |
G |
16: 31,711,617 (GRCm39) |
N581S |
probably damaging |
Het |
Mgat5 |
A |
C |
1: 127,292,926 (GRCm39) |
M149L |
probably benign |
Het |
Myh1 |
A |
G |
11: 67,093,412 (GRCm39) |
T168A |
probably benign |
Het |
Naalad2 |
C |
T |
9: 18,238,673 (GRCm39) |
V681I |
probably benign |
Het |
Or51e2 |
A |
G |
7: 102,391,524 (GRCm39) |
S229P |
probably damaging |
Het |
Or52r1c |
T |
A |
7: 102,735,205 (GRCm39) |
L155Q |
probably damaging |
Het |
Pcnx2 |
T |
C |
8: 126,528,243 (GRCm39) |
T1326A |
probably benign |
Het |
Peg3 |
A |
T |
7: 6,711,944 (GRCm39) |
C1093S |
probably damaging |
Het |
Pidd1 |
T |
C |
7: 141,019,813 (GRCm39) |
S650G |
probably benign |
Het |
Pik3c2b |
T |
C |
1: 133,017,972 (GRCm39) |
S945P |
possibly damaging |
Het |
Plec |
T |
C |
15: 76,060,227 (GRCm39) |
T3237A |
possibly damaging |
Het |
Prpf3 |
A |
T |
3: 95,741,052 (GRCm39) |
|
probably null |
Het |
Prpf4b |
C |
A |
13: 35,085,477 (GRCm39) |
H974Q |
probably benign |
Het |
Ptpn3 |
T |
C |
4: 57,225,863 (GRCm39) |
T451A |
probably benign |
Het |
Ptprs |
A |
G |
17: 56,724,429 (GRCm39) |
Y1577H |
probably damaging |
Het |
Rgr |
C |
T |
14: 36,770,882 (GRCm39) |
M1I |
probably null |
Het |
Rxrg |
A |
T |
1: 167,458,678 (GRCm39) |
N257I |
probably benign |
Het |
Sbno2 |
T |
C |
10: 79,922,146 (GRCm39) |
D9G |
probably damaging |
Het |
Scd1 |
T |
C |
19: 44,395,034 (GRCm39) |
K64E |
probably damaging |
Het |
Serpinb1a |
T |
A |
13: 33,034,308 (GRCm39) |
I28F |
possibly damaging |
Het |
Sfmbt2 |
A |
T |
2: 10,406,818 (GRCm39) |
E39V |
probably damaging |
Het |
Slc29a1 |
A |
G |
17: 45,900,897 (GRCm39) |
M89T |
possibly damaging |
Het |
Slco4a1 |
T |
A |
2: 180,113,856 (GRCm39) |
V431E |
possibly damaging |
Het |
Smg1 |
C |
T |
7: 117,752,131 (GRCm39) |
C2698Y |
unknown |
Het |
Sptlc2 |
C |
T |
12: 87,397,151 (GRCm39) |
D212N |
probably benign |
Het |
St6galnac1 |
T |
C |
11: 116,657,899 (GRCm39) |
T334A |
possibly damaging |
Het |
Stim2 |
A |
T |
5: 54,156,263 (GRCm39) |
D13V |
possibly damaging |
Het |
Syne1 |
A |
G |
10: 5,181,592 (GRCm39) |
W4248R |
probably damaging |
Het |
Tanc1 |
T |
C |
2: 59,627,953 (GRCm39) |
Y584H |
probably benign |
Het |
Thoc6 |
C |
A |
17: 23,892,634 (GRCm39) |
|
probably null |
Het |
Trim30a |
T |
A |
7: 104,078,533 (GRCm39) |
N181I |
possibly damaging |
Het |
Trip11 |
T |
A |
12: 101,850,329 (GRCm39) |
Q1245L |
probably damaging |
Het |
Tshz3 |
A |
G |
7: 36,469,994 (GRCm39) |
D661G |
probably benign |
Het |
Ttll8 |
C |
A |
15: 88,799,630 (GRCm39) |
V604L |
probably damaging |
Het |
Ubtfl1 |
A |
G |
9: 18,320,931 (GRCm39) |
D153G |
probably damaging |
Het |
Ufsp2 |
C |
A |
8: 46,436,661 (GRCm39) |
N137K |
probably benign |
Het |
Ugt2a3 |
A |
G |
5: 87,473,393 (GRCm39) |
I508T |
possibly damaging |
Het |
Uso1 |
G |
A |
5: 92,306,324 (GRCm39) |
E94K |
probably benign |
Het |
Usp54 |
A |
G |
14: 20,611,310 (GRCm39) |
S1169P |
probably benign |
Het |
Vmn1r235 |
C |
T |
17: 21,482,292 (GRCm39) |
P206S |
probably benign |
Het |
Vmn1r69 |
T |
C |
7: 10,314,995 (GRCm39) |
|
probably benign |
Het |
Zfp263 |
T |
A |
16: 3,567,255 (GRCm39) |
C523* |
probably null |
Het |
Zfp799 |
G |
T |
17: 33,039,210 (GRCm39) |
T352K |
probably benign |
Het |
Zfr |
T |
A |
15: 12,180,724 (GRCm39) |
V951E |
probably damaging |
Het |
Zfyve26 |
T |
C |
12: 79,330,926 (GRCm39) |
D431G |
probably benign |
Het |
Zswim9 |
C |
A |
7: 12,993,664 (GRCm39) |
A831S |
probably damaging |
Het |
|
Other mutations in Ctnnd2 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00597:Ctnnd2
|
APN |
15 |
30,647,287 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL01612:Ctnnd2
|
APN |
15 |
31,005,164 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01923:Ctnnd2
|
APN |
15 |
30,480,974 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02183:Ctnnd2
|
APN |
15 |
31,020,886 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02186:Ctnnd2
|
APN |
15 |
30,480,939 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02226:Ctnnd2
|
APN |
15 |
30,847,482 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02307:Ctnnd2
|
APN |
15 |
30,647,357 (GRCm39) |
missense |
possibly damaging |
0.86 |
IGL02407:Ctnnd2
|
APN |
15 |
30,966,914 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02474:Ctnnd2
|
APN |
15 |
30,669,708 (GRCm39) |
missense |
possibly damaging |
0.71 |
IGL02718:Ctnnd2
|
APN |
15 |
31,027,762 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03249:Ctnnd2
|
APN |
15 |
30,683,382 (GRCm39) |
missense |
probably benign |
0.45 |
IGL03328:Ctnnd2
|
APN |
15 |
30,921,993 (GRCm39) |
splice site |
probably benign |
|
carpe
|
UTSW |
15 |
30,905,966 (GRCm39) |
missense |
probably damaging |
1.00 |
diem
|
UTSW |
15 |
30,683,493 (GRCm39) |
missense |
possibly damaging |
0.85 |
P0016:Ctnnd2
|
UTSW |
15 |
30,967,084 (GRCm39) |
missense |
probably benign |
0.00 |
R0130:Ctnnd2
|
UTSW |
15 |
30,922,059 (GRCm39) |
missense |
probably damaging |
1.00 |
R0408:Ctnnd2
|
UTSW |
15 |
30,634,823 (GRCm39) |
missense |
probably damaging |
1.00 |
R0611:Ctnnd2
|
UTSW |
15 |
31,009,230 (GRCm39) |
missense |
possibly damaging |
0.75 |
R0894:Ctnnd2
|
UTSW |
15 |
30,332,301 (GRCm39) |
splice site |
probably benign |
|
R1112:Ctnnd2
|
UTSW |
15 |
30,922,026 (GRCm39) |
missense |
probably damaging |
1.00 |
R1459:Ctnnd2
|
UTSW |
15 |
30,847,445 (GRCm39) |
missense |
probably damaging |
1.00 |
R1529:Ctnnd2
|
UTSW |
15 |
30,887,267 (GRCm39) |
missense |
possibly damaging |
0.91 |
R1532:Ctnnd2
|
UTSW |
15 |
30,922,014 (GRCm39) |
missense |
probably damaging |
1.00 |
R1701:Ctnnd2
|
UTSW |
15 |
30,922,127 (GRCm39) |
missense |
probably damaging |
1.00 |
R1807:Ctnnd2
|
UTSW |
15 |
30,620,017 (GRCm39) |
missense |
probably damaging |
1.00 |
R1881:Ctnnd2
|
UTSW |
15 |
31,005,227 (GRCm39) |
splice site |
probably benign |
|
R1960:Ctnnd2
|
UTSW |
15 |
30,647,257 (GRCm39) |
missense |
probably damaging |
0.96 |
R2121:Ctnnd2
|
UTSW |
15 |
30,669,660 (GRCm39) |
missense |
probably damaging |
1.00 |
R3839:Ctnnd2
|
UTSW |
15 |
31,009,174 (GRCm39) |
splice site |
probably null |
|
R3967:Ctnnd2
|
UTSW |
15 |
30,647,075 (GRCm39) |
missense |
possibly damaging |
0.81 |
R3980:Ctnnd2
|
UTSW |
15 |
30,669,589 (GRCm39) |
missense |
probably benign |
0.14 |
R4207:Ctnnd2
|
UTSW |
15 |
30,972,973 (GRCm39) |
missense |
probably damaging |
0.99 |
R4279:Ctnnd2
|
UTSW |
15 |
30,905,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R4498:Ctnnd2
|
UTSW |
15 |
30,620,020 (GRCm39) |
missense |
probably damaging |
1.00 |
R4622:Ctnnd2
|
UTSW |
15 |
31,009,259 (GRCm39) |
missense |
probably benign |
0.00 |
R4622:Ctnnd2
|
UTSW |
15 |
