Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT4449001:Zfp772'

555732

Institutional Source

Beutler Lab

Gene Symbol

Zfp772

Ensembl Gene

ENSMUSG00000066838

Gene Name

zinc finger protein 772

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

PIT4449001 (G1)

Quality Score

209.009

Status

Not validated

Chromosome

Chromosomal Location

7205121-7212997 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 7207350 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Valine at position 114 (I114V)

Ref Sequence

ENSEMBL: ENSMUSP00000074055 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000074455]

AlphaFold

Q3UQL6

Predicted Effect

probably benign
Transcript: ENSMUST00000074455
AA Change: I114V

PolyPhen 2 Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000074055
Gene: ENSMUSG00000066838
AA Change: I114V

Domain	Start	End	E-Value	Type
KRAB	42	102	1.87e-14	SMART
ZnF_C2H2	193	215	1.36e-2	SMART
ZnF_C2H2	221	243	5.21e-4	SMART
ZnF_C2H2	249	271	1.38e-3	SMART
ZnF_C2H2	277	299	4.24e-4	SMART
ZnF_C2H2	305	327	5.21e-4	SMART
ZnF_C2H2	333	355	2.27e-4	SMART
ZnF_C2H2	361	383	1.18e-2	SMART
ZnF_C2H2	389	411	4.87e-4	SMART

Coding Region Coverage

1x: 93.3%
3x: 90.8%
10x: 84.7%
20x: 71.6%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Asf1b	A	G	8: 84,694,611 (GRCm39)	N125S	probably benign	Het
BC048671	T	A	6: 90,282,145 (GRCm39)	L101I	probably damaging	Het
Camta1	A	G	4: 151,216,043 (GRCm39)	L959P	probably benign	Het
Cfap91	T	C	16: 38,148,720 (GRCm39)	E236G	probably damaging	Het
Cfh	C	A	1: 140,040,303 (GRCm39)	V598F	probably damaging	Het
Cyp2j7	G	T	4: 96,103,575 (GRCm39)	T320K	probably damaging	Het
Ddr1	A	G	17: 35,998,141 (GRCm39)	I468T	possibly damaging	Het
Dhx15	A	G	5: 52,318,300 (GRCm39)	V510A	probably damaging	Het
Dpp4	T	A	2: 62,186,988 (GRCm39)	K507N	probably benign	Het
Evpl	G	A	11: 116,124,225 (GRCm39)	T198M	possibly damaging	Het
Gabbr1	G	A	17: 37,367,242 (GRCm39)	V373I	probably damaging	Het
Gak	A	T	5: 108,728,791 (GRCm39)	S1049T	probably benign	Het
Gipr	C	T	7: 18,894,543 (GRCm39)	R253H	probably benign	Het
Gm3685	T	A	14: 7,043,960 (GRCm38)	M73L	probably benign	Het
Gm5168	C	T	X: 25,994,840 (GRCm39)	R129Q	probably null	Het
Kcnh1	T	A	1: 192,100,992 (GRCm39)	V555D	probably damaging	Het
Kif26b	T	C	1: 178,745,651 (GRCm39)	S1916P	probably damaging	Het
Lingo4	T	C	3: 94,309,239 (GRCm39)	V59A	probably benign	Het
Mroh8	T	A	2: 157,067,454 (GRCm39)	Q635L	probably damaging	Het
Msh6	T	A	17: 88,293,616 (GRCm39)	D790E	probably damaging	Het
Nrxn1	A	T	17: 90,905,007 (GRCm39)	W809R	probably damaging	Het
Or5ac19	C	A	16: 59,089,493 (GRCm39)	C179F	probably damaging	Het
Polr3d	T	C	14: 70,676,903 (GRCm39)	H397R	probably benign	Het
Pwp2	G	A	10: 78,014,304 (GRCm39)	T432I	probably benign	Het
Rad21	G	C	15: 51,836,639 (GRCm39)	F177L	probably benign	Het
Rnf182	G	A	13: 43,822,153 (GRCm39)	V235I	probably benign	Het
Scn11a	C	T	9: 119,599,014 (GRCm39)	C1172Y	probably damaging	Het
Sh2b3	A	G	5: 121,966,742 (GRCm39)	L124P	possibly damaging	Het
Six2	T	C	17: 85,992,906 (GRCm39)	N199S	probably benign	Het
Slc5a3	A	G	16: 91,874,702 (GRCm39)	D253G	probably benign	Het
Synm	A	G	7: 67,385,025 (GRCm39)	M879T	probably benign	Het
Tasp1	A	G	2: 139,752,455 (GRCm39)	I328T	possibly damaging	Het
Tbrg4	T	C	11: 6,569,689 (GRCm39)	Q309R	probably damaging	Het
Tmtc2	A	G	10: 105,139,465 (GRCm39)	L687P	probably damaging	Het
Trgc3	A	T	13: 19,447,532 (GRCm39)	R162*	probably null	Het
Tufm	T	C	7: 126,086,621 (GRCm39)	M1T	probably null	Het
Vmn2r116	A	C	17: 23,607,921 (GRCm39)	L496F	probably benign	Het
Vmn2r75	C	T	7: 85,814,791 (GRCm39)	C234Y	probably damaging	Het
Wars2	G	T	3: 99,112,595 (GRCm39)	V162L	possibly damaging	Het
Zc3h11a	A	T	1: 133,552,349 (GRCm39)	V586D	probably benign	Het
Zdhhc5	A	T	2: 84,520,571 (GRCm39)	N535K	probably damaging	Het
Zfp52	T	C	17: 21,777,478 (GRCm39)	Y38H	probably damaging	Het
Zfp729b	T	C	13: 67,739,542 (GRCm39)	M908V	probably benign	Het

Other mutations in Zfp772

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00480:Zfp772	APN	7	7,207,115 (GRCm39)	missense	probably benign
IGL01589:Zfp772	APN	7	7,208,523 (GRCm39)	missense	possibly damaging	0.53
R1945:Zfp772	UTSW	7	7,206,629 (GRCm39)	missense	probably benign	0.01
R3085:Zfp772	UTSW	7	7,206,699 (GRCm39)	missense	possibly damaging	0.53
R5300:Zfp772	UTSW	7	7,207,157 (GRCm39)	missense	probably benign
R5793:Zfp772	UTSW	7	7,207,283 (GRCm39)	missense	probably benign	0.00
R6252:Zfp772	UTSW	7	7,207,018 (GRCm39)	missense	possibly damaging	0.86
R6605:Zfp772	UTSW	7	7,208,547 (GRCm39)	missense	possibly damaging	0.72
R6751:Zfp772	UTSW	7	7,206,716 (GRCm39)	missense	possibly damaging	0.90
R6812:Zfp772	UTSW	7	7,209,307 (GRCm39)	missense	possibly damaging	0.92
R8171:Zfp772	UTSW	7	7,207,096 (GRCm39)	nonsense	probably null
R8696:Zfp772	UTSW	7	7,208,518 (GRCm39)	missense	possibly damaging	0.53
R9104:Zfp772	UTSW	7	7,207,190 (GRCm39)	missense	possibly damaging	0.53
R9665:Zfp772	UTSW	7	7,212,793 (GRCm39)	start codon destroyed	probably null

Predicted Primers

PCR Primer
(F):5'- GCCACAGTCACTGCATATGC -3'
(R):5'- GCTGCTCCTAAGGTCCATAG -3'

Sequencing Primer
(F):5'- CTCCATGTTCATGGGGGCATC -3'
(R):5'- TGCTCCTAAGGTCCATAGAACATAAG -3'

Posted On

2019-06-07