Incidental Mutation 'R7202:Cyp2c66'
ID 560411
Institutional Source Beutler Lab
Gene Symbol Cyp2c66
Ensembl Gene ENSMUSG00000067229
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 66
Synonyms 2010301M18Rik
MMRRC Submission 045280-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R7202 (G1)
Quality Score 205.009
Status Validated
Chromosome 19
Chromosomal Location 39102342-39175200 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39130348 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 61 (Y61F)
Ref Sequence ENSEMBL: ENSMUSP00000084487 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087234] [ENSMUST00000146494]
AlphaFold Q5GLZ0
Predicted Effect probably damaging
Transcript: ENSMUST00000087234
AA Change: Y61F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000084487
Gene: ENSMUSG00000067229
AA Change: Y61F

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Pfam:p450 30 487 1e-157 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000146494
SMART Domains Protein: ENSMUSP00000120397
Gene: ENSMUSG00000067229

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
SCOP:d1cpt__ 26 55 4e-9 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 99% (74/75)
Allele List at MGI
Other mutations in this stock
Total: 74 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca14 T C 7: 119,917,236 (GRCm39) I1467T probably damaging Het
Abtb3 A G 10: 85,223,629 (GRCm39) E146G unknown Het
Adgrf3 T A 5: 30,409,378 (GRCm39) K38* probably null Het
Ahdc1 T A 4: 132,789,198 (GRCm39) C146* probably null Het
Ahnak A T 19: 8,995,163 (GRCm39) K5482N probably damaging Het
Arhgap23 C T 11: 97,342,819 (GRCm39) A367V possibly damaging Het
Arvcf T C 16: 18,223,948 (GRCm39) S960P probably damaging Het
Asb14 C A 14: 26,622,394 (GRCm39) P74Q probably benign Het
Atad5 T C 11: 79,980,601 (GRCm39) V2A probably damaging Het
Baz2a A G 10: 127,954,428 (GRCm39) I691M possibly damaging Het
Brca2 A G 5: 150,455,819 (GRCm39) T187A probably benign Het
Calr4 T A 4: 109,101,254 (GRCm39) N152K possibly damaging Het
Ccnb2 C T 9: 70,318,128 (GRCm39) A215T probably damaging Het
Cdh16 C T 8: 105,340,780 (GRCm39) D140N unknown Het
Ces1g T C 8: 94,029,595 (GRCm39) T546A probably benign Het
Cfap74 G T 4: 155,510,654 (GRCm39) probably null Het
Cfap91 T C 16: 38,155,959 (GRCm39) Y88C probably benign Het
Col5a1 G T 2: 27,842,390 (GRCm39) D422Y unknown Het
Dnah12 G A 14: 26,500,869 (GRCm39) probably null Het
Dnah6 A G 6: 73,158,688 (GRCm39) probably null Het
Dop1a T G 9: 86,386,220 (GRCm39) probably null Het
Fam163a A G 1: 155,954,834 (GRCm39) F106L probably damaging Het
Gfy T C 7: 44,827,596 (GRCm39) T167A probably benign Het
Gm6525 A T 3: 84,082,341 (GRCm39) R87S probably benign Het
Gramd1c C A 16: 43,879,584 (GRCm39) A19S possibly damaging Het
Herc2 T C 7: 55,781,034 (GRCm39) V1233A probably damaging Het
Hibch G A 1: 52,892,874 (GRCm39) probably null Het
Ibsp A T 5: 104,450,027 (GRCm39) S9C probably benign Het
Il17ra A G 6: 120,452,572 (GRCm39) I252V probably benign Het
Ino80 A T 2: 119,204,918 (GRCm39) M1536K probably benign Het
Ipo11 A T 13: 107,012,078 (GRCm39) L568Q probably damaging Het
Kcnu1 T G 8: 26,409,609 (GRCm39) probably null Het