30,887,315 (GRCm39) |
missense |
probably benign |
0.17 |
R4860:Ctnnd2
|
UTSW |
15 |
30,881,313 (GRCm39) |
missense |
probably damaging |
1.00 |
R4860:Ctnnd2
|
UTSW |
15 |
30,881,313 (GRCm39) |
missense |
probably damaging |
1.00 |
R4979:Ctnnd2
|
UTSW |
15 |
31,009,221 (GRCm39) |
missense |
probably damaging |
1.00 |
R5086:Ctnnd2
|
UTSW |
15 |
30,683,493 (GRCm39) |
missense |
possibly damaging |
0.85 |
R5330:Ctnnd2
|
UTSW |
15 |
30,332,261 (GRCm39) |
missense |
probably damaging |
1.00 |
R5459:Ctnnd2
|
UTSW |
15 |
30,887,334 (GRCm39) |
missense |
probably damaging |
1.00 |
R5595:Ctnnd2
|
UTSW |
15 |
30,669,689 (GRCm39) |
missense |
probably benign |
0.07 |
R5809:Ctnnd2
|
UTSW |
15 |
30,847,523 (GRCm39) |
missense |
probably damaging |
1.00 |
R5987:Ctnnd2
|
UTSW |
15 |
30,683,387 (GRCm39) |
missense |
probably benign |
|
R6245:Ctnnd2
|
UTSW |
15 |
30,905,894 (GRCm39) |
missense |
probably damaging |
1.00 |
R6379:Ctnnd2
|
UTSW |
15 |
30,634,844 (GRCm39) |
missense |
probably damaging |
1.00 |
R6737:Ctnnd2
|
UTSW |
15 |
30,966,980 (GRCm39) |
nonsense |
probably null |
|
R6979:Ctnnd2
|
UTSW |
15 |
30,619,376 (GRCm39) |
missense |
probably damaging |
0.99 |
R7179:Ctnnd2
|
UTSW |
15 |
30,683,510 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7267:Ctnnd2
|
UTSW |
15 |
30,683,501 (GRCm39) |
missense |
probably benign |
0.13 |
R7275:Ctnnd2
|
UTSW |
15 |
30,905,855 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7386:Ctnnd2
|
UTSW |
15 |
30,966,914 (GRCm39) |
missense |
probably damaging |
1.00 |
R7649:Ctnnd2
|
UTSW |
15 |
31,027,630 (GRCm39) |
missense |
probably benign |
0.11 |
R7814:Ctnnd2
|
UTSW |
15 |
31,020,874 (GRCm39) |
missense |
probably benign |
0.00 |
R7849:Ctnnd2
|
UTSW |
15 |
31,027,733 (GRCm39) |
missense |
probably damaging |
1.00 |
R7857:Ctnnd2
|
UTSW |
15 |
30,620,076 (GRCm39) |
missense |
probably benign |
0.01 |
R8057:Ctnnd2
|
UTSW |
15 |
30,847,497 (GRCm39) |
missense |
possibly damaging |
0.89 |
R8236:Ctnnd2
|
UTSW |
15 |
30,647,164 (GRCm39) |
missense |
probably benign |
|
R8260:Ctnnd2
|
UTSW |
15 |
30,634,879 (GRCm39) |
missense |
possibly damaging |
0.84 |
R8411:Ctnnd2
|
UTSW |
15 |
30,647,179 (GRCm39) |
missense |
probably benign |
0.33 |
R8802:Ctnnd2
|
UTSW |
15 |
30,967,022 (GRCm39) |
missense |
probably damaging |
1.00 |
R8891:Ctnnd2
|
UTSW |
15 |
30,620,076 (GRCm39) |
missense |
probably benign |
0.01 |
R8907:Ctnnd2
|
UTSW |
15 |
30,905,873 (GRCm39) |
missense |
probably damaging |
1.00 |
R8989:Ctnnd2
|
UTSW |
15 |
30,669,660 (GRCm39) |
missense |
probably damaging |
1.00 |
R9017:Ctnnd2
|
UTSW |
15 |
30,881,316 (GRCm39) |
missense |
probably damaging |
0.96 |
R9035:Ctnnd2
|
UTSW |
15 |
30,332,162 (GRCm39) |
missense |
possibly damaging |
0.77 |
R9061:Ctnnd2
|
UTSW |
15 |
30,806,884 (GRCm39) |
missense |
probably damaging |
1.00 |
R9303:Ctnnd2
|
UTSW |
15 |
30,967,037 (GRCm39) |
missense |
probably damaging |
0.99 |
R9475:Ctnnd2
|
UTSW |
15 |
30,881,276 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Ctnnd2
|
UTSW |
15 |
30,966,959 (GRCm39) |
missense |
probably benign |
0.28 |
|
Predicted Primers |
PCR Primer
(F):5'- AAGCCCCTGTCTAATTCTCCAG -3'
(R):5'- TCTTAATTCGGGCCCCTTAAAC -3'
Sequencing Primer
(F):5'- TTCTCAAAGTTGCCACCTTGAAAAC -3'
(R):5'- AAACTTCTTTCCCACGTCTAAGTG -3'
|
Posted On |
2019-05-15 |