Incidental Mutation 'R7197:Unc45b'
| ID |
560030 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Unc45b
|
| Ensembl Gene |
ENSMUSG00000018845 |
| Gene Name |
unc-45 myosin chaperone B |
| Synonyms |
UNC45, Cmya4, D230041A13Rik |
| MMRRC Submission |
045276-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7197 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
82802112-82834284 bp(+) (GRCm39) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
A to T
at 82831013 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000018989
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018989]
[ENSMUST00000018989]
[ENSMUST00000108160]
[ENSMUST00000108160]
[ENSMUST00000164945]
[ENSMUST00000164945]
|
| AlphaFold |
Q8CGY6 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000018989
|
| SMART Domains |
Protein: ENSMUSP00000018989
Gene: ENSMUSG00000018845
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
6 |
39 |
1.02e1 |
SMART |
|
TPR
|
43 |
76 |
7.47e0 |
SMART |
|
TPR
|
77 |
110 |
2.52e-1 |
SMART |
|
Blast:ARM
|
167 |
208 |
3e-16 |
BLAST |
|
Blast:ARM
|
210 |
250 |
1e-10 |
BLAST |
|
Pfam:UNC45-central
|
298 |
489 |
1.7e-41 |
PFAM |
|
Blast:ARM
|
541 |
582 |
7e-7 |
BLAST |
|
Blast:ARM
|
661 |
701 |
2e-14 |
BLAST |
|
Blast:ARM
|
704 |
746 |
5e-11 |
BLAST |
|
Blast:ARM
|
747 |
788 |
1e-20 |
BLAST |
|
Blast:ARM
|
789 |
820 |
1e-11 |
BLAST |
|
low complexity region
|
821 |
832 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000018989
|
| SMART Domains |
Protein: ENSMUSP00000018989
Gene: ENSMUSG00000018845
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
6 |
39 |
1.02e1 |
SMART |
|
TPR
|
43 |
76 |
7.47e0 |
SMART |
|
TPR
|
77 |
110 |
2.52e-1 |
SMART |
|
Blast:ARM
|
167 |
208 |
3e-16 |
BLAST |
|
Blast:ARM
|
210 |
250 |
1e-10 |
BLAST |
|
Pfam:UNC45-central
|
298 |
489 |
1.7e-41 |
PFAM |
|
Blast:ARM
|
541 |
582 |
7e-7 |
BLAST |
|
Blast:ARM
|
661 |
701 |
2e-14 |
BLAST |
|
Blast:ARM
|
704 |
746 |
5e-11 |
BLAST |
|
Blast:ARM
|
747 |
788 |
1e-20 |
BLAST |
|
Blast:ARM
|
789 |
820 |
1e-11 |
BLAST |
|
low complexity region
|
821 |
832 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000108160
|
| SMART Domains |
Protein: ENSMUSP00000103795
Gene: ENSMUSG00000018845
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
6 |
39 |
1.02e1 |
SMART |
|
TPR
|
43 |
76 |
7.47e0 |
SMART |
|
TPR
|
77 |
110 |
2.52e-1 |
SMART |
|
Blast:ARM
|
167 |
208 |
3e-16 |
BLAST |
|
Blast:ARM
|
210 |
250 |
1e-10 |
BLAST |
|
Pfam:UNC45-central
|
271 |
489 |
2.2e-52 |
PFAM |
|
Blast:ARM
|
663 |
703 |
2e-14 |
BLAST |
|
Blast:ARM
|
706 |
748 |
5e-11 |
BLAST |
|
Blast:ARM
|
749 |
790 |
1e-20 |
BLAST |
|
Blast:ARM
|
791 |
822 |
1e-11 |
BLAST |
|
low complexity region
|
823 |
834 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000108160
|
| SMART Domains |
Protein: ENSMUSP00000103795
Gene: ENSMUSG00000018845
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
6 |
39 |
1.02e1 |
SMART |
|
TPR
|
43 |
76 |
7.47e0 |
SMART |
|
TPR
|
77 |
110 |
2.52e-1 |
SMART |
|
Blast:ARM
|
167 |
208 |
3e-16 |
BLAST |
|
Blast:ARM
|
210 |
250 |
1e-10 |
BLAST |
|
Pfam:UNC45-central
|
271 |
489 |
2.2e-52 |
PFAM |
|
Blast:ARM
|
663 |
703 |
2e-14 |
BLAST |
|
Blast:ARM
|
706 |
748 |
5e-11 |
BLAST |
|
Blast:ARM
|
749 |
790 |
1e-20 |
BLAST |
|
