Incidental Mutation 'R7184:Gatb'
ID 559160
Institutional Source Beutler Lab
Gene Symbol Gatb
Ensembl Gene ENSMUSG00000028085
Gene Name glutamyl-tRNA amidotransferase subunit B
Synonyms 9430026F02Rik, Pet112, Pet112l
MMRRC Submission 045236-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.957) question?
Stock # R7184 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 85481426-85562929 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 85544258 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 409 (Q409*)
Ref Sequence ENSEMBL: ENSMUSP00000119949 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107672] [ENSMUST00000107674] [ENSMUST00000127348] [ENSMUST00000154148]
AlphaFold Q99JT1
Predicted Effect probably null
Transcript: ENSMUST00000107672
AA Change: Q409*
SMART Domains Protein: ENSMUSP00000103299
Gene: ENSMUSG00000028085
AA Change: Q409*

DomainStartEndE-ValueType
Pfam:GatB_N 65 353 8.3e-103 PFAM
Pfam:GatB_Yqey 406 472 6.3e-19 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000107674
AA Change: Q409*
SMART Domains Protein: ENSMUSP00000103301
Gene: ENSMUSG00000028085
AA Change: Q409*

DomainStartEndE-ValueType
Pfam:GatB_N 64 354 6.7e-105 PFAM
GatB_Yqey 406 518 2.09e-22 SMART
Predicted Effect probably null
Transcript: ENSMUST00000127348
AA Change: Q409*
SMART Domains Protein: ENSMUSP00000119949
Gene: ENSMUSG00000028085
AA Change: Q409*

DomainStartEndE-ValueType
Pfam:GatB_N 65 353 8.3e-101 PFAM
GatB_Yqey 406 555 4.13e-53 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000154148
SMART Domains Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

