Incidental Mutation 'R0605:Vps8'
| ID |
55685 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
038794-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0605 (G1)
|
| Quality Score |
209 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 21378087 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 1033
(T1033S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112636
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118138]
[ENSMUST00000118923]
[ENSMUST00000156580]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096191
AA Change: T1061S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: T1061S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096192
AA Change: T1033S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: T1033S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115397
AA Change: T1063S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: T1063S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000117598
AA Change: T1061S
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: T1061S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000118138
|
| SMART Domains |
Protein: ENSMUSP00000113447
Gene: ENSMUSG00000033653
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
1 |
76 |
7.7e-21 |
PFAM |
|
low complexity region
|
274 |
289 |
N/A |
INTRINSIC |
|
low complexity region
|
367 |
379 |
N/A |
INTRINSIC |
|
low complexity region
|
408 |
419 |
N/A |
INTRINSIC |
|
RING
|
539 |
590 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000118923
AA Change: T1033S
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: T1033S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000125487
AA Change: T631S
|
| SMART Domains |
Protein: ENSMUSP00000114719
Gene: ENSMUSG00000033653
AA Change: T631S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Vps8
|
182 |
365 |
8.5e-62 |
PFAM |
|
low complexity region
|
563 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
656 |
668 |
N/A |
INTRINSIC |
|
low complexity region
|
697 |
708 |
N/A |
INTRINSIC |
|
RING
|
828 |
879 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000156580
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000231484
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000232357
|
| Meta Mutation Damage Score |
0.1213 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.4%
|
| Validation Efficiency |
100% (85/85) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 84 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4933406P04Rik |
G |
A |
10: 20,186,973 (GRCm39) |
|
probably benign |
Het |
| Adam28 |
A |
T |
14: 68,844,049 (GRCm39) |
|
probably benign |
Het |
| Adamts3 |
A |
G |
5: 90,009,334 (GRCm39) |
W110R |
possibly damaging |
Het |
| Add1 |
T |
C |
5: 34,771,568 (GRCm39) |
V342A |
possibly damaging |
Het |
| Aff3 |
A |
G |
1: 38,249,068 (GRCm39) |
S680P |
probably damaging |
Het |
| Ak9 |
T |
C |
10: 41,221,135 (GRCm39) |
Y322H |
probably damaging |
Het |
| Als2 |
A |
G |
1: 59,207,573 (GRCm39) |
L1528S |
probably benign |
Het |
| Ass1 |
A |
T |
2: 31,404,831 (GRCm39) |
N371Y |
probably damaging |
Het |
| Atp6v1a |
A |
C |
16: 43,931,859 (GRCm39) |
|
probably null |
Het |
| Bpi |
T |
C |
2: 158,103,314 (GRCm39) |
L103P |
probably damaging |
Het |
| Cd80 |
G |
A |
16: 38,303,056 (GRCm39) |
V168I |
probably benign |
Het |
| Cfh |
T |
C |
1: 140,030,096 (GRCm39) |
S926G |
probably damaging |
Het |
| Chrd |
A |
T |
16: 20,554,189 (GRCm39) |
T304S |
probably damaging |
Het |
| Chsy3 |
A |
G |
18: 59,542,125 (GRCm39) |
Y421C |
probably damaging |
Het |
| Cmbl |
T |
G |
15: 31,585,455 (GRCm39) |
V101G |
probably damaging |
Het |
| Colgalt2 |
T |
A |
1: 152,371,543 (GRCm39) |
|
probably benign |
Het |
| Coq4 |
C |
T |
2: 29,680,010 (GRCm39) |
Q101* |
probably null |
Het |
| Cr2 |
T |
C |
1: 194,845,904 (GRCm39) |
|
probably benign |
Het |
| Cry1 |
T |
C |
10: 85,020,223 (GRCm39) |
D38G |
probably damaging |
Het |
| Dmxl2 |
T |
C |
9: 54,327,229 (GRCm39) |
D758G |
probably benign |
Het |
| Epsti1 |
C |
T |
14: 78,164,677 (GRCm39) |
|
probably benign |
Het |
| Fam24b |
T |
C |
7: 130,928,915 (GRCm39) |
|
probably benign |
Het |
| Fem1c |
G |
A |
18: 46,638,227 (GRCm39) |
R592C |
probably benign |
Het |
| Foxred1 |
T |
C |
9: 35,116,178 (GRCm39) |
Y490C |
possibly damaging |
Het |
| Gm9875 |
A |
G |
2: 13,562,699 (GRCm39) |
K9R |
unknown |
Het |
| Grid2ip |
T |
C |
5: 143,365,117 (GRCm39) |
S322P |
probably damaging |
Het |
| Gucy1b2 |
A |
G |
14: 62,640,608 (GRCm39) |
|
probably benign |
Het |
| Hmcn1 |
A |
T |
1: 150,533,127 (GRCm39) |
|
probably null |
Het |
| Hpdl |
C |
T |
4: 116,677,984 (GRCm39) |
S159N |
possibly damaging |
Het |
| Hsd17b12 |
A |
T |
2: 93,863,987 (GRCm39) |
M285K |
probably benign |
Het |
| Icam5 |
T |
C |
9: 20,943,493 (GRCm39) |
I23T |
probably benign |
Het |
| Kat5 |
A |
G |
19: 5,658,364 (GRCm39) |
|
probably benign |
Het |
| Lama3 |
A |
G |
18: 12,640,006 (GRCm39) |
N67S |
probably benign |
Het |
| Lamb2 |
T |
C |
9: 108,363,304 (GRCm39) |
|
probably benign |
Het |
| Lgals3bp |
A |
G |
11: 118,284,220 (GRCm39) |
F453S |
probably damaging |
Het |
| Lypd4 |
A |
G |
7: 24,564,800 (GRCm39) |
Y113H |
probably damaging |
Het |
| Mdm1 |
C |
T |
10: 117,982,506 (GRCm39) |
T47M |
probably damaging |
Het |
| Mei1 |
C |
A |
15: 81,954,351 (GRCm39) |
T52K |
probably benign |
Het |
| Meiob |
G |
A |
17: 25,037,236 (GRCm39) |
|
probably benign |
Het |
| Ndufaf6 |
A |
G |
4: 11,051,224 (GRCm39) |
V292A |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,154,038 (GRCm39) |
M2358L |
possibly damaging |
Het |
| Nlrp1b |
A |
G |
11: 71,047,005 (GRCm39) |
S1119P |
possibly damaging |
Het |
| Nsmaf |
A |
G |
4: 6,418,470 (GRCm39) |
|
probably null |
Het |
| Ogfod1 |
T |
C |
8: 94,773,895 (GRCm39) |
|
probably benign |
Het |
| Or5ae2 |
T |
C |
7: 84,506,345 (GRCm39) |
I256T |
probably damaging |
Het |
| Or8h7 |
T |
C |
2: 86,720,763 (GRCm39) |
Y252C |
possibly damaging |
Het |
| Or9s14 |
G |
T |
1: 92,535,618 (GRCm39) |
V20L |
probably benign |
Het |
| Osbpl1a |
T |
A |
18: 13,015,336 (GRCm39) |
|
probably null |
Het |
| Otud7b |
T |
A |
3: 96,052,270 (GRCm39) |
|
probably benign |
Het |
| P3h3 |
T |
A |
6: 124,832,998 (GRCm39) |
H185L |
probably damaging |
Het |
| P4htm |
G |
A |
9: 108,460,923 (GRCm39) |
A183V |
probably null |
Het |
| Peak1 |
C |
T |
9: 56,134,382 (GRCm39) |
|
probably benign |
Het |
| Phf20l1 |
A |
G |
15: 66,466,971 (GRCm39) |
K88R |
probably damaging |
Het |
| Phlpp2 |
A |
G |
8: 110,659,843 (GRCm39) |
N721S |
probably benign |
Het |
| Plagl2 |
T |
C |
2: 153,077,864 (GRCm39) |
K39R |
probably benign |
Het |
| Plppr1 |
A |
T |
4: 49,323,466 (GRCm39) |
N252I |
probably damaging |
Het |
| Pom121l2 |
C |
T |
13: 22,166,206 (GRCm39) |
A159V |
probably damaging |
Het |
| Prom2 |
C |
A |
2: 127,381,915 (GRCm39) |
|
probably null |
Het |
| Prrc2c |
T |
C |
1: 162,509,995 (GRCm39) |
T1017A |
probably damaging |
Het |
| Rimbp3 |
G |
T |
16: 17,029,563 (GRCm39) |
A996S |
probably damaging |
Het |
| Rnf213 |
A |
G |
11: 119,322,543 (GRCm39) |
T1387A |
probably benign |
Het |
| Scaper |
A |
T |
9: 55,722,802 (GRCm39) |
|
probably benign |
Het |
| Scara5 |
A |
G |
14: 65,997,097 (GRCm39) |
E403G |
possibly damaging |
Het |
| Scrib |
T |
C |
15: 75,939,402 (GRCm39) |
I94V |
possibly damaging |
Het |
| Shank3 |
T |
C |
15: 89,408,350 (GRCm39) |
F67L |
possibly damaging |
Het |
| Shprh |
T |
C |
10: 11,082,856 (GRCm39) |
F1562L |
probably damaging |
Het |
| Src |
C |
T |
2: 157,311,841 (GRCm39) |
T529M |
probably damaging |
Het |
| Sycp2l |
T |
A |
13: 41,296,942 (GRCm39) |
M341K |
probably benign |
Het |
| Syde1 |
T |
C |
10: 78,424,929 (GRCm39) |
|
probably benign |
Het |
| Tars3 |
A |
T |
7: 65,327,819 (GRCm39) |
R509S |
probably damaging |
Het |
| Tle6 |
T |
A |
10: 81,430,180 (GRCm39) |
H324L |
probably damaging |
Het |
| Tnfaip8 |
ACTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
ACTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC |
18: 50,179,912 (GRCm39) |
|
probably benign |
Het |
| Tnfrsf14 |
T |
A |
4: 155,009,837 (GRCm39) |
K115* |
probably null |
Het |
| Trappc10 |
T |
C |
10: 78,037,331 (GRCm39) |
N824S |
possibly damaging |
Het |
| Tsc1 |
C |
T |
2: 28,561,790 (GRCm39) |
S309F |
probably damaging |
Het |
| Ttc21a |
A |
G |
9: 119,790,908 (GRCm39) |
I885V |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,570,797 (GRCm39) |
A26699T |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,778,715 (GRCm39) |
Y1262C |
unknown |
Het |
| Usp49 |
T |
C |
17: 47,985,851 (GRCm39) |
|
probably null |
Het |
| Vmn1r226 |
A |
T |
17: 20,908,133 (GRCm39) |
T122S |
probably benign |
Het |
| Vwf |
C |
A |
6: 125,662,800 (GRCm39) |
T2728K |
probably benign |
Het |
| Wdr5b |
T |
C |
16: 35,862,366 (GRCm39) |
S162P |
probably benign |
Het |
| Xrn1 |
C |
T |
9: 95,908,930 (GRCm39) |
Q1235* |
probably null |
Het |
| Zfp1005 |
A |
G |
2: 150,110,523 (GRCm39) |
I404M |
unknown |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCCAGATAAGTTCGCCCTAAGACAG -3'
(R):5'- ACAAGGCACGCACAGCCTTATG -3'
Sequencing Primer
(F):5'- CCTAAGACAGGCTGCACAGAG -3'
(R):5'- AAATATGGAGCCGTTCTCAGTG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation