Incidental Mutation 'R7144:Trip12'
| ID |
553592 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Trip12
|
| Ensembl Gene |
ENSMUSG00000026219 |
| Gene Name |
thyroid hormone receptor interactor 12 |
| Synonyms |
Gtl6, 1110036I07Rik, 6720416K24Rik |
| MMRRC Submission |
045328-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7144 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
84698910-84818237 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 84771435 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 280
(S280T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139682
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027421]
[ENSMUST00000185909]
[ENSMUST00000186465]
[ENSMUST00000186648]
[ENSMUST00000186894]
[ENSMUST00000187818]
[ENSMUST00000189496]
[ENSMUST00000190067]
|
| AlphaFold |
G5E870 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000027421
AA Change: S238T
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: S238T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
765 |
831 |
7.6e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000185909
AA Change: S280T
PolyPhen 2
Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219
AA Change: S280T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186465
AA Change: S238T
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: S238T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
1e-5 |
PDB |
|
Pfam:WWE
|
761 |
831 |
2.2e-22 |
PFAM |
|
low complexity region
|
983 |
1006 |
N/A |
INTRINSIC |
|
low complexity region
|
1033 |
1047 |
N/A |
INTRINSIC |
|
low complexity region
|
1062 |
1073 |
N/A |
INTRINSIC |
|
low complexity region
|
1333 |
1344 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1362 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1363 |
1417 |
8e-8 |
BLAST |
|
Blast:HECTc
|
1573 |
1629 |
2e-24 |
BLAST |
|
HECTc
|
1636 |
2025 |
1.29e-177 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186648
AA Change: S238T
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: S238T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
386 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
421 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
440 |
654 |
5e-20 |
SMART |
|
PDB:1WA5|B
|
441 |
635 |
1e-5 |
PDB |
|
low complexity region
|
950 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1029 |
1040 |
N/A |
INTRINSIC |
|
low complexity region
|
1300 |
1311 |
N/A |
INTRINSIC |
|
low complexity region
|
1312 |
1329 |
N/A |
INTRINSIC |
|
Blast:HECTc
|
1330 |
1384 |
7e-8 |
BLAST |
|
Blast:HECTc
|
1540 |
1596 |
2e-24 |
BLAST |
|
HECTc
|
1603 |
1992 |
6.2e-180 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000186894
AA Change: S238T
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000140267
Gene: ENSMUSG00000026219
AA Change: S238T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
153 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
177 |
188 |
N/A |
INTRINSIC |
|
low complexity region
|
191 |
215 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
247 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
391 |
N/A |
INTRINSIC |
|
low complexity region
|
392 |
406 |
N/A |
INTRINSIC |
|
low complexity region
|
416 |
427 |
N/A |
INTRINSIC |
|
SCOP:d1ee4a_
|
446 |
660 |
3e-20 |
SMART |
|
PDB:1WA5|B
|
447 |
641 |
7e-6 |
PDB |
|
Blast:ARM
|
476 |
516 |
6e-6 |
BLAST |
|
WWE
|
764 |
839 |
6.9e-25 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187818
|
| SMART Domains |
Protein: ENSMUSP00000140917
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000189496
AA Change: S280T
PolyPhen 2
Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000139682
Gene: ENSMUSG00000026219
AA Change: S280T
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
195 |
214 |
N/A |
INTRINSIC |
|
low complexity region
|
219 |
230 |
N/A |
INTRINSIC |
|
low complexity region
|
233 |
257 |
N/A |
INTRINSIC |
|
low complexity region
|
273 |
289 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190067
|
| SMART Domains |
Protein: ENSMUSP00000140817
Gene: ENSMUSG00000026219
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
39 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000190464
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
99% (95/96) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca16 |
A |
T |
7: 120,032,796 (GRCm39) |
I272F |
possibly damaging |
Het |
| Adcy10 |
G |
T |
1: 165,337,939 (GRCm39) |
M184I |
probably benign |
Het |
| Aldoa |
G |
T |
7: 126,396,034 (GRCm39) |
T124N |
possibly damaging |
Het |
| Ap4e1 |
T |
A |
2: 126,853,727 (GRCm39) |
I55N |
probably damaging |
Het |
| Arhgap21 |
T |
C |
2: 20,870,198 (GRCm39) |
T913A |
probably benign |
Het |
| Atrnl1 |
G |
A |
19: 58,030,784 (GRCm39) |
E1309K |
probably damaging |
Het |
| BC034090 |
A |
T |
1: 155,117,777 (GRCm39) |
C114S |
probably damaging |
Het |
| Brinp2 |
A |
G |
1: 158,122,994 (GRCm39) |
|
probably null |
Het |
| Ccn4 |
T |
A |
15: 66,784,879 (GRCm39) |
V184E |
probably damaging |
Het |
| Ccna1 |
G |
T |
3: 54,953,120 (GRCm39) |
H408Q |
probably benign |
Het |
| Cd209g |
T |
G |
8: 4,185,189 (GRCm39) |
|
probably benign |
Het |
| Cdc20b |
A |
G |
13: 113,219,905 (GRCm39) |
I433V |
probably benign |
Het |
| Cdk2ap1 |
G |
A |
5: 124,492,421 (GRCm39) |
P5L |
probably damaging |
Het |
| Cep128 |
T |
C |
12: 91,260,933 (GRCm39) |
E310G |
probably damaging |
Het |
| Cflar |
G |
T |
1: 58,793,007 (GRCm39) |
V458F |
|
Het |
| Clec4b2 |
A |
G |
6: 123,158,343 (GRCm39) |
T70A |
probably benign |
Het |
| Cntnap5c |
A |
G |
17: 58,593,883 (GRCm39) |
T741A |
probably benign |
Het |
| Csf3r |
A |
T |
4: 125,937,515 (GRCm39) |
T800S |
probably benign |
Het |
| Csnk1g2 |
T |
C |
10: 80,473,733 (GRCm39) |
Y67H |
probably damaging |
Het |
| Cyp2c67 |
A |
T |
19: 39,604,138 (GRCm39) |
V406E |
probably benign |
Het |
| Dnah10 |
A |
G |
5: 124,900,006 (GRCm39) |
D3868G |
probably damaging |
Het |
| Dnah7a |
A |
T |
1: 53,737,867 (GRCm39) |
|
probably null |
Het |
| Dst |
A |
G |
1: 34,191,324 (GRCm39) |
N208S |
probably damaging |
Het |
| Echdc3 |
A |
G |
2: 6,211,224 (GRCm39) |
|
probably null |
Het |
| Edrf1 |
T |
C |
7: 133,239,578 (GRCm39) |
S13P |
probably benign |
Het |
| Ephb1 |
T |
C |
9: 101,841,276 (GRCm39) |
Y734C |
probably damaging |
Het |
| Eps8l1 |
A |
G |
7: 4,475,184 (GRCm39) |
Y325C |
probably damaging |
Het |
| Evc2 |
A |
G |
5: 37,544,183 (GRCm39) |
D644G |
probably damaging |
Het |
| Eya4 |
A |
C |
10: 23,048,943 (GRCm39) |
D54E |
probably benign |
Het |
| Filip1 |
T |
C |
9: 79,727,495 (GRCm39) |
S375G |
possibly damaging |
Het |
| Fmo9 |
A |
G |
1: 166,505,189 (GRCm39) |
M68T |
probably benign |
Het |
| Gemin5 |
G |
C |
11: 58,032,489 (GRCm39) |
P772A |
probably benign |
Het |
| Gle1 |
T |
G |
2: 29,833,805 (GRCm39) |
C401G |
probably damaging |
Het |
| Gm7298 |
A |
T |
6: 121,738,546 (GRCm39) |
I376F |
probably damaging |
Het |
| Gpr35 |
A |
C |
1: 92,910,353 (GRCm39) |
I22L |
probably benign |
Het |
| Grin2b |
T |
G |
6: 135,710,474 (GRCm39) |
D1024A |
possibly damaging |
Het |
| Hmcn1 |
T |
C |
1: 150,539,624 (GRCm39) |
N2956D |
probably damaging |
Het |
| Htt |
T |
C |
5: 35,003,350 (GRCm39) |
L1275P |
probably damaging |
Het |
| Ibtk |
T |
C |
9: 85,625,744 (GRCm39) |
D2G |
probably benign |
Het |
| Il16 |
T |
A |
7: 83,295,659 (GRCm39) |
D1170V |
probably damaging |
Het |
| Iqgap3 |
T |
A |
3: 88,024,217 (GRCm39) |
I1513N |
probably damaging |
Het |
| Kiz |
T |
G |
2: 146,792,430 (GRCm39) |
|
probably null |
Het |
| Krt12 |
A |
T |
11: 99,306,839 (GRCm39) |
*488K |
probably null |
Het |
| Lap3 |
A |
T |
5: 45,654,290 (GRCm39) |
T83S |
probably benign |
Het |
| Lars2 |
T |
A |
9: 123,261,058 (GRCm39) |
S410T |
probably damaging |
Het |
| Limch1 |
A |
G |
5: 67,175,001 (GRCm39) |
T518A |
probably benign |
Het |
| Lrrc49 |
A |
T |
9: 60,522,439 (GRCm39) |
S381T |
probably damaging |
Het |
| Lrrk2 |
A |
G |
15: 91,618,258 (GRCm39) |
D919G |
possibly damaging |
Het |
| Mmp1a |
A |
T |
9: 7,475,319 (GRCm39) |
S363C |
probably damaging |
Het |
| Mrps22 |
A |
C |
9: 98,483,524 (GRCm39) |
|
probably null |
