Mutagenetix > Incidental Mutation

Incidental Mutation 'PIT4458001:Prl7c1'

555929

Institutional Source

Beutler Lab

Gene Symbol

Prl7c1

Ensembl Gene

ENSMUSG00000060738

Gene Name

prolactin family 7, subfamily c, member 1

Synonyms

1600017N11Rik, Prlpo, PLP-O

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.058) question?

Stock #

PIT4458001 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

27957583-27964829 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 27957741 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 233 (M233K)

Ref Sequence

ENSEMBL: ENSMUSP00000072712 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072943]

AlphaFold

Q9CRB5

Predicted Effect

probably benign
Transcript: ENSMUST00000072943
AA Change: M233K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000072712
Gene: ENSMUSG00000060738
AA Change: M233K

Domain	Start	End	E-Value	Type
Pfam:Hormone_1	17	242	8.1e-60	PFAM

Coding Region Coverage

1x: 93.1%
3x: 90.8%
10x: 85.3%
20x: 73.0%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca13	G	T	11: 9,248,304 (GRCm39)	V2684L	probably benign	Het
Adamts9	T	A	6: 92,866,886 (GRCm39)	I718F	probably damaging	Het
Adcyap1r1	A	G	6: 55,455,067 (GRCm39)	D110G	probably benign	Het
Adgrd1	G	A	5: 129,208,641 (GRCm39)	G281D	probably damaging	Het
Afg1l	A	T	10: 42,330,366 (GRCm39)	C100*	probably null	Het
Atp2a2	G	A	5: 122,595,372 (GRCm39)	Q993*	probably null	Het
Baz1a	A	G	12: 54,977,095 (GRCm39)	M389T	probably benign	Het
Btnl4	T	A	17: 34,693,242 (GRCm39)	M58L	probably benign	Het
Card6	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	TTGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGTGGATGAGAGGGCTTAGCATGGGAGGACTGCGGATGAGAGGGCTTAGCATGGGAGGACTG	15: 5,128,173 (GRCm39)		probably benign	Het
Cpeb1	A	T	7: 80,998,180 (GRCm39)	F533Y	probably damaging	Het
Ctnna1	T	A	18: 35,308,179 (GRCm39)	N166K	possibly damaging	Het
Ecsit	T	C	9: 21,987,580 (GRCm39)	H153R	probably damaging	Het
Gbp8	T	C	5: 105,162,955 (GRCm39)	K480E	probably benign	Het
Glyat	A	T	19: 12,625,373 (GRCm39)	T66S	probably benign	Het
Gm1110	T	C	9: 26,792,124 (GRCm39)	Q632R	probably benign	Het
Gm12185	C	T	11: 48,798,738 (GRCm39)	R585Q	probably damaging	Het
Gm17669	TAA	TAAA	18: 67,695,819 (GRCm39)		probably null	Het
Gm7489	A	C	15: 53,749,195 (GRCm39)	E89A	unknown	Het
Grb7	C	T	11: 98,344,655 (GRCm39)	Q353*	probably null	Het
Ifi207	G	A	1: 173,562,738 (GRCm39)	T136I	unknown	Het
Ighv3-1	T	C	12: 113,928,224 (GRCm39)	Y45C	probably benign	Het
Ing5	A	G	1: 93,739,668 (GRCm39)	M92V	possibly damaging	Het
Ivl	TTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	TTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTGCTG	3: 92,479,608 (GRCm39)		probably benign	Het
Kdm6b	A	T	11: 69,290,778 (GRCm39)	D1630E	unknown	Het
Lmo7	C	T	14: 102,124,923 (GRCm39)	Q583*	probably null	Het
Lrrc37a	T	C	11: 103,395,338 (GRCm39)	D29G	probably benign	Het
Mpdz	G	T	4: 81,337,263 (GRCm39)	A10D	probably damaging	Het
Myh4	A	G	11: 67,131,821 (GRCm39)	M94V	possibly damaging	Het
Nectin2	A	C	7: 19,472,252 (GRCm39)	L46V	probably benign	Het
Nynrin	A	T	14: 56,101,425 (GRCm39)	T365S	probably benign	Het
Or4c120	A	T	2: 89,000,977 (GRCm39)	I193K	probably benign	Het
Pde4b	A	C	4: 102,459,875 (GRCm39)	E570A	probably damaging	Het
Phf3	T	C	1: 30,855,622 (GRCm39)	H988R	probably damaging	Het
Ppfia2	A	G	10: 106,763,708 (GRCm39)	K1234E	probably benign	Het
Prp2	C	T	6: 132,577,510 (GRCm39)	P266S	unknown	Het
Ralgds	T	C	2: 28,432,486 (GRCm39)	L160P	probably damaging	Het
Rasa1	A	T	13: 85,375,237 (GRCm39)	M664K	possibly damaging	Het
Ryr2	T	C	13: 11,570,334 (GRCm39)	T4930A	probably benign	Het
Senp8	T	C	9: 59,644,763 (GRCm39)	Y131C	probably damaging	Het
Sp100	A	G	1: 85,635,837 (GRCm39)	I547M	probably benign	Het
Spata20	A	G	11: 94,375,434 (GRCm39)	M120T	probably damaging	Het
Spata31	A	G	13: 65,069,664 (GRCm39)	H604R	probably benign	Het
Sycp1	A	T	3: 102,842,149 (GRCm39)	S53T	probably benign	Het
Tgm1	T	C	14: 55,950,022 (GRCm39)	D62G	unknown	Het
Trpm1	G	C	7: 63,918,309 (GRCm39)	E1434Q	possibly damaging	Het
Tshb	A	T	3: 102,685,480 (GRCm39)	Y50N	probably damaging	Het
Wdr17	A	T	8: 55,126,614 (GRCm39)	Y413*	probably null	Het
Zdhhc16	G	A	19: 41,926,209 (GRCm39)	G55R	possibly damaging	Het

