Incidental Mutation 'R7169:Or13a1'
ID 558119
Institutional Source Beutler Lab
Gene Symbol Or13a1
Ensembl Gene ENSMUSG00000053391
Gene Name olfactory receptor family 13 subfamily A member 1
Synonyms GA_x54KRFPKN04-58127726-58128655, Olfr211, MOR253-9
MMRRC Submission 045229-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.640) question?
Stock # R7169 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 116469630-116471501 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 116471025 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 152 (A152S)
Ref Sequence ENSEMBL: ENSMUSP00000145330 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000065786] [ENSMUST00000203700]
AlphaFold Q8VGH2
Predicted Effect probably benign
Transcript: ENSMUST00000065786
AA Change: A152S

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000066524
Gene: ENSMUSG00000053391
AA Change: A152S

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 6.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 304 3.4e-6 PFAM
Pfam:7tm_1 40 289 4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203700
AA Change: A152S

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000145330
Gene: ENSMUSG00000053391
AA Change: A152S

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 6.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 34 304 3.4e-6 PFAM
Pfam:7tm_1 40 289 4e-24 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts14 A G 10: 61,040,707 (GRCm39) V870A probably damaging Het
Ahi1 T G 10: 20,930,918 (GRCm39) D919E probably damaging Het
Angptl6 T A 9: 20,786,475 (GRCm39) R390S probably damaging Het
Arhgef11 A G 3: 87,634,755 (GRCm39) I873V possibly damaging Het
BC024063 T C 10: 81,946,293 (GRCm39) Y638H possibly damaging Het
Brsk1 T C 7: 4,718,403 (GRCm39) S751P probably benign Het
Calhm5 T A 10: 33,968,160 (GRCm39) T298S probably damaging Het
Cdh20 G A 1: 104,875,078 (GRCm39) A287T possibly damaging Het
Clic3 G A 2: 25,348,731 (GRCm39) R237H probably benign Het
Cog6 G T 3: 52,897,387 (GRCm39) P562H possibly damaging Het
Csnk2a2 A G 8: 96,215,006 (GRCm39) Y24H Het
Ctif T C 18: 75,605,087 (GRCm39) D484G probably damaging Het
Cyria A G 12: 12,409,233 (GRCm39) D71G possibly damaging Het
Dennd6b A T 15: 89,073,055 (GRCm39) F161I possibly damaging Het
Dnah14 G T 1: 181,529,930 (GRCm39) V2235L probably benign Het
Dnah6 A T 6: 73,015,729 (GRCm39) V3636D probably damaging Het
Dpm1 A T 2: 168,053,343 (GRCm39) Y207* probably null Het
Eml3 A G 19: 8,910,828 (GRCm39) T227A probably damaging Het
Enpp5 G A 17: 44,396,155 (GRCm39) G356S probably damaging Het
Eppk1 C A 15: 75,990,114 (GRCm39) A2256S probably benign Het
Etnppl A T 3: 130,414,345 (GRCm39) N80I probably damaging Het
Eya4 A T 10: 23,031,845 (GRCm39) N236K probably benign Het
Gm12886 T G 4: 121,273,948 (GRCm39) Q89H probably damaging Het
Gsdme T C 6: 50,204,358 (GRCm39) T200A probably benign Het
Hipk1 C T 3: 103,651,533 (GRCm39) A1122T probably benign Het
Icos A G 1: 61,034,705 (GRCm39) D176G probably damaging Het
Igkv5-43 T A 6: 69,800,519 (GRCm39) Y56F probably damaging Het
Il1r1 T C 1: 40,332,519 (GRCm39) probably null Het
Ildr2 G A 1: 166,135,503 (GRCm39) probably null Het
Ilf3 T A 9: 21,306,722 (GRCm39) H305Q probably damaging Het
Insrr A G 3: 87,715,901 (GRCm39) H532R probably benign Het
