Incidental Mutation 'PIT4687001:Or10al4'
ID 556207
Institutional Source Beutler Lab
Gene Symbol Or10al4
Ensembl Gene ENSMUSG00000063994
Gene Name olfactory receptor family 10 subfamily AL member 4
Synonyms Olfr120, MOR263-3, GA_x6K02T2PSCP-2184981-2185946
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # PIT4687001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 38036890-38037882 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 38037082 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Glycine at position 56 (C56G)
Ref Sequence ENSEMBL: ENSMUSP00000146861 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077498] [ENSMUST00000207771]
AlphaFold Q8VFQ2
Predicted Effect probably benign
Transcript: ENSMUST00000077498
AA Change: C65G

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000094931
Gene: ENSMUSG00000063994
AA Change: C65G

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 5.6e-59 PFAM
Pfam:7TM_GPCR_Srsx 50 320 1e-5 PFAM
Pfam:7tm_1 56 305 6e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207771
AA Change: C56G

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)
Coding Region Coverage
  • 1x: 93.4%
  • 3x: 90.8%
  • 10x: 84.7%
  • 20x: 71.6%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adh1 T G 3: 137,995,596 (GRCm39) V333G probably damaging Het
Aggf1 A G 13: 95,501,383 (GRCm39) L333P probably damaging Het
Ankmy1 A G 1: 92,812,803 (GRCm39) V502A probably benign Het
Atm A G 9: 53,398,112 (GRCm39) probably null Het
Ccdc180 A G 4: 45,949,526 (GRCm39) T1594A probably damaging Het
Cep290 T A 10: 100,373,453 (GRCm39) D1244E probably benign Het
Ctnna3 A G 10: 64,670,385 (GRCm39) D638G probably damaging Het
Ctsr T C 13: 61,308,346 (GRCm39) H266R possibly damaging Het
D630045J12Rik C T 6: 38,172,036 (GRCm39) E711K probably benign Het
Dnah5 T C 15: 28,383,723 (GRCm39) S2982P probably damaging Het
Dsg1a G T 18: 20,464,755 (GRCm39) A417S probably benign Het
Gdpd1 T C 11: 86,950,366 (GRCm39) D69G probably damaging Het
Gp2 C T 7: 119,050,801 (GRCm39) R310H possibly damaging Het
Ifna2 G A 4: 88,601,542 (GRCm39) H159Y possibly damaging Het
Kptn T C 7: 15,859,751 (GRCm39) V325A probably damaging Het
Marchf7 A G 2: 60,062,622 (GRCm39) E143G probably damaging Het
Mcm4 A G 16: 15,454,577 (GRCm39) L47P probably benign Het
Mcm8 T C 2: 132,659,097 (GRCm39) F27S possibly damaging Het
Nod2 T A 8: 89,408,274 (GRCm39) V967E probably damaging Het
Nrxn2 G A 19: 6,531,338 (GRCm39) R659Q probably benign Het
Or4x12-ps1 A G 2: 89,916,733 (GRCm39) V24A probably benign Het
Parp10 C T 15: 76,125,122 (GRCm39) R545Q probably benign Het
Ppp2r3d T C 9: 101,021,579 (GRCm39) E332G probably benign Het
Pramel27 C T 4: 143,573,103 (GRCm39) probably benign Het
Ptpdc1 A G 13: 48,739,766 (GRCm39) V555A probably benign Het
Qsox2 G A 2: 26,112,300 (GRCm39) L81F possibly damaging Het
Sbsn GAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCA GAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCATGGGGTACAGAATGGAGTCAACCAGGCTCAAAAGGAAGCAGAAAAAGTGGCCCA 7: 30,452,391 (GRCm39) probably benign Het
Spata31 A G 13: 65,069,151 (GRCm39) D433G probably benign Het
Stpg2 T C 3: 138,921,026 (GRCm39) I77T possibly damaging Het
Sugp2 T C 8: 70,710,162 (GRCm39) S928P probably damaging Het
Syne1 A G 10: 5,308,390 (GRCm39) S722P possibly damaging Het
Szt2 A T 4: 118,255,398 (GRCm39) S229T possibly damaging Het
Tm9sf3 A G 19: 41,206,630 (GRCm39) L505P probably damaging Het
Ttc39d G A 17: 80,524,354 (GRCm39) A338T probably damaging Het
Ubash3b A G 9: 40,934,814 (GRCm39) F489L probably damaging Het
Xpo7 A T 14: 70,904,589 (GRCm39) Y1015N probably benign Het
Zbtb14 C A 17: 69,695,302 (GRCm39) Y333* probably null Het
Zp2 T C 7: 119,741,102 (GRCm39) T141A probably benign Het
Other mutations in Or10al4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01402:Or10al4 APN 17 38,037,193 (GRCm39) missense probably benign 0.08
IGL01925:Or10al4 APN 17 38,037,002 (GRCm39) missense probably benign 0.18
IGL02901:Or10al4 APN 17 38,037,311 (GRCm39) missense probably damaging 1.00
R1645:Or10al4 UTSW 17 38,037,229 (GRCm39) missense probably benign 0.01
R2218:Or10al4 UTSW 17 38,037,145 (GRCm39) missense probably damaging 0.97
R2336:Or10al4 UTSW 17 38,037,689 (GRCm39) missense probably benign 0.07
R4613:Or10al4 UTSW 17 38,037,587 (GRCm39) missense probably damaging 1.00
R5237:Or10al4 UTSW 17 38,037,268 (GRCm39) missense probably damaging 1.00
R5880:Or10al4 UTSW 17 38,037,545 (GRCm39) missense probably benign 0.09
R6187:Or10al4 UTSW 17 38,037,032 (GRCm39) missense probably damaging 0.99
R9083:Or10al4 UTSW 17 38,037,060 (GRCm39) missense probably damaging 1.00
R9479:Or10al4 UTSW 17 38,036,986 (GRCm39) missense probably damaging 0.99
R9647:Or10al4 UTSW 17 38,037,796 (GRCm39) missense probably damaging 1.00
Z1088:Or10al4 UTSW 17 38,036,983 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGAGATGAGTGTCAACTGCTC -3'
(R):5'- CATATGGCCATGTAGCGGTC -3'

Sequencing Primer
(F):5'- CTCTCTGTGGCAGGAAAATAAGTTG -3'
(R):5'- TCAAAGGCCATAGCTGCCAGTAG -3'
Posted On 2019-06-07