DomainStartEndE-ValueType
Arfaptin 1 227 7.15e-121 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass A G 6: 23,094,219 (GRCm39) S500P possibly damaging Het
Aldh9a1 T A 1: 167,184,965 (GRCm39) N292K probably benign Het
Art2b A T 7: 101,229,658 (GRCm39) S80R probably benign Het
Atp6v1b2 G T 8: 69,555,219 (GRCm39) A194S possibly damaging Het
Bsnd T C 4: 106,349,109 (GRCm39) M44V probably damaging Het
Cadps2 A T 6: 23,583,428 (GRCm39) V383E probably benign Het
Cd93 T C 2: 148,284,459 (GRCm39) T296A possibly damaging Het
Cdk15 G T 1: 59,304,814 (GRCm39) E138D probably benign Het
Cdon A G 9: 35,375,191 (GRCm39) I406V probably benign Het
Cfhr4 A G 1: 139,660,822 (GRCm39) V622A possibly damaging Het
Cyp3a41a A G 5: 145,642,663 (GRCm39) V232A probably benign Het
Dbndd1 T A 8: 124,235,860 (GRCm39) D130V probably damaging Het
Dnah14 C T 1: 181,532,094 (GRCm39) R2294* probably null Het
Eddm3b A G 14: 51,354,387 (GRCm39) Y125C probably damaging Het
Eif1ad14 G A 12: 87,886,492 (GRCm39) R46W possibly damaging Het
Enah A T 1: 181,749,957 (GRCm39) V294E probably damaging Het
Farp2 A G 1: 93,531,137 (GRCm39) E545G probably damaging Het
Farsb T C 1: 78,458,994 (GRCm39) E22G possibly damaging Het
Fcsk G A 8: 111,613,788 (GRCm39) P758S probably damaging Het
Fezf1 A G 6: 23,247,835 (GRCm39) V80A probably benign Het
Fpr2 T C 17: 18,113,533 (GRCm39) Y39H unknown Het
Fsd1l C A 4: 53,694,054 (GRCm39) R344S probably damaging Het
Fxyd1 G T 7: 30,751,401 (GRCm39) R90S unknown Het
Galnt4 T A 10: 98,944,466 (GRCm39) Y64N probably damaging Het
Glipr2 A C 4: 43,968,667 (GRCm39) D73A possibly damaging Het
Gm40460 ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,450 (GRCm39) probably benign Het
Gpr88 C T 3: 116,045,643 (GRCm39) V223I possibly damaging Het
Gtf2h3 A G 5: 124,722,067 (GRCm39) N55S probably benign Het
Htr4 T A 18: 62,570,498 (GRCm39) C184* probably null Het
Ighv6-3 T A 12: 114,355,475 (GRCm39) R71S probably benign Het
Itpr2 G C 6: 146,212,585 (GRCm39) I1510M possibly damaging Het
Keap1 T C 9: 21,145,134 (GRCm39) Q292R probably benign Het
Mab21l4 T C 1: 93,082,237 (GRCm39) N294S probably benign Het
Malt1 A C 18: 65,580,764 (GRCm39) E219D probably benign Het
Manba T C 3: 135,228,915 (GRCm39) V279A possibly damaging Het
Map4k5 T A 12: 69,921,095 (GRCm39) H41L probably benign Het
Mcm2 T G 6: 88,868,776 (GRCm39) Y327S probably damaging Het
Nectin3 A G 16: 46,215,484 (GRCm39) I503T possibly damaging Het
Nqo1 T C 8: 108,119,279 (GRCm39) I99M probably damaging Het
Nrxn2 A G 19: 6,540,582 (GRCm39) H845R probably damaging Het
Otogl C T 10: 107,599,061 (GRCm39) C2254Y probably damaging Het
Pmm1 T C 15: 81,840,415 (GRCm39) N110S probably damaging Het
Poc1b G T 10: 98,970,199 (GRCm39) C68F probably benign Het
Polr1b A G 2: 128,965,842 (GRCm39) Y828C possibly damaging Het
Prl3d1 A G 13: 27,282,619 (GRCm39) H119R probably damaging Het
Pum3 A G 19: 27,403,412 (GRCm39) S30P probably benign Het
Rgl2 T C 17: 34,153,964 (GRCm39) F457L possibly damaging Het
Rusc1 T C 3: 88,999,194 (GRCm39) E196G possibly damaging Het
Sf3a3 A G 4: 124,608,772 (GRCm39) K29E probably benign Het
Slc13a1 A T 6: 24,092,311 (GRCm39) I475K probably damaging Het
Slc26a5 G T 5: 22,042,244 (GRCm39) Y237* probably null Het
Slc7a14 C T 3: 31,281,212 (GRCm39) G366D probably damaging Het
Tbc1d5 A G 17: 51,107,110 (GRCm39) V482A probably benign Het
Tdrd5 G T 1: 156,087,505 (GRCm39) Q883K probably benign Het
Tet2 T C 3: 133,179,391 (GRCm39) Y1258C probably damaging Het
Upf2 A G 2: 6,028,131 (GRCm39) D739G unknown Het
Vmn1r122 A T 7: 20,867,820 (GRCm39) F78L probably benign Het
Vmn1r75 A T 7: 11,614,915 (GRCm39) K216* probably null Het
Vmn2r11 A T 5: 109,201,281 (GRCm39) Y408N probably damaging Het
Wscd1 T A 11: 71,679,543 (GRCm39) V472D probably damaging Het
Zdbf2 G T 1: 63,345,664 (GRCm39) V1348F possibly damaging Het
Zfp442 G T 2: 150,250,056 (GRCm39) H615Q possibly damaging Het
Zfp457 C A 13: 67,442,065 (GRCm39) C170F possibly damaging Het
Zscan10 A G 17: 23,826,003 (GRCm39) probably null Het
Other mutations in Gatb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00094:Gatb APN 3 85,509,227 (GRCm39) missense possibly damaging 0.95
IGL00963:Gatb APN 3 85,526,255 (GRCm39) missense probably benign 0.00
IGL01363:Gatb APN 3 85,559,652 (GRCm39) missense probably damaging 1.00
IGL01650:Gatb APN 3 85,520,791 (GRCm39) missense possibly damaging 0.68
IGL01973:Gatb APN 3 85,518,731 (GRCm39) missense probably damaging 1.00
IGL02195:Gatb APN 3 85,511,755 (GRCm39) missense probably benign 0.00
IGL02670:Gatb APN 3 85,520,858 (GRCm39) splice site probably null
IGL02992:Gatb APN 3 85,526,223 (GRCm39) missense probably damaging 1.00
IGL03025:Gatb APN 3 85,483,181 (GRCm39) missense probably damaging 0.99
IGL03035:Gatb APN 3 85,509,254 (GRCm39) missense probably damaging 1.00
IGL03090:Gatb APN 3 85,526,330 (GRCm39) intron probably benign
R1313:Gatb UTSW 3 85,561,133 (GRCm39) missense probably benign 0.01
R1313:Gatb UTSW 3 85,561,133 (GRCm39) missense probably benign 0.01
R1851:Gatb UTSW 3 85,526,184 (GRCm39) missense probably damaging 0.99
R1852:Gatb UTSW 3 85,526,184 (GRCm39) missense probably damaging 0.99
R2134:Gatb UTSW 3 85,518,677 (GRCm39) missense probably damaging 1.00
R2209:Gatb UTSW 3 85,561,112 (GRCm39) missense probably benign 0.03
R5189:Gatb UTSW 3 85,544,238 (GRCm39) missense probably benign 0.00
R5218:Gatb UTSW 3 85,511,751 (GRCm39) missense probably benign
R5857:Gatb UTSW 3 85,483,239 (GRCm39) missense probably damaging 1.00
R5871:Gatb UTSW 3 85,561,083 (GRCm39) nonsense probably null
R6031:Gatb UTSW 3 85,520,818 (GRCm39) missense possibly damaging 0.82
R6031:Gatb UTSW 3 85,520,818 (GRCm39) missense possibly damaging 0.82
R6430:Gatb UTSW 3 85,544,345 (GRCm39) missense probably benign 0.01
R6661:Gatb UTSW 3 85,559,726 (GRCm39) splice site probably null
R7210:Gatb UTSW 3 85,481,527 (GRCm39) missense probably benign
R7501:Gatb UTSW 3 85,544,297 (GRCm39) missense probably damaging 0.99
R7919:Gatb UTSW 3 85,511,828 (GRCm39) missense probably damaging 1.00
R8335:Gatb UTSW 3 85,481,628 (GRCm39) critical splice donor site probably null
R8536:Gatb UTSW 3 85,511,868 (GRCm39) missense probably damaging 0.99
R8867:Gatb UTSW 3 85,511,716 (GRCm39) missense probably damaging 1.00
R9312:Gatb UTSW 3 85,561,070 (GRCm39) missense probably damaging 1.00
R9330:Gatb UTSW 3 85,559,801 (GRCm39) missense probably benign 0.03
X0013:Gatb UTSW 3 85,509,168 (GRCm39) missense probably damaging 1.00
Z1177:Gatb UTSW 3 85,544,280 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGTGTTTCAGAAGGAAGCG -3'
(R):5'- CTCAAAGGGGATTGTTTGTCATC -3'

Sequencing Primer
(F):5'- CGTAGATGTCCTGTAGCAGCAG -3'
(R):5'- AATTTACCCTGTCCTATTTCAATTGC -3'
Posted On 2019-06-26