Incidental Mutation 'PIT4514001:Zfp764'
ID556271
Institutional Source Beutler Lab
Gene Symbol Zfp764
Ensembl Gene ENSMUSG00000045757
Gene Namezinc finger protein 764
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.060) question?
Stock #PIT4514001 (G1)
Quality Score225.009
Status Not validated
Chromosome7
Chromosomal Location127403668-127406822 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 127404741 bp
ZygosityHeterozygous
Amino Acid Change Histidine to Arginine at position 406 (H406R)
Ref Sequence ENSEMBL: ENSMUSP00000052944 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059199]
Predicted Effect probably benign
Transcript: ENSMUST00000059199
AA Change: H406R

PolyPhen 2 Score 0.258 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000052944
Gene: ENSMUSG00000045757
AA Change: H406R

DomainStartEndE-ValueType
KRAB 22 82 7.33e-31 SMART
low complexity region 102 115 N/A INTRINSIC
ZnF_C2H2 152 174 4.47e-3 SMART
ZnF_C2H2 180 202 1.47e-3 SMART
ZnF_C2H2 208 230 4.3e-5 SMART
ZnF_C2H2 236 258 6.78e-3 SMART
ZnF_C2H2 264 286 1.47e-3 SMART
ZnF_C2H2 292 315 1.45e-2 SMART
ZnF_C2H2 321 343 6.52e-5 SMART
ZnF_C2H2 349 371 6.67e-2 SMART
ZnF_C2H2 377 399 1.67e-2 SMART
Coding Region Coverage
  • 1x: 93.1%
  • 3x: 90.6%
  • 10x: 84.2%
  • 20x: 70.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700007G11Rik T A 5: 98,801,871 H221Q probably benign Het
1700023F06Rik T C 11: 103,201,134 D27G probably benign Het
4930486L24Rik A G 13: 60,853,514 probably null Het
Abcc10 T A 17: 46,305,648 I1247F probably benign Het
Acap3 G A 4: 155,903,378 A524T probably benign Het
Adcy10 T A 1: 165,556,791 N1040K probably benign Het
Adrb2 T C 18: 62,179,727 D9G probably benign Het
Aldh1a7 T C 19: 20,702,240 T391A probably benign Het
Bcam A G 7: 19,764,066 V344A probably benign Het
Birc7 T A 2: 180,931,306 I172N possibly damaging Het
Cfap126 G A 1: 171,125,312 D45N probably damaging Het
Cit G A 5: 115,997,854 probably null Het
Col26a1 A G 5: 136,751,725 V295A probably benign Het
Epha7 C T 4: 28,961,355 Q867* probably null Het
Fn1 A G 1: 71,628,456 S793P probably benign Het
Foxb1 T A 9: 69,760,221 Y9F probably damaging Het
Gm13124 T C 4: 144,555,511 Y237C probably damaging Het
Gpc1 T A 1: 92,857,557 M406K probably benign Het
Gsg1 T C 6: 135,237,576 T312A probably benign Het
Hmcn1 T A 1: 150,669,487 I2790F possibly damaging Het
Kcnma1 C T 14: 23,309,035 probably null Het
Lmntd1 AGACTGTAAGTTTCTCAAATGTGTACCTGGA AGA 6: 145,427,253 probably null Het
Mcph1 A G 8: 18,631,890 K348E probably damaging Het
Olfr122 T A 17: 37,771,867 N71K probably damaging Het
Olfr985 T C 9: 40,127,299 I221V probably damaging Het
Pik3cg T A 12: 32,204,903 R362W probably damaging Het
Pkp3 T C 7: 141,089,710 L765P probably damaging Het
Plxna2 A T 1: 194,794,937 I1252F probably benign Het
Prpf8 T C 11: 75,496,355 F1154S possibly damaging Het
Scn7a A G 2: 66,684,179 F1084L probably damaging Het
Shmt1 G A 11: 60,804,347 S47L probably damaging Het
Snap91 T C 9: 86,879,433 K40R possibly damaging Het
Spag17 A T 3: 100,013,211 T421S possibly damaging Het
Speer4f1 T A 5: 17,478,756 N139K possibly damaging Het
Syne2 T G 12: 76,105,015 N1883K probably damaging Het
Tgfb1i1 C T 7: 128,249,181 R191C probably damaging Het
Tmem39b A C 4: 129,684,497 N310K possibly damaging Het
Trim3 T C 7: 105,618,210 T321A probably benign Het
Vmn2r124 T C 17: 18,073,712 I687T probably benign Het
Zbtb8a T C 4: 129,357,730 D316G probably benign Het
Zfp639 A G 3: 32,520,260 I345V possibly damaging Het
Other mutations in Zfp764
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Zfp764 APN 7 127405204 missense possibly damaging 0.93
R0528:Zfp764 UTSW 7 127404879 missense possibly damaging 0.92
R0619:Zfp764 UTSW 7 127406541 missense probably benign 0.08
R1183:Zfp764 UTSW 7 127406247 missense probably damaging 1.00
R1770:Zfp764 UTSW 7 127405567 nonsense probably null
R1878:Zfp764 UTSW 7 127405042 missense probably benign 0.04
R1885:Zfp764 UTSW 7 127405039 missense probably benign
R2181:Zfp764 UTSW 7 127406499 missense probably damaging 1.00
R4780:Zfp764 UTSW 7 127404771 missense probably benign 0.13
R5242:Zfp764 UTSW 7 127405369 missense probably benign
R5493:Zfp764 UTSW 7 127404933 missense probably benign 0.00
R7109:Zfp764 UTSW 7 127404715 missense possibly damaging 0.92
R7214:Zfp764 UTSW 7 127405278 missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TCTGTGACTTCCGGAAGATGAC -3'
(R):5'- CGCATCCATACAGGTGAAAAGC -3'

Sequencing Primer
(F):5'- GATGACATAGGTTCAACCCTCTGG -3'
(R):5'- GGTGAAAAGCCTTATTCATGCCCTG -3'
Posted On2019-06-07