Het |
| Mybpc3 |
T |
C |
2: 90,964,949 (GRCm39) |
I1066T |
probably benign |
Het |
| Myo10 |
A |
T |
15: 25,724,011 (GRCm39) |
N215I |
probably damaging |
Het |
| Myocd |
A |
C |
11: 65,109,474 (GRCm39) |
L99R |
probably damaging |
Het |
| Nadk |
T |
G |
4: 155,673,793 (GRCm39) |
I394S |
probably damaging |
Het |
| Nadsyn1 |
T |
C |
7: 143,364,952 (GRCm39) |
N251S |
probably damaging |
Het |
| Nbeal1 |
G |
C |
1: 60,276,310 (GRCm39) |
V684L |
probably benign |
Het |
| Ncapd2 |
G |
A |
6: 125,153,633 (GRCm39) |
P694L |
probably benign |
Het |
| Or2ag1 |
T |
A |
7: 106,473,075 (GRCm39) |
I126F |
probably damaging |
Het |
| Or2w3b |
A |
C |
11: 58,623,571 (GRCm39) |
L140R |
probably damaging |
Het |
| Or4a71 |
T |
C |
2: 89,357,901 (GRCm39) |
I284M |
probably damaging |
Het |
| Or5t16 |
G |
T |
2: 86,819,164 (GRCm39) |
R119S |
probably damaging |
Het |
| Pcdhb13 |
T |
A |
18: 37,576,309 (GRCm39) |
I229K |
probably damaging |
Het |
| Pgbd5 |
A |
T |
8: 125,101,056 (GRCm39) |
M400K |
possibly damaging |
Het |
| Phactr3 |
A |
G |
2: 177,944,529 (GRCm39) |
N409S |
probably damaging |
Het |
| Pik3c2g |
C |
A |
6: 139,606,868 (GRCm39) |
P305Q |
probably damaging |
Het |
| Pik3r4 |
G |
A |
9: 105,527,783 (GRCm39) |
V379M |
probably damaging |
Het |
| Pira12 |
A |
G |
7: 3,900,615 (GRCm39) |
V45A |
probably damaging |
Het |
| Pkd1l2 |
A |
T |
8: 117,802,870 (GRCm39) |
C250* |
probably null |
Het |
| Pramel14 |
A |
C |
4: 143,718,103 (GRCm39) |
S447A |
probably benign |
Het |
| Rapgef6 |
A |
C |
11: 54,548,191 (GRCm39) |
T792P |
possibly damaging |
Het |
| Rexo5 |
A |
G |
7: 119,404,414 (GRCm39) |
D170G |
probably damaging |
Het |
| Rnf17 |
G |
A |
14: 56,749,789 (GRCm39) |
|
probably null |
Het |
| Septin11 |
A |
G |
5: 93,304,725 (GRCm39) |
I181V |
probably benign |
Het |
| Serpina1e |
T |
G |
12: 103,913,277 (GRCm39) |
*414C |
probably null |
Het |
| Serpine1 |
C |
A |
5: 137,099,918 (GRCm39) |
Q80H |
probably damaging |
Het |
| Sh3bp2 |
A |
G |
5: 34,718,975 (GRCm39) |
N560S |
probably benign |
Het |
| Slc25a25 |
A |
G |
2: 32,309,178 (GRCm39) |
F221S |
probably damaging |
Het |
| Spag17 |
G |
T |
3: 99,934,717 (GRCm39) |
|
probably null |
Het |
| Sspn |
T |
C |
6: 145,906,881 (GRCm39) |
L104P |
probably damaging |
Het |
| St18 |
A |
C |
1: 6,903,818 (GRCm39) |
E693A |
probably damaging |
Het |
| St6galnac3 |
T |
C |
3: 153,117,169 (GRCm39) |
I185V |
possibly damaging |
Het |
| St8sia1 |
T |
C |
6: 142,822,395 (GRCm39) |
D156G |
probably damaging |
Het |
| Syne2 |
C |
A |
12: 76,052,152 (GRCm39) |
S4092R |
probably benign |
Het |
| Tll1 |
T |
A |
8: 64,577,979 (GRCm39) |
D76V |
possibly damaging |
Het |
| Tmco1 |
C |
T |
1: 167,136,022 (GRCm39) |
|
probably benign |
Het |
| Tnfaip3 |
T |
A |
10: 18,883,029 (GRCm39) |
T179S |
probably benign |
Het |
| Trav16 |
T |
C |
14: 53,981,096 (GRCm39) |
I95T |
possibly damaging |
Het |
| Unc79 |
A |
G |
12: 103,108,885 (GRCm39) |
M2166V |
probably benign |
Het |
| Vmn2r1 |
A |
G |
3: 63,997,362 (GRCm39) |
I339M |
probably damaging |
Het |
| Vwa5b1 |
A |
G |
4: 138,332,742 (GRCm39) |
|
probably null |
Het |
| Washc4 |
A |
T |
10: 83,409,638 (GRCm39) |
|
probably null |
Het |
| Wiz |
A |
G |
17: 32,576,602 (GRCm39) |
S642P |
possibly damaging |
Het |
| Zeb2 |
T |
A |
2: 45,000,053 (GRCm39) |
K60N |
possibly damaging |
Het |
| Zfat |
T |
A |
15: 68,050,631 (GRCm39) |
T797S |
probably benign |
Het |
| Zfp74 |
T |
C |
7: 29,634,590 (GRCm39) |
K373E |
probably damaging |
Het |
| Zswim5 |
T |
C |
4: 116,833,173 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Trip12 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00331:Trip12
|
APN |
1 |
84,708,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00430:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00465:Trip12
|
APN |
1 |
84,741,582 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00819:Trip12
|
APN |
1 |
84,731,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00900:Trip12
|
APN |
1 |
84,702,485 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
IGL00990:Trip12
|
APN |
1 |
84,729,605 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01087:Trip12
|
APN |
1 |
84,735,580 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01400:Trip12
|
APN |
1 |
84,729,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01521:Trip12
|
APN |
1 |
84,743,919 (GRCm39) |
splice site |
probably benign |
|
|
IGL01619:Trip12
|
APN |
1 |
84,792,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01796:Trip12
|
APN |
1 |
84,705,999 (GRCm39) |
missense |
probably benign |
0.42 |
|
IGL01975:Trip12
|
APN |
1 |
84,792,534 (GRCm39) |
splice site |
probably benign |
|
|
IGL02190:Trip12
|
APN |
1 |
84,743,791 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02474:Trip12
|
APN |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
IGL02517:Trip12
|
APN |
1 |
84,721,535 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02631:Trip12
|
APN |
1 |
84,743,729 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02991:Trip12
|
APN |
1 |
84,716,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03161:Trip12
|
APN |
1 |
84,738,853 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03388:Trip12
|
APN |
1 |
84,720,907 (GRCm39) |
missense |
probably damaging |
0.99 |
|
cardamom
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
pungent
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
spices
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
sulfuric
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
Turmeric
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
LCD18:Trip12
|
UTSW |
1 |
84,754,482 (GRCm38) |
unclassified |
probably benign |
|
|
R0090:Trip12
|
UTSW |
1 |
84,709,857 (GRCm39) |
splice site |
probably benign |
|
|
R0111:Trip12
|
UTSW |
1 |
84,736,854 (GRCm39) |
unclassified |
probably benign |
|
|
R0471:Trip12
|
UTSW |
1 |
84,703,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0486:Trip12
|
UTSW |
1 |
84,738,805 (GRCm39) |
nonsense |
probably null |
|
|
R0557:Trip12
|
UTSW |
1 |
84,702,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0570:Trip12
|
UTSW |
1 |
84,729,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Trip12
|
UTSW |
1 |
84,735,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0627:Trip12
|
UTSW |
1 |
84,746,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0630:Trip12
|
UTSW |
1 |
84,771,636 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R0657:Trip12
|
UTSW |
1 |
84,736,771 (GRCm39) |
missense |
probably benign |
0.19 |
|
R0741:Trip12
|
UTSW |
1 |
84,722,902 (GRCm39) |
missense |
probably benign |
0.09 |
|
R0862:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0864:Trip12
|
UTSW |
1 |
84,721,730 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1124:Trip12
|
UTSW |
1 |
84,714,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1252:Trip12
|
UTSW |
1 |
84,754,071 (GRCm39) |
nonsense |
probably null |
|
|
R1455:Trip12
|
UTSW |
1 |
84,736,821 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1487:Trip12
|
UTSW |
1 |
84,746,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1702:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1781:Trip12
|
UTSW |
1 |
84,708,342 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1847:Trip12
|
UTSW |
1 |
84,726,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1854:Trip12
|
UTSW |
1 |
84,705,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1866:Trip12
|
UTSW |
1 |
84,722,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1926:Trip12
|
UTSW |
1 |
84,727,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1935:Trip12
|
UTSW |
1 |
84,771,822 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1950:Trip12
|
UTSW |
1 |
84,738,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1994:Trip12
|
UTSW |
1 |
84,726,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2014:Trip12
|
UTSW |
1 |
84,738,587 (GRCm39) |
nonsense |
probably null |
|
|
R2391:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2423:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R2433:Trip12
|
UTSW |
1 |
84,721,544 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R2905:Trip12
|
UTSW |
1 |
84,732,064 (GRCm39) |
missense |
probably benign |
0.07 |
|
R3040:Trip12
|
UTSW |
1 |
84,719,966 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3735:Trip12
|
UTSW |
1 |
84,792,511 (GRCm39) |
frame shift |
probably null |
|
|
R3907:Trip12
|
UTSW |
1 |
84,709,827 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4394:Trip12
|
UTSW |
1 |
84,703,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4540:Trip12
|
UTSW |
1 |
84,726,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4859:Trip12
|
UTSW |
1 |
84,771,531 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5240:Trip12
|
UTSW |
1 |
84,771,854 (GRCm39) |
missense |
probably benign |
|
|
R5278:Trip12
|
UTSW |
1 |
84,739,868 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5377:Trip12
|
UTSW |
1 |
84,735,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Trip12
|
UTSW |
1 |
84,746,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5542:Trip12
|
UTSW |
1 |
84,727,065 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5550:Trip12
|
UTSW |
1 |
84,738,820 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5886:Trip12
|
UTSW |
1 |
84,708,179 (GRCm39) |
intron |
probably benign |
|
|
R5893:Trip12
|
UTSW |
1 |
84,736,884 (GRCm39) |
unclassified |
probably benign |
|
|
R5914:Trip12
|
UTSW |
1 |
84,741,179 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5925:Trip12
|
UTSW |
1 |
84,726,974 (GRCm39) |
nonsense |
probably null |
|
|
R5985:Trip12
|
UTSW |
1 |
84,703,492 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6135:Trip12
|
UTSW |
1 |
84,738,559 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6158:Trip12
|
UTSW |
1 |
84,738,733 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6419:Trip12
|
UTSW |
1 |
84,771,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6816:Trip12
|
UTSW |
1 |
84,771,435 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7194:Trip12
|
UTSW |
1 |
84,771,943 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7355:Trip12
|
UTSW |
1 |
84,792,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7361:Trip12
|
UTSW |
1 |
84,728,163 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7588:Trip12
|
UTSW |
1 |
84,738,604 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7705:Trip12
|
UTSW |
1 |
84,755,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Trip12
|
UTSW |
1 |
84,738,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Trip12
|
UTSW |
1 |
84,722,784 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8127:Trip12
|
UTSW |
1 |
84,716,463 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8221:Trip12
|
UTSW |
1 |
84,743,771 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8336:Trip12
|
UTSW |
1 |
84,743,762 (GRCm39) |
missense |
probably benign |
0.37 |
|
R8373:Trip12
|
UTSW |
1 |
84,773,488 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8719:Trip12
|
UTSW |
1 |
84,722,790 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8771:Trip12
|
UTSW |
1 |
84,721,018 (GRCm39) |
unclassified |
probably benign |
|
|
R8997:Trip12
|
UTSW |
1 |
84,771,596 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9146:Trip12
|
UTSW |
1 |
84,771,881 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9236:Trip12
|
UTSW |
1 |
84,703,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9338:Trip12
|
UTSW |
1 |
84,727,019 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9391:Trip12
|
UTSW |
1 |
84,773,473 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9516:Trip12
|
UTSW |
1 |
84,735,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0023:Trip12
|
UTSW |
1 |
84,738,508 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0065:Trip12
|
UTSW |
1 |
84,726,884 (GRCm39) |
missense |
probably benign |
0.21 |
|
Z1088:Trip12
|
UTSW |
1 |
84,743,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTGGCCTGTAATCCAGAAGG -3'
(R):5'- CAACTGGTGCCGAAGAGAGATC -3'
Sequencing Primer
(F):5'- CCTGTAATCCAGAAGGTCCAGG -3'
(R):5'- TCAAGCTGGCTTCAAAATCAG -3'
|
| Posted On |
2019-05-15 |
Incidental Mutation