Incidental Mutation 'R0591:Vmn1r184'
ID 55976
Institutional Source Beutler Lab
Gene Symbol Vmn1r184
Ensembl Gene ENSMUSG00000046130
Gene Name vomeronasal 1 receptor, 184
Synonyms
MMRRC Submission 038781-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R0591 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 25966256-25967200 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 25966500 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 82 (D82V)
Ref Sequence ENSEMBL: ENSMUSP00000154576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057123] [ENSMUST00000227230] [ENSMUST00000227232] [ENSMUST00000227534] [ENSMUST00000227790] [ENSMUST00000228145] [ENSMUST00000228369]
AlphaFold E9Q2N4
Predicted Effect probably damaging
Transcript: ENSMUST00000057123
AA Change: D82V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000061885
Gene: ENSMUSG00000046130
AA Change: D82V

DomainStartEndE-ValueType
Pfam:TAS2R 8 308 1.7e-7 PFAM
Pfam:V1R 35 297 7.5e-31 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000227230
AA Change: D82V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000227232
AA Change: D82V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000227534
AA Change: D82V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000227790
AA Change: D82V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000228145
AA Change: D82V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Predicted Effect probably damaging
Transcript: ENSMUST00000228369
AA Change: D82V

PolyPhen 2 Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.7%
  • 3x: 99.2%
  • 10x: 97.7%
  • 20x: 95.3%
Validation Efficiency 100% (62/62)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik G T 3: 137,774,704 (GRCm39) E1298* probably null Het
Aadacl2fm2 C A 3: 59,659,550 (GRCm39) Y334* probably null Het
Adam19 T C 11: 46,012,238 (GRCm39) probably benign Het
Agt A T 8: 125,283,678 (GRCm39) S480R possibly damaging Het
Anapc1 G T 2: 128,461,252 (GRCm39) D1769E probably benign Het
Aox4 T C 1: 58,278,261 (GRCm39) probably benign Het
Apol9b G A 15: 77,619,830 (GRCm39) V209I possibly damaging Het
Appl2 A T 10: 83,460,509 (GRCm39) I116K possibly damaging Het
BC051665 A G 13: 60,932,422 (GRCm39) probably benign Het
Cactin G T 10: 81,159,837 (GRCm39) E89* probably null Het
Carf G T 1: 60,165,073 (GRCm39) probably benign Het
Ccdc167 A G 17: 29,924,235 (GRCm39) probably benign Het
Ceacam3 G A 7: 16,885,808 (GRCm39) probably null Het
Clca4b T A 3: 144,621,353 (GRCm39) K574* probably null Het
Crabp1 T A 9: 54,672,887 (GRCm39) I64N probably damaging Het
Dgkd T A 1: 87,842,826 (GRCm39) I118N probably damaging Het
Dglucy T C 12: 100,825,777 (GRCm39) probably benign Het
Dock10 C T 1: 80,518,936 (GRCm39) probably benign Het
Ednrb A T 14: 104,060,710 (GRCm39) probably null Het
Ercc6 T C 14: 32,279,973 (GRCm39) probably benign Het
Golga3 A C 5: 110,336,609 (GRCm39) Q416P probably damaging Het
Gpr12 A G 5: 146,520,445 (GRCm39) V159A probably benign Het
Heatr5a A T 12: 51,956,884 (GRCm39) probably benign Het
Helz2 A G 2: 180,873,909 (GRCm39) I2195T probably damaging Het
Hikeshi A T 7: 89,569,295 (GRCm39) N76K possibly damaging Het
Hsd11b1 T C 1: 192,911,984 (GRCm39) probably benign Het
Iftap A T 2: 101,406,462 (GRCm39) D155E probably benign Het
Inhba A T 13: 16,201,405 (GRCm39) K322N probably damaging Het
Katnal1 A T 5: 148,829,326 (GRCm39) F291L probably damaging Het
Kcnj9 T C 1: 172,150,665 (GRCm39) E316G probably damaging Het
Lrsam1 A G 2: 32,823,935 (GRCm39) probably benign Het
Mcf2l T G 8: 13,068,751 (GRCm39) S1075A probably benign Het
Mios T C 6: 8,215,470 (GRCm39) V222A possibly damaging Het
Mycbp2 A T 14: 103,433,827 (GRCm39) probably benign Het
Nars1 A T 18: 64,633,638 (GRCm39) I544N probably damaging Het
Or5ak23 A G 2: 85,245,034 (GRCm39) L63P possibly damaging Het
Pbrm1 A G 14: 30,768,387 (GRCm39) probably benign Het
Plcb4 A G 2: 135,796,932 (GRCm39) probably benign Het
Pnliprp1 A G 19: 58,723,138 (GRCm39) D213G probably damaging Het
Psap A G 10: 60,136,634 (GRCm39) N538D possibly damaging Het
Ptdss1 A G 13: 67,120,714 (GRCm39) probably benign Het
Rap1b G A 10: 117,654,522 (GRCm39) probably benign Het
Rhcg T A 7: 79,244,520 (GRCm39) probably benign Het
Ryr1 G A 7: 28,804,220 (GRCm39) T550I possibly damaging Het
Samm50 G A 15: 84,095,369 (GRCm39) G452R probably benign Het
Scin A G 12: 40,130,929 (GRCm39) probably null Het
Sesn3 T C 9: 14,219,854 (GRCm39) L81S probably damaging Het
Skint6 A C 4: 112,715,366 (GRCm39) probably benign Het
Slc30a4 A T 2: 122,527,160 (GRCm39) L411H probably damaging Het
Slc44a5 C T 3: 153,939,782 (GRCm39) probably benign Het
Slc4a3 C T 1: 75,525,665 (GRCm39) A255V probably damaging Het
Slc9b1 A G 3: 135,088,593 (GRCm39) N318S possibly damaging Het
Tcp11l2 A T 10: 84,440,458 (GRCm39) H287L probably benign Het
Tex10 C T 4: 48,456,800 (GRCm39) R637Q probably benign Het
Tnks2 T A 19: 36,849,962 (GRCm39) Y605N probably damaging Het
Topbp1 T A 9: 103,227,037 (GRCm39) N1490K probably benign Het
Ube4b T G 4: 149,442,034 (GRCm39) probably benign Het
Usp4 G A 9: 108,225,228 (GRCm39) probably benign Het
Vezf1 A T 11: 88,068,435 (GRCm38) probably benign Het
Other mutations in Vmn1r184
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01396:Vmn1r184 APN 7 25,966,862 (GRCm39) missense probably damaging 1.00
IGL01411:Vmn1r184 APN 7 25,966,320 (GRCm39) missense probably benign 0.06
IGL02961:Vmn1r184 APN 7 25,967,075 (GRCm39) missense probably benign 0.27
IGL03271:Vmn1r184 APN 7 25,967,034 (GRCm39) missense probably benign
R0302:Vmn1r184 UTSW 7 25,966,968 (GRCm39) missense probably damaging 1.00
R0384:Vmn1r184 UTSW 7 25,967,076 (GRCm39) missense probably benign 0.41
R0620:Vmn1r184 UTSW 7 25,966,602 (GRCm39) missense possibly damaging 0.46
R1644:Vmn1r184 UTSW 7 25,966,670 (GRCm39) missense probably benign 0.00
R2304:Vmn1r184 UTSW 7 25,966,550 (GRCm39) missense probably damaging 1.00
R2329:Vmn1r184 UTSW 7 25,966,387 (GRCm39) missense probably damaging 1.00
R3522:Vmn1r184 UTSW 7 25,967,008 (GRCm39) nonsense probably null
R5020:Vmn1r184 UTSW 7 25,966,955 (GRCm39) missense possibly damaging 0.87
R5030:Vmn1r184 UTSW 7 25,966,881 (GRCm39) missense probably benign 0.25
R5049:Vmn1r184 UTSW 7 25,966,793 (GRCm39) missense possibly damaging 0.49
R5076:Vmn1r184 UTSW 7 25,966,346 (GRCm39) missense probably benign 0.00
R5213:Vmn1r184 UTSW 7 25,967,136 (GRCm39) missense probably damaging 0.99
R5554:Vmn1r184 UTSW 7 25,966,413 (GRCm39) missense probably damaging 1.00
R6146:Vmn1r184 UTSW 7 25,966,817 (GRCm39) missense probably benign 0.08
R6868:Vmn1r184 UTSW 7 25,966,727 (GRCm39) missense probably benign 0.00
R6937:Vmn1r184 UTSW 7 25,966,750 (GRCm39) missense probably benign 0.08
R6943:Vmn1r184 UTSW 7 25,966,563 (GRCm39) missense possibly damaging 0.77
R7190:Vmn1r184 UTSW 7 25,967,105 (GRCm39) missense probably damaging 1.00
R7239:Vmn1r184 UTSW 7 25,966,602 (GRCm39) missense possibly damaging 0.79
R7472:Vmn1r184 UTSW 7 25,966,824 (GRCm39) missense possibly damaging 0.82
R8258:Vmn1r184 UTSW 7 25,966,686 (GRCm39) missense probably benign 0.44
R8259:Vmn1r184 UTSW 7 25,966,686 (GRCm39) missense probably benign 0.44
R8911:Vmn1r184 UTSW 7 25,966,310 (GRCm39) missense possibly damaging 0.89
R9008:Vmn1r184 UTSW 7 25,967,177 (GRCm39) missense probably benign
R9159:Vmn1r184 UTSW 7 25,966,545 (GRCm39) missense possibly damaging 0.65
R9216:Vmn1r184 UTSW 7 25,966,703 (GRCm39) missense probably benign 0.00
R9548:Vmn1r184 UTSW 7 25,966,734 (GRCm39) missense probably benign 0.29
R9588:Vmn1r184 UTSW 7 25,966,347 (GRCm39) missense probably null 0.78
Z1177:Vmn1r184 UTSW 7 25,966,415 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- GGCATCTTCTTTCACACCCAGCTATAA -3'
(R):5'- CAGGGAACATTACGAATGCTGCATAGA -3'

Sequencing Primer
(F):5'- AGCACAGAATAGCCTTCTGG -3'
(R):5'- TGTGCAAGATCCACATGAGG -3'
Posted On 2013-07-11