Incidental Mutation 'IGL00586:Oas1c'
ID5547
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oas1c
Ensembl Gene ENSMUSG00000001166
Gene Name2'-5' oligoadenylate synthetase 1C
SynonymsOasl5
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #IGL00586
Quality Score
Status
Chromosome5
Chromosomal Location120800194-120812514 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 120808679 bp
ZygosityHeterozygous
Amino Acid Change Threonine to Alanine at position 29 (T29A)
Ref Sequence ENSEMBL: ENSMUSP00000112584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086377] [ENSMUST00000117193] [ENSMUST00000125547] [ENSMUST00000183291]
Predicted Effect probably benign
Transcript: ENSMUST00000086377
SMART Domains Protein: ENSMUSP00000083564
Gene: ENSMUSG00000029605

DomainStartEndE-ValueType
Pfam:OAS1_C 158 251 7.1e-37 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117193
AA Change: T29A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000112584
Gene: ENSMUSG00000001166
AA Change: T29A

DomainStartEndE-ValueType
Pfam:OAS1_C 168 354 1.4e-76 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125547
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130045
SMART Domains Protein: ENSMUSP00000122510
Gene: ENSMUSG00000001166

DomainStartEndE-ValueType
Pfam:OAS1_C 89 146 3e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000182725
Predicted Effect probably benign
Transcript: ENSMUST00000183291
SMART Domains Protein: ENSMUSP00000138088
Gene: ENSMUSG00000029605

DomainStartEndE-ValueType
Pfam:OAS1_C 158 345 3.4e-79 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201006
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl5b T C 2: 15,069,935 S76P probably benign Het
Asap3 A C 4: 136,206,568 D17A probably damaging Het
Casc1 A T 6: 145,191,576 F269I possibly damaging Het
Ccdc24 C T 4: 117,872,046 R78H probably damaging Het
Crp T C 1: 172,699,001 F218L probably benign Het
Dab2 T C 15: 6,429,825 L385P probably benign Het
Dip2c C A 13: 9,610,755 T855N probably damaging Het
Ep400 A G 5: 110,739,594 V541A probably damaging Het
Gbgt1 A T 2: 28,502,195 probably null Het
Gm5771 T C 6: 41,396,115 I107T probably damaging Het
Gm6871 A T 7: 41,546,421 D297E possibly damaging Het
Gpr107 T A 2: 31,171,994 F145I probably benign Het
Itgb6 T G 2: 60,620,352 D581A probably benign Het
Lce1a1 C T 3: 92,647,163 M1I probably null Het
Lmbrd2 G A 15: 9,157,295 V207M probably damaging Het
Muc5b T A 7: 141,841,392 V45E unknown Het
Mybpc2 A G 7: 44,505,382 V977A probably damaging Het
Pdzd2 G T 15: 12,365,767 probably null Het
Plk2 T C 13: 110,396,378 Y158H possibly damaging Het
Ptprq A G 10: 107,608,122 probably benign Het
Rnf17 C T 14: 56,421,082 T76I probably damaging Het
Serpinb1c T C 13: 32,883,975 K213E probably damaging Het
Sidt2 A G 9: 45,943,052 V624A possibly damaging Het
Sin3b T C 8: 72,757,000 V1005A probably benign Het
Ubr4 T C 4: 139,455,184 V358A possibly damaging Het
Wdr60 A T 12: 116,241,780 D396E probably benign Het
Zfp120 T C 2: 150,119,828 I67V possibly damaging Het
Zfp942 A T 17: 21,928,624 H341Q probably damaging Het
Other mutations in Oas1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01472:Oas1c APN 5 120802921 missense probably damaging 1.00
IGL01931:Oas1c APN 5 120805495 missense probably benign 0.20
IGL02429:Oas1c APN 5 120802068 missense probably benign 0.30
IGL02498:Oas1c APN 5 120805526 missense possibly damaging 0.83
IGL02696:Oas1c APN 5 120805463 missense probably benign 0.44
IGL02957:Oas1c APN 5 120805413 nonsense probably null
sandshrew UTSW 5 120808139 missense probably damaging 0.99
R0562:Oas1c UTSW 5 120805604 splice site probably benign
R1819:Oas1c UTSW 5 120808735 missense possibly damaging 0.89
R1853:Oas1c UTSW 5 120807995 missense probably damaging 1.00
R1937:Oas1c UTSW 5 120802984 missense probably benign 0.00
R2248:Oas1c UTSW 5 120802861 missense possibly damaging 0.48
R2258:Oas1c UTSW 5 120803017 missense probably null 1.00
R2570:Oas1c UTSW 5 120805438 missense probably benign 0.05
R3965:Oas1c UTSW 5 120808718 missense probably damaging 1.00
R4164:Oas1c UTSW 5 120808139 missense probably damaging 0.99
R5146:Oas1c UTSW 5 120802094 missense probably benign 0.08
R5875:Oas1c UTSW 5 120805562 missense probably damaging 1.00
R5938:Oas1c UTSW 5 120805533 missense probably benign 0.05
R7219:Oas1c UTSW 5 120802892 missense probably damaging 1.00
Posted On2012-04-20