Incidental Mutation 'PIT4280001:Olfml2b'
ID 554392
Institutional Source Beutler Lab
Gene Symbol Olfml2b
Ensembl Gene ENSMUSG00000038463
Gene Name olfactomedin-like 2B
Synonyms 4832415H08Rik, 1110018N05Rik, photomedin-2
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # PIT4280001 (G1)
Quality Score 94.0077
Status Not validated
Chromosome 1
Chromosomal Location 170472101-170510356 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 170475305 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 77 (C77S)
Ref Sequence ENSEMBL: ENSMUSP00000047291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046792]
AlphaFold Q3V1G4
Predicted Effect probably damaging
Transcript: ENSMUST00000046792
AA Change: C77S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000047291
Gene: ENSMUSG00000038463
AA Change: C77S

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
coiled coil region 41 68 N/A INTRINSIC
coiled coil region 179 213 N/A INTRINSIC
low complexity region 233 238 N/A INTRINSIC
Blast:OLF 254 306 1e-6 BLAST
low complexity region 308 319 N/A INTRINSIC
low complexity region 343 382 N/A INTRINSIC
OLF 492 746 4.76e-61 SMART
Coding Region Coverage
  • 1x: 93.1%
  • 3x: 90.9%
  • 10x: 85.5%
  • 20x: 73.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an olfactomedin domain-containing protein. Most olfactomedin domain-containing proteins are secreted glycoproteins. [provided by RefSeq, Dec 2016]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700020L24Rik A G 11: 83,331,660 (GRCm39) D161G probably damaging Het
Acer2 C T 4: 86,805,320 (GRCm39) L95F probably damaging Het
Adam15 C T 3: 89,251,285 (GRCm39) probably null Het
Aoc1l3 A T 6: 48,964,054 (GRCm39) M21L probably benign Het
Bmi1 T A 2: 18,687,820 (GRCm39) Y98* probably null Het
Cdon T C 9: 35,398,231 (GRCm39) C983R probably damaging Het
Cfap91 C T 16: 38,153,135 (GRCm39) V160I probably benign Het
Col12a1 T C 9: 79,585,387 (GRCm39) R1297G probably damaging Het
Cpd A T 11: 76,681,850 (GRCm39) M1132K probably benign Het
Dnah17 T A 11: 117,989,408 (GRCm39) R1267W possibly damaging Het
Dnah9 G A 11: 65,895,839 (GRCm39) A2512V probably benign Het
Eri3 G A 4: 117,439,831 (GRCm39) G175D probably damaging Het
Fbxo9 C A 9: 77,994,793 (GRCm39) W244L probably damaging Het
Fgfr3 A T 5: 33,889,576 (GRCm39) H343L probably benign Het
Fmnl2 G A 2: 53,008,208 (GRCm39) A803T unknown Het
Fmnl3 A G 15: 99,219,134 (GRCm39) probably null Het
Fth1 C A 19: 9,961,973 (GRCm39) A104E probably damaging Het
Gcm1 T C 9: 77,966,915 (GRCm39) Y45H probably damaging Het
Gm5157 C G 7: 20,919,007 (GRCm39) G179R probably damaging Het
Gpr179 A G 11: 97,234,941 (GRCm39) I463T probably damaging Het
Gpr35 T C 1: 92,910,356 (GRCm39) Y23H probably damaging Het
Inpp4b C T 8: 82,761,046 (GRCm39) H647Y probably benign Het
Kif6 A T 17: 50,062,148 (GRCm39) K436M probably benign Het
Lacc1 T A 14: 77,272,517 (GRCm39) Q93L probably damaging Het
Lamc1 T C 1: 153,119,217 (GRCm39) R801G probably damaging Het
Lrp2bp T G 8: 46,476,048 (GRCm39) V263G probably damaging Het
Magi3 T A 3: 103,961,668 (GRCm39) K453N probably damaging Het
Mfsd6 T A 1: 52,700,039 (GRCm39) Y703F probably benign Het
Mms22l A G 4: 24,581,149 (GRCm39) T820A probably benign Het
Ndufa12 T C 10: 94,034,994 (GRCm39) probably null Het
Nlrp12 A T 7: 3,290,063 (GRCm39) C150S possibly damaging Het
Noc4l G A 5: 110,799,305 (GRCm39) T159I probably benign Het
Or4c12 A T 2: 89,774,087 (GRCm39) I124N probably damaging Het
Or9a4 C A 6: 40,548,650 (GRCm39) T110K probably damaging Het
Pdzd2 A G 15: 12,399,374 (GRCm39) V784A probably damaging Het
Pip5kl1 A T 2: 32,473,470 (GRCm39) Y369F probably benign Het
Pkdrej A T 15: 85,704,136 (GRCm39) I600N probably benign Het
Psg19 T C 7: 18,530,831 (GRCm39) I108V probably damaging Het
Pxdn G A 12: 30,045,327 (GRCm39) V539M probably damaging Het
