Mutagenetix > Incidental Mutation

Incidental Mutation 'R0590:Vmn1r23'

55925

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r23

Ensembl Gene

ENSMUSG00000093376

Gene Name

vomeronasal 1 receptor 23

Synonyms

V1rc24

MMRRC Submission

038780-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.124) question?

Stock #

R0590 (G1)

Quality Score

211

Status

Validated

Chromosome

Chromosomal Location

57902868-57903776 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 57903349 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 143 (V143A)

Ref Sequence

ENSEMBL: ENSMUSP00000135676 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000175817]

AlphaFold

Q8R2D0

Predicted Effect

probably benign
Transcript: ENSMUST00000175817
AA Change: V143A

PolyPhen 2 Score 0.429 (Sensitivity: 0.89; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000135676
Gene: ENSMUSG00000093376
AA Change: V143A

Domain	Start	End	E-Value	Type
Pfam:V1R	28	293	3.1e-57	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.4%
3x: 99.0%
10x: 97.7%
20x: 95.7%

Validation Efficiency

100% (47/47)

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acnat2	C	T	4: 49,383,273 (GRCm39)	M93I	probably benign	Het
Adamts16	T	C	13: 70,949,073 (GRCm39)	D196G	probably benign	Het
Adhfe1	T	A	1: 9,618,378 (GRCm39)		probably null	Het
AI661453	A	G	17: 47,777,999 (GRCm39)		probably benign	Het
Apc	G	T	18: 34,449,283 (GRCm39)	E2026*	probably null	Het
Atg2a	GCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC	GCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC	19: 6,295,037 (GRCm39)		probably benign	Het
Cad	T	C	5: 31,219,575 (GRCm39)	S688P	probably damaging	Het
Ccdc191	C	T	16: 43,751,704 (GRCm39)	R345*	probably null	Het
Dcaf13	T	A	15: 39,008,480 (GRCm39)		probably benign	Het
Drc1	A	G	5: 30,520,480 (GRCm39)	D607G	probably benign	Het
Fhip1a	T	C	3: 85,579,683 (GRCm39)	R841G	probably benign	Het
Gli1	G	T	10: 127,167,432 (GRCm39)	A607E	possibly damaging	Het
Gls	G	A	1: 52,251,534 (GRCm39)		probably benign	Het
Gria1	A	T	11: 57,180,235 (GRCm39)	Q728H	probably damaging	Het
Hcrtr1	A	G	4: 130,029,487 (GRCm39)	L198P	probably damaging	Het
Ifngr1	T	A	10: 19,479,690 (GRCm39)		probably benign	Het
Ipo5	T	C	14: 121,181,769 (GRCm39)	V954A	possibly damaging	Het
Kcnh5	G	T	12: 75,012,035 (GRCm39)	A628D	probably damaging	Het
Kif14	T	C	1: 136,410,210 (GRCm39)	S646P	probably damaging	Het
Ksr1	A	G	11: 78,935,966 (GRCm39)	S133P	probably damaging	Het
Neb	T	C	2: 52,027,302 (GRCm39)	M7143V	probably damaging	Het
Nelfa	G	A	5: 34,059,169 (GRCm39)	P229S	probably damaging	Het
Nfatc2	T	C	2: 168,413,119 (GRCm39)	T169A	probably damaging	Het
Nr1h4	A	G	10: 89,292,429 (GRCm39)	Y398H	probably damaging	Het
Nrcam	A	G	12: 44,610,815 (GRCm39)	E511G	probably damaging	Het
Ocstamp	T	A	2: 165,239,671 (GRCm39)	R172W	probably damaging	Het
Or10ag60	A	G	2: 87,438,338 (GRCm39)	E202G	probably damaging	Het
Or8d1	T	A	9: 38,766,766 (GRCm39)	M136K	probably damaging	Het
Or8g19	T	C	9: 39,056,017 (GRCm39)	V207A	probably benign	Het
Phf14	G	A	6: 11,961,577 (GRCm39)	V405I	possibly damaging	Het
Plk5	G	A	10: 80,196,057 (GRCm39)	R238H	probably damaging	Het
Pole	A	G	5: 110,465,792 (GRCm39)	E1240G	probably benign	Het
Prdm15	A	G	16: 97,598,961 (GRCm39)	I899T	possibly damaging	Het
Psip1	T	C	4: 83,376,381 (GRCm39)	N486S	probably benign	Het
Rlf	A	G	4: 121,028,030 (GRCm39)		probably benign	Het
Rttn	T	C	18: 88,997,759 (GRCm39)	S255P	probably damaging	Het
Rusf1	A	G	7: 127,896,642 (GRCm39)	L134P	probably damaging	Het
Sema6c	A	G	3: 95,079,934 (GRCm39)	K711E	probably damaging	Het
Slc4a10	A	T	2: 62,021,237 (GRCm39)		probably benign	Het
Trim36	T	G	18: 46,305,643 (GRCm39)	S435R	probably benign	Het
Ucp1	A	G	8: 84,018,232 (GRCm39)		probably benign	Het
Vmn1r17	T	C	6: 57,337,999 (GRCm39)	Y122C	probably benign	Het
Wdfy4	T	A	14: 32,763,131 (GRCm39)	Q2166L	probably benign	Het
Zc3h7b	C	T	15: 81,661,199 (GRCm39)	T346M	possibly damaging	Het
Zfhx4	T	A	3: 5,467,693 (GRCm39)	V2617D	probably damaging	Het

Other mutations in Vmn1r23

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01563:Vmn1r23	APN	6	57,903,061 (GRCm39)	missense	possibly damaging	0.89
IGL01980:Vmn1r23	APN	6	57,903,475 (GRCm39)	missense	probably damaging	1.00
IGL02934:Vmn1r23	APN	6	57,902,914 (GRCm39)	missense	probably benign	0.26
IGL03153:Vmn1r23	APN	6	57,902,917 (GRCm39)	missense	probably damaging	0.98
R0410:Vmn1r23	UTSW	6	57,903,175 (GRCm39)	missense	probably benign	0.11
R0452:Vmn1r23	UTSW	6	57,903,469 (GRCm39)	missense	possibly damaging	0.90
R0647:Vmn1r23	UTSW	6	57,903,169 (GRCm39)	missense	probably benign
R0692:Vmn1r23	UTSW	6	57,903,110 (GRCm39)	nonsense	probably null
R1674:Vmn1r23	UTSW	6	57,903,046 (GRCm39)	missense	possibly damaging	0.75
R1744:Vmn1r23	UTSW	6	57,902,910 (GRCm39)	missense	possibly damaging	0.81
R1774:Vmn1r23	UTSW	6	57,903,675 (GRCm39)	missense	probably damaging	0.97
R2101:Vmn1r23	UTSW	6	57,903,437 (GRCm39)	missense	possibly damaging	0.90
R2202:Vmn1r23	UTSW	6	57,903,604 (GRCm39)	missense	probably benign	0.01
R2204:Vmn1r23	UTSW	6	57,903,604 (GRCm39)	missense	probably benign	0.01
R2205:Vmn1r23	UTSW	6	57,903,604 (GRCm39)	missense	probably benign	0.01
R4282:Vmn1r23	UTSW	6	57,903,452 (GRCm39)	missense	probably benign	0.27
R4408:Vmn1r23	UTSW	6	57,903,353 (GRCm39)	missense	probably benign	0.01
R4532:Vmn1r23	UTSW	6	57,902,914 (GRCm39)	missense	probably benign	0.21
R4690:Vmn1r23	UTSW	6	57,903,010 (GRCm39)	missense	probably benign
R4700:Vmn1r23	UTSW	6	57,903,190 (GRCm39)	missense	probably benign	0.17
R4894:Vmn1r23	UTSW	6	57,903,310 (GRCm39)	missense	probably benign	0.00
R6164:Vmn1r23	UTSW	6	57,903,040 (GRCm39)	missense	possibly damaging	0.90
R6930:Vmn1r23	UTSW	6	57,903,130 (GRCm39)	missense	probably benign
R7129:Vmn1r23	UTSW	6	57,903,061 (GRCm39)	missense	possibly damaging	0.89
R7731:Vmn1r23	UTSW	6	57,903,319 (GRCm39)	missense	probably benign	0.03
R7877:Vmn1r23	UTSW	6	57,903,541 (GRCm39)	missense	probably benign
R8751:Vmn1r23	UTSW	6	57,903,452 (GRCm39)	missense	probably benign	0.27
R8809:Vmn1r23	UTSW	6	57,903,352 (GRCm39)	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- TGAGGTCTACCCAGTACATGACCAC -3'
(R):5'- TGAGAGGACTCTCTATGGGCATCAC -3'

Sequencing Primer
(F):5'- GCCTGATGCTATGAAGATGC -3'
(R):5'- ATGGGCATCACATGCCTC -3'

Posted On

2013-07-11