Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT4480001:Dnah6'

554856

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.097) question?

Stock #

PIT4480001 (G1)

Quality Score

157.009

Status

Not validated

Chromosome

Chromosomal Location

72994589-73198634 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 73078863 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 2367 (I2367V)

Ref Sequence

ENSEMBL: ENSMUSP00000068758 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000064948
AA Change: I2367V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: I2367V

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040
AA Change: I2315V

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: I2315V

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204053
AA Change: I2367V

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: I2367V

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Coding Region Coverage

1x: 93.3%
3x: 90.7%
10x: 83.8%
20x: 69.1%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Actn3	G	A	19: 4,917,605 (GRCm39)	Q413*	probably null	Het
Ahnak2	C	T	12: 112,740,358 (GRCm39)	S1238N	possibly damaging	Het
Arsk	T	C	13: 76,210,484 (GRCm39)	E521G	probably damaging	Het
Baiap2	A	G	11: 119,887,913 (GRCm39)	T356A	probably benign	Het
Baz1b	G	A	5: 135,246,819 (GRCm39)	R756H	probably damaging	Het
Celsr1	G	A	15: 85,916,615 (GRCm39)	P453S	probably damaging	Het
Cep41	G	A	6: 30,658,412 (GRCm39)	P196S	probably damaging	Het
Cln5	T	A	14: 103,309,214 (GRCm39)	Y89*	probably null	Het
Cntnap3	A	G	13: 64,905,024 (GRCm39)	F919S	probably damaging	Het
Cntrl	C	T	2: 35,045,440 (GRCm39)	H1383Y	probably damaging	Het
Cobl	A	G	11: 12,203,592 (GRCm39)	S1037P	probably benign	Het
Col17a1	A	T	19: 47,659,813 (GRCm39)	S380T	probably benign	Het
Cyrib	G	A	15: 63,828,490 (GRCm39)	T11I	probably benign	Het
Dagla	A	T	19: 10,238,022 (GRCm39)	S323T	probably benign	Het
Dicer1	G	T	12: 104,662,803 (GRCm39)	Q1593K	probably benign	Het
Emc1	T	C	4: 139,086,588 (GRCm39)	S184P	possibly damaging	Het
Eps8l1	G	A	7: 4,474,414 (GRCm39)	S295N	probably benign	Het
Erbb4	A	T	1: 68,114,702 (GRCm39)	M914K	probably damaging	Het
Eva1a	A	G	6: 82,068,784 (GRCm39)	E37G	probably damaging	Het
Fyco1	G	T	9: 123,657,715 (GRCm39)	Y820*	probably null	Het
Gipr	T	C	7: 18,896,859 (GRCm39)	Y137C	probably damaging	Het
Gm5414	A	G	15: 101,536,181 (GRCm39)	V148A	probably damaging	Het
Gpn1	T	C	5: 31,654,685 (GRCm39)	V79A	probably damaging	Het
Grk2	G	A	19: 4,337,437 (GRCm39)	R617C	possibly damaging	Het
Inpp4b	A	C	8: 82,772,896 (GRCm39)	E730A	probably damaging	Het
Inpp5f	C	T	7: 128,286,858 (GRCm39)	T579I	probably benign	Het
Kif15	A	T	9: 122,840,608 (GRCm39)	M1201L	probably benign	Het
Ltbp3	A	G	19: 5,801,254 (GRCm39)	N631S	possibly damaging	Het
Mdh1	G	A	11: 21,508,538 (GRCm39)	S268L	probably damaging	Het
Mgat4e	T	A	1: 134,469,103 (GRCm39)	T314S	possibly damaging	Het
Nsd1	A	G	13: 55,361,731 (GRCm39)	Q233R	probably benign	Het
Or11g1	T	C	14: 50,651,372 (GRCm39)	F124L	probably benign	Het
Or5w17	T	C	2: 87,584,127 (GRCm39)	D70G	possibly damaging	Het
Paqr5	T	A	9: 61,863,438 (GRCm39)	I295L	probably benign	Het
Peg10	C	T	6: 4,756,560 (GRCm39)	H379Y	unknown	Het
Phtf2	A	T	5: 21,018,242 (GRCm39)	I33N	probably damaging	Het
Plcb2	T	C	2: 118,553,977 (GRCm39)	M115V	probably benign	Het
Ppp2r3d	A	G	9: 101,003,576 (GRCm39)	Y431H	possibly damaging	Het
Prph2	GT	G	17: 47,222,039 (GRCm39)		probably null	Het
Psmd1	C	T	1: 86,055,960 (GRCm39)	P774L	probably damaging	Het
Ranbp17	A	T	11: 33,247,340 (GRCm39)		probably null	Het
Rptn	A	G	3: 93,304,977 (GRCm39)	D770G	possibly damaging	Het
Serac1	A	G	17: 6,101,087 (GRCm39)	L439P	probably damaging	Het
Slitrk6	TTTTAGTCTGTTCTACCAACACCTT	TTT	14: 110,987,257 (GRCm39)		probably null	Het
Sox6	T	C	7: 115,196,744 (GRCm39)	I295M	probably benign	Het
Spata31h1	T	C	10: 82,119,586 (GRCm39)	M4475V	probably benign	Het
Sulf1	T	A	1: 12,929,637 (GRCm39)	D301E	probably benign	Het
Tas2r117	G	A	6: 132,780,014 (GRCm39)	V51I	possibly damaging	Het
Tbx2	C	T	11: 85,725,561 (GRCm39)	R171C	probably damaging	Het
Tgfbr1	A	G	4: 47,402,955 (GRCm39)	I320V	probably benign	Het
Tjp3	C	A	10: 81,115,091 (GRCm39)	G396W	probably damaging	Het
Tmprss2	T	C	16: 97,400,460 (GRCm39)	N4D	possibly damaging	Het
Tnfaip3	T	C	10: 18,883,071 (GRCm39)	N165D	probably benign	Het
Tnfrsf21	A	T	17: 43,348,802 (GRCm39)	Y138F	probably benign	Het
Utp4	T	C	8: 107,632,817 (GRCm39)	S267P	probably benign	Het
Wnk1	A	T	6: 119,940,328 (GRCm39)	L803*	probably null	Het
Zbbx	T	A	3: 75,043,794 (GRCm39)	D35V	probably damaging	Het
Zscan12	T	G	13: 21,552,744 (GRCm39)	N189K	possibly damaging	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,172,720 (GRCm39)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,063,190 (GRCm39)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,172,744 (GRCm39)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,189,417 (GRCm39)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,100,754 (GRCm39)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,172,603 (GRCm39)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,133,333 (GRCm39)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,010,509 (GRCm39)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,060,140 (GRCm39)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,150,373 (GRCm39)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,051,764 (GRCm39)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,042,708 (GRCm39)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,150,439 (GRCm39)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,069,161 (GRCm39)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,051,731 (GRCm39)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,001,235 (GRCm39)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,121,701 (GRCm39)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,052,785 (GRCm39)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,053,643 (GRCm39)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,165,360 (GRCm39)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,042,759 (GRCm39)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,112,784 (GRCm39)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,009,552 (GRCm39)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,037,126 (GRCm39)	missense	probably benign
