Incidental Mutation 'R7190:Or6c5c'
ID 559557
Institutional Source Beutler Lab
Gene Symbol Or6c5c
Ensembl Gene ENSMUSG00000096497
Gene Name olfactory receptor family 6 subfamily C member 5C
Synonyms MOR111-10, GA_x6K02T2PULF-11141498-11142436, Olfr787
MMRRC Submission 045273-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R7190 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129297809-129299485 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 129298626 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 27 (I27T)
Ref Sequence ENSEMBL: ENSMUSP00000149391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077836] [ENSMUST00000213329]
AlphaFold Q7TRI1
Predicted Effect probably benign
Transcript: ENSMUST00000077836
AA Change: I27T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000077005
Gene: ENSMUSG00000096497
AA Change: I27T

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 4e-49 PFAM
Pfam:7tm_1 39 288 2.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213329
AA Change: I27T

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (50/50)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actmap G A 7: 26,900,548 (GRCm39) A176T probably damaging Het
Add3 C T 19: 53,205,330 (GRCm39) R27* probably null Het
Armc3 T A 2: 19,297,947 (GRCm39) Y573N probably damaging Het
Bod1l A C 5: 41,977,281 (GRCm39) N1344K probably benign Het
Camta1 T G 4: 151,232,980 (GRCm39) N231T possibly damaging Het
Capza2 T A 6: 17,654,120 (GRCm39) Y57* probably null Het
Ccdc168 A C 1: 44,100,775 (GRCm39) S108A probably benign Het
Ccdc186 T A 19: 56,780,432 (GRCm39) I871F probably damaging Het
Cntnap5b A G 1: 100,359,574 (GRCm39) probably null Het
Dnah2 G T 11: 69,439,923 (GRCm39) probably null Het
Fhod3 T C 18: 25,223,812 (GRCm39) F1053L probably damaging Het
Foxj1 A G 11: 116,223,201 (GRCm39) Y201H possibly damaging Het
Gatad2b T A 3: 90,257,722 (GRCm39) I210N probably benign Het
Gba1 T A 3: 89,111,669 (GRCm39) I112N probably damaging Het
Gbp2 T C 3: 142,339,208 (GRCm39) V420A probably benign Het
Golga3 T A 5: 110,357,721 (GRCm39) H1072Q probably damaging Het
Gpr150 C T 13: 76,203,992 (GRCm39) A318T probably benign Het
Gpr6 T C 10: 40,946,956 (GRCm39) N209D probably damaging Het
Grin2b T C 6: 135,709,946 (GRCm39) N1200S possibly damaging Het
Ifi207 G A 1: 173,557,818 (GRCm39) H307Y unknown Het
Il20ra A T 10: 19,618,689 (GRCm39) I46F probably damaging Het
Lvrn A G 18: 47,033,570 (GRCm39) D927G probably benign Het
Nlrc4 G T 17: 74,752,198 (GRCm39) D728E probably damaging Het
Nup107 T C 10: 117,598,040 (GRCm39) D630G probably benign Het
Or1e19 A T 11: 73,315,990 (GRCm39) I273N probably benign Het
Pclo C A 5: 14,729,743 (GRCm39) A2867D unknown Het
Perm1 A G 4: 156,304,272 (GRCm39) T754A possibly damaging Het
Plpbp G T 8: 27,541,325 (GRCm39) V162L probably benign Het
Plscr4 A T 9: 92,370,694 (GRCm39) E220D probably benign Het
Ppp2r3d A T 9: 101,089,726 (GRCm39) M199K probably benign Het
Pramel38 T G 5: 94,366,096 (GRCm39) N71K probably benign Het
Rassf6 T C 5: 90,754,666 (GRCm39) E204G probably damaging Het
Reln A C 5: 22,252,945 (GRCm39) D667E probably damaging Het
Rere A G 4: 150,695,410 (GRCm39) I462V unknown Het
Rpain A G 11: 70,862,735 (GRCm39) E76G possibly damaging Het
Strc T G 2: 121,199,507 (GRCm39) I1311L probably benign Het
Svil A G 18: 5,092,937 (GRCm39) M1385V probably benign Het
Syne2 T A 12: 76,113,361 (GRCm39) D1083E probably benign Het
Szt2 T A 4: 118,246,203 (GRCm39) H986L probably damaging Het
Tcl1b2 G T 12: 105,113,493 (GRCm39) probably null Het
Thy1 T A 9: 43,958,222 (GRCm39) S117T possibly damaging Het
Tmem183a A T 1: 134,282,496 (GRCm39) I203N probably damaging Het
Tmprss11g T C 5: 86,644,491 (GRCm39) I118V probably benign Het
Tsen34 T C 7: 3,697,806 (GRCm39) V69A possibly damaging Het
Ttn T C 2: 76,717,143 (GRCm39) Q7506R unknown Het
Vmn1r184 T C 7: 25,967,105 (GRCm39) S284P probably damaging Het
Wdr19 A G 5: 65,398,205 (GRCm39) D810G probably benign Het
Zer1 T C 2: 29,993,444 (GRCm39) D554G probably damaging Het
Zfp626 A T 7: 27,517,768 (GRCm39) T250S probably benign Het
Other mutations in Or6c5c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0384:Or6c5c UTSW 10 129,298,909 (GRCm39) nonsense probably null
R1851:Or6c5c UTSW 10 129,299,370 (GRCm39) missense probably damaging 1.00
R2211:Or6c5c UTSW 10 129,298,809 (GRCm39) missense probably damaging 1.00
R3613:Or6c5c UTSW 10 129,298,937 (GRCm39) missense probably benign 0.29
R3701:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R3702:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R4496:Or6c5c UTSW 10 129,299,430 (GRCm39) missense possibly damaging 0.93
R5745:Or6c5c UTSW 10 129,299,307 (GRCm39) missense probably damaging 1.00
R6791:Or6c5c UTSW 10 129,299,023 (GRCm39) missense probably benign 0.00
R7278:Or6c5c UTSW 10 129,298,620 (GRCm39) missense probably damaging 1.00
R7313:Or6c5c UTSW 10 129,298,856 (GRCm39) missense probably damaging 0.98
R7369:Or6c5c UTSW 10 129,299,390 (GRCm39) missense probably benign
R7824:Or6c5c UTSW 10 129,298,665 (GRCm39) missense probably damaging 1.00
R7851:Or6c5c UTSW 10 129,299,429 (GRCm39) missense probably benign 0.36
R8961:Or6c5c UTSW 10 129,299,225 (GRCm39) missense probably damaging 1.00
R9635:Or6c5c UTSW 10 129,299,463 (GRCm39) missense probably benign 0.00
R9775:Or6c5c UTSW 10 129,298,677 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GATGGTATCATCAGACATACCAATC -3'
(R):5'- ACTGAGCCAAACAGTTGTTATAGG -3'

Sequencing Primer
(F):5'- TCTGACATCTAAAGGCTTATTTTGG -3'
(R):5'- GCCAAACAGTTGTTATAGGAAATTG -3'
Posted On 2019-06-26