Incidental Mutation 'R7199:Rapgef6'
| ID |
560180 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Rapgef6
|
| Ensembl Gene |
ENSMUSG00000037533 |
| Gene Name |
Rap guanine nucleotide exchange factor (GEF) 6 |
| Synonyms |
PDZ-GEF2, C030018K18Rik, Pdzgef2, RA-GEF-2 |
| MMRRC Submission |
045277-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7199 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
54413673-54590111 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 54437252 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Tyrosine
at position 65
(F65Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104523
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000101206]
[ENSMUST00000102743]
[ENSMUST00000108895]
[ENSMUST00000207429]
|
| AlphaFold |
Q5NCJ1 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000101206
AA Change: F65Y
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000098766
Gene: ENSMUSG00000037533
AA Change: F65Y
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.45e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1095 |
5.35e-87 |
SMART |
|
low complexity region
|
1237 |
1250 |
N/A |
INTRINSIC |
|
low complexity region
|
1270 |
1293 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1368 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1452 |
N/A |
INTRINSIC |
|
low complexity region
|
1555 |
1568 |
N/A |
INTRINSIC |
|
low complexity region
|
1591 |
1604 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102743
AA Change: F65Y
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000099804
Gene: ENSMUSG00000037533
AA Change: F65Y
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.42e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
525 |
4.35e-33 |
SMART |
|
PDZ
|
540 |
612 |
8.86e-16 |
SMART |
|
low complexity region
|
694 |
705 |
N/A |
INTRINSIC |
|
RA
|
749 |
835 |
1.47e-20 |
SMART |
|
RasGEF
|
856 |
1138 |
3.88e-84 |
SMART |
|
low complexity region
|
1229 |
1242 |
N/A |
INTRINSIC |
|
low complexity region
|
1262 |
1285 |
N/A |
INTRINSIC |
|
low complexity region
|
1337 |
1356 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1372 |
N/A |
INTRINSIC |
|
low complexity region
|
1436 |
1444 |
N/A |
INTRINSIC |
|
low complexity region
|
1547 |
1560 |
N/A |
INTRINSIC |
|
low complexity region
|
1583 |
1596 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108895
AA Change: F65Y
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000104523
Gene: ENSMUSG00000037533
AA Change: F65Y
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
10 |
82 |
1.95e-5 |
PROSPERO |
|
low complexity region
|
187 |
205 |
N/A |
INTRINSIC |
|
low complexity region
|
231 |
239 |
N/A |
INTRINSIC |
|
cNMP
|
280 |
398 |
4.8e-13 |
SMART |
|
RasGEFN
|
412 |
526 |
1.03e-25 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207429
AA Change: F65Y
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a null allele exhibit an inlarged spleen, increased IgE and IgG levels and altered cytokine production. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(16) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(13) |
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310034C09Rik |
A |
G |
16: 88,555,902 (GRCm39) |
T39A |
probably damaging |
Het |
| Abca3 |
G |
A |
17: 24,596,681 (GRCm39) |
G378D |
probably damaging |
Het |
| Abtb2 |
T |
C |
2: 103,397,565 (GRCm39) |
V165A |
possibly damaging |
Het |
| Ache |
A |
G |
5: 137,288,504 (GRCm39) |
E70G |
probably damaging |
Het |
| Adamtsl4 |
T |
C |
3: 95,588,119 (GRCm39) |
T623A |
probably benign |
Het |
| Ahdc1 |
G |
A |
4: 132,791,935 (GRCm39) |
V1059I |
probably benign |
Het |
| Ajuba |
G |
A |
14: 54,810,915 (GRCm39) |
Q357* |
probably null |
Het |
| Ano7 |
A |
T |
1: 93,330,700 (GRCm39) |
D54V |
|
Het |
| Apob |
A |
T |
12: 8,055,072 (GRCm39) |
D1357V |
probably damaging |
Het |
| Atad2b |
T |
A |
12: 5,067,992 (GRCm39) |
Y997N |
probably damaging |
Het |
| Bhlhe22 |
