Incidental Mutation 'PIT4544001:Eif4e3'
ID 556410
Institutional Source Beutler Lab
Gene Symbol Eif4e3
Ensembl Gene ENSMUSG00000093661
Gene Name eukaryotic translation initiation factor 4E member 3
Synonyms eIF4E-3, 1300018P11Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # PIT4544001 (G1)
Quality Score 134.008
Status Not validated
Chromosome 6
Chromosomal Location 99602096-99643732 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 99609314 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 161 (W161R)
Ref Sequence ENSEMBL: ENSMUSP00000032151 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032151] [ENSMUST00000155466]
AlphaFold Q9DBB5
PDB Structure Solution structure of eIF4E3 in complex with m7GDP [SOLUTION NMR]
The third member of the eIF4E family represses gene expression via a novel mode of recognition of the methyl-7 guanosine cap moiety [SOLUTION NMR]
Predicted Effect probably damaging
Transcript: ENSMUST00000032151
AA Change: W161R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000032151
Gene: ENSMUSG00000093661
AA Change: W161R

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
Pfam:IF4E 31 193 2.1e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155466
SMART Domains Protein: ENSMUSP00000135058
Gene: ENSMUSG00000030068

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
Pfam:IF4E 31 68 2.6e-7 PFAM
Coding Region Coverage
  • 1x: 92.9%
  • 3x: 90.6%
  • 10x: 84.5%
  • 20x: 71.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome (Joshi et al., 2004 [PubMed 15153109]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased bone trabecula number. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc1 A G 16: 14,222,943 (GRCm39) D248G probably damaging Het
Abcc12 A T 8: 87,231,875 (GRCm39) M1358K possibly damaging Het
Adgrl2 C T 3: 148,596,157 (GRCm39) E60K probably damaging Het
Aff3 C T 1: 38,249,443 (GRCm39) A555T probably benign Het
Aspn A T 13: 49,707,458 (GRCm39) K106* probably null Het
Atp8b3 A T 10: 80,366,420 (GRCm39) L281Q probably benign Het
Ccdc54 A T 16: 50,410,343 (GRCm39) C308S possibly damaging Het
Cpa1 T C 6: 30,641,857 (GRCm39) V227A probably benign Het
Dld G A 12: 31,385,556 (GRCm39) Q262* probably null Het
Epha5 T A 5: 84,479,471 (GRCm39) T178S possibly damaging Het
Erbb2 A T 11: 98,311,865 (GRCm39) T134S probably benign Het
Golga3 A T 5: 110,336,556 (GRCm39) E358D possibly damaging Het
Gon7 A T 12: 102,720,409 (GRCm39) D74E probably benign Het
Hmcn2 A G 2: 31,318,262 (GRCm39) E3869G probably damaging Het
Ifit1bl1 C T 19: 34,571,415 (GRCm39) M347I possibly damaging Het
Ipo5 T A 14: 121,165,949 (GRCm39) D331E probably damaging Het
Mep1a C T 17: 43,793,178 (GRCm39) C355Y probably damaging Het
Nkain1 A G 4: 130,532,098 (GRCm38) S196P probably damaging Het
Nudt21 A T 8: 94,746,225 (GRCm39) F158I unknown Het
Padi3 T C 4: 140,518,794 (GRCm39) T443A probably benign Het
Parpbp A G 10: 87,950,411 (GRCm39) V323A possibly damaging Het
Phkb A G 8: 86,738,266 (GRCm39) I520V probably benign Het
Plxna1 A G 6: 89,334,411 (GRCm39) S73P probably benign Het
Rfk T C 19: 17,372,708 (GRCm39) S77P probably damaging Het
Sdk1 A G 5: 141,941,987 (GRCm39) N545S probably benign Het
Setd2 A G 9: 110,380,232 (GRCm39) N1349S probably damaging Het
Slc22a27 T A 19: 7,887,103 (GRCm39) Q262L probably damaging Het
Slc34a3 T C 2: 25,120,607 (GRCm39) D440G probably benign Het
Slc4a4 T C 5: 89,186,402 (GRCm39) L161P probably damaging Het
Stxbp5 A C 10: 9,693,048 (GRCm39) probably null Het
Tekt1 C T 11: 72,245,660 (GRCm39) R165H probably damaging Het
Tmpo T C 10: 90,997,976 (GRCm39) N604D probably benign Het
Trpm1 A T 7: 63,848,998 (GRCm39) probably benign Het
Ubqln3 A C 7: 103,790,550 (GRCm39) H513Q probably damaging Het
Ubr4 A G 4: 139,129,871 (GRCm39) N664D possibly damaging Het
Usp37 G A 1: 74,509,738 (GRCm39) T477I possibly damaging Het
Zbtb11 T G 16: 55,818,556 (GRCm39) L660* probably null Het
Other mutations in Eif4e3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1846:Eif4e3 UTSW 6 99,617,662 (GRCm39) missense probably benign 0.02
R3764:Eif4e3 UTSW 6 99,617,586 (GRCm39) missense probably damaging 0.99
R4598:Eif4e3 UTSW 6 99,617,671 (GRCm39) missense probably benign 0.00
R7816:Eif4e3 UTSW 6 99,617,599 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACTCGCAATGTGCTTCTAGCTC -3'
(R):5'- TTACTGAATCCCCGGCTAAC -3'

Sequencing Primer
(F):5'- TCTACAAGTCTGGCAGGAGAATCTC -3'
(R):5'- AACTGGCTTCCCTCGGC -3'
Posted On 2019-06-07