Incidental Mutation 'PIT4514001:Or10al6'
ID 556286
Institutional Source Beutler Lab
Gene Symbol Or10al6
Ensembl Gene ENSMUSG00000083947
Gene Name olfactory receptor family 10 subfamily AL member 6
Synonyms GA_x6K02T2PSCP-2230932-2231897, MOR263-10, Olfr122
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # PIT4514001 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 38079533-38083511 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38082758 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 71 (N71K)
Ref Sequence ENSEMBL: ENSMUSP00000134283 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000119082] [ENSMUST00000172582] [ENSMUST00000217119]
AlphaFold W4VSP0
Predicted Effect probably damaging
Transcript: ENSMUST00000119082
AA Change: N80K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113170
Gene: ENSMUSG00000083947
AA Change: N80K

DomainStartEndE-ValueType
Pfam:7tm_4 46 323 2.2e-58 PFAM
Pfam:7TM_GPCR_Srsx 50 320 2.7e-6 PFAM
Pfam:7tm_1 56 305 3.8e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000172582
AA Change: N71K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000134283
Gene: ENSMUSG00000083947
AA Change: N71K

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 41 311 9.5e-8 PFAM
Pfam:7tm_1 47 296 7.8e-36 PFAM
Pfam:7tm_4 145 289 1e-46 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217119
AA Change: N71K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 93.1%
  • 3x: 90.6%
  • 10x: 84.2%
  • 20x: 70.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik A G 13: 61,001,328 (GRCm39) probably null Het
Aadacl4fm2 T C 4: 144,282,081 (GRCm39) Y237C probably damaging Het
Abcc10 T A 17: 46,616,574 (GRCm39) I1247F probably benign Het
Acap3 G A 4: 155,987,835 (GRCm39) A524T probably benign Het
Adcy10 T A 1: 165,384,360 (GRCm39) N1040K probably benign Het
Adrb2 T C 18: 62,312,798 (GRCm39) D9G probably benign Het
Aldh1a7 T C 19: 20,679,604 (GRCm39) T391A probably benign Het
Bcam A G 7: 19,497,991 (GRCm39) V344A probably benign Het
Birc7 T A 2: 180,573,099 (GRCm39) I172N possibly damaging Het
Cfap126 G A 1: 170,952,881 (GRCm39) D45N probably damaging Het
Cfap299 T A 5: 98,949,730 (GRCm39) H221Q probably benign Het
Cit G A 5: 116,135,913 (GRCm39) probably null Het
Col26a1 A G 5: 136,780,579 (GRCm39) V295A probably benign Het
Efcab15 T C 11: 103,091,960 (GRCm39) D27G probably benign Het
Epha7 C T 4: 28,961,355 (GRCm39) Q867* probably null Het
Fn1 A G 1: 71,667,615 (GRCm39) S793P probably benign Het
Foxb1 T A 9: 69,667,503 (GRCm39) Y9F probably damaging Het
Gpc1 T A 1: 92,785,279 (GRCm39) M406K probably benign Het
Gsg1 T C 6: 135,214,574 (GRCm39) T312A probably benign Het
Hmcn1 T A 1: 150,545,238 (GRCm39) I2790F possibly damaging Het
Kcnma1 C T 14: 23,359,103 (GRCm39) probably null Het
Lmntd1 AGACTGTAAGTTTCTCAAATGTGTACCTGGA AGA 6: 145,372,979 (GRCm39) probably null Het
Mcph1 A G 8: 18,681,906 (GRCm39) K348E probably damaging Het
Or8d4 T C 9: 40,038,595 (GRCm39) I221V probably damaging Het
Pik3cg T A 12: 32,254,902 (GRCm39) R362W probably damaging Het
Pkp3 T C 7: 140,669,623 (GRCm39) L765P probably damaging Het
Plxna2 A T 1: 194,477,245 (GRCm39) I1252F probably benign Het
Prpf8 T C 11: 75,387,181 (GRCm39) F1154S possibly damaging Het
Scn7a A G 2: 66,514,523 (GRCm39) F1084L probably damaging Het
Shmt1 G A 11: 60,695,173 (GRCm39) S47L probably damaging Het
Snap91 T C 9: 86,761,486 (GRCm39) K40R possibly damaging Het
Spag17 A T 3: 99,920,527 (GRCm39) T421S possibly damaging Het
Speer4f1 T A 5: 17,683,754 (GRCm39) N139K possibly damaging Het
Syne2 T G 12: 76,151,789 (GRCm39) N1883K probably damaging Het
Tgfb1i1 C T 7: 127,848,353 (GRCm39) R191C probably damaging Het
Tmem39b A C 4: 129,578,290 (GRCm39) N310K possibly damaging Het
Trim3 T C 7: 105,267,417 (GRCm39) T321A probably benign Het
Vmn2r124 T C 17: 18,293,974 (GRCm39) I687T probably benign Het
Zbtb8a T C 4: 129,251,523 (GRCm39) D316G probably benign Het
Zfp639 A G 3: 32,574,409 (GRCm39) I345V possibly damaging Het
Zfp764 T C 7: 127,003,913 (GRCm39) H406R probably benign Het
Other mutations in Or10al6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00954:Or10al6 APN 17 38,083,505 (GRCm39) missense probably benign 0.00
IGL01338:Or10al6 APN 17 38,082,730 (GRCm39) missense possibly damaging 0.90
IGL01447:Or10al6 APN 17 38,083,122 (GRCm39) missense probably damaging 1.00
R0402:Or10al6 UTSW 17 38,083,284 (GRCm39) missense probably damaging 1.00
R0830:Or10al6 UTSW 17 38,082,804 (GRCm39) missense probably damaging 0.99
R2018:Or10al6 UTSW 17 38,083,467 (GRCm39) missense probably benign 0.00
R4258:Or10al6 UTSW 17 38,082,949 (GRCm39) missense probably damaging 1.00
R6371:Or10al6 UTSW 17 38,083,326 (GRCm39) missense probably benign
R6481:Or10al6 UTSW 17 38,083,194 (GRCm39) missense probably damaging 1.00
R7468:Or10al6 UTSW 17 38,082,910 (GRCm39) missense probably damaging 1.00
R7492:Or10al6 UTSW 17 38,082,571 (GRCm39) missense possibly damaging 0.53
R8114:Or10al6 UTSW 17 38,082,880 (GRCm39) missense possibly damaging 0.67
R8172:Or10al6 UTSW 17 38,083,326 (GRCm39) missense probably benign
R8728:Or10al6 UTSW 17 38,082,642 (GRCm39) missense probably damaging 1.00
R8894:Or10al6 UTSW 17 38,082,940 (GRCm39) missense probably damaging 1.00
R9659:Or10al6 UTSW 17 38,082,880 (GRCm39) missense probably damaging 0.99
Z1177:Or10al6 UTSW 17 38,083,082 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- AGTATCAACTGCTCTCTGTGGC -3'
(R):5'- GGGAGCATATGGCCATGTAG -3'

Sequencing Primer
(F):5'- CTCTCTGTGGCAGGAGAACAG -3'
(R):5'- AGCATATGGCCATGTAGCGGTC -3'
Posted On 2019-06-07