Resf1 T G 6: 149,227,023 (GRCm39) I23S probably benign Het
Rsbn1l T A 5: 21,124,653 (GRCm39) H383L probably damaging Het
Scamp2 A T 9: 57,488,076 (GRCm39) N118I probably damaging Het
Scn2a T C 2: 65,546,074 (GRCm39) V879A probably damaging Het
Scn8a G A 15: 100,855,370 (GRCm39) E172K probably damaging Het
Slc16a6 C T 11: 109,349,419 (GRCm39) C214Y possibly damaging Het
Stag1 A G 9: 100,824,769 (GRCm39) T922A possibly damaging Het
Tarbp1 T C 8: 127,157,586 (GRCm39) H1307R probably damaging Het
Tut1 T G 19: 8,936,626 (GRCm39) V150G probably benign Het
Ubr2 G A 17: 47,255,789 (GRCm39) R1371W probably damaging Het
Vmn2r124 A G 17: 18,283,487 (GRCm39) N394D probably benign Het
Vmn2r63 T C 7: 42,553,409 (GRCm39) T616A probably damaging Het
Zp3 G A 5: 136,013,318 (GRCm39) V217M possibly damaging Het
Other mutations in Olfml2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00422:Olfml2b APN 1 170,496,635 (GRCm39) missense probably damaging 0.96
IGL01871:Olfml2b APN 1 170,489,924 (GRCm39) splice site probably benign
IGL02475:Olfml2b APN 1 170,509,743 (GRCm39) missense probably damaging 1.00
IGL02657:Olfml2b APN 1 170,508,645 (GRCm39) missense probably benign 0.00
IGL03375:Olfml2b APN 1 170,477,401 (GRCm39) missense probably benign 0.35
R0040:Olfml2b UTSW 1 170,496,320 (GRCm39) missense probably benign 0.00
R0194:Olfml2b UTSW 1 170,508,684 (GRCm39) missense possibly damaging 0.89
R0834:Olfml2b UTSW 1 170,475,413 (GRCm39) missense probably benign 0.00
R1218:Olfml2b UTSW 1 170,477,351 (GRCm39) missense probably damaging 1.00
R1386:Olfml2b UTSW 1 170,508,731 (GRCm39) missense probably damaging 0.97
R1420:Olfml2b UTSW 1 170,496,596 (GRCm39) missense probably benign 0.01
R1699:Olfml2b UTSW 1 170,472,642 (GRCm39) missense possibly damaging 0.89
R1730:Olfml2b UTSW 1 170,509,358 (GRCm39) missense probably damaging 1.00
R1755:Olfml2b UTSW 1 170,509,346 (GRCm39) missense probably damaging 1.00
R1869:Olfml2b UTSW 1 170,496,812 (GRCm39) missense probably damaging 0.96
R2295:Olfml2b UTSW 1 170,490,107 (GRCm39) splice site probably benign
R2394:Olfml2b UTSW 1 170,477,319 (GRCm39) missense possibly damaging 0.82
R3784:Olfml2b UTSW 1 170,509,551 (GRCm39) missense probably damaging 0.96
R4523:Olfml2b UTSW 1 170,496,791 (GRCm39) missense probably benign
R4611:Olfml2b UTSW 1 170,472,516 (GRCm39) missense probably damaging 0.99
R4900:Olfml2b UTSW 1 170,489,947 (GRCm39) missense probably damaging 1.00
R5201:Olfml2b UTSW 1 170,496,433 (GRCm39) missense probably benign
R5245:Olfml2b UTSW 1 170,496,443 (GRCm39) missense probably benign
R5268:Olfml2b UTSW 1 170,477,330 (GRCm39) missense probably damaging 1.00
R5283:Olfml2b UTSW 1 170,508,758 (GRCm39) nonsense probably null
R5348:Olfml2b UTSW 1 170,489,995 (GRCm39) missense probably benign 0.02
R5408:Olfml2b UTSW 1 170,472,545 (GRCm39) missense probably damaging 1.00
R5673:Olfml2b UTSW 1 170,509,698 (GRCm39) missense probably damaging 1.00
R5758:Olfml2b UTSW 1 170,496,833 (GRCm39) critical splice donor site probably null
R5893:Olfml2b UTSW 1 170,490,042 (GRCm39) missense probably benign
R6290:Olfml2b UTSW 1 170,477,359 (GRCm39) nonsense probably null
R6380:Olfml2b UTSW 1 170,496,800 (GRCm39) missense probably benign 0.00
R6778:Olfml2b UTSW 1 170,472,639 (GRCm39) missense probably damaging 1.00
R7155:Olfml2b UTSW 1 170,494,354 (GRCm39) missense probably benign 0.01
R7538:Olfml2b UTSW 1 170,477,402 (GRCm39) missense possibly damaging 0.79
R8354:Olfml2b UTSW 1 170,509,793 (GRCm39) missense possibly damaging 0.96
R8377:Olfml2b UTSW 1 170,496,353 (GRCm39) missense probably damaging 0.99
R8792:Olfml2b UTSW 1 170,508,669 (GRCm39) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- TCAGGGCTGAATGCAGTCTC -3'
(R):5'- AGCTCCTACCTTCAAATCTCGG -3'

Sequencing Primer
(F):5'- CTCTGGCTAGGGCAACACATTTG -3'
(R):5'- TCAAATCTCGGCTGTCAGC -3'
Posted On 2019-06-07