C |
A |
3: 18,110,006 (GRCm39) |
T352K |
probably damaging |
Het |
| Bsn |
T |
C |
9: 107,992,533 (GRCm39) |
E1073G |
probably damaging |
Het |
| Bzw2 |
G |
A |
12: 36,180,054 (GRCm39) |
R58* |
probably null |
Het |
| C7 |
G |
T |
15: 5,023,725 (GRCm39) |
S694R |
probably benign |
Het |
| Cbr2 |
T |
A |
11: 120,621,087 (GRCm39) |
H170L |
probably benign |
Het |
| Cdcp3 |
G |
A |
7: 130,837,641 (GRCm39) |
W512* |
probably null |
Het |
| Cgas |
C |
A |
9: 78,340,315 (GRCm39) |
K472N |
probably benign |
Het |
| Ckap2l |
T |
C |
2: 129,126,975 (GRCm39) |
N401S |
probably benign |
Het |
| Cldn1 |
A |
G |
16: 26,190,346 (GRCm39) |
F11L |
probably benign |
Het |
| Cmtr1 |
A |
G |
17: 29,895,174 (GRCm39) |
T118A |
probably benign |
Het |
| Cog6 |
T |
C |
3: 52,890,610 (GRCm39) |
E610G |
probably benign |
Het |
| Col3a1 |
G |
T |
1: 45,371,301 (GRCm39) |
A451S |
probably null |
Het |
| Cr1l |
T |
A |
1: 194,799,878 (GRCm39) |
R265S |
probably benign |
Het |
| Dapk1 |
T |
C |
13: 60,902,024 (GRCm39) |
I951T |
probably benign |
Het |
| Dnah9 |
T |
C |
11: 66,009,770 (GRCm39) |
N706D |
probably benign |
Het |
| Dpysl5 |
A |
T |
5: 30,940,539 (GRCm39) |
T239S |
probably benign |
Het |
| Ect2l |
T |
A |
10: 18,004,894 (GRCm39) |
Y913F |
probably benign |
Het |
| Elf5 |
C |
A |
2: 103,269,641 (GRCm39) |
A74D |
possibly damaging |
Het |
| Erap1 |
T |
C |
13: 74,814,258 (GRCm39) |
V399A |
probably benign |
Het |
| Ercc4 |
A |
G |
16: 12,965,657 (GRCm39) |
D763G |
probably damaging |
Het |
| Fam222b |
T |
A |
11: 78,045,683 (GRCm39) |
C415S |
possibly damaging |
Het |
| Fat4 |
A |
C |
3: 39,031,511 (GRCm39) |
N2432T |
probably damaging |
Het |
| Fbn2 |
G |
T |
18: 58,186,833 (GRCm39) |
C1689* |
probably null |
Het |
| Frrs1l |
T |
A |
4: 56,972,282 (GRCm39) |
T140S |
probably damaging |
Het |
| Gm5141 |
A |
T |
13: 62,924,877 (GRCm39) |
H10Q |
possibly damaging |
Het |
| Inafm1 |
A |
T |
7: 16,007,079 (GRCm39) |
L46Q |
probably damaging |
Het |
| Irak2 |
T |
C |
6: 113,650,045 (GRCm39) |
L260P |
probably damaging |
Het |
| Kat2b |
T |
C |
17: 53,977,706 (GRCm39) |
L751P |
probably damaging |
Het |
| Kcnh1 |
T |
A |
1: 192,019,913 (GRCm39) |
I413N |
probably benign |
Het |
| Kirrel1 |
T |
C |
3: 86,990,695 (GRCm39) |
D709G |
probably benign |
Het |
| Lama4 |
T |
C |
10: 38,956,536 (GRCm39) |
V1153A |
possibly damaging |
Het |
| Lipg |
A |
T |
18: 75,088,655 (GRCm39) |
F98L |
probably benign |
Het |
| Lman1 |
T |
C |
18: 66,127,936 (GRCm39) |
E236G |
probably damaging |
Het |
| Lrp1 |
T |
A |
10: 127,409,325 (GRCm39) |
D1598V |
probably damaging |
Het |
| Lrrc71 |
T |
A |
3: 87,650,384 (GRCm39) |
N230Y |
probably damaging |
Het |
| Maneal |
T |
C |
4: 124,750,983 (GRCm39) |
S258G |
possibly damaging |
Het |
| Marchf10 |
T |
A |
11: 105,281,532 (GRCm39) |
E251V |
probably damaging |
Het |
| Mpdz |
A |
G |
4: 81,215,570 (GRCm39) |
I1484T |
probably damaging |
Het |
| Mtcl1 |
T |
A |
17: 66,647,534 (GRCm39) |
N1882I |
probably benign |
Het |
| Neb |
G |
A |
2: 52,110,212 (GRCm39) |
A212V |
probably benign |
Het |
| Obscn |
G |
A |
11: 58,903,672 (GRCm39) |
S7434L |
probably benign |
Het |
| Or14j8 |
A |
C |
17: 38,263,048 (GRCm39) |
I289S |
probably damaging |
Het |
| Or1ad8 |
T |
A |
11: 50,898,223 (GRCm39) |
C141* |
probably null |
Het |
| Or1j12 |
A |
T |
2: 36,342,872 (GRCm39) |
I92F |
probably damaging |
Het |
| Or4k47 |
T |
C |
2: 111,451,538 (GRCm39) |
M294V |
probably benign |
Het |
| Or8g2b |
A |
G |
9: 39,750,753 (GRCm39) |
M8V |
probably benign |
Het |
| Orc6 |
T |
C |
8: 86,029,590 (GRCm39) |
|
probably null |
Het |
| Otogl |
T |
G |
10: 107,710,394 (GRCm39) |
E565A |
possibly damaging |
Het |
| Papss1 |
A |
G |
3: 131,290,899 (GRCm39) |
Q214R |
probably benign |
Het |
| Pck2 |
G |
A |
14: 55,786,169 (GRCm39) |
V653M |
probably benign |
Het |
| Plxna4 |
G |
A |
6: 32,192,113 (GRCm39) |
Q826* |
probably null |
Het |
| Pms1 |
T |
A |
1: 53,295,889 (GRCm39) |
T161S |
probably benign |
Het |
| Prkar2a |
C |
A |
9: 108,617,669 (GRCm39) |
N242K |
probably damaging |
Het |
| Prss1 |
T |
A |
6: 41,439,690 (GRCm39) |
I141N |
probably damaging |
Het |
| Puf60 |
A |
G |
15: 75,943,717 (GRCm39) |
V235A |
probably damaging |
Het |
| Rasgef1b |
T |
C |
5: 99,447,898 (GRCm39) |
E104G |
unknown |
Het |
| Rcn3 |
T |
C |
7: 44,734,333 (GRCm39) |
Y225C |
probably damaging |
Het |
| Rhot1 |
G |
C |
11: 80,137,560 (GRCm39) |
W354S |
probably damaging |
Het |
| Rp1 |
T |
C |
1: 4,417,513 (GRCm39) |
S1200G |
possibly damaging |
Het |
| Scaper |
T |
A |
9: 55,745,460 (GRCm39) |
K603* |
probably null |
Het |
| Selenbp1 |
G |
A |
3: 94,851,745 (GRCm39) |
V429I |
possibly damaging |
Het |
| Setd5 |
T |
G |
6: 113,098,099 (GRCm39) |
S713A |
probably benign |
Het |
| Shank1 |
T |
C |
7: 44,002,564 (GRCm39) |
Y1428H |
possibly damaging |
Het |
| Slc11a1 |
G |
T |
1: 74,422,830 (GRCm39) |
W361L |
possibly damaging |
Het |
| Spta1 |
A |
T |
1: 174,050,837 (GRCm39) |
D1772V |
possibly damaging |
Het |
| St8sia6 |
T |
C |
2: 13,661,721 (GRCm39) |
H370R |
probably damaging |
Het |
| Stkld1 |
A |
T |
2: 26,842,726 (GRCm39) |
D566V |
probably damaging |
Het |
| Tango6 |
T |
C |
8: 107,415,791 (GRCm39) |
V204A |
probably benign |
Het |
| Tdrd5 |
G |
A |
1: 156,129,293 (GRCm39) |
A139V |
probably damaging |
Het |
| Tenm2 |
A |
T |
11: 36,062,263 (GRCm39) |
V534E |
probably damaging |
Het |
| Tfip11 |
A |
T |
5: 112,479,044 (GRCm39) |
Q204L |
probably benign |
Het |
| Tlr4 |
A |
T |
4: 66,759,430 (GRCm39) |
Q741L |
probably damaging |
Het |
| Tmem18 |
A |
G |
12: 30,638,654 (GRCm39) |
M111V |
probably benign |
Het |
| Togaram1 |
A |
G |
12: 65,042,292 (GRCm39) |
N1167S |
probably benign |
Het |
| Trappc3 |
C |
T |
4: 126,168,945 (GRCm39) |
A145V |
possibly damaging |
Het |
| Trbj2-3 |
T |
C |
6: 41,520,176 (GRCm39) |
F7S |
probably damaging |
Het |
| Vinac1 |
A |
G |
2: 128,880,238 (GRCm39) |
S563P |
|
Het |
| Vmn1r212 |
T |
A |
13: 23,067,731 (GRCm39) |
M201L |
probably benign |
Het |
| Xaf1 |
C |
A |
11: 72,194,201 (GRCm39) |
C27* |
probably null |
Het |
| Zeb1 |
T |
C |
18: 5,767,703 (GRCm39) |
V738A |
probably benign |
Het |
| Zfp524 |
A |
T |
7: 5,020,883 (GRCm39) |
H137L |
probably damaging |
Het |
| Zfyve19 |
A |
T |
2: 119,047,118 (GRCm39) |
H367L |
probably damaging |
Het |
| Zim1 |
G |
A |
7: 6,680,872 (GRCm39) |
Q264* |
probably null |
Het |
|
| Other mutations in Rapgef6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00436:Rapgef6
|
APN |
11 |
54,570,091 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00507:Rapgef6
|
APN |
11 |
54,554,935 (GRCm39) |
nonsense |
probably null |
|
|
IGL00809:Rapgef6
|
APN |
11 |
54,540,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00843:Rapgef6
|
APN |
11 |
54,582,099 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00899:Rapgef6
|
APN |
11 |
54,510,844 (GRCm39) |
nonsense |
probably null |
|
|
IGL01372:Rapgef6
|
APN |
11 |
54,559,437 (GRCm39) |
splice site |
probably benign |
|
|
IGL01604:Rapgef6
|
APN |
11 |
54,585,389 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01935:Rapgef6
|
APN |
11 |
54,501,668 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01991:Rapgef6
|
APN |
11 |
54,443,695 (GRCm39) |
missense |
probably benign |
0.37 |
|
IGL02243:Rapgef6
|
APN |
11 |
54,567,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02407:Rapgef6
|
APN |
11 |
54,567,181 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02676:Rapgef6
|
APN |
11 |
54,540,172 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02934:Rapgef6
|
APN |
11 |
54,516,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03076:Rapgef6
|
APN |
11 |
54,516,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03110:Rapgef6
|
APN |
11 |
54,586,915 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03256:Rapgef6
|
APN |
11 |
54,548,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shocker
