Incidental Mutation 'R7135:Naip6'
ID 553026
Institutional Source Beutler Lab
Gene Symbol Naip6
Ensembl Gene ENSMUSG00000078942
Gene Name NLR family, apoptosis inhibitory protein 6
Synonyms Naip-rs4, Birc1f, Naip-rs4A
MMRRC Submission 045247-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R7135 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 100417629-100453124 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 100436927 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 532 (E532G)
Ref Sequence ENSEMBL: ENSMUSP00000041766 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042220] [ENSMUST00000118574]
AlphaFold Q9JIB6
Predicted Effect probably damaging
Transcript: ENSMUST00000042220
AA Change: E532G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000041766
Gene: ENSMUSG00000078942
AA Change: E532G

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 7.6e-37 PFAM
low complexity region 851 862 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000118574
AA Change: E532G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000112867
Gene: ENSMUSG00000078942
AA Change: E532G

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 2.5e-35 PFAM
low complexity region 851 862 N/A INTRINSIC
Meta Mutation Damage Score 0.4143 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (83/83)
MGI Phenotype FUNCTION: Closest sequence match is AF381772. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aars2 T A 17: 45,819,887 (GRCm39) Y221* probably null Het
AC166344.1 T A 14: 43,158,245 (GRCm39) F97I Het
Ankmy2 T C 12: 36,246,311 (GRCm39) S412P probably benign Het
Ap1s3 T C 1: 79,586,919 (GRCm39) T144A probably benign Het
Armh2 T C 13: 24,925,489 (GRCm39) S78P probably benign Het
Asb3 T A 11: 30,948,501 (GRCm39) L59* probably null Het
Asxl3 G T 18: 22,650,758 (GRCm39) G916* probably null Het
Asxl3 G C 18: 22,650,759 (GRCm39) G916A probably damaging Het
Birc2 A C 9: 7,818,762 (GRCm39) F610V probably damaging Het
Camk4 G A 18: 33,240,996 (GRCm39) probably null Het
Ccdc162 A G 10: 41,549,855 (GRCm39) S343P probably benign Het
Ccnk T A 12: 108,152,734 (GRCm39) L17Q probably damaging Het
Cd59b G A 2: 103,914,792 (GRCm39) W63* probably null Het
Chrm3 C T 13: 9,927,837 (GRCm39) V400I probably benign Het
Crb1 C A 1: 139,171,105 (GRCm39) V762F probably damaging Het
Cspp1 C T 1: 10,159,161 (GRCm39) T529I possibly damaging Het
Cttnbp2 A G 6: 18,448,446 (GRCm39) I71T possibly damaging Het
Cyb561 C A 11: 105,826,393 (GRCm39) G90V probably damaging Het
Cyld T A 8: 89,471,520 (GRCm39) D804E possibly damaging Het
Ddx31 G A 2: 28,738,318 (GRCm39) V160I probably benign Het
Dgkg T C 16: 22,319,132 (GRCm39) D643G probably damaging Het
Dnah12 G A 14: 26,500,869 (GRCm39) probably null Het
Dnah12 T G 14: 26,523,370 (GRCm39) I1953S probably damaging Het
Dnah7b T C 1: 46,178,870 (GRCm39) W848R probably damaging Het
Dnah7c C T 1: 46,572,368 (GRCm39) T947M probably damaging Het
Dnmt3c C A 2: 153,556,872 (GRCm39) probably null Het
Dsp A T 13: 38,363,049 (GRCm39) Y443F probably damaging Het
Espl1 T A 15: 102,227,959 (GRCm39) C1603* probably null Het
Faiml G T 9: 99,116,496 (GRCm39) R65S probably benign Het
Gfpt2 T C 11: 49,695,782 (GRCm39) I4T probably damaging Het
Gm10376 T A 14: 42,867,950 (GRCm39) M179L probably benign Het
Gm4302 T A 10: 100,177,589 (GRCm39) M291K unknown Het
Gnb1l T A 16: 18,363,918 (GRCm39) D154E probably benign Het
Igkv10-94 T C 6: 68,681,727 (GRCm39) R38G possibly damaging Het
Inmt A T 6: 55,148,013 (GRCm39) Y205* probably null Het
Krba1 A G 6: 48,393,233 (GRCm39) Q1049R probably benign Het
Lpxn T A 19: 12,810,683 (GRCm39) C376S probably damaging Het
Lrrc52 T A 1: 167,294,019 (GRCm39) I89F probably damaging Het
Map9 A T 3: 82,270,765 (GRCm39) T110S probably benign Het
Mccc1 T C 3: 36,049,967 (GRCm39) Y75C probably damaging Het
Mff T A 1: 82,724,812 (GRCm39) L203* probably null Het
Micall1 C A 15: 78,993,624 (GRCm39) D47E unknown Het
Mink1 T C 11: 70,494,329 (GRCm39) F243S probably damaging Het
Mlycd C T 8: 120,129,216 (GRCm39) R228W probably damaging Het
Msr1 A T 8: 40,042,465 (GRCm39) V370E possibly damaging Het
Nepn G A 10: 52,267,815 (GRCm39) C27Y probably damaging Het
Ninl T C 2: 150,797,524 (GRCm39) H592R probably benign Het
Nr4a2 A G 2: 57,002,261 (GRCm39) M64T possibly damaging Het
Oprm1 A T 10: 6,780,203 (GRCm39) I171F possibly damaging Het
Or4g16 T A 2: 111,137,365 (GRCm39) F272I probably benign Het
Or5p60 T C 7: 107,723,781 (GRCm39) K230E probably damaging Het
Pcbp1 A T 6: 86,502,488 (GRCm39) M137K possibly damaging Het
Pcf11 A T 7: 92,306,524 (GRCm39) S1215T probably benign Het
Pdlim5 A T 3: 142,017,683 (GRCm39) probably null Het
Pecam1 T C 11: 106,579,857 (GRCm39) I402V probably damaging Het
Pex12 T C 11: 83,188,468 (GRCm39) T176A probably benign Het
Phf3 T C 1: 30,870,190 (GRCm39) K286R possibly damaging Het
Pik3ap1 T A 19: 41,320,760 (GRCm39) D153V probably damaging Het
Pkhd1l1 T A 15: 44,448,374 (GRCm39) probably null Het
Plekhn1 A G 4: 156,307,792 (GRCm39) V378A probably benign Het
Pramel26 A T 4: 143,537,233 (GRCm39) L366Q probably damaging Het
Ptprm A T 17: 67,251,283 (GRCm39) D531E possibly damaging Het
Pum2 A T 12: 8,778,952 (GRCm39) Q508L possibly damaging Het
Rad54l A G 4: 115,963,027 (GRCm39) S324P probably damaging Het
Recql5 C T 11: 115,821,498 (GRCm39) probably null Het
Reln A T 5: 22,181,594 (GRCm39) V1763D possibly damaging Het
Rp1 T C 1: 4,418,391 (GRCm39) N907S possibly damaging Het
Scaf11 T A 15: 96,318,209 (GRCm39) N452Y possibly damaging Het
Scgb2b3 T A 7: 31,059,639 (GRCm39) H45L possibly damaging Het
Sim1 A G 10: 50,772,023 (GRCm39) T11A probably damaging Het
Slc5a12 T A 2: 110,447,059 (GRCm39) M189K possibly damaging Het
Slco2b1 C T 7: 99,344,270 (GRCm39) G10S probably null Het
Speer1j C T 5: 11,555,198 (GRCm39) P83S probably damaging Het
Stxbp3 A G 3: 108,708,071 (GRCm39) L410P probably damaging Het
Sugct T C 13: 17,476,594 (GRCm39) N297D probably benign Het
Syne1 A G 10: 5,183,409 (GRCm39) I4132T probably benign Het
Teddm1b A T 1: 153,750,912 (GRCm39) L240F probably damaging Het
Tlr5 C A 1: 182,803,088 (GRCm39) D797E possibly damaging Het
Tmprss13 G T 9: 45,249,643 (GRCm39) G327C probably damaging Het
Tnrc18 G T 5: 142,773,572 (GRCm39) A419D Het
Ttc28 T C 5: 111,427,873 (GRCm39) Y1790H probably damaging Het
Vmn1r125 T G 7: 21,006,327 (GRCm39) M75R probably damaging Het
Vwa3a T A 7: 120,372,253 (GRCm39) D276E possibly damaging Het
Wdfy3 C T 5: 102,063,303 (GRCm39) V1322M probably damaging Het
Wdr11 T C 7: 129,229,830 (GRCm39) S872P possibly damaging Het
Zc3h13 T C 14: 75,559,161 (GRCm39) S357P unknown Het
Other mutations in Naip6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Naip6 APN 13 100,452,525 (GRCm39) missense probably benign 0.03
IGL01123:Naip6 APN 13 100,440,946 (GRCm39) missense probably benign 0.02
IGL01151:Naip6 APN 13 100,435,601 (GRCm39) missense probably benign 0.00
IGL01382:Naip6 APN 13 100,436,364 (GRCm39) missense possibly damaging 0.95
IGL01415:Naip6 APN 13 100,439,798 (GRCm39) missense probably benign 0.17
IGL01654:Naip6 APN 13 100,435,853 (GRCm39) missense probably benign 0.00
IGL01662:Naip6 APN 13 100,436,862 (GRCm39) missense probably damaging 1.00
IGL01726:Naip6 APN 13 100,439,760 (GRCm39) missense probably benign 0.02
IGL01810:Naip6 APN 13 100,424,603 (GRCm39) splice site probably benign
IGL01867:Naip6 APN 13 100,436,820 (GRCm39) missense probably benign 0.40
IGL01926:Naip6 APN 13 100,436,704 (GRCm39) missense probably damaging 1.00
IGL01964:Naip6 APN 13 100,435,238 (GRCm39) splice site probably benign
IGL02145:Naip6 APN 13 100,433,486 (GRCm39) missense possibly damaging 0.77
IGL02160:Naip6 APN 13 100,435,933 (GRCm39) missense probably benign 0.01
IGL02214:Naip6 APN 13 100,452,567 (GRCm39) missense probably damaging 1.00
IGL02342:Naip6 APN 13 100,439,748 (GRCm39) missense possibly damaging 0.69
IGL02568:Naip6 APN 13 100,452,780 (GRCm39) missense probably damaging 1.00
IGL02573:Naip6 APN 13 100,435,979 (GRCm39) nonsense probably null
IGL02680:Naip6 APN 13 100,420,256 (GRCm39) missense probably benign
IGL02829:Naip6 APN 13 100,437,273 (GRCm39) missense probably benign 0.11
IGL02833:Naip6 APN 13 100,436,121 (GRCm39) missense probably damaging 1.00
IGL02851:Naip6 APN 13 100,437,168 (GRCm39) missense probably benign 0.01
IGL02860:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL02886:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL03155:Naip6 APN 13 100,452,932 (GRCm39) missense possibly damaging 0.62
R0032:Naip6 UTSW 13 100,439,745 (GRCm39) missense probably benign 0.00
R0310:Naip6 UTSW 13 100,444,721 (GRCm39) missense possibly damaging 0.72
R0437:Naip6 UTSW 13 100,433,432 (GRCm39) missense possibly damaging 0.75
R0472:Naip6 UTSW 13 100,438,768 (GRCm39) missense probably benign 0.02
R0560:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R0638:Naip6 UTSW 13 100,437,036 (GRCm39) missense probably benign 0.00
R0792:Naip6 UTSW 13 100,420,274 (GRCm39) missense possibly damaging 0.78
R0963:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign 0.11
R1102:Naip6 UTSW 13 100,440,923 (GRCm39) missense possibly damaging 0.62
R1278:Naip6 UTSW 13 100,436,870 (GRCm39) missense probably damaging 1.00
R1462:Naip6 UTSW 13 100,436,748 (GRCm39) missense possibly damaging 0.64
R1462:Naip6 UTSW 13 100,436,748 (GRCm39) missense possibly damaging 0.64
R1544:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign
R1595:Naip6 UTSW 13 100,435,602 (GRCm39) missense probably damaging 0.96
R1749:Naip6 UTSW 13 100,444,763 (GRCm39) missense probably benign 0.03
R1838:Naip6 UTSW 13 100,452,644 (GRCm39) missense probably damaging 0.99
R1863:Naip6 UTSW 13 100,437,067 (GRCm39) missense probably benign 0.03
R1914:Naip6 UTSW 13 100,435,936 (GRCm39) missense probably benign 0.13
R2001:Naip6 UTSW 13 100,437,237 (GRCm39) missense probably benign 0.44
R2082:Naip6 UTSW 13 100,440,852 (GRCm39) splice site probably null
R2143:Naip6 UTSW 13 100,436,367 (GRCm39) missense probably damaging 1.00
R2174:Naip6 UTSW 13 100,435,495 (GRCm39) missense probably benign
R2266:Naip6 UTSW 13 100,420,067 (GRCm39) missense possibly damaging 0.46
R2284:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2285:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2286:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2351:Naip6 UTSW 13 100,420,169 (GRCm39) missense probably damaging 1.00
R2363:Naip6 UTSW 13 100,452,928 (GRCm39) missense possibly damaging 0.90
R2445:Naip6 UTSW 13 100,437,176 (GRCm39) missense probably damaging 0.99
R2971:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2975:Naip6 UTSW 13 100,424,695 (GRCm39) missense probably damaging 1.00
R3081:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R3082:Naip6 UTSW 13 100,452,925 (GRCm39) missense probably benign 0.00
R3122:Naip6 UTSW 13 100,453,031 (GRCm39) missense probably benign 0.00
R3417:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R3943:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R3944:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R4080:Naip6 UTSW 13 100,435,815 (GRCm39) missense probably damaging 1.00
R4166:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R4396:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4397:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4418:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4512:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4670:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4671:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4722:Naip6 UTSW 13 100,443,580 (GRCm39) missense possibly damaging 0.72
R4811:Naip6 UTSW 13 100,422,299 (GRCm39) missense probably damaging 1.00
R4900:Naip6 UTSW 13 100,433,477 (GRCm39) missense probably damaging 0.99
R5162:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R5316:Naip6 UTSW 13 100,420,290 (GRCm39) missense probably benign 0.00
R5403:Naip6 UTSW 13 100,436,585 (GRCm39) missense probably benign 0.12
R5437:Naip6 UTSW 13 100,439,812 (GRCm39) nonsense probably null
R5507:Naip6 UTSW 13 100,435,423 (GRCm39) missense probably benign 0.01
R5631:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R5657:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R5684:Naip6 UTSW 13 100,436,888 (GRCm39) missense probably damaging 1.00
R5786:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5787:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5788:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5878:Naip6 UTSW 13 100,436,181 (GRCm39) missense probably damaging 1.00
R5895:Naip6 UTSW 13 100,452,500 (GRCm39) missense possibly damaging 0.90
R5898:Naip6 UTSW 13 100,435,829 (GRCm39) missense possibly damaging 0.93
R6113:Naip6 UTSW 13 100,435,794 (GRCm39) missense possibly damaging 0.96
R6141:Naip6 UTSW 13 100,444,741 (GRCm39) missense possibly damaging 0.91
R6199:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R6321:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6402:Naip6 UTSW 13 100,437,226 (GRCm39) missense probably benign 0.30
R6435:Naip6 UTSW 13 100,431,249 (GRCm39) missense probably benign 0.04
R6477:Naip6 UTSW 13 100,452,516 (GRCm39) missense probably damaging 1.00
R6601:Naip6 UTSW 13 100,420,266 (GRCm39) missense probably benign
R6638:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6639:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6804:Naip6 UTSW 13 100,435,675 (GRCm39) missense probably benign
R6922:Naip6 UTSW 13 100,438,706 (GRCm39) missense possibly damaging 0.88
R6975:Naip6 UTSW 13 100,452,773 (GRCm39) missense probably damaging 1.00
R7050:Naip6 UTSW 13 100,452,007 (GRCm39) missense probably damaging 1.00
R7140:Naip6 UTSW 13 100,436,708 (GRCm39) missense possibly damaging 0.95
R7182:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R7196:Naip6 UTSW 13 100,436,666 (GRCm39) missense probably benign 0.10
R7234:Naip6 UTSW 13 100,452,011 (GRCm39) nonsense probably null
R7259:Naip6 UTSW 13 100,440,863 (GRCm39) missense probably damaging 1.00
R7322:Naip6 UTSW 13 100,435,896 (GRCm39) missense possibly damaging 0.94
R7332:Naip6 UTSW 13 100,437,209 (GRCm39) missense possibly damaging 0.62
R7339:Naip6 UTSW 13 100,452,527 (GRCm39) missense probably damaging 1.00
R7353:Naip6 UTSW 13 100,436,259 (GRCm39) missense probably benign 0.00
R7485:Naip6 UTSW 13 100,420,359 (GRCm39) missense probably benign 0.07
R7597:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R7835:Naip6 UTSW 13 100,452,512 (GRCm39) missense probably benign 0.19
R7840:Naip6 UTSW 13 100,451,979 (GRCm39) missense probably damaging 1.00
R8082:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R8082:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R8103:Naip6 UTSW 13 100,437,851 (GRCm39) missense probably benign 0.00
R8164:Naip6 UTSW 13 100,452,797 (GRCm39) missense probably benign 0.00
R8206:Naip6 UTSW 13 100,431,344 (GRCm39) nonsense probably null
R8258:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8259:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8348:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8405:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8406:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8441:Naip6 UTSW 13 100,422,265 (GRCm39) missense possibly damaging 0.77
R8448:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8465:Naip6 UTSW 13 100,433,423 (GRCm39) missense possibly damaging 0.95
R8501:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8502:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8687:Naip6 UTSW 13 100,435,636 (GRCm39) missense probably benign 0.10
R8806:Naip6 UTSW 13 100,437,161 (GRCm39) missense possibly damaging 0.93
R9186:Naip6 UTSW 13 100,436,390 (GRCm39) missense possibly damaging 0.89
R9340:Naip6 UTSW 13 100,452,494 (GRCm39) missense probably damaging 1.00
R9352:Naip6 UTSW 13 100,437,893 (GRCm39) missense possibly damaging 0.85
R9585:Naip6 UTSW 13 100,436,577 (GRCm39) missense probably damaging 0.96
R9597:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R9601:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
X0066:Naip6 UTSW 13 100,451,970 (GRCm39) nonsense probably null
Z1177:Naip6 UTSW 13 100,437,308 (GRCm39) missense probably damaging 1.00
Z1177:Naip6 UTSW 13 100,435,925 (GRCm39) missense probably benign 0.20
Z1177:Naip6 UTSW 13 100,452,638 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACCTAGGTATGGGCGGATG -3'
(R):5'- AATCTCAGCTCTGTCATGTGTG -3'

Sequencing Primer
(F):5'- ATGTCTCTGACCCTGTTTGTATGAAC -3'
(R):5'- GCTGGAAGTGGAAAGACAACCTTC -3'
Posted On 2019-05-15