Incidental Mutation 'R0585:Zfp773'
| ID |
55709 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp773
|
| Ensembl Gene |
ENSMUSG00000063535 |
| Gene Name |
zinc finger protein 773 |
| Synonyms |
2810409K11Rik |
| MMRRC Submission |
038775-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.052)
|
| Stock # |
R0585 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
7133677-7139754 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 7135574 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 341
(I341L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032622
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032622]
[ENSMUST00000211240]
|
| AlphaFold |
Q9CZ29 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000032622
AA Change: I341L
PolyPhen 2
Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000032622
Gene: ENSMUSG00000063535
AA Change: I341L
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
75 |
134 |
6.82e-8 |
SMART |
|
ZnF_C2H2
|
241 |
263 |
1.31e0 |
SMART |
|
ZnF_C2H2
|
269 |
291 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
297 |
319 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
2.05e-2 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
2.24e-3 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
8.81e-2 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
7.26e-3 |
SMART |
|
ZnF_C2H2
|
437 |
459 |
7.26e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000211240
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.9%
- 10x: 97.6%
- 20x: 95.2%
|
| Validation Efficiency |
100% (38/38) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Brdt |
T |
G |
5: 107,504,748 (GRCm39) |
|
probably null |
Het |
| Ccdc162 |
C |
T |
10: 41,462,375 (GRCm39) |
C1474Y |
probably benign |
Het |
| Ces2e |
T |
C |
8: 105,656,453 (GRCm39) |
S228P |
probably damaging |
Het |
| Clca3a1 |
G |
T |
3: 144,738,386 (GRCm39) |
H41N |
probably benign |
Het |
| Cyp2c39 |
A |
T |
19: 39,525,203 (GRCm39) |
I169F |
probably benign |
Het |
| Cyp2c65 |
A |
G |
19: 39,057,686 (GRCm39) |
K107R |
probably benign |
Het |
| Cyp2c67 |
T |
A |
19: 39,627,138 (GRCm39) |
N231Y |
possibly damaging |
Het |
| Eps8l3 |
G |
C |
3: 107,788,513 (GRCm39) |
D33H |
probably damaging |
Het |
| Evi5 |
T |
C |
5: 107,961,402 (GRCm39) |
|
probably benign |
Het |
| Fcho1 |
T |
C |
8: 72,168,369 (GRCm39) |
Y218C |
probably damaging |
Het |
| Gm3993 |
T |
A |
12: 20,122,149 (GRCm39) |
|
probably null |
Het |
| Gtf2ird1 |
A |
C |
5: 134,405,796 (GRCm39) |
L28R |
probably damaging |
Het |
| Hsf4 |
A |
G |
8: 105,997,663 (GRCm39) |
D75G |
probably damaging |
Het |
| Iqca1l |
A |
G |
5: 24,755,721 (GRCm39) |
V267A |
probably benign |
Het |
| Larp4b |
A |
G |
13: 9,197,529 (GRCm39) |
T249A |
probably damaging |
Het |
| Larp4b |
A |
G |
13: 9,220,737 (GRCm39) |
D578G |
probably benign |
Het |
| Lyz3 |
T |
A |
10: 117,074,356 (GRCm39) |
I44F |
possibly damaging |
Het |
| Matn3 |
A |
T |
12: 9,011,103 (GRCm39) |
|
probably benign |
Het |
| Myo10 |
T |
A |
15: 25,736,541 (GRCm39) |
Y428N |
probably damaging |
Het |
| Nf1 |
T |
A |
11: 79,459,527 (GRCm39) |
D661E |
probably damaging |
Het |
| Nktr |
A |
G |
9: 121,583,346 (GRCm39) |
|
probably benign |
Het |
| Npbwr1 |
G |
A |
1: 5,986,677 (GRCm39) |
T279I |
possibly damaging |
Het |
| Or52n3 |
A |
C |
7: 104,530,706 (GRCm39) |
H264P |
probably damaging |
Het |
| Osmr |
T |
C |
15: 6,867,274 (GRCm39) |
I341V |
probably benign |
Het |
| Pan2 |
T |
C |
10: 128,146,384 (GRCm39) |
|
probably null |
Het |
| Pknox2 |
G |
A |
9: 36,821,056 (GRCm39) |
|
probably benign |
Het |
| Pla2g2d |
A |
C |
4: 138,506,704 (GRCm39) |
D50A |
probably benign |
Het |
| Ptprk |
C |
T |
10: 28,451,664 (GRCm39) |
L1051F |
probably damaging |
Het |
| Rap1gds1 |
G |
A |
3: 138,727,633 (GRCm39) |
T59M |
probably benign |
Het |
| Rps5 |
T |
C |
7: 12,659,332 (GRCm39) |
V41A |
possibly damaging |
Het |
| Ryr1 |
G |
T |
7: 28,735,501 (GRCm39) |
D4092E |
probably damaging |
Het |
| Spic |
T |
C |
10: 88,511,905 (GRCm39) |
Y117C |
probably damaging |
Het |
| Thrap3 |
A |
T |
4: 126,072,367 (GRCm39) |
|
probably null |
Het |
| Tlr9 |
C |
T |
9: 106,102,275 (GRCm39) |
T522I |
probably benign |
Het |
| Tspan3 |
A |
T |
9: 56,053,216 (GRCm39) |
|
probably benign |
Het |
| Ttn |
T |
C |
2: 76,703,503 (GRCm39) |
|
probably benign |
Het |
| Zmat3 |
G |
A |
3: 32,415,254 (GRCm39) |
P19S |
probably damaging |
Het |
|
| Other mutations in Zfp773 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00764:Zfp773
|
APN |
7 |
7,135,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00780:Zfp773
|
APN |
7 |
7,136,113 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01348:Zfp773
|
APN |
7 |
7,138,314 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL02224:Zfp773
|
APN |
7 |
7,135,975 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02447:Zfp773
|
APN |
7 |
7,139,655 (GRCm39) |
utr 5 prime |
probably benign |
|
|
IGL02869:Zfp773
|
APN |
7 |
7,137,232 (GRCm39) |
missense |
probably benign |
0.22 |
|
R0505:Zfp773
|
UTSW |
7 |
7,136,023 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0804:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R0846:Zfp773
|
UTSW |
7 |
7,135,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1179:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R2847:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R3841:Zfp773
|
UTSW |
7 |
7,135,390 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4116:Zfp773
|
UTSW |
7 |
7,136,092 (GRCm39) |
intron |
probably benign |
|
|
R4638:Zfp773
|
UTSW |
7 |
7,138,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5126:Zfp773
|
UTSW |
7 |
7,139,623 (GRCm39) |
missense |
unknown |
|
|
R6142:Zfp773
|
UTSW |
7 |
7,135,481 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7072:Zfp773
|
UTSW |
7 |
7,135,874 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7232:Zfp773
|
UTSW |
7 |
7,135,984 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7748:Zfp773
|
UTSW |
7 |
7,135,907 (GRCm39) |
missense |
probably benign |
0.04 |
|
R7888:Zfp773
|
UTSW |
7 |
7,135,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8681:Zfp773
|
UTSW |
7 |
7,139,482 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8784:Zfp773
|
UTSW |
7 |
7,135,570 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8946:Zfp773
|
UTSW |
7 |
7,135,469 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9056:Zfp773
|
UTSW |
7 |
7,135,989 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9154:Zfp773
|
UTSW |
7 |
7,138,302 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9295:Zfp773
|
UTSW |
7 |
7,135,694 (GRCm39) |
missense |
probably benign |
0.06 |
|
RF007:Zfp773
|
UTSW |
7 |
7,135,689 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCGGTGTCTAGAAAGTCCAGTCCTG -3'
(R):5'- GCGAGTGTGAGAAGTCCTTCATCC -3'
Sequencing Primer
(F):5'- cccctgctgtgaactttctg -3'
(R):5'- GTCCTTCATCCAAAAGACTGATCTG -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation