Incidental Mutation 'R7196:Naip6'
ID 559963
Institutional Source Beutler Lab
Gene Symbol Naip6
Ensembl Gene ENSMUSG00000078942
Gene Name NLR family, apoptosis inhibitory protein 6
Synonyms Naip-rs4, Birc1f, Naip-rs4A
MMRRC Submission 045275-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.142) question?
Stock # R7196 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 100417629-100453124 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 100436666 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 619 (I619K)
Ref Sequence ENSEMBL: ENSMUSP00000041766 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042220] [ENSMUST00000118574]
AlphaFold Q9JIB6
Predicted Effect probably benign
Transcript: ENSMUST00000042220
AA Change: I619K

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000041766
Gene: ENSMUSG00000078942
AA Change: I619K

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 7.6e-37 PFAM
low complexity region 851 862 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000118574
AA Change: I619K

PolyPhen 2 Score 0.101 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000112867
Gene: ENSMUSG00000078942
AA Change: I619K

DomainStartEndE-ValueType
BIR 58 129 6.21e-20 SMART
BIR 157 229 8.04e-37 SMART
BIR 276 347 5.19e-31 SMART
Pfam:NACHT 464 618 2.5e-35 PFAM
low complexity region 851 862 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 99% (94/95)
MGI Phenotype FUNCTION: Closest sequence match is AF381772. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik AGCTTCCCTGCTT AGCTT 9: 57,165,505 (GRCm39) probably null Het
4921504E06Rik A C 2: 19,498,806 (GRCm39) S396A probably benign Het
Actr6 C A 10: 89,550,784 (GRCm39) V337F possibly damaging Het
Agtpbp1 T C 13: 59,680,994 (GRCm39) T73A possibly damaging Het
AI182371 A T 2: 34,976,441 (GRCm39) probably null Het
Apob A G 12: 8,033,893 (GRCm39) E202G possibly damaging Het
Asb4 A T 6: 5,423,356 (GRCm39) M168L probably benign Het
AU018091 T C 7: 3,213,788 (GRCm39) Y152C probably damaging Het
Casp3 G A 8: 47,088,498 (GRCm39) G132R possibly damaging Het
Cbfa2t3 C A 8: 123,365,729 (GRCm39) A229S probably benign Het
Cdh23 A T 10: 60,143,759 (GRCm39) Y2949N probably damaging Het
Ceacam3 T C 7: 16,888,881 (GRCm39) Y217H Het
Cldn5 A T 16: 18,595,630 (GRCm39) probably benign Het
Cltc T C 11: 86,597,657 (GRCm39) D1093G probably damaging Het
Cnn3 G A 3: 121,248,437 (GRCm39) probably null Het
Col4a2 A G 8: 11,448,693 (GRCm39) Y71C probably damaging Het
Csf1 T C 3: 107,661,214 (GRCm39) D77G possibly damaging Het
Cyp2j7 T A 4: 96,103,651 (GRCm39) T295S probably benign Het
Dnah7a A T 1: 53,724,000 (GRCm39) M133K probably benign Het
Dock5 G A 14: 67,993,919 (GRCm39) P1852L probably damaging Het
Dpysl3 T A 18: 43,462,910 (GRCm39) D489V probably damaging Het
Dsg4 T C 18: 20,599,537 (GRCm39) Y718H probably damaging Het
Dync2h1 G A 9: 7,147,715 (GRCm39) Q972* probably null Het
Epn1 G A 7: 5,096,380 (GRCm39) D225N possibly damaging Het
Esp4 A G 17: 40,913,256 (GRCm39) E41G probably benign Het
Fam171a2 T C 11: 102,329,172 (GRCm39) D529G probably benign Het
Fbxl13 A T 5: 21,691,301 (GRCm39) I694N probably damaging Het
Fshr C T 17: 89,292,897 (GRCm39) A594T probably damaging Het
Galnt3 A G 2: 65,921,268 (GRCm39) Y533H probably damaging Het
Gja5 C A 3: 96,958,422 (GRCm39) R160S probably damaging Het
Gm12353 A T 4: 19,608,938 (GRCm39) D7V unknown Het
Gm17669 T C 18: 67,695,572 (GRCm39) F39S probably damaging Het
Gm7145 T A 1: 117,913,791 (GRCm39) N224K possibly damaging Het
Gpd1 G T 15: 99,619,936 (GRCm39) G245C probably benign Het
Gpr4 G A 7: 18,957,089 (GRCm39) G337D probably benign Het
Hgd G A 16: 37,409,078 (GRCm39) C14Y probably benign Het
Ibtk A T 9: 85,625,709 (GRCm39) S14T probably damaging Het
Ifi205 G T 1: 173,854,109 (GRCm39) N181K probably damaging Het
Inppl1 G A 7: 101,477,993 (GRCm39) A673V probably benign Het
Itgb3 C A 11: 104,524,438 (GRCm39) Y191* probably null Het
Jrkl G T 9: 13,244,162 (GRCm39) P500T probably benign Het
Kcnq1 G A 7: 142,912,478 (GRCm39) V515I possibly damaging Het
Kifc3 A G 8: 95,833,239 (GRCm39) V453A probably benign Het
Krt10 C T 11: 99,278,371 (GRCm39) E263K probably damaging Het
Lingo1 A T 9: 56,527,903 (GRCm39) F235I probably damaging Het
Lmo7 T A 14: 102,133,936 (GRCm39) D660E possibly damaging Het
Magi3 A C 3: 103,956,484 (GRCm39) C661W probably benign Het
Mmp1a C T 9: 7,476,018 (GRCm39) Q428* probably null Het
Msrb1 A T 17: 24,958,556 (GRCm39) T47S probably benign Het
Ndfip2 T C 14: 105,535,472 (GRCm39) S253P probably damaging Het
Nebl A T 2: 17,457,329 (GRCm39) V77E probably damaging Het
Nit1 T C 1: 171,172,003 (GRCm39) E65G probably benign Het
Ntn4 C T 10: 93,569,576 (GRCm39) H430Y probably benign Het
Nxpe5 A T 5: 138,237,586 (GRCm39) I49F probably benign Het
Or10a2 A G 7: 106,673,935 (GRCm39) N300S probably benign Het
Or10c1 A G 17: 37,522,084 (GRCm39) I220T probably damaging Het
Or14c46 A T 7: 85,918,649 (GRCm39) M116K probably damaging Het
Or1e23 A G 11: 73,407,957 (GRCm39) Y23H probably benign Het
Or1m1 A T 9: 18,666,886 (GRCm39) L15* probably null Het
Or4k49 T G 2: 111,495,042 (GRCm39) L157W probably damaging Het
Or52s6 A T 7: 103,092,204 (GRCm39) M42K probably benign Het
Or7e178 A G 9: 20,225,494 (GRCm39) Y241H probably benign Het
Oxct2a T A 4: 123,217,165 (GRCm39) N72I probably damaging Het
Pappa G A 4: 65,242,128 (GRCm39) probably null Het
Pcnx1 G A 12: 82,042,312 (GRCm39) R34H possibly damaging Het
Plekha5 G T 6: 140,489,648 (GRCm39) V236L possibly damaging Het
Prdm1 A G 10: 44,332,988 (GRCm39) S44P probably benign Het
Prss46 T A 9: 110,680,533 (GRCm39) L226Q probably benign Het
Prss47 C A 13: 65,192,640 (GRCm39) W380C probably benign Het
Ptch2 T G 4: 116,971,946 (GRCm39) V1156G probably benign Het
Rab3gap2 T C 1: 185,013,864 (GRCm39) F1190S probably damaging Het
Raver2 T G 4: 100,960,056 (GRCm39) Y179D probably damaging Het
Rgl2 C T 17: 34,152,403 (GRCm39) R367W probably damaging Het
Ripor2 T G 13: 24,888,808 (GRCm39) I629S possibly damaging Het
Robo4 T A 9: 37,314,001 (GRCm39) M84K possibly damaging Het
Rps6ka5 A T 12: 100,562,123 (GRCm39) S252T possibly damaging Het
Rtl1 C T 12: 109,559,221 (GRCm39) V873M possibly damaging Het
Sla T A 15: 66,703,420 (GRCm39) R4W probably benign Het
Smco1 A G 16: 32,092,620 (GRCm39) D97G probably damaging Het
Srgap1 T C 10: 121,676,753 (GRCm39) T414A probably benign Het
Syt14 A G 1: 192,717,936 (GRCm39) I3T probably benign Het
Tnpo2 G A 8: 85,773,766 (GRCm39) V303M possibly damaging Het
Tstd2 A C 4: 46,119,955 (GRCm39) S332R probably damaging Het
Ttn C A 2: 76,582,386 (GRCm39) A22836S possibly damaging Het
Ufl1 A G 4: 25,250,669 (GRCm39) V728A probably benign Het
Usp33 A T 3: 152,089,828 (GRCm39) K789N possibly damaging Het
Usp54 T A 14: 20,638,438 (GRCm39) Q214L probably damaging Het
Vmn2r7 T G 3: 64,623,198 (GRCm39) N374T probably benign Het
Zbtb7a T A 10: 80,980,434 (GRCm39) N209K probably damaging Het
Zc3hav1 A G 6: 38,306,207 (GRCm39) V615A probably benign Het
Zdhhc20 A G 14: 58,111,348 (GRCm39) probably null Het
Zfp90 G T 8: 107,151,780 (GRCm39) V498L probably damaging Het
Other mutations in Naip6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00677:Naip6 APN 13 100,452,525 (GRCm39) missense probably benign 0.03
IGL01123:Naip6 APN 13 100,440,946 (GRCm39) missense probably benign 0.02
IGL01151:Naip6 APN 13 100,435,601 (GRCm39) missense probably benign 0.00
IGL01382:Naip6 APN 13 100,436,364 (GRCm39) missense possibly damaging 0.95
IGL01415:Naip6 APN 13 100,439,798 (GRCm39) missense probably benign 0.17
IGL01654:Naip6 APN 13 100,435,853 (GRCm39) missense probably benign 0.00
IGL01662:Naip6 APN 13 100,436,862 (GRCm39) missense probably damaging 1.00
IGL01726:Naip6 APN 13 100,439,760 (GRCm39) missense probably benign 0.02
IGL01810:Naip6 APN 13 100,424,603 (GRCm39) splice site probably benign
IGL01867:Naip6 APN 13 100,436,820 (GRCm39) missense probably benign 0.40
IGL01926:Naip6 APN 13 100,436,704 (GRCm39) missense probably damaging 1.00
IGL01964:Naip6 APN 13 100,435,238 (GRCm39) splice site probably benign
IGL02145:Naip6 APN 13 100,433,486 (GRCm39) missense possibly damaging 0.77
IGL02160:Naip6 APN 13 100,435,933 (GRCm39) missense probably benign 0.01
IGL02214:Naip6 APN 13 100,452,567 (GRCm39) missense probably damaging 1.00
IGL02342:Naip6 APN 13 100,439,748 (GRCm39) missense possibly damaging 0.69
IGL02568:Naip6 APN 13 100,452,780 (GRCm39) missense probably damaging 1.00
IGL02573:Naip6 APN 13 100,435,979 (GRCm39) nonsense probably null
IGL02680:Naip6 APN 13 100,420,256 (GRCm39) missense probably benign
IGL02829:Naip6 APN 13 100,437,273 (GRCm39) missense probably benign 0.11
IGL02833:Naip6 APN 13 100,436,121 (GRCm39) missense probably damaging 1.00
IGL02851:Naip6 APN 13 100,437,168 (GRCm39) missense probably benign 0.01
IGL02860:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL02886:Naip6 APN 13 100,436,984 (GRCm39) missense possibly damaging 0.95
IGL03155:Naip6 APN 13 100,452,932 (GRCm39) missense possibly damaging 0.62
R0032:Naip6 UTSW 13 100,439,745 (GRCm39) missense probably benign 0.00
R0310:Naip6 UTSW 13 100,444,721 (GRCm39) missense possibly damaging 0.72
R0437:Naip6 UTSW 13 100,433,432 (GRCm39) missense possibly damaging 0.75
R0472:Naip6 UTSW 13 100,438,768 (GRCm39) missense probably benign 0.02
R0560:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R0638:Naip6 UTSW 13 100,437,036 (GRCm39) missense probably benign 0.00
R0792:Naip6 UTSW 13 100,420,274 (GRCm39) missense possibly damaging 0.78
R0963:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign 0.11
R1102:Naip6 UTSW 13 100,440,923 (GRCm39) missense possibly damaging 0.62
R1278:Naip6 UTSW 13 100,436,870 (GRCm39) missense probably damaging 1.00
R1462:Naip6 UTSW 13 100,436,748 (GRCm39) missense possibly damaging 0.64
R1462:Naip6 UTSW 13 100,436,748 (GRCm39) missense possibly damaging 0.64
R1544:Naip6 UTSW 13 100,452,983 (GRCm39) missense probably benign
R1595:Naip6 UTSW 13 100,435,602 (GRCm39) missense probably damaging 0.96
R1749:Naip6 UTSW 13 100,444,763 (GRCm39) missense probably benign 0.03
R1838:Naip6 UTSW 13 100,452,644 (GRCm39) missense probably damaging 0.99
R1863:Naip6 UTSW 13 100,437,067 (GRCm39) missense probably benign 0.03
R1914:Naip6 UTSW 13 100,435,936 (GRCm39) missense probably benign 0.13
R2001:Naip6 UTSW 13 100,437,237 (GRCm39) missense probably benign 0.44
R2082:Naip6 UTSW 13 100,440,852 (GRCm39) splice site probably null
R2143:Naip6 UTSW 13 100,436,367 (GRCm39) missense probably damaging 1.00
R2174:Naip6 UTSW 13 100,435,495 (GRCm39) missense probably benign
R2266:Naip6 UTSW 13 100,420,067 (GRCm39) missense possibly damaging 0.46
R2284:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2285:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2286:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2351:Naip6 UTSW 13 100,420,169 (GRCm39) missense probably damaging 1.00
R2363:Naip6 UTSW 13 100,452,928 (GRCm39) missense possibly damaging 0.90
R2445:Naip6 UTSW 13 100,437,176 (GRCm39) missense probably damaging 0.99
R2971:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R2975:Naip6 UTSW 13 100,424,695 (GRCm39) missense probably damaging 1.00
R3081:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R3082:Naip6 UTSW 13 100,452,925 (GRCm39) missense probably benign 0.00
R3122:Naip6 UTSW 13 100,453,031 (GRCm39) missense probably benign 0.00
R3417:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R3943:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R3944:Naip6 UTSW 13 100,431,247 (GRCm39) missense probably benign 0.01
R4080:Naip6 UTSW 13 100,435,815 (GRCm39) missense probably damaging 1.00
R4166:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R4396:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4397:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4418:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4512:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R4670:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4671:Naip6 UTSW 13 100,431,239 (GRCm39) critical splice donor site probably null
R4722:Naip6 UTSW 13 100,443,580 (GRCm39) missense possibly damaging 0.72
R4811:Naip6 UTSW 13 100,422,299 (GRCm39) missense probably damaging 1.00
R4900:Naip6 UTSW 13 100,433,477 (GRCm39) missense probably damaging 0.99
R5162:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R5316:Naip6 UTSW 13 100,420,290 (GRCm39) missense probably benign 0.00
R5403:Naip6 UTSW 13 100,436,585 (GRCm39) missense probably benign 0.12
R5437:Naip6 UTSW 13 100,439,812 (GRCm39) nonsense probably null
R5507:Naip6 UTSW 13 100,435,423 (GRCm39) missense probably benign 0.01
R5631:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R5657:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R5684:Naip6 UTSW 13 100,436,888 (GRCm39) missense probably damaging 1.00
R5786:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5787:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5788:Naip6 UTSW 13 100,436,724 (GRCm39) missense probably benign
R5878:Naip6 UTSW 13 100,436,181 (GRCm39) missense probably damaging 1.00
R5895:Naip6 UTSW 13 100,452,500 (GRCm39) missense possibly damaging 0.90
R5898:Naip6 UTSW 13 100,435,829 (GRCm39) missense possibly damaging 0.93
R6113:Naip6 UTSW 13 100,435,794 (GRCm39) missense possibly damaging 0.96
R6141:Naip6 UTSW 13 100,444,741 (GRCm39) missense possibly damaging 0.91
R6199:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R6321:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6402:Naip6 UTSW 13 100,437,226 (GRCm39) missense probably benign 0.30
R6435:Naip6 UTSW 13 100,431,249 (GRCm39) missense probably benign 0.04
R6477:Naip6 UTSW 13 100,452,516 (GRCm39) missense probably damaging 1.00
R6601:Naip6 UTSW 13 100,420,266 (GRCm39) missense probably benign
R6638:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6639:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R6804:Naip6 UTSW 13 100,435,675 (GRCm39) missense probably benign
R6922:Naip6 UTSW 13 100,438,706 (GRCm39) missense possibly damaging 0.88
R6975:Naip6 UTSW 13 100,452,773 (GRCm39) missense probably damaging 1.00
R7050:Naip6 UTSW 13 100,452,007 (GRCm39) missense probably damaging 1.00
R7135:Naip6 UTSW 13 100,436,927 (GRCm39) missense probably damaging 1.00
R7140:Naip6 UTSW 13 100,436,708 (GRCm39) missense possibly damaging 0.95
R7182:Naip6 UTSW 13 100,452,657 (GRCm39) missense probably benign 0.23
R7234:Naip6 UTSW 13 100,452,011 (GRCm39) nonsense probably null
R7259:Naip6 UTSW 13 100,440,863 (GRCm39) missense probably damaging 1.00
R7322:Naip6 UTSW 13 100,435,896 (GRCm39) missense possibly damaging 0.94
R7332:Naip6 UTSW 13 100,437,209 (GRCm39) missense possibly damaging 0.62
R7339:Naip6 UTSW 13 100,452,527 (GRCm39) missense probably damaging 1.00
R7353:Naip6 UTSW 13 100,436,259 (GRCm39) missense probably benign 0.00
R7485:Naip6 UTSW 13 100,420,359 (GRCm39) missense probably benign 0.07
R7597:Naip6 UTSW 13 100,437,108 (GRCm39) missense probably benign 0.08
R7835:Naip6 UTSW 13 100,452,512 (GRCm39) missense probably benign 0.19
R7840:Naip6 UTSW 13 100,451,979 (GRCm39) missense probably damaging 1.00
R8082:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
R8082:Naip6 UTSW 13 100,436,909 (GRCm39) missense probably benign
R8103:Naip6 UTSW 13 100,437,851 (GRCm39) missense probably benign 0.00
R8164:Naip6 UTSW 13 100,452,797 (GRCm39) missense probably benign 0.00
R8206:Naip6 UTSW 13 100,431,344 (GRCm39) nonsense probably null
R8258:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8259:Naip6 UTSW 13 100,452,920 (GRCm39) missense probably benign 0.02
R8348:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8405:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8406:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8441:Naip6 UTSW 13 100,422,265 (GRCm39) missense possibly damaging 0.77
R8448:Naip6 UTSW 13 100,436,894 (GRCm39) missense possibly damaging 0.61
R8465:Naip6 UTSW 13 100,433,423 (GRCm39) missense possibly damaging 0.95
R8501:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8502:Naip6 UTSW 13 100,436,784 (GRCm39) missense possibly damaging 0.89
R8687:Naip6 UTSW 13 100,435,636 (GRCm39) missense probably benign 0.10
R8806:Naip6 UTSW 13 100,437,161 (GRCm39) missense possibly damaging 0.93
R9186:Naip6 UTSW 13 100,436,390 (GRCm39) missense possibly damaging 0.89
R9340:Naip6 UTSW 13 100,452,494 (GRCm39) missense probably damaging 1.00
R9352:Naip6 UTSW 13 100,437,893 (GRCm39) missense possibly damaging 0.85
R9585:Naip6 UTSW 13 100,436,577 (GRCm39) missense probably damaging 0.96
R9597:Naip6 UTSW 13 100,436,646 (GRCm39) missense probably benign 0.02
R9601:Naip6 UTSW 13 100,436,961 (GRCm39) missense probably benign
X0066:Naip6 UTSW 13 100,451,970 (GRCm39) nonsense probably null
Z1177:Naip6 UTSW 13 100,437,308 (GRCm39) missense probably damaging 1.00
Z1177:Naip6 UTSW 13 100,435,925 (GRCm39) missense probably benign 0.20
Z1177:Naip6 UTSW 13 100,452,638 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTAAGGACAGGTATTGCATGTAGG -3'
(R):5'- GCAGTTACAACACCAGGTGC -3'

Sequencing Primer
(F):5'- TAGGAATGGAAAAGTGTCACATCTTG -3'
(R):5'- AGTTACAACACCAGGTGCTGTTC -3'
Posted On 2019-06-26