Incidental Mutation 'R7178:Tas2r140'
ID 558763
Institutional Source Beutler Lab
Gene Symbol Tas2r140
Ensembl Gene ENSMUSG00000071147
Gene Name taste receptor, type 2, member 140
Synonyms TRB5, mt2r64, Tas2r40, Tas2r13, mTRB3, TRB3, T2R40
MMRRC Submission 045232-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R7178 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 133031818-133032756 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 133032623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 45 (D45V)
Ref Sequence ENSEMBL: ENSMUSP00000093040 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095391]
AlphaFold Q7TQA4
Predicted Effect probably damaging
Transcript: ENSMUST00000095391
AA Change: D45V

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000093040
Gene: ENSMUSG00000071147
AA Change: D45V

DomainStartEndE-ValueType
Pfam:TAS2R 1 301 6.7e-86 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (75/75)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsbg1 A G 9: 54,535,745 (GRCm39) I130T possibly damaging Het
Adam24 T A 8: 41,133,039 (GRCm39) L169* probably null Het
Als2 A T 1: 59,246,971 (GRCm39) I556N probably damaging Het
Ankrd44 A T 1: 54,688,599 (GRCm39) N212K Het
Anpep T C 7: 79,490,736 (GRCm39) D260G probably benign Het
Arhgap17 A T 7: 122,884,581 (GRCm39) probably null Het
Atad2 C T 15: 57,980,689 (GRCm39) R383Q probably damaging Het
Atp11b T A 3: 35,874,099 (GRCm39) M696K probably benign Het
Atp13a2 A G 4: 140,726,462 (GRCm39) T350A probably damaging Het
Atp8b2 T C 3: 89,850,979 (GRCm39) D29G possibly damaging Het
Baz2a C T 10: 127,960,326 (GRCm39) R1514W probably damaging Het
Cep250 T A 2: 155,815,375 (GRCm39) L631* probably null Het
Cimip2a G A 2: 25,110,252 (GRCm39) V55I probably damaging Het
Clec4a3 T C 6: 122,941,251 (GRCm39) I82T probably benign Het
Csmd3 T A 15: 47,454,170 (GRCm39) I2648F Het
Cul5 A G 9: 53,555,826 (GRCm39) F247L probably benign Het
Dnajc24 A T 2: 105,800,807 (GRCm39) M101K probably damaging Het
Dnhd1 T A 7: 105,344,200 (GRCm39) V1848E probably damaging Het
Dspp A G 5: 104,321,932 (GRCm39) T14A probably benign Het
Gm7298 T G 6: 121,762,855 (GRCm39) I1392S probably damaging Het
Gm9955 A T 18: 24,842,220 (GRCm39) S62R unknown Het
Gtsf1 T G 15: 103,328,388 (GRCm39) N130T probably benign Het
Heatr5a C A 12: 51,971,925 (GRCm39) S755I probably damaging Het
Hrc A G 7: 44,985,685 (GRCm39) T279A possibly damaging Het
Hvcn1 T C 5: 122,371,573 (GRCm39) W38R probably damaging Het
Hyal6 A G 6: 24,734,834 (GRCm39) S256G probably benign Het
Insyn2b G T 11: 34,352,359 (GRCm39) V134F probably damaging Het
Ipo13 A G 4: 117,761,081 (GRCm39) S546P possibly damaging Het
Katnip T C 7: 125,465,499 (GRCm39) V1317A probably benign Het
Kif24 A G 4: 41,395,085 (GRCm39) V730A probably benign Het
L3mbtl2 T C 15: 81,555,275 (GRCm39) V176A probably benign Het
Lgi1 T C 19: 38,294,733 (GRCm39) Y502H probably damaging Het
Liph T A 16: 21,795,078 (GRCm39) D178V probably damaging Het
Maea T C 5: 33,515,854 (GRCm39) V47A probably damaging Het
Mak16 A C 8: 31,656,602 (GRCm39) S42A probably benign Het
Mamdc4 T C 2: 25,458,977 (GRCm39) I269V probably benign Het
Mapk8ip3 A T 17: 25,120,728 (GRCm39) M812K probably benign Het
Muc4 T A 16: 32,752,788 (GRCm38) S889T unknown Het
Npy6r A G 18: 44,409,551 (GRCm39) N324S probably damaging Het
Ntrk3 T G 7: 78,005,895 (GRCm39) T489P possibly damaging Het
Or52a5b G A 7: 103,417,182 (GRCm39) Q141* probably null Het
Or5h19 T A 16: 58,856,296 (GRCm39) D268V probably benign Het
Or5t17 G A 2: 86,832,879 (GRCm39) V189I probably benign Het
Otof G C 5: 30,540,878 (GRCm39) T887S possibly damaging Het
Papola T C 12: 105,773,443 (GRCm39) V154A probably damaging Het
Pde4dip T C 3: 97,622,946 (GRCm39) H1421R probably benign Het
Plpp5 T C 8: 26,210,606 (GRCm39) S66P probably benign Het
Ppp6r3 T A 19: 3,568,337 (GRCm39) I154L probably benign Het
Prr18 A C 17: 8,560,741 (GRCm39) D299A possibly damaging Het
Psmb1 G A 17: 15,697,521 (GRCm39) S198F possibly damaging Het
Qars1 T C 9: 108,392,322 (GRCm39) V723A possibly damaging Het
Rab6a A T 7: 100,285,959 (GRCm39) R185* probably null Het
Scn2a C T 2: 65,579,197 (GRCm39) Q1511* probably null Het
Serpinb3d T A 1: 107,008,506 (GRCm39) I120F possibly damaging Het
Serpini2 T C 3: 75,165,455 (GRCm39) T175A probably damaging Het
Skic2 T C 17: 35,058,440 (GRCm39) T1226A probably benign Het
Slc17a6 A G 7: 51,317,259 (GRCm39) I427V possibly damaging Het
Slc2a2 C T 3: 28,773,631 (GRCm39) A312V possibly damaging Het
Snx33 C T 9: 56,833,151 (GRCm39) R306H probably damaging Het
Spcs1 G A 14: 30,722,438 (GRCm39) S127F possibly damaging Het
Speg T C 1: 75,399,027 (GRCm39) V2158A possibly damaging Het
Sptbn4 T A 7: 27,117,481 (GRCm39) I423F probably damaging Het
Synj2 T A 17: 6,076,754 (GRCm39) I930N possibly damaging Het
Tcf3 C A 10: 80,257,433 (GRCm39) V11F unknown Het
Tead1 A T 7: 112,441,144 (GRCm39) Q91L probably benign Het
Tgm5 T A 2: 120,916,249 (GRCm39) probably benign Het
Tgoln1 C T 6: 72,593,028 (GRCm39) G151S probably benign Het
Tnfrsf11a C A 1: 105,755,264 (GRCm39) N445K probably benign Het
Ttn G C 2: 76,540,514 (GRCm39) F34157L probably benign Het
Vmn2r91 C A 17: 18,356,424 (GRCm39) P697Q probably damaging Het
Zeb2 G A 2: 44,887,006 (GRCm39) L684F probably damaging Het
Zfp661 T C 2: 127,419,456 (GRCm39) D228G probably benign Het
Zfp738 T C 13: 67,821,147 (GRCm39) K77E probably damaging Het
Zkscan1 T A 5: 138,099,192 (GRCm39) D378E probably damaging Het
Zswim9 T A 7: 12,993,924 (GRCm39) D744V possibly damaging Het
Other mutations in Tas2r140
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Tas2r140 APN 6 40,468,274 (GRCm39) missense probably benign 0.20
IGL00951:Tas2r140 APN 6 40,468,913 (GRCm39) nonsense probably null
IGL00980:Tas2r140 APN 6 40,468,352 (GRCm39) missense possibly damaging 0.60
IGL02055:Tas2r140 APN 6 40,468,493 (GRCm39) missense probably damaging 1.00
IGL03101:Tas2r140 APN 6 40,468,764 (GRCm39) missense probably benign 0.03
R0149:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0244:Tas2r140 UTSW 6 133,032,290 (GRCm39) missense possibly damaging 0.46
R0361:Tas2r140 UTSW 6 40,468,232 (GRCm39) missense probably benign 0.08
R0666:Tas2r140 UTSW 6 133,032,405 (GRCm39) missense probably benign 0.22
R0755:Tas2r140 UTSW 6 40,468,344 (GRCm39) missense probably damaging 0.99
R1174:Tas2r140 UTSW 6 133,031,834 (GRCm39) missense probably benign 0.27
R1237:Tas2r140 UTSW 6 133,032,171 (GRCm39) missense probably benign 0.04
R1553:Tas2r140 UTSW 6 133,032,471 (GRCm39) missense probably damaging 0.99
R2030:Tas2r140 UTSW 6 133,032,213 (GRCm39) missense probably benign 0.23
R2030:Tas2r140 UTSW 6 40,469,154 (GRCm39) missense possibly damaging 0.58
R3123:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R3124:Tas2r140 UTSW 6 133,032,204 (GRCm39) missense probably benign 0.05
R4233:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4234:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4236:Tas2r140 UTSW 6 133,031,915 (GRCm39) missense probably damaging 1.00
R4525:Tas2r140 UTSW 6 133,032,207 (GRCm39) missense possibly damaging 0.66
R4803:Tas2r140 UTSW 6 133,032,743 (GRCm39) missense possibly damaging 0.77
R4840:Tas2r140 UTSW 6 133,032,528 (GRCm39) missense probably benign 0.01
R4885:Tas2r140 UTSW 6 40,468,334 (GRCm39) missense probably damaging 0.98
R5092:Tas2r140 UTSW 6 40,468,200 (GRCm39) missense probably benign
R5182:Tas2r140 UTSW 6 40,468,866 (GRCm39) missense probably benign 0.01
R5317:Tas2r140 UTSW 6 133,032,543 (GRCm39) missense probably benign 0.06
R5937:Tas2r140 UTSW 6 133,032,236 (GRCm39) missense probably benign 0.01
R5952:Tas2r140 UTSW 6 40,468,476 (GRCm39) missense probably benign 0.43
R6142:Tas2r140 UTSW 6 133,032,698 (GRCm39) missense probably damaging 1.00
R7127:Tas2r140 UTSW 6 133,031,922 (GRCm39) missense possibly damaging 0.62
R7143:Tas2r140 UTSW 6 133,032,482 (GRCm39) missense probably benign 0.00
R7494:Tas2r140 UTSW 6 40,468,254 (GRCm39) missense probably damaging 0.99
R7513:Tas2r140 UTSW 6 40,469,084 (GRCm39) missense probably damaging 1.00
R7875:Tas2r140 UTSW 6 40,469,097 (GRCm39) missense probably damaging 1.00
R7979:Tas2r140 UTSW 6 40,468,601 (GRCm39) missense probably damaging 1.00
R8804:Tas2r140 UTSW 6 133,032,326 (GRCm39) missense probably damaging 0.98
R9029:Tas2r140 UTSW 6 133,032,181 (GRCm39) missense possibly damaging 0.69
R9055:Tas2r140 UTSW 6 133,032,380 (GRCm39) missense possibly damaging 0.77
R9257:Tas2r140 UTSW 6 40,468,592 (GRCm39) missense probably damaging 0.98
R9385:Tas2r140 UTSW 6 133,032,241 (GRCm39) missense probably benign 0.03
R9530:Tas2r140 UTSW 6 133,032,494 (GRCm39) missense probably benign 0.00
R9760:Tas2r140 UTSW 6 40,469,036 (GRCm39) missense probably benign 0.41
X0022:Tas2r140 UTSW 6 40,468,275 (GRCm39) missense possibly damaging 0.63
Predicted Primers PCR Primer
(F):5'- GCTGAGACATGTAGCAAGCC -3'
(R):5'- CATAGAACTTCTGGCTGTTGTG -3'

Sequencing Primer
(F):5'- TGAGACATGTAGCAAGCCAAATATTG -3'
(R):5'- CTGGGCTTTCTTGGACAAAAATG -3'
Posted On 2019-06-26