Incidental Mutation 'R7199:Or14j8'
ID 560206
Institutional Source Beutler Lab
Gene Symbol Or14j8
Ensembl Gene ENSMUSG00000109376
Gene Name olfactory receptor family 14 subfamily J member 8
Synonyms Olfr1552-ps1, MOR218-6P, GA_x6K02T2PSCP-2403971-2403000, Olfr761, MOR218-12, MOR218-5P, MOR218-6P
MMRRC Submission 045277-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.784) question?
Stock # R7199 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 38262942-38263913 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 38263048 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 289 (I289S)
Ref Sequence ENSEMBL: ENSMUSP00000092917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049620]
AlphaFold Q7TRJ0
Predicted Effect probably damaging
Transcript: ENSMUST00000049620
AA Change: I289S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000092917
Gene: ENSMUSG00000109376
AA Change: I289S

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.8e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.1e-6 PFAM
Pfam:7tm_1 41 290 3.7e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 93 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310034C09Rik A G 16: 88,555,902 (GRCm39) T39A probably damaging Het
Abca3 G A 17: 24,596,681 (GRCm39) G378D probably damaging Het
Abtb2 T C 2: 103,397,565 (GRCm39) V165A possibly damaging Het
Ache A G 5: 137,288,504 (GRCm39) E70G probably damaging Het
Adamtsl4 T C 3: 95,588,119 (GRCm39) T623A probably benign Het
Ahdc1 G A 4: 132,791,935 (GRCm39) V1059I probably benign Het
Ajuba G A 14: 54,810,915 (GRCm39) Q357* probably null Het
Ano7 A T 1: 93,330,700 (GRCm39) D54V Het
Apob A T 12: 8,055,072 (GRCm39) D1357V probably damaging Het
Atad2b T A 12: 5,067,992 (GRCm39) Y997N probably damaging Het
Bhlhe22 C A 3: 18,110,006 (GRCm39) T352K probably damaging Het
Bsn T C 9: 107,992,533 (GRCm39) E1073G probably damaging Het
Bzw2 G A 12: 36,180,054 (GRCm39) R58* probably null Het
C7 G T 15: 5,023,725 (GRCm39) S694R probably benign Het
Cbr2 T A 11: 120,621,087 (GRCm39) H170L probably benign Het
Cdcp3 G A 7: 130,837,641 (GRCm39) W512* probably null Het
Cgas C A 9: 78,340,315 (GRCm39) K472N probably benign Het
Ckap2l T C 2: 129,126,975 (GRCm39) N401S probably benign Het
Cldn1 A G 16: 26,190,346 (GRCm39) F11L probably benign Het
Cmtr1 A G 17: 29,895,174 (GRCm39) T118A probably benign Het
Cog6 T C 3: 52,890,610 (GRCm39) E610G probably benign Het
Col3a1 G T 1: 45,371,301 (GRCm39) A451S probably null Het
Cr1l T A 1: 194,799,878 (GRCm39) R265S probably benign Het
Dapk1 T C 13: 60,902,024 (GRCm39) I951T probably benign Het
Dnah9 T C 11: 66,009,770 (GRCm39) N706D probably benign Het
Dpysl5 A T 5: 30,940,539 (GRCm39) T239S probably benign Het
Ect2l T A 10: 18,004,894 (GRCm39) Y913F probably benign Het
Elf5 C A 2: 103,269,641 (GRCm39) A74D possibly damaging Het
Erap1 T C 13: 74,814,258 (GRCm39) V399A probably benign Het
Ercc4 A G 16: 12,965,657 (GRCm39) D763G probably damaging Het
Fam222b T A 11: 78,045,683 (GRCm39) C415S possibly damaging Het
Fat4 A C 3: 39,031,511 (GRCm39) N2432T probably damaging Het
Fbn2 G T 18: 58,186,833 (GRCm39) C1689* probably null Het
Frrs1l T A 4: 56,972,282 (GRCm39) T140S probably damaging Het
Gm5141 A T 13: 62,924,877 (GRCm39) H10Q possibly damaging Het
Inafm1 A T 7: 16,007,079 (GRCm39) L46Q probably damaging Het
Irak2 T C 6: 113,650,045 (GRCm39) L260P probably damaging Het
Kat2b T C 17: 53,977,706 (GRCm39) L751P probably damaging Het
Kcnh1 T A 1: 192,019,913 (GRCm39) I413N probably benign Het
Kirrel1 T C 3: 86,990,695 (GRCm39) D709G probably benign Het
Lama4 T C 10: 38,956,536 (GRCm39) V1153A possibly damaging Het
Lipg A T 18: 75,088,655 (GRCm39) F98L probably benign Het
Lman1 T C 18: 66,127,936 (GRCm39) E236G probably damaging Het
Lrp1 T A 10: 127,409,325 (GRCm39) D1598V probably damaging Het
Lrrc71 T A 3: 87,650,384 (GRCm39) N230Y probably damaging Het
Maneal T C 4: 124,750,983 (GRCm39) S258G possibly damaging Het
Marchf10 T A 11: 105,281,532 (GRCm39) E251V probably damaging Het
Mpdz A G 4: 81,215,570 (GRCm39) I1484T probably damaging Het
Mtcl1 T A 17: 66,647,534 (GRCm39) N1882I probably benign Het
Neb G A 2: 52,110,212 (GRCm39) A212V probably benign Het
Obscn G A 11: 58,903,672 (GRCm39) S7434L probably benign Het
Or1ad8 T A 11: 50,898,223 (GRCm39) C141* probably null Het
Or1j12 A T 2: 36,342,872 (GRCm39) I92F probably damaging Het
Or4k47 T C 2: 111,451,538 (GRCm39) M294V probably benign Het
Or8g2b A G 9: 39,750,753 (GRCm39) M8V probably benign Het
Orc6 T C 8: 86,029,590 (GRCm39) probably null Het
Otogl T G 10: 107,710,394 (GRCm39) E565A possibly damaging Het
Papss1 A G 3: 131,290,899 (GRCm39) Q214R probably benign Het
Pck2 G A 14: 55,786,169 (GRCm39) V653M probably benign Het
Plxna4 G A 6: 32,192,113 (GRCm39) Q826* probably null Het
Pms1 T A 1: 53,295,889 (GRCm39) T161S probably benign Het
Prkar2a C A 9: 108,617,669 (GRCm39) N242K probably damaging Het
Prss1 T A 6: 41,439,690 (GRCm39) I141N probably damaging Het
Puf60 A G 15: 75,943,717 (GRCm39) V235A probably damaging Het
Rapgef6 T A 11: 54,437,252 (GRCm39) F65Y probably benign Het
Rasgef1b T C 5: 99,447,898 (GRCm39) E104G unknown Het
Rcn3 T C 7: 44,734,333 (GRCm39) Y225C probably damaging Het
Rhot1 G C 11: 80,137,560 (GRCm39) W354S probably damaging Het
Rp1 T C 1: 4,417,513 (GRCm39) S1200G possibly damaging Het
Scaper T A 9: 55,745,460 (GRCm39) K603* probably null Het
Selenbp1 G A 3: 94,851,745 (GRCm39) V429I possibly damaging Het
Setd5 T G 6: 113,098,099 (GRCm39) S713A probably benign Het
Shank1 T C 7: 44,002,564 (GRCm39) Y1428H possibly damaging Het
Slc11a1 G T 1: 74,422,830 (GRCm39) W361L possibly damaging Het
Spta1 A T 1: 174,050,837 (GRCm39) D1772V possibly damaging Het
St8sia6 T C 2: 13,661,721 (GRCm39) H370R probably damaging Het
Stkld1 A T 2: 26,842,726 (GRCm39) D566V probably damaging Het
Tango6 T C 8: 107,415,791 (GRCm39) V204A probably benign Het
Tdrd5 G A 1: 156,129,293 (GRCm39) A139V probably damaging Het
Tenm2 A T 11: 36,062,263 (GRCm39) V534E probably damaging Het
Tfip11 A T 5: 112,479,044 (GRCm39) Q204L probably benign Het
Tlr4 A T 4: 66,759,430 (GRCm39) Q741L probably damaging Het
Tmem18 A G 12: 30,638,654 (GRCm39) M111V probably benign Het
Togaram1 A G 12: 65,042,292 (GRCm39) N1167S probably benign Het
Trappc3 C T 4: 126,168,945 (GRCm39) A145V possibly damaging Het
Trbj2-3 T C 6: 41,520,176 (GRCm39) F7S probably damaging Het
Vinac1 A G 2: 128,880,238 (GRCm39) S563P Het
Vmn1r212 T A 13: 23,067,731 (GRCm39) M201L probably benign Het
Xaf1 C A 11: 72,194,201 (GRCm39) C27* probably null Het
Zeb1 T C 18: 5,767,703 (GRCm39) V738A probably benign Het
Zfp524 A T 7: 5,020,883 (GRCm39) H137L probably damaging Het
Zfyve19 A T 2: 119,047,118 (GRCm39) H367L probably damaging Het
Zim1 G A 7: 6,680,872 (GRCm39) Q264* probably null Het
Other mutations in Or14j8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01557:Or14j8 APN 17 38,263,742 (GRCm39) missense probably damaging 1.00
IGL02104:Or14j8 APN 17 38,263,182 (GRCm39) missense probably damaging 1.00
IGL02431:Or14j8 APN 17 38,263,413 (GRCm39) missense probably benign 0.06
IGL02649:Or14j8 APN 17 38,263,864 (GRCm39) missense probably damaging 1.00
IGL03109:Or14j8 APN 17 38,263,378 (GRCm39) missense probably damaging 1.00
IGL03261:Or14j8 APN 17 38,263,697 (GRCm39) missense possibly damaging 0.76
R0898:Or14j8 UTSW 17 38,263,127 (GRCm39) missense probably benign 0.17
R1373:Or14j8 UTSW 17 38,263,251 (GRCm39) missense probably damaging 1.00
R1527:Or14j8 UTSW 17 38,263,720 (GRCm39) missense possibly damaging 0.88
R1664:Or14j8 UTSW 17 38,263,784 (GRCm39) missense probably benign 0.44
R1835:Or14j8 UTSW 17 38,263,276 (GRCm39) missense possibly damaging 0.79
R4124:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4125:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4128:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4534:Or14j8 UTSW 17 38,263,613 (GRCm39) missense probably benign
R4557:Or14j8 UTSW 17 38,263,142 (GRCm39) missense probably benign 0.10
R4790:Or14j8 UTSW 17 38,263,633 (GRCm39) missense probably damaging 0.99
R4856:Or14j8 UTSW 17 38,262,962 (GRCm39) missense probably benign 0.15
R4886:Or14j8 UTSW 17 38,262,962 (GRCm39) missense probably benign 0.15
R4955:Or14j8 UTSW 17 38,263,789 (GRCm39) missense probably damaging 1.00
R5162:Or14j8 UTSW 17 38,263,255 (GRCm39) missense probably benign 0.00
R6016:Or14j8 UTSW 17 38,262,967 (GRCm39) missense probably benign 0.13
R6282:Or14j8 UTSW 17 38,263,315 (GRCm39) missense possibly damaging 0.80
R7018:Or14j8 UTSW 17 38,263,393 (GRCm39) missense probably damaging 1.00
R7340:Or14j8 UTSW 17 38,263,413 (GRCm39) missense probably benign 0.06
R7360:Or14j8 UTSW 17 38,263,900 (GRCm39) missense probably damaging 1.00
R7464:Or14j8 UTSW 17 38,263,171 (GRCm39) missense probably damaging 1.00
R7974:Or14j8 UTSW 17 38,263,672 (GRCm39) missense probably damaging 1.00
R8719:Or14j8 UTSW 17 38,263,895 (GRCm39) missense probably damaging 0.97
R8738:Or14j8 UTSW 17 38,263,673 (GRCm39) missense possibly damaging 0.79
R8817:Or14j8 UTSW 17 38,263,273 (GRCm39) missense probably damaging 0.99
R8856:Or14j8 UTSW 17 38,263,091 (GRCm39) missense possibly damaging 0.87
R9006:Or14j8 UTSW 17 38,263,545 (GRCm39) nonsense probably null
R9432:Or14j8 UTSW 17 38,263,559 (GRCm39) missense probably damaging 1.00
X0064:Or14j8 UTSW 17 38,263,705 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGTACCAGTGTGGATGGACTG -3'
(R):5'- AAGGCAGATCTAAGGTCTTCTCC -3'

Sequencing Primer
(F):5'- GTTCAAAGAATCACATCAAAACTTGC -3'
(R):5'- GCAGATCTAAGGTCTTCTCCACCTG -3'
Posted On 2019-06-26