IGL02126:Dnah6	APN	6	73,080,149 (GRCm39)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	72,994,780 (GRCm39)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,110,633 (GRCm39)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,145,894 (GRCm39)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,078,881 (GRCm39)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,053,623 (GRCm39)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,004,431 (GRCm39)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	72,998,210 (GRCm39)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,072,087 (GRCm39)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,098,806 (GRCm39)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,185,582 (GRCm39)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,115,698 (GRCm39)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,009,570 (GRCm39)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,126,123 (GRCm39)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,121,987 (GRCm39)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,018,037 (GRCm39)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,121,683 (GRCm39)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,030,630 (GRCm39)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,060,068 (GRCm39)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,052,833 (GRCm39)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,140,487 (GRCm39)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,042,738 (GRCm39)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,185,624 (GRCm39)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,091,565 (GRCm39)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,037,243 (GRCm39)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,069,155 (GRCm39)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,132,262 (GRCm39)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,015,717 (GRCm39)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,165,518 (GRCm39)	splice site	probably benign
R0165:Dnah6	UTSW	6	72,998,306 (GRCm39)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,059,906 (GRCm39)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,046,403 (GRCm39)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,136,098 (GRCm39)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,150,541 (GRCm39)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,046,382 (GRCm39)	splice site	probably benign
R0345:Dnah6	UTSW	6	72,998,240 (GRCm39)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,165,342 (GRCm39)	missense	probably benign
R0362:Dnah6	UTSW	6	73,185,592 (GRCm39)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,060,107 (GRCm39)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,021,757 (GRCm39)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	72,999,395 (GRCm39)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,100,794 (GRCm39)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,106,457 (GRCm39)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,189,605 (GRCm39)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,064,585 (GRCm39)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,012,276 (GRCm39)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,101,740 (GRCm39)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,136,176 (GRCm39)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,121,948 (GRCm39)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,136,118 (GRCm39)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,101,692 (GRCm39)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,185,528 (GRCm39)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,168,602 (GRCm39)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,004,425 (GRCm39)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,026,031 (GRCm39)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,128,536 (GRCm39)	missense	probably benign
R1557:Dnah6	UTSW	6	73,026,114 (GRCm39)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,053,583 (GRCm39)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,044,452 (GRCm39)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,121,946 (GRCm39)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,077,095 (GRCm39)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,021,735 (GRCm39)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,132,279 (GRCm39)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,182,715 (GRCm39)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,101,761 (GRCm39)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,106,523 (GRCm39)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,021,744 (GRCm39)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,137,965 (GRCm39)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,001,941 (GRCm39)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,158,780 (GRCm39)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,077,071 (GRCm39)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,158,745 (GRCm39)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,061,704 (GRCm39)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,098,953 (GRCm39)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,072,027 (GRCm39)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,069,175 (GRCm39)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,044,449 (GRCm39)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,150,402 (GRCm39)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,004,405 (GRCm39)	missense	probably benign
R2041:Dnah6	UTSW	6	73,050,422 (GRCm39)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	72,998,165 (GRCm39)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,121,018 (GRCm39)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,026,149 (GRCm39)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,066,729 (GRCm39)	splice site	probably null
R2193:Dnah6	UTSW	6	73,115,623 (GRCm39)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,077,068 (GRCm39)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,090,564 (GRCm39)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	72,998,092 (GRCm39)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,133,404 (GRCm39)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,068,950 (GRCm39)	splice site	probably null
R2436:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,106,314 (GRCm39)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,150,333 (GRCm39)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,098,797 (GRCm39)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,009,616 (GRCm39)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,168,481 (GRCm39)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,104,910 (GRCm39)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,098,975 (GRCm39)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,066,575 (GRCm39)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,106,431 (GRCm39)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,126,467 (GRCm39)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,095,009 (GRCm39)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,106,274 (GRCm39)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,168,462 (GRCm39)	missense	probably benign
R4486:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,155,399 (GRCm39)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,169,388 (GRCm39)	missense	probably benign
R4573:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,063,164 (GRCm39)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,129,695 (GRCm39)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,106,643 (GRCm39)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,047,580 (GRCm39)	missense	probably benign
R4653:Dnah6	UTSW	6	73,050,440 (GRCm39)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,014,671 (GRCm39)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,169,405 (GRCm39)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,001,995 (GRCm39)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,106,513 (GRCm39)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,072,057 (GRCm39)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,066,651 (GRCm39)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,066,681 (GRCm39)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	72,999,407 (GRCm39)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,021,745 (GRCm39)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,098,771 (GRCm39)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,169,659 (GRCm39)	intron	probably benign
R4948:Dnah6	UTSW	6	73,030,672 (GRCm39)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,165,366 (GRCm39)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,121,798 (GRCm39)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,021,674 (GRCm39)	missense	probably benign
R5044:Dnah6	UTSW	6	73,014,605 (GRCm39)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,158,744 (GRCm39)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,172,617 (GRCm39)	missense	probably benign
R5186:Dnah6	UTSW	6	73,044,410 (GRCm39)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,172,715 (GRCm39)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,090,471 (GRCm39)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,104,844 (GRCm39)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,051,573 (GRCm39)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,189,603 (GRCm39)	missense	probably benign
R5343:Dnah6	UTSW	6	73,189,599 (GRCm39)	missense	probably benign
R5375:Dnah6	UTSW	6	73,100,838 (GRCm39)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,014,598 (GRCm39)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,037,121 (GRCm39)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,052,717 (GRCm39)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,063,168 (GRCm39)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,069,140 (GRCm39)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,069,099 (GRCm39)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,167,402 (GRCm39)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,136,212 (GRCm39)	missense	probably benign
R5541:Dnah6	UTSW	6	73,169,971 (GRCm39)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,128,672 (GRCm39)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,126,508 (GRCm39)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	72,998,210 (GRCm39)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,037,262 (GRCm39)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,158,705 (GRCm39)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,063,149 (GRCm39)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,091,680 (GRCm39)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,165,477 (GRCm39)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,042,798 (GRCm39)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,063,200 (GRCm39)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,168,588 (GRCm39)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,132,401 (GRCm39)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,051,569 (GRCm39)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,051,687 (GRCm39)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,021,715 (GRCm39)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,150,516 (GRCm39)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,030,678 (GRCm39)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,012,263 (GRCm39)	splice site	probably null