Blast:ARM
|
791 |
822 |
1e-11 |
BLAST |
|
low complexity region
|
823 |
834 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000164945
|
| SMART Domains |
Protein: ENSMUSP00000129405
Gene: ENSMUSG00000018845
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
6 |
39 |
1.02e1 |
SMART |
|
TPR
|
43 |
76 |
7.47e0 |
SMART |
|
TPR
|
77 |
110 |
2.52e-1 |
SMART |
|
Blast:ARM
|
167 |
208 |
3e-16 |
BLAST |
|
Blast:ARM
|
210 |
250 |
1e-10 |
BLAST |
|
Pfam:UNC45-central
|
298 |
489 |
1.7e-41 |
PFAM |
|
Blast:ARM
|
663 |
703 |
2e-14 |
BLAST |
|
Blast:ARM
|
706 |
748 |
5e-11 |
BLAST |
|
Blast:ARM
|
749 |
790 |
1e-20 |
BLAST |
|
Blast:ARM
|
791 |
822 |
1e-11 |
BLAST |
|
low complexity region
|
823 |
834 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000164945
|
| SMART Domains |
Protein: ENSMUSP00000129405
Gene: ENSMUSG00000018845
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
6 |
39 |
1.02e1 |
SMART |
|
TPR
|
43 |
76 |
7.47e0 |
SMART |
|
TPR
|
77 |
110 |
2.52e-1 |
SMART |
|
Blast:ARM
|
167 |
208 |
3e-16 |
BLAST |
|
Blast:ARM
|
210 |
250 |
1e-10 |
BLAST |
|
Pfam:UNC45-central
|
298 |
489 |
1.7e-41 |
PFAM |
|
Blast:ARM
|
663 |
703 |
2e-14 |
BLAST |
|
Blast:ARM
|
706 |
748 |
5e-11 |
BLAST |
|
Blast:ARM
|
749 |
790 |
1e-20 |
BLAST |
|
Blast:ARM
|
791 |
822 |
1e-11 |
BLAST |
|
low complexity region
|
823 |
834 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
97% (77/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E9 without placental abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700017B05Rik |
AGCTTCCCTGCTT |
AGCTT |
9: 57,165,505 (GRCm39) |
|
probably null |
Het |
| Aars2 |
T |
C |
17: 45,819,885 (GRCm39) |
Y221H |
probably damaging |
Het |
| Abca8b |
G |
A |
11: 109,836,648 (GRCm39) |
R1216* |
probably null |
Het |
| Acad8 |
A |
T |
9: 26,888,967 (GRCm39) |
|
probably null |
Het |
| Acer2 |
A |
G |
4: 86,805,287 (GRCm39) |
T84A |
probably null |
Het |
| Adgrb2 |
A |
G |
4: 129,903,315 (GRCm39) |
N613S |
probably damaging |
Het |
| Arap2 |
T |
C |
5: 62,798,729 (GRCm39) |
D1300G |
possibly damaging |
Het |
| Castor1 |
T |
C |
11: 4,168,949 (GRCm39) |
C39R |
probably damaging |
Het |
| Ccl11 |
A |
T |
11: 81,948,665 (GRCm39) |
|
probably benign |
Het |
| Cfh |
A |
T |
1: 140,016,505 (GRCm39) |
Y1151* |
probably null |
Het |
| Cobll1 |
A |
G |
2: 64,928,882 (GRCm39) |
S815P |
probably benign |
Het |
| Cryz |
T |
C |
3: 154,327,205 (GRCm39) |
S240P |
probably damaging |
Het |
| Csmd2 |
A |
G |
4: 128,404,826 (GRCm39) |
Y2404C |
|
Het |
| F13a1 |
T |
C |
13: 37,100,860 (GRCm39) |
D428G |
probably damaging |
Het |
| Fbxo42 |
A |
G |
4: 140,927,396 (GRCm39) |
S559G |
probably benign |
Het |
| Fry |
A |
G |
5: 150,393,232 (GRCm39) |
S263G |
|
Het |
| Fshr |
C |
T |
17: 89,292,897 (GRCm39) |
A594T |
probably damaging |
Het |
| Gm1527 |
A |
G |
3: 28,980,690 (GRCm39) |
M597V |
probably null |
Het |
| Gpr158 |
A |
T |
2: 21,815,412 (GRCm39) |
T602S |
probably damaging |
Het |
| Hmgxb4 |
C |
A |
8: 75,756,624 (GRCm39) |
T583K |
probably damaging |
Het |
| Igkv8-30 |
C |
T |
6: 70,094,069 (GRCm39) |
C114Y |
probably damaging |
Het |
| Igsf5 |
T |
A |
16: 96,204,546 (GRCm39) |
N366K |
probably damaging |
Het |
| Kif15 |
T |
C |
9: 122,838,991 (GRCm39) |
|
probably null |
Het |
| Klk1b26 |
T |
A |
7: 43,665,821 (GRCm39) |
|
probably null |
Het |
| Lama1 |
G |
T |
17: 68,044,700 (GRCm39) |
E200* |
probably null |
Het |
| Lpar5 |
C |
T |
6: 125,059,347 (GRCm39) |
T356I |
probably benign |
Het |
| Lrch3 |
A |
T |
16: 32,810,665 (GRCm39) |
T538S |
probably damaging |
Het |
| Mansc4 |
A |
G |
6: 146,977,203 (GRCm39) |
S138P |
probably damaging |
Het |
| Mief1 |
T |
C |
15: 80,134,061 (GRCm39) |
S373P |
possibly damaging |
Het |
| Nbas |
G |
T |
12: 13,570,751 (GRCm39) |
V2053F |
possibly damaging |
Het |
| Nek11 |
T |
C |
9: 105,121,614 (GRCm39) |
E435G |
probably damaging |
Het |
| Nynrin |
A |
T |
14: 56,109,380 (GRCm39) |
I1496F |
probably benign |
Het |
| Odf1 |
A |
T |
15: 38,219,794 (GRCm39) |
M41L |
probably benign |
Het |
| Or10a5 |
A |
G |
7: 106,635,364 (GRCm39) |
M8V |
probably benign |
Het |
| Or4c115 |
A |
G |
2: 88,927,626 (GRCm39) |
V215A |
probably benign |
Het |
| Or4c29 |
A |
T |
2: 88,740,708 (GRCm39) |
F10I |
probably benign |
Het |
| Or7h8 |
T |
G |
9: 20,123,851 (GRCm39) |
S69A |
probably benign |
Het |
| Oxnad1 |
T |
C |
14: 31,818,473 (GRCm39) |
V106A |
possibly damaging |
Het |
| Padi4 |
C |
A |
4: 140,488,969 (GRCm39) |
E157* |
probably null |
Het |
| Parp10 |
A |
T |
15: 76,126,616 (GRCm39) |
F217L |
probably damaging |
Het |
| Pcdhb18 |
T |
A |
18: 37,623,436 (GRCm39) |
S255R |
probably benign |
Het |
| Pde4c |
G |
T |
8: 71,197,978 (GRCm39) |
G102W |
probably damaging |
Het |
| Pde6a |
T |
C |
18: 61,391,295 (GRCm39) |
Y547H |
probably damaging |
Het |
| Phf11b |
A |
T |
14: 59,563,507 (GRCm39) |
L137I |
probably benign |
Het |
| Pigh |
A |
C |
12: 79,130,463 (GRCm39) |
I134S |
probably damaging |
Het |
| Pigt |
G |
A |
2: 164,344,436 (GRCm39) |
V362M |
probably damaging |
Het |
| Pld1 |
A |
G |
3: 28,078,401 (GRCm39) |
D20G |
probably damaging |
Het |
| Pou3f2 |
T |
C |
4: 22,487,288 (GRCm39) |
R282G |
probably damaging |
Het |
| Ppp2r5d |
A |
G |
17: 46,996,527 (GRCm39) |
V382A |
probably damaging |
Het |
| Prdm16 |
T |
C |
4: 154,425,967 (GRCm39) |
E606G |
probably damaging |
Het |
| Psg28 |
A |
G |
7: 18,164,509 (GRCm39) |
Y68H |
probably damaging |
Het |
| Qpctl |
C |
A |
7: 18,882,944 (GRCm39) |
W56L |
probably damaging |
Het |
| Rab11fip5 |
G |
A |
6: 85,319,137 (GRCm39) |
P584L |
probably damaging |
Het |
| Sde2 |
C |
T |
1: 180,678,843 (GRCm39) |
H36Y |
probably benign |
Het |
| Sema4d |
T |
C |
13: 51,856,872 (GRCm39) |
S787G |
probably benign |
Het |
| Sgca |
C |
T |
11: 94,864,014 (GRCm39) |
|
probably null |
Het |
| Shroom3 |
A |
G |
5: 93,090,463 (GRCm39) |
E1071G |
probably damaging |
Het |
| Skint5 |
A |
G |
4: 113,437,679 (GRCm39) |
|
probably null |
Het |
| Slc44a3 |
T |
A |
3: 121,319,411 (GRCm39) |
D110V |
probably benign |
Het |
| Slc4a4 |
A |
C |
5: 89,082,433 (GRCm39) |
|
probably benign |
Het |
| Slc4a8 |
A |
G |
15: 100,688,857 (GRCm39) |
D389G |
probably damaging |
Het |
| Sp3 |
C |
G |
2: 72,809,953 (GRCm39) |
E11Q |
probably benign |
Het |
| Srrm2 |
A |
G |
17: 24,037,198 (GRCm39) |
S1281G |
unknown |
Het |
| Tat |
A |
T |
8: 110,723,459 (GRCm39) |
I316F |
probably benign |
Het |
| Thoc5 |
A |
G |
11: 4,865,563 (GRCm39) |
T381A |
probably benign |
Het |
| Tiam1 |
T |
C |
16: 89,681,826 (GRCm39) |
Y384C |
probably damaging |
Het |
| Tmem45a |
A |
T |
16: 56,632,026 (GRCm39) |
F197L |
probably damaging |
Het |
| Trav8d-1 |
A |
G |
14: 53,016,435 (GRCm39) |
Y107C |
probably damaging |
Het |
| Trim10 |
T |
A |
17: 37,187,846 (GRCm39) |
V354D |
probably damaging |
Het |
| Unc79 |
A |
G |
12: 103,078,765 (GRCm39) |
I1643M |
probably benign |
Het |
| Unc80 |
G |
T |
1: 66,560,725 (GRCm39) |
G818* |
probably null |
Het |
| Usp15 |
A |
T |
10: 122,966,910 (GRCm39) |
M470K |
possibly damaging |
Het |
| Vldlr |
T |
C |
19: 27,212,241 (GRCm39) |
V85A |
probably benign |
Het |
| Vma21-ps |
A |
G |
4: 52,496,994 (GRCm39) |
V84A |
probably benign |
Het |
| Vmn2r67 |
C |
T |
7: 84,785,774 (GRCm39) |
V744I |
possibly damaging |
Het |
| Wdr73 |
A |
G |
7: 80,542,946 (GRCm39) |
C221R |
probably benign |
Het |
| Zxdc |
C |
T |
6: 90,355,819 (GRCm39) |
H443Y |
probably damaging |
Het |
|
| Other mutations in Unc45b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01320:Unc45b
|
APN |
11 |
82,803,219 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01983:Unc45b
|
APN |
11 |
82,827,687 (GRCm39) |
missense |
probably benign |
|
|
IGL02083:Unc45b
|
APN |
11 |
82,813,745 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02159:Unc45b
|
APN |
11 |
82,831,007 (GRCm39) |
splice site |
probably benign |
|
|
IGL02160:Unc45b
|
APN |
11 |
82,831,007 (GRCm39) |
splice site |
probably benign |
|
|
IGL02165:Unc45b
|
APN |
11 |
82,831,007 (GRCm39) |
splice site |
probably benign |
|
|
IGL02166:Unc45b
|
APN |
11 |
82,831,007 (GRCm39) |
splice site |
probably benign |
|
|
IGL02986:Unc45b
|
APN |
11 |
82,808,005 (GRCm39) |
missense |
probably damaging |
0.98 |
|
fife
|
UTSW |
11 |
82,827,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0195:Unc45b
|
UTSW |
11 |
82,828,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0197:Unc45b
|
UTSW |
11 |
82,831,031 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0218:Unc45b
|
UTSW |
11 |
82,802,686 (GRCm39) |
splice site |
probably benign |
|
|
R0436:Unc45b
|
UTSW |
11 |
82,820,393 (GRCm39) |
splice site |
probably benign |
|
|
R0569:Unc45b
|
UTSW |
11 |
82,827,638 (GRCm39) |
splice site |
probably benign |
|
|
R0701:Unc45b
|
UTSW |
11 |
82,831,031 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R0883:Unc45b
|
UTSW |
11 |
82,831,031 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1146:Unc45b
|
UTSW |
11 |
82,813,733 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1146:Unc45b
|
UTSW |
11 |
82,813,733 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1378:Unc45b
|
UTSW |
11 |
82,827,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1446:Unc45b
|
UTSW |
11 |
82,819,496 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1532:Unc45b
|
UTSW |
11 |
82,827,700 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1559:Unc45b
|
UTSW |
11 |
82,808,672 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R1582:Unc45b
|
UTSW |
11 |
82,816,771 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1628:Unc45b
|
UTSW |
11 |
82,820,206 (GRCm39) |
splice site |
probably null |
|
|
R1666:Unc45b
|
UTSW |
11 |
82,808,565 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1677:Unc45b
|
UTSW |
11 |
82,802,531 (GRCm39) |
splice site |
probably null |
|
|
R1759:Unc45b
|
UTSW |
11 |
82,820,325 (GRCm39) |
missense |
probably benign |
0.33 |
|
R1909:Unc45b
|
UTSW |
11 |
82,816,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2067:Unc45b
|
UTSW |
11 |
82,802,515 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2111:Unc45b
|
UTSW |
11 |
82,802,515 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2145:Unc45b
|
UTSW |
11 |
82,808,580 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2258:Unc45b
|
UTSW |
11 |
82,808,625 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2259:Unc45b
|
UTSW |
11 |
82,808,625 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2497:Unc45b
|
UTSW |
11 |
82,827,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2507:Unc45b
|
UTSW |
11 |
82,830,963 (GRCm39) |
splice site |
probably null |
|
|
R4352:Unc45b
|
UTSW |
11 |
82,804,035 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4569:Unc45b
|
UTSW |
11 |
82,827,315 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4624:Unc45b
|
UTSW |
11 |
82,816,835 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5236:Unc45b
|
UTSW |
11 |
82,805,888 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5512:Unc45b
|
UTSW |
11 |
82,805,898 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5688:Unc45b
|
UTSW |
11 |
82,813,643 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6029:Unc45b
|
UTSW |
11 |
82,804,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6616:Unc45b
|
UTSW |
11 |
82,802,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6857:Unc45b
|
UTSW |
11 |
82,804,038 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6876:Unc45b
|
UTSW |
11 |
82,813,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7368:Unc45b
|
UTSW |
11 |
82,833,321 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7531:Unc45b
|
UTSW |
11 |
82,819,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7743:Unc45b
|
UTSW |
11 |
82,813,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8198:Unc45b
|
UTSW |
11 |
82,816,814 (GRCm39) |
frame shift |
probably null |
|
|
R8214:Unc45b
|
UTSW |
11 |
82,824,714 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8235:Unc45b
|
UTSW |
11 |
82,810,681 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8916:Unc45b
|
UTSW |
11 |
82,804,038 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9004:Unc45b
|
UTSW |
11 |
82,819,515 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Unc45b
|
UTSW |
11 |
82,808,586 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9687:Unc45b
|
UTSW |
11 |
82,810,562 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9757:Unc45b
|
UTSW |
11 |
82,810,558 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9784:Unc45b
|
UTSW |
11 |
82,816,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
T0970:Unc45b
|
UTSW |
11 |
82,813,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Unc45b
|
UTSW |
11 |
82,833,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Unc45b
|
UTSW |
11 |
82,819,480 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1177:Unc45b
|
UTSW |
11 |
82,833,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGAGTTATACCTGCTTCACG -3'
(R):5'- AAGTTTGCTCTGCTATCCAACC -3'
Sequencing Primer
(F):5'- TGCTTCACGCAGGCAATCAG -3'
(R):5'- TGCTATCCAACCTGTTATGAGAC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation