Incidental Mutation 'R7198:Wnt11'
ID 560080
Institutional Source Beutler Lab
Gene Symbol Wnt11
Ensembl Gene ENSMUSG00000015957
Gene Name wingless-type MMTV integration site family, member 11
Synonyms
MMRRC Submission 045337-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.885) question?
Stock # R7198 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 98484293-98503954 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98496588 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 176 (M176T)
Ref Sequence ENSEMBL: ENSMUSP00000132166 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000067495] [ENSMUST00000163913] [ENSMUST00000165122] [ENSMUST00000165240] [ENSMUST00000167303]
AlphaFold P48615
Predicted Effect possibly damaging
Transcript: ENSMUST00000067495
AA Change: M176T

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000064333
Gene: ENSMUSG00000015957
AA Change: M176T

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
WNT1 47 354 7.5e-170 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000163913
Predicted Effect probably benign
Transcript: ENSMUST00000165122
SMART Domains Protein: ENSMUSP00000125789
Gene: ENSMUSG00000015957

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
Pfam:wnt 44 98 6.1e-12 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000165240
SMART Domains Protein: ENSMUSP00000131770
Gene: ENSMUSG00000015957

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
WNT1 47 149 1.35e-8 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000167303
AA Change: M176T

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000132166
Gene: ENSMUSG00000015957
AA Change: M176T

DomainStartEndE-ValueType
transmembrane domain 7 29 N/A INTRINSIC
WNT1 47 354 7.5e-170 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 98% (62/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in extensive embryonic lethality and mutants surviving to birth die within the first 2 days of life. The kidneys are small and exhibit delayed development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a C T 11: 109,969,481 (GRCm39) S365N probably damaging Het
Baiap3 G A 17: 25,462,814 (GRCm39) R1075C probably benign Het
Baz2b A G 2: 59,792,550 (GRCm39) L526P probably benign Het
Bbs1 A T 19: 4,945,043 (GRCm39) L376Q probably damaging Het
Bcl9 T A 3: 97,112,511 (GRCm39) M1315L possibly damaging Het
Bcl9 T C 3: 97,116,183 (GRCm39) Q837R probably damaging Het
Cct2 A G 10: 116,889,029 (GRCm39) V490A probably benign Het
Cdh23 T C 10: 60,148,378 (GRCm39) Y2663C possibly damaging Het
Chit1 A G 1: 134,078,229 (GRCm39) K346E possibly damaging Het
Chl1 A G 6: 103,683,517 (GRCm39) Y781C probably damaging Het
Col12a1 A C 9: 79,557,314 (GRCm39) L1938R possibly damaging Het
Cpxm2 T A 7: 131,681,813 (GRCm39) N239Y probably damaging Het
Cyp3a41b A G 5: 145,519,330 (GRCm39) Y54H probably benign Het
Dclk1 A C 3: 55,385,296 (GRCm39) D369A possibly damaging Het
Dnai4 A G 4: 102,919,610 (GRCm39) V498A probably damaging Het
Dpy19l3 T C 7: 35,449,190 (GRCm39) N71S possibly damaging Het
Efcab3 T A 11: 104,642,711 (GRCm39) N1111K probably benign Het
Fer T A 17: 64,228,683 (GRCm39) V186E possibly damaging Het
Gm11042 T A 12: 74,361,888 (GRCm39) H39L unknown Het
Gm14325 A G 2: 177,473,798 (GRCm39) I428T probably benign Het
Gm47995 A G 1: 151,074,404 (GRCm39) E69G possibly damaging Het
Gm6176 T A 7: 21,750,596 (GRCm39) I112F probably damaging Het
Hivep2 T A 10: 14,005,710 (GRCm39) D769E probably benign Het
Hsdl1 C T 8: 120,294,607 (GRCm39) V40I probably benign Het
Ipmk A G 10: 71,183,882 (GRCm39) H34R probably damaging Het
Kcnd3 T C 3: 105,366,856 (GRCm39) L242P probably damaging Het
Kdm4d T C 9: 14,375,316 (GRCm39) M181V probably damaging Het
Lats2 A T 14: 57,934,582 (GRCm39) I716N probably damaging Het
Liph T C 16: 21,784,772 (GRCm39) Y305C probably damaging Het
Ltbp1 T C 17: 75,533,962 (GRCm39) V150A possibly damaging Het
Ly6d A T 15: 74,634,384 (GRCm39) S69T probably benign Het
Meltf A G 16: 31,702,617 (GRCm39) R115G possibly damaging Het
Msgn1 G T 12: 11,258,902 (GRCm39) D16E probably benign Het
Mthfd2l T A 5: 91,094,705 (GRCm39) I58K probably damaging Het
Mup18 G C 4: 61,591,573 (GRCm39) probably null Het
Nek10 T A 14: 14,850,947 (GRCm38) W331R probably damaging Het
Nphp3 A G 9: 103,881,974 (GRCm39) Y148C probably damaging Het
Or4a47 T C 2: 89,666,076 (GRCm39) Y71C probably damaging Het
Or5h19 C T 16: 58,856,456 (GRCm39) V215I probably benign Het
Or6c33 T A 10: 129,853,760 (GRCm39) C177S probably damaging Het
Oscp1 A G 4: 125,980,459 (GRCm39) T325A possibly damaging Het
Pcdha4 T A 18: 37,086,613 (GRCm39) N265K probably damaging Het
Pigq C T 17: 26,153,199 (GRCm39) V331I probably benign Het
Plekhg4 A G 8: 106,105,329 (GRCm39) E598G probably damaging Het
Pou6f2 G A 13: 18,303,748 (GRCm39) T120M probably damaging Het
Psg27 T A 7: 18,295,726 (GRCm39) T240S probably damaging Het
Samd12 T A 15: 53,723,649 (GRCm39) I15F probably damaging Het
Scaf4 A T 16: 90,049,318 (GRCm39) D256E unknown Het
Scaf8 T A 17: 3,213,373 (GRCm39) M154K unknown Het
Slc27a1 T C 8: 72,032,071 (GRCm39) V64A possibly damaging Het
Smc5 G A 19: 23,237,064 (GRCm39) R256* probably null Het
Snx31 A G 15: 36,555,455 (GRCm39) F31L probably benign Het
Spag17 T C 3: 100,002,888 (GRCm39) S1871P probably benign Het
Tdpoz4 T G 3: 93,704,662 (GRCm39) S320A probably benign Het
Tmprss11c A T 5: 86,379,691 (GRCm39) C406S probably damaging Het
Tnip1 G A 11: 54,808,630 (GRCm39) A519V probably benign Het
Tssc4 T A 7: 142,624,724 (GRCm39) probably null Het
Uba3 A T 6: 97,182,512 (GRCm39) M1K probably null Het
Usp32 GAACAAGTCCACAACAA GAACAA 11: 84,913,681 (GRCm39) probably null Het
Wrn C T 8: 33,814,346 (GRCm39) G366D probably benign Het
Xylt1 T A 7: 117,255,807 (GRCm39) I793N probably damaging Het
Zfp677 T G 17: 21,618,679 (GRCm39) C579G probably damaging Het
Zscan4-ps1 T A 7: 10,799,626 (GRCm39) K421M probably damaging Het
Other mutations in Wnt11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02889:Wnt11 APN 7 98,499,566 (GRCm39) missense probably damaging 1.00
R0277:Wnt11 UTSW 7 98,496,590 (GRCm39) missense probably damaging 0.99
R0323:Wnt11 UTSW 7 98,496,590 (GRCm39) missense probably damaging 0.99
R0674:Wnt11 UTSW 7 98,495,735 (GRCm39) missense probably damaging 1.00
R3110:Wnt11 UTSW 7 98,495,771 (GRCm39) missense probably damaging 1.00
R3112:Wnt11 UTSW 7 98,495,771 (GRCm39) missense probably damaging 1.00
R5534:Wnt11 UTSW 7 98,488,349 (GRCm39) missense probably damaging 0.98
R5899:Wnt11 UTSW 7 98,488,383 (GRCm39) nonsense probably null
R6481:Wnt11 UTSW 7 98,502,481 (GRCm39) missense probably damaging 1.00
R9148:Wnt11 UTSW 7 98,488,241 (GRCm39) start gained probably benign
R9301:Wnt11 UTSW 7 98,495,796 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGTCAGCCTTCGTGTATGCC -3'
(R):5'- GAATCTTGGAGACTCCCTAAAGG -3'

Sequencing Primer
(F):5'- CGTGTATGCCCTGTCGG -3'
(R):5'- TCCCTAAAGGAGAAGGAGCCC -3'
Posted On 2019-06-26