Incidental Mutation 'R7175:Or2g7'
ID 558577
Institutional Source Beutler Lab
Gene Symbol Or2g7
Ensembl Gene ENSMUSG00000094878
Gene Name olfactory receptor family 2 subfamily G member 7
Synonyms GA_x6K02T2PSCP-2515350-2516303, MOR256-19, Olfr130
MMRRC Submission 045231-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.119) question?
Stock # R7175 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38378064-38379017 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38378370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 103 (S103T)
Ref Sequence ENSEMBL: ENSMUSP00000149963 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087129] [ENSMUST00000215726] [ENSMUST00000217390]
AlphaFold Q8VFC1
Predicted Effect probably damaging
Transcript: ENSMUST00000087129
AA Change: S103T

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000084369
Gene: ENSMUSG00000094878
AA Change: S103T

DomainStartEndE-ValueType
Pfam:7tm_4 29 307 1.8e-44 PFAM
Pfam:7TM_GPCR_Srsx 34 223 1.9e-5 PFAM
Pfam:7tm_1 40 289 1.9e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215726
AA Change: S103T

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
Predicted Effect probably damaging
Transcript: ENSMUST00000217390
AA Change: S103T

PolyPhen 2 Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb5 G A 12: 118,831,611 (GRCm39) T1247I probably benign Het
Afdn T C 17: 14,108,869 (GRCm39) L1479P probably damaging Het
Alox12e T C 11: 70,210,534 (GRCm39) R363G probably damaging Het
Ank2 A T 3: 126,740,590 (GRCm39) S1765T unknown Het
Anks6 T C 4: 47,046,268 (GRCm39) probably null Het
Apob A C 12: 8,057,034 (GRCm39) I1839L probably benign Het
Bdp1 C A 13: 100,186,478 (GRCm39) R1658I probably damaging Het
Ccs T A 19: 4,883,390 (GRCm39) D136V probably damaging Het
Cd200 T C 16: 45,220,578 (GRCm39) probably null Het
Cirbp T C 10: 80,006,297 (GRCm39) S130P probably benign Het
Cpb1 A G 3: 20,317,927 (GRCm39) I199T probably benign Het
Csn3 C T 5: 88,077,586 (GRCm39) R31C probably damaging Het
Dcaf1 A T 9: 106,735,775 (GRCm39) I908F probably benign Het
Dhcr7 C T 7: 143,399,227 (GRCm39) T199I probably damaging Het
Dnah9 T A 11: 66,024,463 (GRCm39) Q277L probably benign Het
Echdc2 C A 4: 108,031,366 (GRCm39) P237T probably damaging Het
Efcab3 T C 11: 104,838,237 (GRCm39) V3625A unknown Het
Eif4g3 A G 4: 137,853,526 (GRCm39) N364S probably damaging Het
Eml6 T A 11: 29,734,231 (GRCm39) I1170L probably benign Het
Epha3 C T 16: 63,403,863 (GRCm39) R746Q probably damaging Het
Exosc5 G A 7: 25,363,794 (GRCm39) C102Y probably damaging Het
Fam91a1 A T 15: 58,302,527 (GRCm39) Y289F probably benign Het
Fbxo38 A C 18: 62,648,544 (GRCm39) F665V probably benign Het
Fcrl5 T C 3: 87,353,645 (GRCm39) V330A probably benign Het
Fer T A 17: 64,231,090 (GRCm39) D280E probably benign Het
Gpr158 A G 2: 21,373,113 (GRCm39) H16R probably benign Het
Gzmg C T 14: 56,396,979 (GRCm39) M1I probably null Het
Hectd4 C T 5: 121,411,692 (GRCm39) A456V possibly damaging Het
Hk2 T A 6: 82,711,830 (GRCm39) Q613L probably benign Het
Inhca A G 9: 103,128,988 (GRCm39) probably null Het
Itsn1 T C 16: 91,664,938 (GRCm39) F1121L unknown Het
Lztr1 G T 16: 17,340,895 (GRCm39) C557F possibly damaging Het
Mdn1 A G 4: 32,694,634 (GRCm39) Y1119C probably damaging Het
Nfkb1 A T 3: 135,319,751 (GRCm39) L248Q probably damaging Het
Or1a1 T A 11: 74,087,004 (GRCm39) L225* probably null Het
Or1p1b T C 11: 74,130,803 (GRCm39) F138L probably benign Het
Or52e19 T C 7: 102,959,054 (GRCm39) V42A probably benign Het
Otulinl A C 15: 27,658,374 (GRCm39) D165E probably damaging Het
Pate1 T G 9: 35,596,408 (GRCm39) D119A probably damaging Het
Pcdhgc4 T C 18: 37,949,424 (GRCm39) V280A possibly damaging Het
Pik3ap1 T C 19: 41,275,929 (GRCm39) D717G probably damaging Het
Prdm13 A T 4: 21,679,473 (GRCm39) L339Q unknown Het
Rasgrf1 T A 9: 89,862,802 (GRCm39) N519K probably benign Het
Rergl A G 6: 139,473,533 (GRCm39) V39A probably benign Het
Runx2 G A 17: 45,125,079 (GRCm39) P80L probably damaging Het
Sema4b T A 7: 79,848,402 (GRCm39) M1K probably null Het
Slc20a1 T G 2: 129,052,662 (GRCm39) L648R probably damaging Het
Spata31h1 T A 10: 82,122,583 (GRCm39) S3476C probably damaging Het
Speg A G 1: 75,399,134 (GRCm39) T2194A probably benign Het
Spns1 T C 7: 125,972,961 (GRCm39) D215G probably damaging Het
Tle4 A T 19: 14,429,071 (GRCm39) V717E probably damaging Het
Trim50 T A 5: 135,382,151 (GRCm39) M1K probably null Het
Trpa1 A G 1: 14,963,431 (GRCm39) V597A possibly damaging Het
Usp13 C T 3: 32,971,757 (GRCm39) Q746* probably null Het
Vmn1r35 A T 6: 66,655,906 (GRCm39) W255R probably benign Het
Vps35 A T 8: 85,990,189 (GRCm39) probably null Het
Vps54 T C 11: 21,265,028 (GRCm39) probably null Het
Zfp318 T A 17: 46,697,774 (GRCm39) L210Q probably damaging Het
Zfp319 C A 8: 96,055,410 (GRCm39) K264N probably damaging Het
Zfp62 C T 11: 49,107,580 (GRCm39) S557L probably damaging Het
Zgrf1 T C 3: 127,357,239 (GRCm39) S822P probably damaging Het
Zxdc A G 6: 90,346,645 (GRCm39) D2G possibly damaging Het
Zzef1 T C 11: 72,742,727 (GRCm39) I769T possibly damaging Het
Other mutations in Or2g7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01527:Or2g7 APN 17 38,378,986 (GRCm39) missense probably benign
IGL02158:Or2g7 APN 17 38,378,158 (GRCm39) missense probably damaging 0.97
IGL03172:Or2g7 APN 17 38,378,275 (GRCm39) missense probably damaging 0.99
R0389:Or2g7 UTSW 17 38,378,562 (GRCm39) missense possibly damaging 0.58
R0448:Or2g7 UTSW 17 38,378,563 (GRCm39) missense probably benign 0.00
R0616:Or2g7 UTSW 17 38,378,131 (GRCm39) missense probably damaging 1.00
R0961:Or2g7 UTSW 17 38,378,814 (GRCm39) missense probably damaging 1.00
R1789:Or2g7 UTSW 17 38,378,839 (GRCm39) missense probably damaging 1.00
R2108:Or2g7 UTSW 17 38,378,746 (GRCm39) missense possibly damaging 0.82
R4600:Or2g7 UTSW 17 38,378,853 (GRCm39) missense probably damaging 0.99
R4977:Or2g7 UTSW 17 38,378,638 (GRCm39) missense possibly damaging 0.67
R5120:Or2g7 UTSW 17 38,378,157 (GRCm39) missense probably damaging 0.97
R5930:Or2g7 UTSW 17 38,378,641 (GRCm39) missense probably benign 0.11
R6273:Or2g7 UTSW 17 38,378,686 (GRCm39) missense probably damaging 1.00
R6636:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R6637:Or2g7 UTSW 17 38,378,115 (GRCm39) missense probably damaging 0.98
R7030:Or2g7 UTSW 17 38,378,948 (GRCm39) missense probably benign 0.13
R7045:Or2g7 UTSW 17 38,378,862 (GRCm39) missense probably benign 0.01
R7359:Or2g7 UTSW 17 38,378,506 (GRCm39) nonsense probably null
R7762:Or2g7 UTSW 17 38,378,566 (GRCm39) missense probably damaging 1.00
R7980:Or2g7 UTSW 17 38,378,412 (GRCm39) missense possibly damaging 0.64
R8050:Or2g7 UTSW 17 38,378,370 (GRCm39) missense probably damaging 1.00
R9035:Or2g7 UTSW 17 38,378,179 (GRCm39) missense probably benign 0.00
X0019:Or2g7 UTSW 17 38,378,613 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TTGTGCTGGTGCTAATCTCC -3'
(R):5'- GGTGATGGTACCCTGAATCAGAG -3'

Sequencing Primer
(F):5'- TCCTGACACTGGTAGGCAAC -3'
(R):5'- TGAATCAGAGTGTTGCCCAC -3'
Posted On 2019-06-26