Incidental Mutation 'R7158:Zfp239'
ID557433
Institutional Source Beutler Lab
Gene Symbol Zfp239
Ensembl Gene ENSMUSG00000042097
Gene Namezinc finger protein 239
SynonymsMok-2, Mok2
Accession Numbers
Is this an essential gene? Non essential (E-score: 0.000) question?
Stock #R7158 (G1)
Quality Score225.009
Status Validated
Chromosome6
Chromosomal Location117862100-117873291 bp(+) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to T at 117871729 bp
ZygosityHeterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 143 (E143*)
Ref Sequence ENSEMBL: ENSMUSP00000078374 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079405] [ENSMUST00000172088]
Predicted Effect probably null
Transcript: ENSMUST00000079405
AA Change: E143*
SMART Domains Protein: ENSMUSP00000078374
Gene: ENSMUSG00000042097
AA Change: E143*

DomainStartEndE-ValueType
ZnF_C2H2 6 28 2.95e-3 SMART
ZnF_C2H2 34 56 2.2e-2 SMART
ZnF_C2H2 62 84 5.59e-4 SMART
ZnF_C2H2 90 112 1.76e-1 SMART
ZnF_C2H2 118 140 1.12e-3 SMART
ZnF_C2H2 146 168 1.03e-2 SMART
ZnF_C2H2 174 196 1.2e-3 SMART
Predicted Effect probably null
Transcript: ENSMUST00000172088
AA Change: E143*
SMART Domains Protein: ENSMUSP00000128270
Gene: ENSMUSG00000042097
AA Change: E143*

DomainStartEndE-ValueType
ZnF_C2H2 6 28 2.95e-3 SMART
ZnF_C2H2 34 56 2.2e-2 SMART
ZnF_C2H2 62 84 5.59e-4 SMART
ZnF_C2H2 90 112 1.76e-1 SMART
ZnF_C2H2 118 140 1.12e-3 SMART
ZnF_C2H2 146 168 1.03e-2 SMART
ZnF_C2H2 174 196 1.2e-3 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.8%
Validation Efficiency 100% (68/68)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A T 11: 9,273,982 M454L probably benign Het
Abca8b T A 11: 109,934,589 E1595V probably damaging Het
Actr5 T A 2: 158,626,414 C155S possibly damaging Het
Acvr1b T A 15: 101,194,058 V73E probably benign Het
Add2 T C 6: 86,085,952 Y31H probably damaging Het
Akap13 G T 7: 75,579,594 V92F probably damaging Het
Alox8 T A 11: 69,185,870 M568L probably benign Het
Birc6 A T 17: 74,594,376 E1145V probably benign Het
Cacng1 A T 11: 107,703,839 M166K probably damaging Het
Ces1f A G 8: 93,268,016 F256L probably benign Het
Clpb A G 7: 101,663,832 R8G probably benign Het
Col6a5 A G 9: 105,864,208 V2504A possibly damaging Het
Coq8a T C 1: 180,179,184 D93G probably benign Het
Cry2 A T 2: 92,413,715 I371N probably damaging Het
Ddx43 A C 9: 78,412,219 Q276H probably damaging Het
Dock10 T C 1: 80,586,872 probably null Het
Dst A G 1: 34,274,285 T4378A probably benign Het
Fezf1 T C 6: 23,245,790 T459A probably benign Het
Gm10097 C T 10: 5,069,407 A72V unknown Het
Hydin A G 8: 110,609,671 S5027G possibly damaging Het
Inhbb A T 1: 119,421,022 L22* probably null Het
Kat8 G A 7: 127,922,159 G228S probably benign Het
Kif15 T A 9: 122,999,314 S897T probably benign Het
Kndc1 A G 7: 139,931,860 Y1460C possibly damaging Het
Krt78 T A 15: 101,951,806 D225V probably benign Het
Lama3 A T 18: 12,456,812 I800F probably benign Het
Mdn1 C A 4: 32,725,121 T2580K probably benign Het
Mest T C 6: 30,744,914 F201S possibly damaging Het
Mtmr9 A G 14: 63,526,869 F470L probably benign Het
Nfic C T 10: 81,420,605 R75Q probably damaging Het
Nme2 G A 11: 93,955,658 probably benign Het
Nrg4 A G 9: 55,242,100 L71P probably damaging Het
Pacsin2 C T 15: 83,379,742 E365K possibly damaging Het
Pappa T C 4: 65,204,867 I813T possibly damaging Het
Pcdhgb4 A G 18: 37,720,885 E111G probably damaging Het
Pdzd8 C T 19: 59,300,157 R937H probably damaging Het
Per1 T G 11: 69,104,104 probably benign Het
Pex2 A G 3: 5,561,336 F138L probably benign Het
Pold1 A T 7: 44,538,866 N529K probably damaging Het
Pou6f2 T C 13: 18,152,038 I316V Het
Prom1 A C 5: 44,012,913 I682S probably damaging Het
Prpf40a T C 2: 53,152,553 K481E probably damaging Het
Prrg4 A T 2: 104,832,613 V216E probably damaging Het
Ptch2 C T 4: 117,114,784 P1168S possibly damaging Het
Pvr C A 7: 19,918,637 E118* probably null Het
R3hcc1l C T 19: 42,583,429 P716S probably damaging Het
Rasa4 A G 5: 136,102,021 E382G probably damaging Het
Rbp3 T A 14: 33,955,556 M487K probably benign Het
Rsad2 A T 12: 26,450,780 probably null Het
Shmt1 T C 11: 60,790,242 I353V probably benign Het
Shprh C T 10: 11,166,730 T819I probably damaging Het
Skap1 T A 11: 96,526,057 F56Y possibly damaging Het
Slc22a16 G T 10: 40,573,741 V79L possibly damaging Het
Slc34a1 A G 13: 55,401,231 T165A probably damaging Het
Smchd1 A C 17: 71,400,150 I941R probably damaging Het
Syne1 C A 10: 5,057,931 V98F probably damaging Het
Tcaim A G 9: 122,818,990 D190G possibly damaging Het
Tdrd9 G C 12: 112,036,366 E816D probably benign Het
Tmem132d T C 5: 128,137,019 K326E possibly damaging Het
Uhrf1bp1 T A 17: 27,886,433 C644* probably null Het
Usp35 T C 7: 97,325,964 M1V probably null Het
Wdr62 C T 7: 30,270,738 V215I possibly damaging Het
Zan T C 5: 137,400,644 T4153A unknown Het
Zfp292 T C 4: 34,808,679 D1460G probably benign Het
Zfp647 C T 15: 76,917,305 G90R probably benign Het
Other mutations in Zfp239
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1959:Zfp239 UTSW 6 117871817 missense probably benign 0.24
R4328:Zfp239 UTSW 6 117871784 missense probably damaging 1.00
R4750:Zfp239 UTSW 6 117871739 missense probably damaging 1.00
R4970:Zfp239 UTSW 6 117870517 utr 5 prime probably benign
R7284:Zfp239 UTSW 6 117871755 nonsense probably null
Predicted Primers PCR Primer
(F):5'- TCAGTCAGCGATCCAACCTG -3'
(R):5'- CATGTTACTTAGTGAAGCTCCTTGC -3'

Sequencing Primer
(F):5'- CAACGTGTCCACACCGG -3'
(R):5'- CTCCTTGCGGTGAACCC -3'
Posted On2019-06-26