Other mutations in Prl7c1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01388:Prl7c1	APN	13	27,960,198 (GRCm39)	missense	probably damaging	1.00
IGL03096:Prl7c1	APN	13	27,957,689 (GRCm39)	missense	probably damaging	0.96
R0566:Prl7c1	UTSW	13	27,962,961 (GRCm39)	missense	probably damaging	1.00
R0856:Prl7c1	UTSW	13	27,957,717 (GRCm39)	missense	possibly damaging	0.84
R0908:Prl7c1	UTSW	13	27,957,717 (GRCm39)	missense	possibly damaging	0.84
R1585:Prl7c1	UTSW	13	27,962,838 (GRCm39)	missense	probably damaging	0.99
R4193:Prl7c1	UTSW	13	27,960,261 (GRCm39)	missense	probably benign	0.01
R4628:Prl7c1	UTSW	13	27,962,065 (GRCm39)	missense	probably benign
R4728:Prl7c1	UTSW	13	27,960,268 (GRCm39)	missense	probably benign	0.00
R4873:Prl7c1	UTSW	13	27,957,742 (GRCm39)	missense	probably benign	0.01
R4875:Prl7c1	UTSW	13	27,957,742 (GRCm39)	missense	probably benign	0.01
R5714:Prl7c1	UTSW	13	27,962,949 (GRCm39)	nonsense	probably null
R6353:Prl7c1	UTSW	13	27,957,709 (GRCm39)	missense	possibly damaging	0.64
R6505:Prl7c1	UTSW	13	27,957,776 (GRCm39)	missense	probably damaging	1.00
R6878:Prl7c1	UTSW	13	27,962,827 (GRCm39)	missense	possibly damaging	0.66
R7104:Prl7c1	UTSW	13	27,962,952 (GRCm39)	nonsense	probably null
R7879:Prl7c1	UTSW	13	27,962,817 (GRCm39)	missense	probably damaging	1.00
R7896:Prl7c1	UTSW	13	27,962,070 (GRCm39)	missense	possibly damaging	0.86
R8828:Prl7c1	UTSW	13	27,957,854 (GRCm39)	missense	probably benign	0.14
R9142:Prl7c1	UTSW	13	27,964,751 (GRCm39)	start gained	probably benign
R9215:Prl7c1	UTSW	13	27,960,204 (GRCm39)	missense	probably benign	0.32
R9296:Prl7c1	UTSW	13	27,962,812 (GRCm39)	missense	probably benign	0.06
R9453:Prl7c1	UTSW	13	27,957,870 (GRCm39)	missense	probably benign	0.44

Predicted Primers

PCR Primer
(F):5'- CAAGTTGGCATCACCTGTGTG -3'
(R):5'- GTCTGACTATGCTTTTGACCATTAG -3'

Sequencing Primer
(F):5'- CACCTGTGTGATGGCATAATTGAATG -3'
(R):5'- ATTAGGTTCATCCTGGAATGGAGGAG -3'

Posted On

2019-06-07