Incidental Mutation 'R7199:Dapk1'
| ID |
560194 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
045277-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7199 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 60902024 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 951
(I951T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076666
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044083
AA Change: I951T
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: I951T
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077453
AA Change: I951T
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: I951T
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226059
AA Change: I951T
PolyPhen 2
Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310034C09Rik |
A |
G |
16: 88,555,902 (GRCm39) |
T39A |
probably damaging |
Het |
| Abca3 |
G |
A |
17: 24,596,681 (GRCm39) |
G378D |
probably damaging |
Het |
| Abtb2 |
T |
C |
2: 103,397,565 (GRCm39) |
V165A |
possibly damaging |
Het |
| Ache |
A |
G |
5: 137,288,504 (GRCm39) |
E70G |
probably damaging |
Het |
| Adamtsl4 |
T |
C |
3: 95,588,119 (GRCm39) |
T623A |
probably benign |
Het |
| Ahdc1 |
G |
A |
4: 132,791,935 (GRCm39) |
V1059I |
probably benign |
Het |
| Ajuba |
G |
A |
14: 54,810,915 (GRCm39) |
Q357* |
probably null |
Het |
| Ano7 |
A |
T |
1: 93,330,700 (GRCm39) |
D54V |
|
Het |
| Apob |
A |
T |
12: 8,055,072 (GRCm39) |
D1357V |
probably damaging |
Het |
| Atad2b |
T |
A |
12: 5,067,992 (GRCm39) |
Y997N |
probably damaging |
Het |
| Bhlhe22 |
C |
A |
3: 18,110,006 (GRCm39) |
T352K |
probably damaging |
Het |
| Bsn |
T |
C |
9: 107,992,533 (GRCm39) |
E1073G |
probably damaging |
Het |
| Bzw2 |
G |
A |
12: 36,180,054 (GRCm39) |
R58* |
probably null |
Het |
| C7 |
G |
T |
15: 5,023,725 (GRCm39) |
S694R |
probably benign |
Het |
| Cbr2 |
T |
A |
11: 120,621,087 (GRCm39) |
H170L |
probably benign |
Het |
| Cdcp3 |
G |
A |
7: 130,837,641 (GRCm39) |
W512* |
probably null |
Het |
| Cgas |
C |
A |
9: 78,340,315 (GRCm39) |
K472N |
probably benign |
Het |
| Ckap2l |
T |
C |
2: 129,126,975 (GRCm39) |
N401S |
probably benign |
Het |
| Cldn1 |
A |
G |
16: 26,190,346 (GRCm39) |
F11L |
probably benign |
Het |
| Cmtr1 |
A |
G |
17: 29,895,174 (GRCm39) |
T118A |
probably benign |
Het |
| Cog6 |
T |
C |
3: 52,890,610 (GRCm39) |
E610G |
probably benign |
Het |
| Col3a1 |
G |
T |
1: 45,371,301 (GRCm39) |
A451S |
probably null |
Het |
| Cr1l |
T |
A |
1: 194,799,878 (GRCm39) |
R265S |
probably benign |
Het |
| Dnah9 |
T |
C |
11: 66,009,770 (GRCm39) |
N706D |
probably benign |
Het |
| Dpysl5 |
A |
T |
5: 30,940,539 (GRCm39) |
T239S |
probably benign |
Het |
| Ect2l |
T |
A |
10: 18,004,894 (GRCm39) |
Y913F |
probably benign |
Het |
| Elf5 |
C |
A |
2: 103,269,641 (GRCm39) |
A74D |
possibly damaging |
Het |
| Erap1 |
T |
C |
13: 74,814,258 (GRCm39) |
V399A |
probably benign |
Het |
| Ercc4 |
A |
G |
16: 12,965,657 (GRCm39) |
D763G |
probably damaging |
Het |
| Fam222b |
T |
A |
11: 78,045,683 (GRCm39) |
C415S |
possibly damaging |
Het |
| Fat4 |
A |
C |
3: 39,031,511 (GRCm39) |
N2432T |
probably damaging |
Het |
| Fbn2 |
G |
T |
18: 58,186,833 (GRCm39) |
C1689* |
probably null |
Het |
| Frrs1l |
T |
A |
4: 56,972,282 (GRCm39) |
T140S |
probably damaging |
Het |
| Gm5141 |
A |
T |
13: 62,924,877 (GRCm39) |
H10Q |
possibly damaging |
Het |
| Inafm1 |
A |
T |
7: 16,007,079 (GRCm39) |
L46Q |
probably damaging |
Het |
| Irak2 |
T |
C |
6: 113,650,045 (GRCm39) |
L260P |
probably damaging |
Het |
| Kat2b |
T |
C |
17: 53,977,706 (GRCm39) |
L751P |
probably damaging |
Het |
| Kcnh1 |
T |
A |
1: 192,019,913 (GRCm39) |
I413N |
probably benign |
Het |
| Kirrel1 |
T |
C |
3: 86,990,695 (GRCm39) |
D709G |
probably benign |
Het |
| Lama4 |
T |
C |
10: 38,956,536 (GRCm39) |
V1153A |
possibly damaging |
Het |
| Lipg |
A |
T |
18: 75,088,655 (GRCm39) |
F98L |
probably benign |
Het |
| Lman1 |
T |
C |
18: 66,127,936 (GRCm39) |
E236G |
probably damaging |
Het |
| Lrp1 |
T |
A |
10: 127,409,325 (GRCm39) |
D1598V |
probably damaging |
Het |
| Lrrc71 |
T |
A |
3: 87,650,384 (GRCm39) |
N230Y |
probably damaging |
Het |
| Maneal |
T |
C |
4: 124,750,983 (GRCm39) |
S258G |
possibly damaging |
Het |
| Marchf10 |
T |
A |
11: 105,281,532 (GRCm39) |
E251V |
probably damaging |
Het |
| Mpdz |
A |
G |
4: 81,215,570 (GRCm39) |
I1484T |
probably damaging |
Het |
| Mtcl1 |
T |
A |
17: 66,647,534 (GRCm39) |
N1882I |
probably benign |
Het |
| Neb |
G |
A |
2: 52,110,212 (GRCm39) |
A212V |
probably benign |
Het |
| Obscn |
G |
A |
11: 58,903,672 (GRCm39) |
S7434L |
probably benign |
Het |
| Or14j8 |
A |
C |
17: 38,263,048 (GRCm39) |
I289S |
probably damaging |
Het |
| Or1ad8 |
T |
A |
11: 50,898,223 (GRCm39) |
C141* |
probably null |
Het |
| Or1j12 |
A |
T |
2: 36,342,872 (GRCm39) |
I92F |
probably damaging |
Het |
| Or4k47 |
T |
C |
2: 111,451,538 (GRCm39) |
M294V |
probably benign |
Het |
| Or8g2b |
A |
G |
9: 39,750,753 (GRCm39) |
M8V |
probably benign |
Het |
| Orc6 |
T |
C |
8: 86,029,590 (GRCm39) |
|
probably null |
Het |
| Otogl |
T |
G |
10: 107,710,394 (GRCm39) |
E565A |
possibly damaging |
Het |
| Papss1 |
A |
G |
3: 131,290,899 (GRCm39) |
Q214R |
probably benign |
Het |
| Pck2 |
G |
A |
14: 55,786,169 (GRCm39) |
V653M |
probably benign |
Het |
| Plxna4 |
G |
A |
6: 32,192,113 (GRCm39) |
Q826* |
probably null |
Het |
| Pms1 |
T |
A |
1: 53,295,889 (GRCm39) |
T161S |
probably benign |
Het |
| Prkar2a |
C |
A |
9: 108,617,669 (GRCm39) |
N242K |
probably damaging |
Het |
| Prss1 |
T |
A |
6: 41,439,690 (GRCm39) |
I141N |
probably damaging |
Het |
| Puf60 |
A |
G |
15: 75,943,717 (GRCm39) |
V235A |
probably damaging |
Het |
| Rapgef6 |
T |
A |
11: 54,437,252 (GRCm39) |
F65Y |
probably benign |
Het |
| Rasgef1b |
T |
C |
5: 99,447,898 (GRCm39) |
E104G |
unknown |
Het |
| Rcn3 |
T |
C |
7: 44,734,333 (GRCm39) |
Y225C |
probably damaging |
Het |
| Rhot1 |
G |
C |
11: 80,137,560 (GRCm39) |
W354S |
probably damaging |
Het |
| Rp1 |
T |
C |
1: 4,417,513 (GRCm39) |
S1200G |
possibly damaging |
Het |
| Scaper |
T |
A |
9: 55,745,460 (GRCm39) |
K603* |
probably null |
Het |
| Selenbp1 |
G |
A |
3: 94,851,745 (GRCm39) |
V429I |
possibly damaging |
Het |
| Setd5 |
T |
G |
6: 113,098,099 (GRCm39) |
S713A |
probably benign |
Het |
| Shank1 |
T |
C |
7: 44,002,564 (GRCm39) |
Y1428H |
possibly damaging |
Het |
| Slc11a1 |
G |
T |
1: 74,422,830 (GRCm39) |
W361L |
possibly damaging |
Het |
| Spta1 |
A |
T |
1: 174,050,837 (GRCm39) |
D1772V |
possibly damaging |
Het |
| St8sia6 |
T |
C |
2: 13,661,721 (GRCm39) |
H370R |
probably damaging |
Het |
| Stkld1 |
A |
T |
2: 26,842,726 (GRCm39) |
D566V |
probably damaging |
Het |
| Tango6 |
T |
C |
8: 107,415,791 (GRCm39) |
V204A |
probably benign |
Het |
| Tdrd5 |
G |
A |
1: 156,129,293 (GRCm39) |
A139V |
probably damaging |
Het |
| Tenm2 |
A |
T |
11: 36,062,263 (GRCm39) |
V534E |
probably damaging |
Het |
| Tfip11 |
A |
T |
5: 112,479,044 (GRCm39) |
Q204L |
probably benign |
Het |
| Tlr4 |
A |
T |
4: 66,759,430 (GRCm39) |
Q741L |
probably damaging |
Het |
| Tmem18 |
A |
G |
12: 30,638,654 (GRCm39) |
M111V |
probably benign |
Het |
| Togaram1 |
A |
G |
12: 65,042,292 (GRCm39) |
N1167S |
probably benign |
Het |
| Trappc3 |
C |
T |
4: 126,168,945 (GRCm39) |
A145V |
possibly damaging |
Het |
| Trbj2-3 |
T |
C |
6: 41,520,176 (GRCm39) |
F7S |
probably damaging |
Het |
| Vinac1 |
A |
G |
2: 128,880,238 (GRCm39) |
S563P |
|
Het |
| Vmn1r212 |
T |
A |
13: 23,067,731 (GRCm39) |
M201L |
probably benign |
Het |
| Xaf1 |
C |
A |
11: 72,194,201 (GRCm39) |
C27* |
probably null |
Het |
| Zeb1 |
T |
C |
18: 5,767,703 (GRCm39) |
V738A |
probably benign |
Het |
| Zfp524 |
A |
T |
7: 5,020,883 (GRCm39) |
H137L |
probably damaging |
Het |
| Zfyve19 |
A |
T |
2: 119,047,118 (GRCm39) |
H367L |
probably damaging |
Het |
| Zim1 |
G |
A |
7: 6,680,872 (GRCm39) |
Q264* |
probably null |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTAGGAACATGGCCCCTAC -3'
(R):5'- TCTGAGGTGGTCCACTATTGTC -3'
Sequencing Primer
(F):5'- CCTACATGGGAAGACTAAAGTTGGC -3'
(R):5'- GAGGTGGTCCACTATTGTCCATAAC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation