Incidental Mutation 'R7143:Or4a74'
ID 553516
Institutional Source Beutler Lab
Gene Symbol Or4a74
Ensembl Gene ENSMUSG00000075081
Gene Name olfactory receptor family 4 subfamily A member 74
Synonyms GA_x6K02T2Q125-51051555-51050611, Olfr1247, MOR231-6
MMRRC Submission 045222-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R7143 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 89439433-89440497 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 89440363 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 28 (M28V)
Ref Sequence ENSEMBL: ENSMUSP00000107157 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099771] [ENSMUST00000111532] [ENSMUST00000216424]
AlphaFold A2AT78
Predicted Effect probably benign
Transcript: ENSMUST00000099771
AA Change: M28V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000097359
Gene: ENSMUSG00000075081
AA Change: M28V

DomainStartEndE-ValueType
Pfam:7tm_1 39 285 4.9e-29 PFAM
Pfam:7tm_4 137 278 4.2e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111532
AA Change: M28V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000107157
Gene: ENSMUSG00000075081
AA Change: M28V

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 1.2e-48 PFAM
Pfam:7tm_1 39 285 1.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216424
AA Change: M28V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930516K23Rik C T 7: 103,708,422 (GRCm39) C129Y probably damaging Het
Agbl4 A G 4: 111,474,333 (GRCm39) N374S probably damaging Het
Agl A G 3: 116,585,670 (GRCm39) S153P probably damaging Het
Akap6 T G 12: 52,934,147 (GRCm39) D546E probably benign Het
Ankrd17 C A 5: 90,433,820 (GRCm39) A650S possibly damaging Het
Ankrd53 A G 6: 83,739,893 (GRCm39) R16G possibly damaging Het
Apba2 T C 7: 64,394,165 (GRCm39) L570P probably damaging Het
Asap1 A G 15: 64,063,377 (GRCm39) F101L probably damaging Het
Cadm4 T A 7: 24,198,992 (GRCm39) I89N possibly damaging Het
Cadps C T 14: 12,491,838 (GRCm38) V771I probably benign Het
Cenph A G 13: 100,898,285 (GRCm39) V206A possibly damaging Het
Cenpn A G 8: 117,663,966 (GRCm39) T253A probably benign Het
Cep120 C T 18: 53,816,457 (GRCm39) G939R probably benign Het
Cfap57 G A 4: 118,477,906 (GRCm39) probably benign Het
Clip1 T C 5: 123,791,673 (GRCm39) I166V probably benign Het
Cstf3 T A 2: 104,476,961 (GRCm39) V144E probably benign Het
Cyp21a1 T A 17: 35,021,300 (GRCm39) H357L probably damaging Het
Cyth3 T A 5: 143,670,151 (GRCm39) V12E unknown Het
Dgat2 T C 7: 98,806,331 (GRCm39) I289V probably benign Het
Dip2a A G 10: 76,133,625 (GRCm39) C527R probably damaging Het
Dnah17 A C 11: 117,976,956 (GRCm39) W1879G probably damaging Het
Dnai2 A G 11: 114,645,076 (GRCm39) T504A possibly damaging Het
Efl1 C T 7: 82,411,888 (GRCm39) P759L probably damaging Het
Egfr A C 11: 16,821,627 (GRCm39) I351L probably benign Het
Ercc6 G A 14: 32,292,262 (GRCm39) E1209K probably damaging Het
Fam135b A T 15: 71,351,000 (GRCm39) M292K probably benign Het
Fbxl7 C A 15: 26,543,244 (GRCm39) V468L probably benign Het
Fhl2 G T 1: 43,181,011 (GRCm39) H60N probably damaging Het
G6pc1 G T 11: 101,261,549 (GRCm39) R83L probably damaging Het
Gata4 C A 14: 63,442,066 (GRCm39) R252L probably damaging Het
Glt8d1 T A 14: 30,728,602 (GRCm39) I10N probably damaging Het
Gm10803 T A 2: 93,394,304 (GRCm39) Y25* probably null Het
Gm19345 T C 7: 19,591,759 (GRCm39) F108S unknown Het
Gm4952 A G 19: 12,595,771 (GRCm39) T54A possibly damaging Het
Gprc6a C T 10: 51,490,986 (GRCm39) R921H probably benign Het
Hc A T 2: 34,940,450 (GRCm39) H129Q probably benign Het
Heatr5a T C 12: 52,008,251 (GRCm39) R31G probably benign Het
Hephl1 T C 9: 14,972,106 (GRCm39) K945E possibly damaging Het
Ik G T 18: 36,884,230 (GRCm39) M237I probably damaging Het
Izumo1 T A 7: 45,276,519 (GRCm39) S361T probably benign Het
Kcnq4 A G 4: 120,568,436 (GRCm39) F427L probably benign Het
Kifap3 T A 1: 163,683,609 (GRCm39) M430K possibly damaging Het
Kifap3 A T 1: 163,653,428 (GRCm39) N338I possibly damaging Het
Lamb3 A G 1: 192,986,873 (GRCm39) E53G probably damaging Het
Lrp1b A T 2: 41,202,655 (GRCm39) I1266K Het
Nat8 A T 6: 85,807,485 (GRCm39) I216K probably benign Het
Ncapd2 T C 6: 125,156,524 (GRCm39) I454V probably benign Het
Nlrp4f A T 13: 65,343,120 (GRCm39) V153E probably damaging Het
Nlrp4f G C 13: 65,347,166 (GRCm39) Q9E possibly damaging Het
Npy2r A T 3: 82,448,250 (GRCm39) I175N probably benign Het
Nutm1 G A 2: 112,080,401 (GRCm39) R505C probably damaging Het
Or1l4b A G 2: 37,036,886 (GRCm39) T221A probably benign Het
Or52n3 C T 7: 104,530,393 (GRCm39) P160S probably damaging Het
Pcdh9 T C 14: 94,125,708 (GRCm39) N154S probably damaging Het
Pcdhb2 A T 18: 37,428,934 (GRCm39) E302D probably benign Het
Pclo T A 5: 14,908,836 (GRCm39) V5048E unknown Het
Pcnt A G 10: 76,224,894 (GRCm39) L1870S possibly damaging Het
Pigc T C 1: 161,798,161 (GRCm39) Y48H probably damaging Het
Pisd C T 5: 32,895,846 (GRCm39) V241I possibly damaging Het
Pkhd1l1 A T 15: 44,437,033 (GRCm39) M3464L possibly damaging Het
Pofut2 T A 10: 77,095,260 (GRCm39) I35N probably benign Het
Prss27 A G 17: 24,264,632 (GRCm39) Y265C probably damaging Het
Prss56 T A 1: 87,115,875 (GRCm39) I583K probably benign Het
Rnpep T C 1: 135,211,487 (GRCm39) E87G probably benign Het
Shtn1 T C 19: 59,007,338 (GRCm39) H304R probably damaging Het
Slc23a4 A T 6: 34,955,848 (GRCm39) I62N probably damaging Het
Slc35e2 A T 4: 155,703,051 (GRCm39) I355F probably benign Het
Snx25 T C 8: 46,488,752 (GRCm39) I868V possibly damaging Het
Spatc1l T A 10: 76,405,765 (GRCm39) L323Q probably damaging Het
Speer4a2 T A 5: 26,290,674 (GRCm39) I166F probably benign Het
Taok1 A G 11: 77,428,814 (GRCm39) V962A probably benign Het
Tas2r140 A G 6: 133,032,482 (GRCm39) I92T probably benign Het
Trim17 C A 11: 58,856,010 (GRCm39) Y22* probably null Het
Tti1 T A 2: 157,849,596 (GRCm39) M548L probably benign Het
Unc93b1 T C 19: 3,985,204 (GRCm39) V4A unknown Het
Utp3 G C 5: 88,702,376 (GRCm39) probably benign Het
Vmn1r225 A T 17: 20,722,646 (GRCm39) Y29F probably benign Het
Vmn1r34 A T 6: 66,614,648 (GRCm39) I30N probably benign Het
Vmn2r67 T A 7: 84,801,846 (GRCm39) M152L probably benign Het
Wdr20rt T G 12: 65,272,692 (GRCm39) F52V probably benign Het
Zfp869 G T 8: 70,159,306 (GRCm39) H422Q probably damaging Het
Other mutations in Or4a74
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01101:Or4a74 APN 2 89,440,191 (GRCm39) missense probably benign 0.00
IGL01337:Or4a74 APN 2 89,439,720 (GRCm39) missense probably damaging 0.97
IGL02537:Or4a74 APN 2 89,439,739 (GRCm39) missense possibly damaging 0.88
IGL02651:Or4a74 APN 2 89,439,842 (GRCm39) missense possibly damaging 0.67
IGL02734:Or4a74 APN 2 89,440,303 (GRCm39) missense probably benign 0.04
IGL03177:Or4a74 APN 2 89,439,826 (GRCm39) missense probably benign 0.03
IGL03184:Or4a74 APN 2 89,439,912 (GRCm39) missense probably damaging 1.00
R0207:Or4a74 UTSW 2 89,440,207 (GRCm39) missense probably damaging 0.97
R0278:Or4a74 UTSW 2 89,440,108 (GRCm39) missense probably damaging 1.00
R0278:Or4a74 UTSW 2 89,440,107 (GRCm39) missense probably damaging 1.00
R0601:Or4a74 UTSW 2 89,439,564 (GRCm39) missense probably benign 0.00
R0633:Or4a74 UTSW 2 89,439,718 (GRCm39) missense probably benign 0.10
R1824:Or4a74 UTSW 2 89,439,693 (GRCm39) missense probably damaging 1.00
R1863:Or4a74 UTSW 2 89,440,053 (GRCm39) nonsense probably null
R2073:Or4a74 UTSW 2 89,439,822 (GRCm39) missense probably benign 0.01
R2074:Or4a74 UTSW 2 89,439,822 (GRCm39) missense probably benign 0.01
R2075:Or4a74 UTSW 2 89,439,822 (GRCm39) missense probably benign 0.01
R3921:Or4a74 UTSW 2 89,439,853 (GRCm39) missense probably benign 0.00
R4559:Or4a74 UTSW 2 89,440,043 (GRCm39) missense probably damaging 0.99
R5128:Or4a74 UTSW 2 89,439,647 (GRCm39) missense probably damaging 1.00
R5140:Or4a74 UTSW 2 89,439,627 (GRCm39) missense probably damaging 1.00
R5426:Or4a74 UTSW 2 89,440,083 (GRCm39) missense probably damaging 1.00
R5896:Or4a74 UTSW 2 89,439,667 (GRCm39) missense probably damaging 0.98
R5902:Or4a74 UTSW 2 89,439,595 (GRCm39) missense probably damaging 1.00
R6478:Or4a74 UTSW 2 89,439,790 (GRCm39) missense probably damaging 1.00
R7221:Or4a74 UTSW 2 89,440,272 (GRCm39) missense probably damaging 1.00
R7599:Or4a74 UTSW 2 89,439,571 (GRCm39) missense possibly damaging 0.89
R8709:Or4a74 UTSW 2 89,440,366 (GRCm39) missense probably benign 0.00
R8711:Or4a74 UTSW 2 89,440,291 (GRCm39) missense probably benign 0.05
R8721:Or4a74 UTSW 2 89,440,186 (GRCm39) missense probably benign 0.05
R9278:Or4a74 UTSW 2 89,439,948 (GRCm39) missense probably damaging 1.00
R9630:Or4a74 UTSW 2 89,440,349 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GAGCTGAACCAGACAAGCTG -3'
(R):5'- TGGGTTCACCATTGCATAAGG -3'

Sequencing Primer
(F):5'- CTGAACCAGACAAGCTGTGAAG -3'
(R):5'- GTTCACCATTGCATAAGGTAATAATG -3'
Posted On 2019-05-15