|Institutional Source||Beutler Lab|
|Gene Name||nicolin 1|
|Is this an essential gene?||Not available|
|Stock #||R7148 (G1)|
|Chromosomal Location||108290429-108296498 bp(+) (GRCm38)|
|Type of Mutation||makesense|
|DNA Base Change (assembly)||T to A at 108295107 bp|
|Amino Acid Change||Stop codon to Arginine at position 214 (*214R)|
|Ref Sequence||ENSEMBL: ENSMUSP00000035227 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000035227] [ENSMUST00000035230]|
|Predicted Effect||probably null
AA Change: *214R
|Predicted Effect||probably benign
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This protein encoded by this gene localizes to the nucleus and is expressed in numerous tissues including brain, testis, liver, and kidney. This refseq contains genomic sequence in its 3' UTR which is not supported by experimental evidence. Computer predictions indicate that this region of the 3' UTR contains hairpin-forming self-complementary sequence which is possibly excised after transcription. This gene has a pseudogene on chromosome X. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Nicn1||
(F):5'- ACTGACAGAGATGATTCGGGC -3'
(R):5'- TTAGAACCGGTGAATTCTGAGAG -3'
(F):5'- ATGATTCGGGCTAGTCACAC -3'
(R):5'- TTACATGTCAGACAGTCAGAGAC -3'