R6640:Dnah6	UTSW	6	73,001,276 (GRCm39)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,115,743 (GRCm39)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,014,532 (GRCm39)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,110,591 (GRCm39)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,110,525 (GRCm39)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,189,505 (GRCm39)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,158,738 (GRCm39)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,021,756 (GRCm39)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	72,998,161 (GRCm39)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,064,545 (GRCm39)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,112,663 (GRCm39)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,015,729 (GRCm39)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,158,688 (GRCm39)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,150,528 (GRCm39)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,061,743 (GRCm39)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,121,705 (GRCm39)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,189,595 (GRCm39)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,169,300 (GRCm39)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,189,475 (GRCm39)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,104,887 (GRCm39)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,095,082 (GRCm39)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,004,423 (GRCm39)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,126,413 (GRCm39)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,069,151 (GRCm39)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,072,189 (GRCm39)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,101,742 (GRCm39)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,146,063 (GRCm39)	splice site	probably null
R7735:Dnah6	UTSW	6	73,046,412 (GRCm39)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,002,703 (GRCm39)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,104,902 (GRCm39)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,112,450 (GRCm39)	splice site	probably null
R8034:Dnah6	UTSW	6	73,106,208 (GRCm39)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,137,896 (GRCm39)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,002,769 (GRCm39)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,037,208 (GRCm39)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,014,549 (GRCm39)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,021,711 (GRCm39)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,145,810 (GRCm39)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,172,664 (GRCm39)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,053,582 (GRCm39)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,001,983 (GRCm39)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,051,634 (GRCm39)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,115,757 (GRCm39)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,172,798 (GRCm39)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,155,440 (GRCm39)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,072,171 (GRCm39)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,145,850 (GRCm39)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,052,873 (GRCm39)	intron	probably benign
R8737:Dnah6	UTSW	6	73,044,428 (GRCm39)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,156,811 (GRCm39)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,042,756 (GRCm39)	missense	probably benign
R8809:Dnah6	UTSW	6	73,009,546 (GRCm39)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,104,937 (GRCm39)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,121,156 (GRCm39)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	72,998,131 (GRCm39)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,155,481 (GRCm39)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,121,734 (GRCm39)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,119,275 (GRCm39)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,061,640 (GRCm39)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,126,156 (GRCm39)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,121,029 (GRCm39)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,044,469 (GRCm39)	missense	probably benign
R9106:Dnah6	UTSW	6	73,121,752 (GRCm39)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,037,186 (GRCm39)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,098,882 (GRCm39)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,121,924 (GRCm39)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,121,688 (GRCm39)	nonsense	probably null
R9200:Dnah6	UTSW	6	73,004,497 (GRCm39)	missense	probably benign	0.06
R9265:Dnah6	UTSW	6	73,060,040 (GRCm39)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	72,998,261 (GRCm39)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,189,513 (GRCm39)	missense	probably benign
R9439:Dnah6	UTSW	6	73,012,330 (GRCm39)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,119,299 (GRCm39)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,115,750 (GRCm39)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,168,589 (GRCm39)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,078,872 (GRCm39)	missense	probably benign
RF020:Dnah6	UTSW	6	73,095,040 (GRCm39)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,155,501 (GRCm39)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,168,483 (GRCm39)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,014,656 (GRCm39)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,110,542 (GRCm39)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,064,766 (GRCm39)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,009,509 (GRCm39)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	72,998,220 (GRCm39)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,132,255 (GRCm39)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,018,121 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTTACGTTGTTGTGCTTAGCC -3'
(R):5'- CCAACTAAAATGGTATGTTGTTGGC -3'

Sequencing Primer
(F):5'- TGAAGTCCAATCAGTACTGCCTG -3'
(R):5'- GGCATGGCTGTCTCTCAG -3'

Posted On

2019-06-07