Incidental Mutation 'R7168:Or4g17'
ID 558037
Institutional Source Beutler Lab
Gene Symbol Or4g17
Ensembl Gene ENSMUSG00000108931
Gene Name olfactory receptor family 4 subfamily G member 17
Synonyms GA_x6K02T2Q125-72430580-72431515, MOR245-13, Olfr1284
MMRRC Submission 045263-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.186) question?
Stock # R7168 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 111209347-111210282 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 111210224 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 293 (D293V)
Ref Sequence ENSEMBL: ENSMUSP00000052153 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062407] [ENSMUST00000209096]
AlphaFold Q8VF29
Predicted Effect probably damaging
Transcript: ENSMUST00000062407
AA Change: D293V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052153
Gene: ENSMUSG00000108931
AA Change: D293V

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 7.2e-45 PFAM
Pfam:7TM_GPCR_Srsx 34 302 2.4e-5 PFAM
Pfam:7tm_1 41 287 2e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000209096
AA Change: D293V

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik A T 12: 71,262,831 (GRCm39) D1388V probably damaging Het
2900026A02Rik C A 5: 113,285,659 (GRCm39) R65L probably damaging Het
Abcb10 A T 8: 124,693,350 (GRCm39) L318Q Het
Abhd18 T A 3: 40,889,371 (GRCm39) V417D probably damaging Het
Actl7a A G 4: 56,743,769 (GRCm39) K99E probably benign Het
Adam2 A T 14: 66,296,241 (GRCm39) I206N possibly damaging Het
Adgrv1 G T 13: 81,545,328 (GRCm39) S5652R possibly damaging Het
Aebp2 C T 6: 140,579,426 (GRCm39) T221M probably damaging Het
Ahi1 T A 10: 20,893,831 (GRCm39) M854K probably benign Het
Alpi T A 1: 87,027,155 (GRCm39) T375S possibly damaging Het
Apip T A 2: 102,922,813 (GRCm39) C210* probably null Het
Arid3b A T 9: 57,712,818 (GRCm39) D232E probably benign Het
Asic5 G A 3: 81,919,282 (GRCm39) C342Y probably damaging Het
BC035947 T C 1: 78,476,230 (GRCm39) M101V probably benign Het
Brd3 G A 2: 27,344,411 (GRCm39) R440C possibly damaging Het
Deaf1 C T 7: 140,904,509 (GRCm39) probably benign Het
Eif2ak3 A G 6: 70,858,610 (GRCm39) T300A probably benign Het
Eml6 T A 11: 29,788,529 (GRCm39) I519F probably benign Het
Fat4 T C 3: 39,034,808 (GRCm39) F2820S probably damaging Het
Fcho2 A G 13: 98,925,971 (GRCm39) I132T probably benign Het
Garnl3 A G 2: 32,885,090 (GRCm39) V810A probably damaging Het
Gm14403 A C 2: 177,201,318 (GRCm39) Q179P probably damaging Het
Gm3127 A G 14: 15,432,250 (GRCm39) M251V probably benign Het
Hook3 A G 8: 26,561,114 (GRCm39) S298P probably benign Het
Impact T A 18: 13,119,370 (GRCm39) probably null Het
Itgal T C 7: 126,929,385 (GRCm39) F1101L probably benign Het
Itih1 C T 14: 30,656,064 (GRCm39) R579Q probably null Het
Kansl2 T C 15: 98,427,425 (GRCm39) probably null Het
Kng1 A G 16: 22,898,391 (GRCm39) D597G probably benign Het
Kpna1 A G 16: 35,836,332 (GRCm39) probably benign Het
Lama2 C T 10: 27,242,148 (GRCm39) probably null Het
Ltbp1 G T 17: 75,598,361 (GRCm39) C614F probably damaging Het
Luc7l3 T C 11: 94,190,810 (GRCm39) E168G unknown Het
Lvrn A C 18: 47,014,389 (GRCm39) K525T probably benign Het
Mdn1 G A 4: 32,719,184 (GRCm39) R2249H probably damaging Het
Mmp16 G T 4: 18,110,550 (GRCm39) G449C probably damaging Het
Mst1r T C 9: 107,785,392 (GRCm39) V350A probably benign Het
Muc5b A G 7: 141,417,754 (GRCm39) M3567V probably benign Het
Mybl1 A T 1: 9,748,513 (GRCm39) L361Q probably damaging Het
Myom1 T A 17: 71,396,942 (GRCm39) S1063R probably benign Het
Notch4 A C 17: 34,791,667 (GRCm39) H582P probably benign Het
