Incidental Mutation 'R7167:Or6c66b'
ID 557999
Institutional Source Beutler Lab
Gene Symbol Or6c66b
Ensembl Gene ENSMUSG00000094496
Gene Name olfactory receptor family 6 subfamily C member 66B
Synonyms Olfr792, MOR108-2, GA_x6K02T2PULF-11219415-11220350
MMRRC Submission 045228-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R7167 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129376408-129377343 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129376607 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 67 (L67P)
Ref Sequence ENSEMBL: ENSMUSP00000149872 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076575] [ENSMUST00000215436]
AlphaFold Q7TRH9
Predicted Effect possibly damaging
Transcript: ENSMUST00000076575
AA Change: L67P

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000096707
Gene: ENSMUSG00000094496
AA Change: L67P

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 1.9e-53 PFAM
Pfam:7tm_1 39 288 4.7e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215436
AA Change: L67P

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 94% (65/69)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,624,930 (GRCm39) V436A probably benign Het
Abcc5 T C 16: 20,224,251 (GRCm39) T111A possibly damaging Het
Acsbg2 T A 17: 57,164,000 (GRCm39) D203V probably benign Het
Alpk2 G T 18: 65,440,049 (GRCm39) T448K probably benign Het
Arhgef2 A G 3: 88,551,179 (GRCm39) N780S possibly damaging Het
Atxn2l T C 7: 126,098,394 (GRCm39) N252S possibly damaging Het
Bmpr1b A T 3: 141,568,841 (GRCm39) L163Q probably benign Het
Clca3a2 T C 3: 144,803,545 (GRCm39) R100G probably benign Het
Col2a1 A G 15: 97,898,337 (GRCm39) I79T unknown Het
Csmd1 A G 8: 15,976,524 (GRCm39) V2898A probably benign Het
Cux1 G A 5: 136,338,895 (GRCm39) probably null Het
Cyp2u1 A G 3: 131,096,773 (GRCm39) S2P probably benign Het
Daam1 C A 12: 72,035,678 (GRCm39) H958N probably damaging Het
Dnah7a C T 1: 53,542,935 (GRCm39) V2412I probably benign Het
Ergic2 T C 6: 148,108,133 (GRCm39) R2G probably damaging Het
Fat2 T C 11: 55,175,827 (GRCm39) T1629A possibly damaging Het
Ftl1 T A 7: 45,109,202 (GRCm39) probably benign Het
Fut8 T C 12: 77,495,406 (GRCm39) V332A possibly damaging Het
Gm28363 T C 1: 117,655,119 (GRCm39) S113P probably damaging Het
Hfe A T 13: 23,892,052 (GRCm39) V104E probably damaging Het
Ifih1 A T 2: 62,429,240 (GRCm39) N899K probably benign Het
Krt75 A G 15: 101,476,750 (GRCm39) S380P possibly damaging Het
Meiob T G 17: 25,055,419 (GRCm39) F409V probably damaging Het
Mkrn2os A T 6: 115,562,474 (GRCm39) I163N probably damaging Het
Nanos1 G T 19: 60,745,046 (GRCm39) G115W probably damaging Het
Naprt C T 15: 75,764,461 (GRCm39) A276T probably damaging Het
Oas1e G T 5: 120,933,487 (GRCm39) T26N probably benign Het
Oog2 T G 4: 143,921,745 (GRCm39) D218E probably benign Het
Optn T C 2: 5,047,294 (GRCm39) N207S probably benign Het
Or13a20 T A 7: 140,232,466 (GRCm39) C191* probably null Het
Or1l8 T C 2: 36,817,533 (GRCm39) I198V probably benign Het
Or4g16 T C 2: 111,136,793 (GRCm39) M81T probably benign Het
Or4p18 A G 2: 88,232,552 (GRCm39) V242A possibly damaging Het
Or6c63-ps1 T G 10: 128,899,141 (GRCm39) Q245P probably damaging Het
Or8g4 T C 9: 39,661,865 (GRCm39) F61S probably damaging Het
Oxnad1 G T 14: 31,822,976 (GRCm39) E236* probably null Het
Pcdha3 G A 18: 37,080,046 (GRCm39) A263T probably damaging Het
Pex13 A T 11: 23,605,472 (GRCm39) W253R possibly damaging Het
Pip5k1b T A 19: 24,374,433 (GRCm39) E49D probably benign Het
Plau C A 14: 20,889,518 (GRCm39) F194L possibly damaging Het
Ppm1n A G 7: 19,013,666 (GRCm39) L95S probably damaging Het
Pramel40 G A 5: 94,464,984 (GRCm39) A457T possibly damaging Het
Radil G T 5: 142,471,260 (GRCm39) probably null Het
Ralgapa2 C T 2: 146,190,374 (GRCm39) M1266I probably benign Het
Reln A T 5: 22,147,618 (GRCm39) L2444Q probably damaging Het
Rims2 T C 15: 39,300,473 (GRCm39) V260A probably benign Het
Rnase2b T A 14: 51,400,222 (GRCm39) V101E probably damaging Het
Rtp3 T A 9: 110,815,772 (GRCm39) T198S probably benign Het
Shisal2b A G 13: 105,000,166 (GRCm39) V19A probably damaging Het
Smad3 T A 9: 63,573,435 (GRCm39) D201V probably benign Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,222 (GRCm39) probably benign Het
Spata7 T G 12: 98,630,555 (GRCm39) F371C probably damaging Het
Stag1 T G 9: 100,827,942 (GRCm39) N990K probably benign Het
Tbx18 C T 9: 87,589,883 (GRCm39) A352T probably damaging Het
Thada C T 17: 84,538,391 (GRCm39) R1539Q probably benign Het
Thrap3 A C 4: 126,078,920 (GRCm39) probably benign Het
Tnks G A 8: 35,316,458 (GRCm39) T887M probably damaging Het
Trap1 A C 16: 3,870,792 (GRCm39) V393G probably damaging Het
Trpm4 A G 7: 44,977,143 (GRCm39) probably null Het
Trrap G T 5: 144,776,424 (GRCm39) G3007C probably benign Het
U2surp A T 9: 95,363,726 (GRCm39) N611K probably damaging Het
Usp12 A G 5: 146,705,745 (GRCm39) probably null Het
Vmn1r200 A G 13: 22,579,487 (GRCm39) T97A possibly damaging Het
Vmn2r110 C T 17: 20,794,441 (GRCm39) V743I probably benign Het
Vps50 C T 6: 3,600,256 (GRCm39) T905M probably damaging Het
Wdr48 T A 9: 119,736,855 (GRCm39) probably null Het
Zfp446 C T 7: 12,712,049 (GRCm39) probably benign Het
Zfr T C 15: 12,181,015 (GRCm39) S1012P probably benign Het
Other mutations in Or6c66b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01285:Or6c66b APN 10 129,376,711 (GRCm39) missense probably benign 0.07
IGL01459:Or6c66b APN 10 129,376,410 (GRCm39) start codon destroyed probably null 1.00
IGL02090:Or6c66b APN 10 129,377,176 (GRCm39) missense probably damaging 1.00
IGL03338:Or6c66b APN 10 129,376,925 (GRCm39) missense probably damaging 0.99
R0382:Or6c66b UTSW 10 129,376,883 (GRCm39) missense probably benign 0.01
R1672:Or6c66b UTSW 10 129,376,561 (GRCm39) missense probably benign 0.00
R2285:Or6c66b UTSW 10 129,376,537 (GRCm39) missense probably benign 0.22
R2938:Or6c66b UTSW 10 129,376,484 (GRCm39) missense probably damaging 1.00
R3498:Or6c66b UTSW 10 129,376,778 (GRCm39) missense probably damaging 1.00
R5309:Or6c66b UTSW 10 129,377,134 (GRCm39) missense probably benign 0.01
R5312:Or6c66b UTSW 10 129,377,134 (GRCm39) missense probably benign 0.01
R6004:Or6c66b UTSW 10 129,376,759 (GRCm39) missense probably benign 0.31
R6800:Or6c66b UTSW 10 129,377,132 (GRCm39) missense probably damaging 1.00
R7127:Or6c66b UTSW 10 129,376,936 (GRCm39) missense probably damaging 1.00
R7763:Or6c66b UTSW 10 129,377,324 (GRCm39) missense probably benign
R7819:Or6c66b UTSW 10 129,376,562 (GRCm39) missense probably benign 0.01
R8104:Or6c66b UTSW 10 129,376,826 (GRCm39) missense probably benign
R8189:Or6c66b UTSW 10 129,377,122 (GRCm39) missense probably damaging 0.99
R8672:Or6c66b UTSW 10 129,376,596 (GRCm39) missense probably damaging 0.99
Z1189:Or6c66b UTSW 10 129,377,246 (GRCm39) missense probably benign 0.44
Predicted Primers PCR Primer
(F):5'- TCACAATTACAGACCTGGCAG -3'
(R):5'- TAGCCACATAGCGGTCATAGG -3'

Sequencing Primer
(F):5'- CGAACATCTGTGAGTGAGTTTATTC -3'
(R):5'- CGGTCATAGGACATAGCAGTC -3'
Posted On 2019-06-26