Kdm5b T G 1: 134,552,497 (GRCm39) S1158A probably benign Het
Kmt2a T C 9: 44,759,012 (GRCm39) T946A probably benign Het
Kmt2e A T 5: 23,697,292 (GRCm39) probably benign Het
Krba1 G A 6: 48,389,261 (GRCm39) V594M probably damaging Het
Lamb1 T C 12: 31,374,314 (GRCm39) L1559P probably damaging Het
Lig1 C T 7: 13,025,175 (GRCm39) P227S probably benign Het
Lims2 T A 18: 32,090,017 (GRCm39) D255E probably benign Het
Marchf3 C T 18: 56,909,161 (GRCm39) C208Y probably benign Het
Mei1 A G 15: 81,976,843 (GRCm39) E142G Het
Melk G T 4: 44,351,106 (GRCm39) R549L probably benign Het
Muc6 AGGCGCAGAAACCCTGGC AGGC 7: 141,214,363 (GRCm39) probably null Het
Myorg T C 4: 41,498,268 (GRCm39) Y454C probably damaging Het
Nae1 T C 8: 105,250,215 (GRCm39) Y226C possibly damaging Het
Nap1l1 T C 10: 111,326,964 (GRCm39) F175S probably damaging Het
Ndn T C 7: 61,998,709 (GRCm39) L185P probably damaging Het
Ndst3 T A 3: 123,465,388 (GRCm39) I195F possibly damaging Het
Ndufaf1 A T 2: 119,488,907 (GRCm39) S206T probably benign Het
Nek10 C A 14: 14,836,171 (GRCm38) H131N probably benign Het
Obsl1 T A 1: 75,466,360 (GRCm39) D1456V possibly damaging Het
Or10a2 A G 7: 106,673,448 (GRCm39) N138D probably benign Het
Or10ak7 C T 4: 118,791,215 (GRCm39) V277I probably benign Het
Or52s6 T A 7: 103,092,292 (GRCm39) T13S probably benign Het
Otog C T 7: 45,937,474 (GRCm39) L1728F probably damaging Het
Pcx A T 19: 4,652,361 (GRCm39) M150L possibly damaging Het
Pole A G 5: 110,444,973 (GRCm39) D443G possibly damaging Het
Prr14 G T 7: 127,075,648 (GRCm39) R552L probably damaging Het
Rasgrf1 T G 9: 89,899,125 (GRCm39) S1156A possibly damaging Het
Rfc4 T A 16: 22,946,359 (GRCm39) probably benign Het
Rfx5 G T 3: 94,866,272 (GRCm39) A524S unknown Het
Ryr3 G A 2: 112,596,664 (GRCm39) P2497S probably damaging Het
Scg3 T C 9: 75,590,992 (GRCm39) T6A probably benign Het
Slc26a9 A T 1: 131,690,526 (GRCm39) D510V possibly damaging Het
Stpg3 A G 2: 25,104,586 (GRCm39) F10L probably damaging Het
Tmc5 T A 7: 118,239,179 (GRCm39) H357Q possibly damaging Het
Tmem40 A T 6: 115,707,420 (GRCm39) L253H probably damaging Het
Tmie A G 9: 110,696,632 (GRCm39) V83A probably damaging Het
Uck2 A T 1: 167,054,084 (GRCm39) I218N probably damaging Het
Vtn A G 11: 78,391,626 (GRCm39) D310G possibly damaging Het
Wdr49 A T 3: 75,240,580 (GRCm39) S430T probably benign Het
Wtip A G 7: 33,832,087 (GRCm39) V133A probably benign Het
Zbtb9 T A 17: 27,193,666 (GRCm39) V357E probably damaging Het
Zfp953 G A 13: 67,491,706 (GRCm39) T82M probably benign Het
Other mutations in Cyp2c66
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01145:Cyp2c66 APN 19 39,159,405 (GRCm39) missense probably benign 0.00
IGL01589:Cyp2c66 APN 19 39,172,379 (GRCm39) critical splice donor site probably null
IGL02098:Cyp2c66 APN 19 39,159,473 (GRCm39) missense probably damaging 1.00
IGL02114:Cyp2c66 APN 19 39,159,519 (GRCm39) splice site probably benign
IGL02567:Cyp2c66 APN 19 39,175,084 (GRCm39) utr 3 prime probably benign
IGL03181:Cyp2c66 APN 19 39,130,483 (GRCm39) missense probably benign 0.00
IGL03230:Cyp2c66 APN 19 39,172,302 (GRCm39) missense possibly damaging 0.91
R0007:Cyp2c66 UTSW 19 39,159,402 (GRCm39) nonsense probably null
R0092:Cyp2c66 UTSW 19 39,172,224 (GRCm39) splice site probably benign
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0242:Cyp2c66 UTSW 19 39,130,369 (GRCm39) missense probably damaging 1.00
R0324:Cyp2c66 UTSW 19 39,165,135 (GRCm39) missense probably benign 0.27
R0675:Cyp2c66 UTSW 19 39,175,060 (GRCm39) missense possibly damaging 0.93
R1127:Cyp2c66 UTSW 19 39,151,812 (GRCm39) missense probably damaging 1.00
R1871:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R3404:Cyp2c66 UTSW 19 39,151,771 (GRCm39) missense probably benign
R3429:Cyp2c66 UTSW 19 39,151,892 (GRCm39) missense probably damaging 0.97
R3896:Cyp2c66 UTSW 19 39,130,722 (GRCm39) missense possibly damaging 0.82
R4115:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4116:Cyp2c66 UTSW 19 39,165,003 (GRCm39) missense possibly damaging 0.66
R4667:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4668:Cyp2c66 UTSW 19 39,165,100 (GRCm39) missense probably damaging 1.00
R4711:Cyp2c66 UTSW 19 39,151,843 (GRCm39) missense possibly damaging 0.74
R4960:Cyp2c66 UTSW 19 39,151,766 (GRCm39) critical splice acceptor site probably null
R5070:Cyp2c66 UTSW 19 39,151,914 (GRCm39) missense probably benign 0.15
R5113:Cyp2c66 UTSW 19 39,151,882 (GRCm39) missense probably benign 0.00
R5125:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5178:Cyp2c66 UTSW 19 39,159,473 (GRCm39) missense probably damaging 1.00
R5588:Cyp2c66 UTSW 19 39,151,858 (GRCm39) missense possibly damaging 0.66
R6011:Cyp2c66 UTSW 19 39,130,380 (GRCm39) missense probably benign 0.00
R6497:Cyp2c66 UTSW 19 39,151,821 (GRCm39) missense probably damaging 0.96
R6707:Cyp2c66 UTSW 19 39,174,944 (GRCm39) missense probably damaging 1.00
R7173:Cyp2c66 UTSW 19 39,159,401 (GRCm39) missense probably benign 0.01
R7469:Cyp2c66 UTSW 19 39,172,307 (GRCm39) missense probably damaging 1.00
R7614:Cyp2c66 UTSW 19 39,159,472 (GRCm39) missense probably damaging 0.98
R7985:Cyp2c66 UTSW 19 39,102,430 (GRCm39) missense probably null 1.00
R8012:Cyp2c66 UTSW 19 39,172,369 (GRCm39) missense probably damaging 1.00
R8056:Cyp2c66 UTSW 19 39,130,485 (GRCm39) missense probably benign 0.00
R8302:Cyp2c66 UTSW 19 39,165,078 (GRCm39) missense probably damaging 1.00
R8329:Cyp2c66 UTSW 19 39,174,906 (GRCm39) nonsense probably null
R8365:Cyp2c66 UTSW 19 39,165,048 (GRCm39) missense probably benign 0.00
R8472:Cyp2c66 UTSW 19 39,165,021 (GRCm39) missense probably benign 0.03
R8502:Cyp2c66 UTSW 19 39,130,773 (GRCm39) missense probably benign 0.01
R8688:Cyp2c66 UTSW 19 39,151,884 (GRCm39) missense probably benign 0.00
R8715:Cyp2c66 UTSW 19 39,159,388 (GRCm39) missense probably benign 0.01
R9199:Cyp2c66 UTSW 19 39,130,800 (GRCm39) missense probably benign 0.16
R9551:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9552:Cyp2c66 UTSW 19 39,172,246 (GRCm39) missense probably damaging 0.99
R9601:Cyp2c66 UTSW 19 39,175,054 (GRCm39) missense probably benign
R9777:Cyp2c66 UTSW 19 39,102,520 (GRCm39) missense probably benign 0.15
Z1177:Cyp2c66 UTSW 19 39,175,070 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- GAGGAGATGCAGCCTGTATTC -3'
(R):5'- TCATGGACACTTAGGCACATGG -3'

Sequencing Primer
(F):5'- CTGCTGTGCTAGGGTTCACC -3'
(R):5'- CACTTAGGCACATGGACATATTGG -3'
Posted On 2019-06-26