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
D4216:Rapgef6
|
UTSW |
11 |
54,559,572 (GRCm39) |
splice site |
probably benign |
|
|
PIT4305001:Rapgef6
|
UTSW |
11 |
54,570,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4366001:Rapgef6
|
UTSW |
11 |
54,582,446 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0047:Rapgef6
|
UTSW |
11 |
54,437,204 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0125:Rapgef6
|
UTSW |
11 |
54,516,701 (GRCm39) |
nonsense |
probably null |
|
|
R0189:Rapgef6
|
UTSW |
11 |
54,582,075 (GRCm39) |
missense |
probably benign |
|
|
R0201:Rapgef6
|
UTSW |
11 |
54,510,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Rapgef6
|
UTSW |
11 |
54,516,789 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0524:Rapgef6
|
UTSW |
11 |
54,581,110 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0853:Rapgef6
|
UTSW |
11 |
54,559,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1203:Rapgef6
|
UTSW |
11 |
54,582,525 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1440:Rapgef6
|
UTSW |
11 |
54,517,534 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1453:Rapgef6
|
UTSW |
11 |
54,530,553 (GRCm39) |
splice site |
probably null |
|
|
R1530:Rapgef6
|
UTSW |
11 |
54,552,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1593:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1620:Rapgef6
|
UTSW |
11 |
54,517,420 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1628:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1629:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1630:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1634:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1640:Rapgef6
|
UTSW |
11 |
54,548,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Rapgef6
|
UTSW |
11 |
54,582,458 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1722:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1743:Rapgef6
|
UTSW |
11 |
54,567,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1816:Rapgef6
|
UTSW |
11 |
54,585,314 (GRCm39) |
missense |
probably benign |
|
|
R1851:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1852:Rapgef6
|
UTSW |
11 |
54,533,637 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1868:Rapgef6
|
UTSW |
11 |
54,437,223 (GRCm39) |
frame shift |
probably null |
|
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1888:Rapgef6
|
UTSW |
11 |
54,551,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1942:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1943:Rapgef6
|
UTSW |
11 |
54,548,089 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2031:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2087:Rapgef6
|
UTSW |
11 |
54,522,075 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Rapgef6
|
UTSW |
11 |
54,559,512 (GRCm39) |
missense |
probably benign |
0.17 |
|
R2362:Rapgef6
|
UTSW |
11 |
54,585,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2484:Rapgef6
|
UTSW |
11 |
54,533,582 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2566:Rapgef6
|
UTSW |
11 |
54,578,537 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2872:Rapgef6
|
UTSW |
11 |
54,552,001 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3744:Rapgef6
|
UTSW |
11 |
54,516,760 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3848:Rapgef6
|
UTSW |
11 |
54,582,134 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4823:Rapgef6
|
UTSW |
11 |
54,585,326 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4859:Rapgef6
|
UTSW |
11 |
54,526,989 (GRCm39) |
missense |
probably benign |
|
|
R4906:Rapgef6
|
UTSW |
11 |
54,443,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4911:Rapgef6
|
UTSW |
11 |
54,513,143 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4937:Rapgef6
|
UTSW |
11 |
54,548,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5033:Rapgef6
|
UTSW |
11 |
54,582,207 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5249:Rapgef6
|
UTSW |
11 |
54,413,943 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5304:Rapgef6
|
UTSW |
11 |
54,548,200 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5656:Rapgef6
|
UTSW |
11 |
54,526,962 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5701:Rapgef6
|
UTSW |
11 |
54,567,220 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R5758:Rapgef6
|
UTSW |
11 |
54,559,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5973:Rapgef6
|
UTSW |
11 |
54,530,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6177:Rapgef6
|
UTSW |
11 |
54,510,842 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6268:Rapgef6
|
UTSW |
11 |
54,540,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6287:Rapgef6
|
UTSW |
11 |
54,517,164 (GRCm39) |
splice site |
probably null |
|
|
R6293:Rapgef6
|
UTSW |
11 |
54,525,607 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Rapgef6
|
UTSW |
11 |
54,582,563 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6863:Rapgef6
|
UTSW |
11 |
54,437,206 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6950:Rapgef6
|
UTSW |
11 |
54,567,206 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7144:Rapgef6
|
UTSW |
11 |
54,548,191 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7171:Rapgef6
|
UTSW |
11 |
54,567,189 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7291:Rapgef6
|
UTSW |
11 |
54,582,065 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7436:Rapgef6
|
UTSW |
11 |
54,501,747 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7498:Rapgef6
|
UTSW |
11 |
54,510,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7506:Rapgef6
|
UTSW |
11 |
54,526,997 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7527:Rapgef6
|
UTSW |
11 |
54,525,787 (GRCm39) |
missense |
unknown |
|
|
R7646:Rapgef6
|
UTSW |
11 |
54,516,780 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7655:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7656:Rapgef6
|
UTSW |
11 |
54,585,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7687:Rapgef6
|
UTSW |
11 |
54,551,901 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7768:Rapgef6
|
UTSW |
11 |
54,517,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7788:Rapgef6
|
UTSW |
11 |
54,585,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7890:Rapgef6
|
UTSW |
11 |
54,517,549 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8113:Rapgef6
|
UTSW |
11 |
54,516,784 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8337:Rapgef6
|
UTSW |
11 |
54,522,127 (GRCm39) |
nonsense |
probably null |
|
|
R8393:Rapgef6
|
UTSW |
11 |
54,578,487 (GRCm39) |
missense |
probably benign |
|
|
R8465:Rapgef6
|
UTSW |
11 |
54,582,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8492:Rapgef6
|
UTSW |
11 |
54,581,063 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8791:Rapgef6
|
UTSW |
11 |
54,459,295 (GRCm39) |
missense |
probably benign |
0.15 |
|
R8866:Rapgef6
|
UTSW |
11 |
54,443,700 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8917:Rapgef6
|
UTSW |
11 |
54,582,392 (GRCm39) |
nonsense |
probably null |
|
|
R8921:Rapgef6
|
UTSW |
11 |
54,570,065 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9031:Rapgef6
|
UTSW |
11 |
54,578,667 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9093:Rapgef6
|
UTSW |
11 |
54,487,912 (GRCm39) |
nonsense |
probably null |
|
|
R9354:Rapgef6
|
UTSW |
11 |
54,510,749 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9514:Rapgef6
|
UTSW |
11 |
54,443,684 (GRCm39) |
missense |
probably benign |
0.14 |
|
R9516:Rapgef6
|
UTSW |
11 |
54,582,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9739:Rapgef6
|
UTSW |
11 |
54,513,189 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9789:Rapgef6
|
UTSW |
11 |
54,540,097 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGACTGCCTCAGCCTCAATC -3'
(R):5'- AGCCAGTGTCTTTAGCAACAG -3'
Sequencing Primer
(F):5'- GCATATGCCTCAGTCACAGG -3'
(R):5'- GCCAGTGTCTTTAGCAACAGTAGTC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation