Incidental Mutation 'R0586:Or8g4'
ID 55765
Institutional Source Beutler Lab
Gene Symbol Or8g4
Ensembl Gene ENSMUSG00000055820
Gene Name olfactory receptor family 8 subfamily G member 4
Synonyms Olfr967, GA_x6K02T2PVTD-33447884-33448816, MOR171-30P
MMRRC Submission 038776-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R0586 (G1)
Quality Score 195
Status Validated
Chromosome 9
Chromosomal Location 39661684-39662616 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39662414 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 244 (H244L)
Ref Sequence ENSEMBL: ENSMUSP00000150183 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069561] [ENSMUST00000213358]
AlphaFold Q7TRA6
Predicted Effect probably damaging
Transcript: ENSMUST00000069561
AA Change: H244L

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000064201
Gene: ENSMUSG00000055820
AA Change: H244L

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.6e-50 PFAM
Pfam:7tm_1 41 290 6.8e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213358
AA Change: H244L

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.1%
  • 10x: 97.5%
  • 20x: 94.4%
Validation Efficiency 100% (74/74)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca1 A T 4: 53,092,860 (GRCm39) V308E probably benign Het
Amy1 A G 3: 113,356,418 (GRCm39) probably benign Het
Astn2 C T 4: 66,103,379 (GRCm39) V345M unknown Het
Brwd1 T C 16: 95,844,286 (GRCm39) E756G probably damaging Het
Ccpg1 C T 9: 72,909,103 (GRCm39) L135F probably benign Het
Cecr2 C T 6: 120,734,845 (GRCm39) H694Y probably damaging Het
Cfh G A 1: 140,110,920 (GRCm39) T14I probably damaging Het
Cfhr2 G A 1: 139,741,172 (GRCm39) R268* probably null Het
Clca3a1 T A 3: 144,738,350 (GRCm39) I53L probably benign Het
Clcn6 A G 4: 148,123,206 (GRCm39) probably benign Het
Cnfn C T 7: 25,067,256 (GRCm39) V98I probably benign Het
Cntnap1 C T 11: 101,077,840 (GRCm39) R1122W probably damaging Het
Cpne9 A T 6: 113,272,024 (GRCm39) E384V probably damaging Het
Ctr9 T C 7: 110,648,705 (GRCm39) probably benign Het
Ctsj T A 13: 61,151,515 (GRCm39) probably benign Het
Cyp2c39 A C 19: 39,501,934 (GRCm39) probably benign Het
Dock5 A C 14: 68,046,481 (GRCm39) I767S probably damaging Het
Eftud2 T C 11: 102,737,446 (GRCm39) T552A probably damaging Het
Epdr1 A G 13: 19,778,715 (GRCm39) I25T probably damaging Het
Fcgbp A T 7: 27,789,138 (GRCm39) D568V probably damaging Het
Fcgbpl1 T A 7: 27,836,516 (GRCm39) V145D probably damaging Het
Fhip1b T C 7: 105,038,654 (GRCm39) E195G probably damaging Het
Frem2 T A 3: 53,555,342 (GRCm39) T1732S probably damaging Het
Fuz T C 7: 44,547,982 (GRCm39) V183A possibly damaging Het
Grb7 T C 11: 98,344,046 (GRCm39) S284P probably damaging Het
Hoxb4 G T 11: 96,209,713 (GRCm39) G40C probably damaging Het
Kcnn1 T C 8: 71,316,513 (GRCm39) probably benign Het
Kmt2d C A 15: 98,733,088 (GRCm39) probably benign Het
L3mbtl3 A G 10: 26,203,732 (GRCm39) V366A unknown Het
Ldlr G A 9: 21,651,040 (GRCm39) R486H probably benign Het
Lnpep A T 17: 17,795,658 (GRCm39) probably benign Het
Mical3 A T 6: 121,006,602 (GRCm39) probably benign Het
Myh15 T C 16: 48,992,250 (GRCm39) probably benign Het
Nup155 T A 15: 8,159,716 (GRCm39) H542Q probably benign Het
Opn4 A G 14: 34,320,930 (GRCm39) probably benign Het
Or13a20 T C 7: 140,231,976 (GRCm39) F28S probably benign Het
Or4a68 T A 2: 89,269,698 (GRCm39) R308S possibly damaging Het
Or6c68 A G 10: 129,157,916 (GRCm39) I141M probably benign Het
Or8h10 T C 2: 86,809,126 (GRCm39) N5D probably damaging Het
Pak3 TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC TTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTC X: 142,526,889 (GRCm39) probably benign Het
Parp14 T C 16: 35,661,382 (GRCm39) K1522R probably benign Het
Pkhd1 A T 1: 20,594,335 (GRCm39) D1259E probably benign Het
Pogz C T 3: 94,786,664 (GRCm39) A1084V probably damaging Het
Popdc3 G A 10: 45,191,359 (GRCm39) V157M probably benign Het
Prrt4 T C 6: 29,171,183 (GRCm39) Y423C probably damaging Het
Qrich1 C T 9: 108,411,719 (GRCm39) H415Y probably damaging Het
Rabgap1 A G 2: 37,433,235 (GRCm39) N801D probably benign Het
Rb1 A G 14: 73,525,124 (GRCm39) probably benign Het
Rp1 A T 1: 4,418,060 (GRCm39) N1017K possibly damaging Het
Ryr2 T C 13: 11,650,445 (GRCm39) D356G probably null Het
Skint8 C G 4: 111,794,126 (GRCm39) P172R probably damaging Het
Slc12a8 T G 16: 33,478,600 (GRCm39) M643R possibly damaging Het
Sult1c2 A T 17: 54,271,113 (GRCm39) probably benign Het
Tasor2 A G 13: 3,640,321 (GRCm39) L272P probably damaging Het
Tcaf1 T A 6: 42,650,473 (GRCm39) M869L probably damaging Het
Tecpr1 T C 5: 144,154,219 (GRCm39) N78S probably damaging Het
Tectb A T 19: 55,170,356 (GRCm39) Y69F probably damaging Het
Them4 A T 3: 94,237,101 (GRCm39) N187I possibly damaging Het
Tm9sf3 A G 19: 41,244,582 (GRCm39) probably null Het
Tnik G T 3: 28,631,510 (GRCm39) probably benign Het
Tns2 G T 15: 102,018,020 (GRCm39) probably benign Het
Tnxb A G 17: 34,891,118 (GRCm39) D487G probably damaging Het
Trim33 T A 3: 103,217,660 (GRCm39) C202S probably damaging Het
Trpm2 T A 10: 77,759,350 (GRCm39) I1145F probably damaging Het
Trpv2 A G 11: 62,483,596 (GRCm39) T478A probably benign Het
Ube2e3 T C 2: 78,750,334 (GRCm39) Y187H probably benign Het
Ubxn11 A G 4: 133,836,963 (GRCm39) R64G possibly damaging Het
Wwtr1 T C 3: 57,366,487 (GRCm39) T407A probably damaging Het
Zfyve26 A T 12: 79,315,502 (GRCm39) S1325T possibly damaging Het
Other mutations in Or8g4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02418:Or8g4 APN 9 39,661,787 (GRCm39) missense probably damaging 0.99
IGL02900:Or8g4 APN 9 39,661,901 (GRCm39) missense probably benign 0.01
R0099:Or8g4 UTSW 9 39,661,957 (GRCm39) missense possibly damaging 0.95
R0653:Or8g4 UTSW 9 39,661,934 (GRCm39) missense probably benign 0.26
R0839:Or8g4 UTSW 9 39,661,687 (GRCm39) missense probably benign
R1701:Or8g4 UTSW 9 39,662,365 (GRCm39) missense probably damaging 1.00
R1744:Or8g4 UTSW 9 39,661,711 (GRCm39) missense probably benign 0.33
R1902:Or8g4 UTSW 9 39,662,102 (GRCm39) missense probably benign 0.01
R4696:Or8g4 UTSW 9 39,662,024 (GRCm39) missense probably damaging 0.98
R5252:Or8g4 UTSW 9 39,661,784 (GRCm39) missense probably damaging 0.98
R5660:Or8g4 UTSW 9 39,662,063 (GRCm39) missense probably damaging 1.00
R6272:Or8g4 UTSW 9 39,661,816 (GRCm39) missense probably benign 0.39
R6976:Or8g4 UTSW 9 39,662,540 (GRCm39) missense probably damaging 1.00
R7078:Or8g4 UTSW 9 39,661,787 (GRCm39) missense possibly damaging 0.92
R7167:Or8g4 UTSW 9 39,661,865 (GRCm39) missense probably damaging 0.96
R7701:Or8g4 UTSW 9 39,662,597 (GRCm39) missense probably benign
R7980:Or8g4 UTSW 9 39,662,417 (GRCm39) missense probably damaging 0.99
R8026:Or8g4 UTSW 9 39,662,092 (GRCm39) missense possibly damaging 0.80
R8701:Or8g4 UTSW 9 39,662,210 (GRCm39) missense probably damaging 1.00
R8790:Or8g4 UTSW 9 39,662,204 (GRCm39) missense probably damaging 1.00
R8822:Or8g4 UTSW 9 39,661,700 (GRCm39) missense probably benign 0.01
R8825:Or8g4 UTSW 9 39,661,994 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTATGATGTCCTATCAAGTCTGCACC -3'
(R):5'- TCTCAGGCTGTAGATCAAGGGGTTTAG -3'

Sequencing Primer
(F):5'- ATCAAGTCTGCACCTGGATG -3'
(R):5'- TTTAGCATGGGCACAACAATG -3'
Posted On 2013-07-11