Incidental Mutation 'R7197:Adgrb2'
| ID |
560000 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Adgrb2
|
| Ensembl Gene |
ENSMUSG00000028782 |
| Gene Name |
adhesion G protein-coupled receptor B2 |
| Synonyms |
Bai2 |
| MMRRC Submission |
045276-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7197 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
129878663-129916426 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 129903315 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 613
(N613S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112524
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030571]
[ENSMUST00000097868]
[ENSMUST00000106015]
[ENSMUST00000106017]
[ENSMUST00000106018]
[ENSMUST00000120204]
[ENSMUST00000121049]
|
| AlphaFold |
Q8CGM1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030571
AA Change: N668S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000030571
Gene: ENSMUSG00000028782
AA Change: N668S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:GAIN
|
600 |
842 |
1.6e-41 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
1.7e-67 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000097868
AA Change: N668S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000095480
Gene: ENSMUSG00000028782
AA Change: N668S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
1.2e-54 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1159 |
2.6e-69 |
PFAM |
|
low complexity region
|
1324 |
1338 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106015
AA Change: N668S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101636
Gene: ENSMUSG00000028782
AA Change: N668S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.4e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1192 |
4.1e-68 |
PFAM |
|
low complexity region
|
1357 |
1371 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106017
AA Change: N668S
PolyPhen 2
Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000101638
Gene: ENSMUSG00000028782
AA Change: N668S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
1.86e-13 |
SMART |
|
TSP1
|
413 |
463 |
9.89e-9 |
SMART |
|
TSP1
|
469 |
519 |
3.09e-10 |
SMART |
|
HormR
|
521 |
587 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
597 |
859 |
6.3e-55 |
PFAM |
|
GPS
|
864 |
917 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
923 |
1180 |
4.6e-68 |
PFAM |
|
low complexity region
|
1345 |
1359 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106018
AA Change: N613S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000101639
Gene: ENSMUSG00000028782
AA Change: N613S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
1.1e-54 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
2.4e-69 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000120204
AA Change: N613S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112524
Gene: ENSMUSG00000028782
AA Change: N613S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
9.52e-11 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
8.2e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1104 |
9.6e-70 |
PFAM |
|
low complexity region
|
1269 |
1283 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000121049
AA Change: N613S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000112869
Gene: ENSMUSG00000028782
AA Change: N613S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
117 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
160 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
197 |
208 |
N/A |
INTRINSIC |
|
low complexity region
|
272 |
278 |
N/A |
INTRINSIC |
|
TSP1
|
303 |
353 |
1.86e-13 |
SMART |
|
TSP1
|
358 |
408 |
9.89e-9 |
SMART |
|
TSP1
|
414 |
464 |
3.09e-10 |
SMART |
|
HormR
|
466 |
532 |
3.27e-18 |
SMART |
|
Pfam:DUF3497
|
542 |
804 |
6.1e-55 |
PFAM |
|
GPS
|
809 |
862 |
2.57e-19 |
SMART |
|
Pfam:7tm_2
|
868 |
1137 |
3.8e-68 |
PFAM |
|
low complexity region
|
1302 |
1316 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
97% (77/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
PHENOTYPE: Mice homozygous for disruptions in this gene show a lessening of depression like behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
AGCTTCCCTGCTT |
AGCTT |
9: 57,165,505 (GRCm39) |
|
probably null |
Het |
| Aars2 |
T |
C |
17: 45,819,885 (GRCm39) |
