Incidental Mutation 'R7184:Vmn2r11'
ID 559170
Institutional Source Beutler Lab
Gene Symbol Vmn2r11
Ensembl Gene ENSMUSG00000091450
Gene Name vomeronasal 2, receptor 11
Synonyms EG384219
MMRRC Submission 045236-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R7184 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 109194739-109207318 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 109201281 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 408 (Y408N)
Ref Sequence ENSEMBL: ENSMUSP00000133218 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000164875]
AlphaFold E9Q4X4
Predicted Effect probably damaging
Transcript: ENSMUST00000164875
AA Change: Y408N

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000133218
Gene: ENSMUSG00000091450
AA Change: Y408N

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 167 475 1.6e-29 PFAM
Pfam:NCD3G 520 574 9.1e-19 PFAM
Pfam:7tm_3 607 842 4.6e-55 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (63/63)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass A G 6: 23,094,219 (GRCm39) S500P possibly damaging Het
Aldh9a1 T A 1: 167,184,965 (GRCm39) N292K probably benign Het
Art2b A T 7: 101,229,658 (GRCm39) S80R probably benign Het
Atp6v1b2 G T 8: 69,555,219 (GRCm39) A194S possibly damaging Het
Bsnd T C 4: 106,349,109 (GRCm39) M44V probably damaging Het
Cadps2 A T 6: 23,583,428 (GRCm39) V383E probably benign Het
Cd93 T C 2: 148,284,459 (GRCm39) T296A possibly damaging Het
Cdk15 G T 1: 59,304,814 (GRCm39) E138D probably benign Het
Cdon A G 9: 35,375,191 (GRCm39) I406V probably benign Het
Cfhr4 A G 1: 139,660,822 (GRCm39) V622A possibly damaging Het
Cyp3a41a A G 5: 145,642,663 (GRCm39) V232A probably benign Het
Dbndd1 T A 8: 124,235,860 (GRCm39) D130V probably damaging Het
Dnah14 C T 1: 181,532,094 (GRCm39) R2294* probably null Het
Eddm3b A G 14: 51,354,387 (GRCm39) Y125C probably damaging Het
Eif1ad14 G A 12: 87,886,492 (GRCm39) R46W possibly damaging Het
Enah A T 1: 181,749,957 (GRCm39) V294E probably damaging Het
Farp2 A G 1: 93,531,137 (GRCm39) E545G probably damaging Het
Farsb T C 1: 78,458,994 (GRCm39) E22G possibly damaging Het
Fcsk G A 8: 111,613,788 (GRCm39) P758S probably damaging Het
Fezf1 A G 6: 23,247,835 (GRCm39) V80A probably benign Het
Fpr2 T C 17: 18,113,533 (GRCm39) Y39H unknown Het
Fsd1l C A 4: 53,694,054 (GRCm39) R344S probably damaging Het
Fxyd1 G T 7: 30,751,401 (GRCm39) R90S unknown Het
Galnt4 T A 10: 98,944,466 (GRCm39) Y64N probably damaging Het
Gatb C T 3: 85,544,258 (GRCm39) Q409* probably null Het
Glipr2 A C 4: 43,968,667 (GRCm39) D73A possibly damaging Het
Gm40460 ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,450 (GRCm39) probably benign Het
Gpr88 C T 3: 116,045,643 (GRCm39) V223I possibly damaging Het
Gtf2h3 A G 5: 124,722,067 (GRCm39) N55S probably benign Het
Htr4 T A 18: 62,570,498 (GRCm39) C184* probably null Het
Ighv6-3 T A 12: 114,355,475 (GRCm39) R71S probably benign Het
Itpr2 G C 6: 146,212,585 (GRCm39) I1510M possibly damaging Het
Keap1 T C 9: 21,145,134 (GRCm39) Q292R probably benign Het
Mab21l4 T C 1: 93,082,237 (GRCm39) N294S probably benign Het
Malt1 A C 18: 65,580,764 (GRCm39) E219D probably benign Het
Manba T C 3: 135,228,915 (GRCm39) V279A possibly damaging Het
Map4k5 T A 12: 69,921,095 (GRCm39) H41L probably benign Het
Mcm2 T G 6: 88,868,776 (GRCm39) Y327S probably damaging Het
Nectin3 A G 16: 46,215,484 (GRCm39) I503T possibly damaging Het
Nqo1 T C 8: 108,119,279 (GRCm39) I99M probably damaging Het
Nrxn2 A G 19: 6,540,582 (GRCm39) H845R probably damaging Het
Otogl C T 10: 107,599,061 (GRCm39) C2254Y probably damaging Het
Pmm1 T C 15: 81,840,415 (GRCm39) N110S probably damaging Het
Poc1b G T 10: 98,970,199 (GRCm39) C68F probably benign Het
Polr1b A G 2: 128,965,842 (GRCm39) Y828C possibly damaging Het
Prl3d1 A G 13: 27,282,619 (GRCm39) H119R probably damaging Het
Pum3 A G 19: 27,403,412 (GRCm39) S30P probably benign Het
Rgl2 T C 17: 34,153,964 (GRCm39) F457L possibly damaging Het
Rusc1 T C 3: 88,999,194 (GRCm39) E196G possibly damaging Het
Sf3a3 A G 4: 124,608,772 (GRCm39) K29E probably benign Het
Slc13a1 A T 6: 24,092,311 (GRCm39) I475K probably damaging Het
Slc26a5 G T 5: 22,042,244 (GRCm39) Y237* probably null Het
Slc7a14 C T 3: 31,281,212 (GRCm39) G366D probably damaging Het
Tbc1d5 A G 17: 51,107,110 (GRCm39) V482A probably benign Het
Tdrd5 G T 1: 156,087,505 (GRCm39) Q883K probably benign Het
Tet2 T C 3: 133,179,391 (GRCm39) Y1258C probably damaging Het
Upf2 A G 2: 6,028,131 (GRCm39) D739G unknown Het
Vmn1r122 A T 7: 20,867,820 (GRCm39) F78L probably benign Het
Vmn1r75 A T 7: 11,614,915 (GRCm39) K216* probably null Het
Wscd1 T A 11: 71,679,543 (GRCm39) V472D probably damaging Het
Zdbf2 G T 1: 63,345,664 (GRCm39) V1348F possibly damaging Het
Zfp442 G T 2: 150,250,056 (GRCm39) H615Q possibly damaging Het
Zfp457 C A 13: 67,442,065 (GRCm39) C170F possibly damaging Het
Zscan10 A G 17: 23,826,003 (GRCm39) probably null Het
Other mutations in Vmn2r11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00925:Vmn2r11 APN 5 109,194,885 (GRCm39) missense probably benign 0.00
IGL01677:Vmn2r11 APN 5 109,201,823 (GRCm39) missense possibly damaging 0.50
IGL02048:Vmn2r11 APN 5 109,202,658 (GRCm39) missense probably benign 0.00
IGL02559:Vmn2r11 APN 5 109,200,046 (GRCm39) missense probably damaging 0.98
IGL02879:Vmn2r11 APN 5 109,201,704 (GRCm39) missense possibly damaging 0.95
IGL03084:Vmn2r11 APN 5 109,207,209 (GRCm39) missense probably benign 0.00
IGL03163:Vmn2r11 APN 5 109,201,692 (GRCm39) missense probably benign 0.41
IGL03289:Vmn2r11 APN 5 109,196,788 (GRCm39) splice site probably benign
IGL03294:Vmn2r11 APN 5 109,201,935 (GRCm39) missense probably benign 0.22
R0233:Vmn2r11 UTSW 5 109,201,968 (GRCm39) missense probably benign 0.16
R0233:Vmn2r11 UTSW 5 109,201,968 (GRCm39) missense probably benign 0.16
R0421:Vmn2r11 UTSW 5 109,207,294 (GRCm39) missense probably benign 0.00
R0549:Vmn2r11 UTSW 5 109,199,963 (GRCm39) missense possibly damaging 0.80
R0628:Vmn2r11 UTSW 5 109,195,597 (GRCm39) missense possibly damaging 0.88
R1523:Vmn2r11 UTSW 5 109,201,707 (GRCm39) missense probably benign 0.25
R1660:Vmn2r11 UTSW 5 109,201,724 (GRCm39) missense possibly damaging 0.79
R1827:Vmn2r11 UTSW 5 109,199,938 (GRCm39) missense probably benign 0.01
R1913:Vmn2r11 UTSW 5 109,202,654 (GRCm39) missense probably benign
R2260:Vmn2r11 UTSW 5 109,201,657 (GRCm39) nonsense probably null
R2400:Vmn2r11 UTSW 5 109,199,928 (GRCm39) missense probably benign 0.03
R3933:Vmn2r11 UTSW 5 109,201,260 (GRCm39) missense probably damaging 0.97
R4091:Vmn2r11 UTSW 5 109,202,616 (GRCm39) critical splice donor site probably null
R4624:Vmn2r11 UTSW 5 109,200,101 (GRCm39) missense probably damaging 0.99
R4762:Vmn2r11 UTSW 5 109,195,436 (GRCm39) missense probably damaging 1.00
R5256:Vmn2r11 UTSW 5 109,202,658 (GRCm39) missense probably benign 0.26
R5370:Vmn2r11 UTSW 5 109,195,421 (GRCm39) missense probably damaging 1.00
R5419:Vmn2r11 UTSW 5 109,207,224 (GRCm39) missense possibly damaging 0.55
R5516:Vmn2r11 UTSW 5 109,195,032 (GRCm39) missense probably damaging 0.98
R5643:Vmn2r11 UTSW 5 109,194,869 (GRCm39) missense probably damaging 1.00
R5671:Vmn2r11 UTSW 5 109,202,772 (GRCm39) missense probably benign 0.03
R5679:Vmn2r11 UTSW 5 109,202,708 (GRCm39) missense probably benign 0.00
R5739:Vmn2r11 UTSW 5 109,207,114 (GRCm39) critical splice donor site probably null
R5746:Vmn2r11 UTSW 5 109,201,560 (GRCm39) missense probably benign 0.41
R5995:Vmn2r11 UTSW 5 109,194,921 (GRCm39) missense probably damaging 1.00
R6147:Vmn2r11 UTSW 5 109,202,700 (GRCm39) missense probably benign 0.04
R6220:Vmn2r11 UTSW 5 109,201,434 (GRCm39) missense probably benign 0.09
R6374:Vmn2r11 UTSW 5 109,201,679 (GRCm39) missense possibly damaging 0.65
R6491:Vmn2r11 UTSW 5 109,196,800 (GRCm39) missense possibly damaging 0.95
R6804:Vmn2r11 UTSW 5 109,201,350 (GRCm39) missense probably damaging 1.00
R6814:Vmn2r11 UTSW 5 109,194,976 (GRCm39) missense possibly damaging 0.81
R6872:Vmn2r11 UTSW 5 109,194,976 (GRCm39) missense possibly damaging 0.81
R7014:Vmn2r11 UTSW 5 109,201,289 (GRCm39) missense probably damaging 1.00
R7041:Vmn2r11 UTSW 5 109,202,816 (GRCm39) missense probably damaging 1.00
R7043:Vmn2r11 UTSW 5 109,200,098 (GRCm39) missense probably benign 0.00
R7050:Vmn2r11 UTSW 5 109,202,657 (GRCm39) missense probably benign 0.05
R7388:Vmn2r11 UTSW 5 109,202,742 (GRCm39) missense probably benign 0.05
R7477:Vmn2r11 UTSW 5 109,207,214 (GRCm39) missense possibly damaging 0.67
R7524:Vmn2r11 UTSW 5 109,201,848 (GRCm39) missense probably benign 0.01
R7682:Vmn2r11 UTSW 5 109,195,481 (GRCm39) missense probably benign 0.02
R7715:Vmn2r11 UTSW 5 109,195,307 (GRCm39) missense probably damaging 0.99
R7869:Vmn2r11 UTSW 5 109,199,986 (GRCm39) missense probably damaging 1.00
R8094:Vmn2r11 UTSW 5 109,201,626 (GRCm39) missense probably damaging 1.00
R8277:Vmn2r11 UTSW 5 109,202,833 (GRCm39) missense probably benign 0.00
R8506:Vmn2r11 UTSW 5 109,207,270 (GRCm39) missense probably benign 0.00
R8676:Vmn2r11 UTSW 5 109,201,626 (GRCm39) missense probably damaging 1.00
R8701:Vmn2r11 UTSW 5 109,195,556 (GRCm39) missense probably damaging 1.00
R8749:Vmn2r11 UTSW 5 109,195,319 (GRCm39) missense probably damaging 0.97
R9046:Vmn2r11 UTSW 5 109,202,850 (GRCm39) missense probably benign 0.00
R9138:Vmn2r11 UTSW 5 109,201,904 (GRCm39) missense probably damaging 1.00
R9267:Vmn2r11 UTSW 5 109,199,929 (GRCm39) missense possibly damaging 0.93
R9306:Vmn2r11 UTSW 5 109,196,831 (GRCm39) missense probably damaging 1.00
R9384:Vmn2r11 UTSW 5 109,201,266 (GRCm39) missense probably damaging 1.00
R9443:Vmn2r11 UTSW 5 109,195,159 (GRCm39) nonsense probably null
R9520:Vmn2r11 UTSW 5 109,201,455 (GRCm39) missense probably benign 0.35
R9596:Vmn2r11 UTSW 5 109,201,563 (GRCm39) missense possibly damaging 0.67
R9677:Vmn2r11 UTSW 5 109,201,332 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- CTCTGGGTCCATTTAAAAGATCCC -3'
(R):5'- CTTTTGAACACCACCACAGTG -3'

Sequencing Primer
(F):5'- TGGGTACTGCCATTTGCT -3'
(R):5'- ACCACAGTGAGATTGCTAAATTTAAG -3'
Posted On 2019-06-26