Lmbr1l CACTACATACTACATACTACATACTACATACTACATACTACATAC CACTACATACTACATACTACATACTACATACTACATACTACATACTACATAC 15: 98,807,039 (GRCm39) probably null Het
Lmbr1l ACTACAT ACTACATGCTACAT 15: 98,807,075 (GRCm39) probably benign Het
Lratd1 A G 12: 14,200,619 (GRCm39) F36S probably damaging Het
Lrrc25 T G 8: 71,070,437 (GRCm39) S73A probably benign Het
Lrrn1 T C 6: 107,544,565 (GRCm39) L121P probably damaging Het
Ly6c1 C A 15: 74,916,495 (GRCm39) V116L probably benign Het
Meltf A G 16: 31,698,980 (GRCm39) D30G probably benign Het
Mroh7 T A 4: 106,548,836 (GRCm39) D1009V probably damaging Het
Mybpc3 T C 2: 90,948,524 (GRCm39) V4A possibly damaging Het
Mycbp2 A G 14: 103,497,636 (GRCm39) S979P possibly damaging Het
Ntn5 C T 7: 45,336,198 (GRCm39) R210* probably null Het
Nuak1 T C 10: 84,210,609 (GRCm39) D493G probably damaging Het
Oprk1 T A 1: 5,659,304 (GRCm39) D11E probably benign Het
Or4f14 A G 2: 111,742,939 (GRCm39) M112T possibly damaging Het
Or4k37 T A 2: 111,158,943 (GRCm39) Y60N probably damaging Het
Or56a41 T C 7: 104,740,397 (GRCm39) I150V possibly damaging Het
Pkd1l2 T A 8: 117,767,574 (GRCm39) T1239S possibly damaging Het
Pkm A G 9: 59,578,908 (GRCm39) D296G possibly damaging Het
Pof1b A G X: 111,554,042 (GRCm39) I544T probably benign Het
Pop5 T A 5: 115,378,287 (GRCm39) V77E possibly damaging Het
Ppp1r10 T C 17: 36,240,365 (GRCm39) S552P probably damaging Het
Rabggta C G 14: 55,958,358 (GRCm39) R101P probably damaging Het
Rorc A T 3: 94,296,487 (GRCm39) E243V probably benign Het
Setmar C A 6: 108,042,049 (GRCm39) A3E possibly damaging Het
Skor2 T A 18: 76,948,681 (GRCm39) V801E probably benign Het
Slc12a7 G A 13: 73,932,679 (GRCm39) V56M probably benign Het
Snph T A 2: 151,436,307 (GRCm39) N207I probably damaging Het
Snx14 A G 9: 88,280,362 (GRCm39) V531A probably damaging Het
Thap1 CAGCATCTGCTCGGAGCA CAGCA 8: 26,650,884 (GRCm39) probably null Het
Tlr3 A T 8: 45,850,056 (GRCm39) M871K probably damaging Het
Tnfrsf11a A T 1: 105,772,421 (GRCm39) R569S possibly damaging Het
Trim66 A G 7: 109,054,328 (GRCm39) V1294A probably benign Het
Vldlr G A 19: 27,221,728 (GRCm39) V698I probably benign Het
Vmn2r73 G A 7: 85,507,663 (GRCm39) Q550* probably null Het
Zdhhc5 A T 2: 84,532,675 (GRCm39) probably null Het
Zfhx3 T A 8: 109,678,030 (GRCm39) Y3027N possibly damaging Het
Zfp663 C T 2: 165,194,359 (GRCm39) S620N probably benign Het
Other mutations in Or13a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0681:Or13a1 UTSW 6 116,471,361 (GRCm39) missense probably damaging 1.00
R1443:Or13a1 UTSW 6 116,471,386 (GRCm39) missense probably benign 0.08
R1502:Or13a1 UTSW 6 116,471,242 (GRCm39) missense probably damaging 1.00
R1962:Or13a1 UTSW 6 116,470,725 (GRCm39) missense probably benign
R2421:Or13a1 UTSW 6 116,470,674 (GRCm39) missense probably benign
R5151:Or13a1 UTSW 6 116,470,765 (GRCm39) nonsense probably null
R5844:Or13a1 UTSW 6 116,470,900 (GRCm39) missense probably damaging 1.00
R7596:Or13a1 UTSW 6 116,471,158 (GRCm39) missense probably benign 0.02
R9131:Or13a1 UTSW 6 116,470,881 (GRCm39) missense probably benign 0.02
R9429:Or13a1 UTSW 6 116,471,292 (GRCm39) missense probably damaging 1.00
Z1176:Or13a1 UTSW 6 116,471,337 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTGTCAAAGAGGAACCCCATC -3'
(R):5'- AGCCGTATGACACAATGGTC -3'

Sequencing Primer
(F):5'- ATCTCCTACGGTGGCTGCATG -3'
(R):5'- GGTCATCAGGAAGTTCAATATGCC -3'
Posted On 2019-06-26