Nwd2 T A 5: 63,964,837 (GRCm39) C1474S probably benign Het
Or10ak14 A T 4: 118,611,048 (GRCm39) I231N probably damaging Het
Or5d36 A C 2: 87,900,921 (GRCm39) N268K probably benign Het
Or8b40 G T 9: 38,027,959 (GRCm39) S294I probably damaging Het
Pcmt1 A T 10: 7,513,946 (GRCm39) V241D probably damaging Het
Plcl1 T A 1: 55,736,622 (GRCm39) N654K probably damaging Het
Plg G A 17: 12,607,446 (GRCm39) G121D probably damaging Het
Ptch1 A G 13: 63,659,874 (GRCm39) S1260P probably benign Het
Pwp1 G T 10: 85,720,401 (GRCm39) R346I probably damaging Het
R3hdm1 C T 1: 128,144,232 (GRCm39) T800I probably benign Het
Rab3gap2 A G 1: 184,936,494 (GRCm39) D19G possibly damaging Het
Resf1 T G 6: 149,229,341 (GRCm39) F796V probably benign Het
Slc1a3 G T 15: 8,675,386 (GRCm39) N206K possibly damaging Het
Slc6a3 T C 13: 73,719,591 (GRCm39) V540A probably benign Het
Sntb1 G A 15: 55,654,661 (GRCm39) P265S probably benign Het
Timm29 T C 9: 21,504,749 (GRCm39) V139A probably damaging Het
Tktl2 A G 8: 66,965,753 (GRCm39) E437G probably damaging Het
Tm2d3 T A 7: 65,343,674 (GRCm39) V56E probably benign Het
Trhr2 T A 8: 123,087,276 (GRCm39) T55S probably damaging Het
Trim17 T G 11: 58,859,404 (GRCm39) V206G probably benign Het
Trpm1 A G 7: 63,918,445 (GRCm39) N1479S probably benign Het
Trpv2 T A 11: 62,473,914 (GRCm39) C190S probably benign Het
Umod A T 7: 119,077,549 (GRCm39) probably benign Het
Usp34 T A 11: 23,414,585 (GRCm39) Y2862N Het
Vmn1r158 A G 7: 22,490,101 (GRCm39) V36A possibly damaging Het
Zfp420 A G 7: 29,574,791 (GRCm39) Y337C probably damaging Het
Other mutations in Or4g17
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03024:Or4g17 APN 2 111,209,935 (GRCm39) missense possibly damaging 0.94
R0526:Or4g17 UTSW 2 111,209,837 (GRCm39) missense possibly damaging 0.95
R0731:Or4g17 UTSW 2 111,209,638 (GRCm39) missense probably damaging 0.99
R1762:Or4g17 UTSW 2 111,209,918 (GRCm39) missense probably damaging 0.99
R1765:Or4g17 UTSW 2 111,209,491 (GRCm39) missense probably benign 0.39
R3106:Or4g17 UTSW 2 111,209,840 (GRCm39) missense probably benign 0.23
R3803:Or4g17 UTSW 2 111,209,638 (GRCm39) missense possibly damaging 0.95
R3894:Or4g17 UTSW 2 111,209,982 (GRCm39) missense probably benign 0.09
R4005:Or4g17 UTSW 2 111,210,088 (GRCm39) missense probably benign 0.05
R4227:Or4g17 UTSW 2 111,209,410 (GRCm39) missense probably benign
R4637:Or4g17 UTSW 2 111,209,927 (GRCm39) missense probably benign 0.03
R4707:Or4g17 UTSW 2 111,209,990 (GRCm39) missense probably damaging 1.00
R4762:Or4g17 UTSW 2 111,210,082 (GRCm39) missense probably damaging 1.00
R5150:Or4g17 UTSW 2 111,209,598 (GRCm39) missense probably damaging 1.00
R5309:Or4g17 UTSW 2 111,210,179 (GRCm39) missense possibly damaging 0.52
R5312:Or4g17 UTSW 2 111,210,179 (GRCm39) missense possibly damaging 0.52
R6554:Or4g17 UTSW 2 111,209,504 (GRCm39) missense possibly damaging 0.95
R6913:Or4g17 UTSW 2 111,209,347 (GRCm39) start codon destroyed probably null 0.03
R6980:Or4g17 UTSW 2 111,209,620 (GRCm39) missense possibly damaging 0.77
R6995:Or4g17 UTSW 2 111,209,708 (GRCm39) missense probably damaging 1.00
R7332:Or4g17 UTSW 2 111,209,738 (GRCm39) missense not run
R7464:Or4g17 UTSW 2 111,209,543 (GRCm39) missense probably damaging 1.00
R8125:Or4g17 UTSW 2 111,210,086 (GRCm39) missense probably damaging 0.99
R8963:Or4g17 UTSW 2 111,209,645 (GRCm39) missense probably damaging 1.00
R9660:Or4g17 UTSW 2 111,210,239 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- TTGTCAAAGGCGCTTGTCAC -3'
(R):5'- ACACTGTGATAAGTTTCCTGTTTCC -3'

Sequencing Primer
(F):5'- AAAGGCGCTTGTCACTCTGTC -3'
(R):5'- TGCTGATTCTGGCCTGAA -3'
Posted On 2019-06-26