Y221H |
probably damaging |
Het |
| Abca8b |
G |
A |
11: 109,836,648 (GRCm39) |
R1216* |
probably null |
Het |
| Acad8 |
A |
T |
9: 26,888,967 (GRCm39) |
|
probably null |
Het |
| Acer2 |
A |
G |
4: 86,805,287 (GRCm39) |
T84A |
probably null |
Het |
| Arap2 |
T |
C |
5: 62,798,729 (GRCm39) |
D1300G |
possibly damaging |
Het |
| Castor1 |
T |
C |
11: 4,168,949 (GRCm39) |
C39R |
probably damaging |
Het |
| Ccl11 |
A |
T |
11: 81,948,665 (GRCm39) |
|
probably benign |
Het |
| Cfh |
A |
T |
1: 140,016,505 (GRCm39) |
Y1151* |
probably null |
Het |
| Cobll1 |
A |
G |
2: 64,928,882 (GRCm39) |
S815P |
probably benign |
Het |
| Cryz |
T |
C |
3: 154,327,205 (GRCm39) |
S240P |
probably damaging |
Het |
| Csmd2 |
A |
G |
4: 128,404,826 (GRCm39) |
Y2404C |
|
Het |
| F13a1 |
T |
C |
13: 37,100,860 (GRCm39) |
D428G |
probably damaging |
Het |
| Fbxo42 |
A |
G |
4: 140,927,396 (GRCm39) |
S559G |
probably benign |
Het |
| Fry |
A |
G |
5: 150,393,232 (GRCm39) |
S263G |
|
Het |
| Fshr |
C |
T |
17: 89,292,897 (GRCm39) |
A594T |
probably damaging |
Het |
| Gm1527 |
A |
G |
3: 28,980,690 (GRCm39) |
M597V |
probably null |
Het |
| Gpr158 |
A |
T |
2: 21,815,412 (GRCm39) |
T602S |
probably damaging |
Het |
| Hmgxb4 |
C |
A |
8: 75,756,624 (GRCm39) |
T583K |
probably damaging |
Het |
| Igkv8-30 |
C |
T |
6: 70,094,069 (GRCm39) |
C114Y |
probably damaging |
Het |
| Igsf5 |
T |
A |
16: 96,204,546 (GRCm39) |
N366K |
probably damaging |
Het |
| Kif15 |
T |
C |
9: 122,838,991 (GRCm39) |
|
probably null |
Het |
| Klk1b26 |
T |
A |
7: 43,665,821 (GRCm39) |
|
probably null |
Het |
| Lama1 |
G |
T |
17: 68,044,700 (GRCm39) |
E200* |
probably null |
Het |
| Lpar5 |
C |
T |
6: 125,059,347 (GRCm39) |
T356I |
probably benign |
Het |
| Lrch3 |
A |
T |
16: 32,810,665 (GRCm39) |
T538S |
probably damaging |
Het |
| Mansc4 |
A |
G |
6: 146,977,203 (GRCm39) |
S138P |
probably damaging |
Het |
| Mief1 |
T |
C |
15: 80,134,061 (GRCm39) |
S373P |
possibly damaging |
Het |
| Nbas |
G |
T |
12: 13,570,751 (GRCm39) |
V2053F |
possibly damaging |
Het |
| Nek11 |
T |
C |
9: 105,121,614 (GRCm39) |
E435G |
probably damaging |
Het |
| Nynrin |
A |
T |
14: 56,109,380 (GRCm39) |
I1496F |
probably benign |
Het |
| Odf1 |
A |
T |
15: 38,219,794 (GRCm39) |
M41L |
probably benign |
Het |
| Or10a5 |
A |
G |
7: 106,635,364 (GRCm39) |
M8V |
probably benign |
Het |
| Or4c115 |
A |
G |
2: 88,927,626 (GRCm39) |
V215A |
probably benign |
Het |
| Or4c29 |
A |
T |
2: 88,740,708 (GRCm39) |
F10I |
probably benign |
Het |
| Or7h8 |
T |
G |
9: 20,123,851 (GRCm39) |
S69A |
probably benign |
Het |
| Oxnad1 |
T |
C |
14: 31,818,473 (GRCm39) |
V106A |
possibly damaging |
Het |
| Padi4 |
C |
A |
4: 140,488,969 (GRCm39) |
E157* |
probably null |
Het |
| Parp10 |
A |
T |
15: 76,126,616 (GRCm39) |
F217L |
probably damaging |
Het |
| Pcdhb18 |
T |
A |
18: 37,623,436 (GRCm39) |
S255R |
probably benign |
Het |
| Pde4c |
G |
T |
8: 71,197,978 (GRCm39) |
G102W |
probably damaging |
Het |
| Pde6a |
T |
C |
18: 61,391,295 (GRCm39) |
Y547H |
probably damaging |
Het |
| Phf11b |
A |
T |
14: 59,563,507 (GRCm39) |
L137I |
probably benign |
Het |
| Pigh |
A |
C |
12: 79,130,463 (GRCm39) |
I134S |
probably damaging |
Het |
| Pigt |
G |
A |
2: 164,344,436 (GRCm39) |
V362M |
probably damaging |
Het |
| Pld1 |
A |
G |
3: 28,078,401 (GRCm39) |
D20G |
probably damaging |
Het |
| Pou3f2 |
T |
C |
4: 22,487,288 (GRCm39) |
R282G |
probably damaging |
Het |
| Ppp2r5d |
A |
G |
17: 46,996,527 (GRCm39) |
V382A |
probably damaging |
Het |
| Prdm16 |
T |
C |
4: 154,425,967 (GRCm39) |
E606G |
probably damaging |
Het |
| Psg28 |
A |
G |
7: 18,164,509 (GRCm39) |
Y68H |
probably damaging |
Het |
| Qpctl |
C |
A |
7: 18,882,944 (GRCm39) |
W56L |
probably damaging |
Het |
| Rab11fip5 |
G |
A |
6: 85,319,137 (GRCm39) |
P584L |
probably damaging |
Het |
| Sde2 |
C |
T |
1: 180,678,843 (GRCm39) |
H36Y |
probably benign |
Het |
| Sema4d |
T |
C |
13: 51,856,872 (GRCm39) |
S787G |
probably benign |
Het |
| Sgca |
C |
T |
11: 94,864,014 (GRCm39) |
|
probably null |
Het |
| Shroom3 |
A |
G |
5: 93,090,463 (GRCm39) |
E1071G |
probably damaging |
Het |
| Skint5 |
A |
G |
4: 113,437,679 (GRCm39) |
|
probably null |
Het |
| Slc44a3 |
T |
A |
3: 121,319,411 (GRCm39) |
D110V |
probably benign |
Het |
| Slc4a4 |
A |
C |
5: 89,082,433 (GRCm39) |
|
probably benign |
Het |
| Slc4a8 |
A |
G |
15: 100,688,857 (GRCm39) |
D389G |
probably damaging |
Het |
| Sp3 |
C |
G |
2: 72,809,953 (GRCm39) |
E11Q |
probably benign |
Het |
| Srrm2 |
A |
G |
17: 24,037,198 (GRCm39) |
S1281G |
unknown |
Het |
| Tat |
A |
T |
8: 110,723,459 (GRCm39) |
I316F |
probably benign |
Het |
| Thoc5 |
A |
G |
11: 4,865,563 (GRCm39) |
T381A |
probably benign |
Het |
| Tiam1 |
T |
C |
16: 89,681,826 (GRCm39) |
Y384C |
probably damaging |
Het |
| Tmem45a |
A |
T |
16: 56,632,026 (GRCm39) |
F197L |
probably damaging |
Het |
| Trav8d-1 |
A |
G |
14: 53,016,435 (GRCm39) |
Y107C |
probably damaging |
Het |
| Trim10 |
T |
A |
17: 37,187,846 (GRCm39) |
V354D |
probably damaging |
Het |
| Unc45b |
A |
T |
11: 82,831,013 (GRCm39) |
|
probably null |
Het |
| Unc79 |
A |
G |
12: 103,078,765 (GRCm39) |
I1643M |
probably benign |
Het |
| Unc80 |
G |
T |
1: 66,560,725 (GRCm39) |
G818* |
probably null |
Het |
| Usp15 |
A |
T |
10: 122,966,910 (GRCm39) |
M470K |
possibly damaging |
Het |
| Vldlr |
T |
C |
19: 27,212,241 (GRCm39) |
V85A |
probably benign |
Het |
| Vma21-ps |
A |
G |
4: 52,496,994 (GRCm39) |
V84A |
probably benign |
Het |
| Vmn2r67 |
C |
T |
7: 84,785,774 (GRCm39) |
V744I |
possibly damaging |
Het |
| Wdr73 |
A |
G |
7: 80,542,946 (GRCm39) |
C221R |
probably benign |
Het |
| Zxdc |
C |
T |
6: 90,355,819 (GRCm39) |
H443Y |
probably damaging |
Het |
|
| Other mutations in Adgrb2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Adgrb2
|
APN |
4 |
129,912,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00425:Adgrb2
|
APN |
4 |
129,912,865 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL00490:Adgrb2
|
APN |
4 |
129,905,665 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL00928:Adgrb2
|
APN |
4 |
129,886,096 (GRCm39) |
missense |
probably benign |
|
|
IGL01353:Adgrb2
|
APN |
4 |
129,906,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01521:Adgrb2
|
APN |
4 |
129,886,085 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01590:Adgrb2
|
APN |
4 |
129,907,606 (GRCm39) |
splice site |
probably benign |
|
|
IGL01813:Adgrb2
|
APN |
4 |
129,906,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01831:Adgrb2
|
APN |
4 |
129,903,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01939:Adgrb2
|
APN |
4 |
129,885,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01960:Adgrb2
|
APN |
4 |
129,906,177 (GRCm39) |
splice site |
probably benign |
|
|
IGL01993:Adgrb2
|
APN |
4 |
129,912,635 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02646:Adgrb2
|
APN |
4 |
129,913,075 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02655:Adgrb2
|
APN |
4 |
129,885,972 (GRCm39) |
nonsense |
probably null |
|
|
IGL02695:Adgrb2
|
APN |
4 |
129,912,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02998:Adgrb2
|
APN |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL03372:Adgrb2
|
APN |
4 |
129,911,362 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0098:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0206:Adgrb2
|
UTSW |
4 |
129,886,352 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0311:Adgrb2
|
UTSW |
4 |
129,910,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0380:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0382:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0492:Adgrb2
|
UTSW |
4 |
129,901,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0544:Adgrb2
|
UTSW |
4 |
129,911,335 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0965:Adgrb2
|
UTSW |
4 |
129,886,209 (GRCm39) |
small deletion |
probably benign |
|
|
R1458:Adgrb2
|
UTSW |
4 |
129,908,384 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R1601:Adgrb2
|
UTSW |
4 |
129,886,630 (GRCm39) |
missense |
probably benign |
0.43 |
|
R1711:Adgrb2
|
UTSW |
4 |
129,886,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1758:Adgrb2
|
UTSW |
4 |
129,905,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1783:Adgrb2
|
UTSW |
4 |
129,903,098 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1827:Adgrb2
|
UTSW |
4 |
129,906,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1838:Adgrb2
|
UTSW |
4 |
129,904,024 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1881:Adgrb2
|
UTSW |
4 |
129,904,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1894:Adgrb2
|
UTSW |
4 |
129,907,419 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2275:Adgrb2
|
UTSW |
4 |
129,900,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2926:Adgrb2
|
UTSW |
4 |
129,902,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4472:Adgrb2
|
UTSW |
4 |
129,902,146 (GRCm39) |
missense |
probably benign |
0.12 |
|
R4490:Adgrb2
|
UTSW |
4 |
129,906,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4499:Adgrb2
|
UTSW |
4 |
129,886,454 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4758:Adgrb2
|
UTSW |
4 |
129,903,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4900:Adgrb2
|
UTSW |
4 |
129,907,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4904:Adgrb2
|
UTSW |
4 |
129,906,332 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R4922:Adgrb2
|
UTSW |
4 |
129,901,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5331:Adgrb2
|
UTSW |
4 |
129,915,995 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5550:Adgrb2
|
UTSW |
4 |
129,908,727 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5995:Adgrb2
|
UTSW |
4 |
129,910,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6047:Adgrb2
|
UTSW |
4 |
129,912,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6534:Adgrb2
|
UTSW |
4 |
129,916,012 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6565:Adgrb2
|
UTSW |
4 |
129,913,069 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6813:Adgrb2
|
UTSW |
4 |
129,903,284 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R6966:Adgrb2
|
UTSW |
4 |
129,908,155 (GRCm39) |
frame shift |
probably null |
|
|
R7409:Adgrb2
|
UTSW |
4 |
129,912,862 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7451:Adgrb2
|
UTSW |
4 |
129,908,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7453:Adgrb2
|
UTSW |
4 |
129,908,430 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7461:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7511:Adgrb2
|
UTSW |
4 |
129,915,904 (GRCm39) |
missense |
probably benign |
|
|
R7613:Adgrb2
|
UTSW |
4 |
129,915,006 (GRCm39) |
critical splice acceptor site |
probably benign |
|
|
R7729:Adgrb2
|
UTSW |
4 |
129,885,917 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,762 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7818:Adgrb2
|
UTSW |
4 |
129,908,353 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8033:Adgrb2
|
UTSW |
4 |
129,912,805 (GRCm39) |
missense |
probably benign |
|
|
R8039:Adgrb2
|
UTSW |
4 |
129,916,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8097:Adgrb2
|
UTSW |
4 |
129,901,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8256:Adgrb2
|
UTSW |
4 |
129,901,921 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8425:Adgrb2
|
UTSW |
4 |
129,898,850 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8804:Adgrb2
|
UTSW |
4 |
129,899,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9011:Adgrb2
|
UTSW |
4 |
129,916,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9018:Adgrb2
|
UTSW |
4 |
129,907,659 (GRCm39) |
missense |
probably benign |
0.34 |
|
R9102:Adgrb2
|
UTSW |
4 |
129,912,802 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9113:Adgrb2
|
UTSW |
4 |
129,910,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Adgrb2
|
UTSW |
4 |
129,906,302 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R9211:Adgrb2
|
UTSW |
4 |
129,886,199 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9267:Adgrb2
|
UTSW |
4 |
129,885,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9328:Adgrb2
|
UTSW |
4 |
129,915,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9470:Adgrb2
|
UTSW |
4 |
129,903,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9608:Adgrb2
|
UTSW |
4 |
129,907,352 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF020:Adgrb2
|
UTSW |
4 |
129,903,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Adgrb2
|
UTSW |
4 |
129,911,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,912,912 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Adgrb2
|
UTSW |
4 |
129,905,619 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACGTCACTGACACCTTCAAG -3'
(R):5'- CGTGACAATGAGAGAGCTCTG -3'
Sequencing Primer
(F):5'- ATGGAGGTTCACACCTC -3'
(R):5'- GCCCACGAGGTGAATGAAATCTTC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation