Incidental Mutation 'R7204:Nynrin'
ID |
560471 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Nynrin
|
Ensembl Gene |
ENSMUSG00000075592 |
Gene Name |
NYN domain and retroviral integrase containing |
Synonyms |
|
MMRRC Submission |
045282-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R7204 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
14 |
Chromosomal Location |
56091572-56112193 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
G to C
at 56110190 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Glutamine
at position 1766
(E1766Q)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000098098
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100529]
[ENSMUST00000168479]
|
AlphaFold |
Q5DTZ0 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000100529
AA Change: E1766Q
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000098098 Gene: ENSMUSG00000075592 AA Change: E1766Q
Domain | Start | End | E-Value | Type |
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
Pfam:RNase_Zc3h12a
|
739 |
890 |
1.6e-54 |
PFAM |
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000168479
AA Change: E1766Q
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000129557 Gene: ENSMUSG00000075592 AA Change: E1766Q
Domain | Start | End | E-Value | Type |
low complexity region
|
581 |
606 |
N/A |
INTRINSIC |
Pfam:RNase_Zc3h12a
|
739 |
890 |
5.5e-54 |
PFAM |
low complexity region
|
938 |
952 |
N/A |
INTRINSIC |
low complexity region
|
1212 |
1228 |
N/A |
INTRINSIC |
low complexity region
|
1390 |
1397 |
N/A |
INTRINSIC |
PDB:3S3O|B
|
1478 |
1706 |
6e-8 |
PDB |
SCOP:d1cxqa_
|
1552 |
1646 |
2e-12 |
SMART |
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
Validation Efficiency |
99% (75/76) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 75 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700067K01Rik |
T |
C |
8: 84,730,636 (GRCm39) |
S227P |
probably damaging |
Het |
Acot6 |
A |
G |
12: 84,153,301 (GRCm39) |
H181R |
probably benign |
Het |
Adam15 |
A |
T |
3: 89,254,244 (GRCm39) |
H184Q |
probably benign |
Het |
Agl |
A |
G |
3: 116,587,469 (GRCm39) |
F29L |
probably benign |
Het |
Ak7 |
A |
G |
12: 105,708,502 (GRCm39) |
Y319C |
probably benign |
Het |
Ano8 |
C |
A |
8: 71,931,669 (GRCm39) |
V813L |
probably benign |
Het |
Apbb2 |
T |
G |
5: 66,608,946 (GRCm39) |
K234Q |
probably damaging |
Het |
Arfgef3 |
A |
T |
10: 18,522,210 (GRCm39) |
D605E |
probably damaging |
Het |
Bfsp2 |
C |
A |
9: 103,309,865 (GRCm39) |
R340L |
probably damaging |
Het |
Birc6 |
C |
A |
17: 74,947,103 (GRCm39) |
P2956T |
probably damaging |
Het |
C1rb |
T |
C |
6: 124,554,386 (GRCm39) |
I389T |
probably benign |
Het |
Ccdc146 |
A |
G |
5: 21,513,624 (GRCm39) |
F498S |
probably benign |
Het |
Cdc14b |
A |
C |
13: 64,358,012 (GRCm39) |
V361G |
possibly damaging |
Het |
Cdc25b |
A |
T |
2: 131,033,552 (GRCm39) |
I164F |
probably damaging |
Het |
Col18a1 |
A |
G |
10: 76,921,110 (GRCm39) |
S297P |
unknown |
Het |
Col3a1 |
A |
T |
1: 45,361,578 (GRCm39) |
I117F |
unknown |
Het |
Cox4i2 |
AG |
A |
2: 152,602,618 (GRCm39) |
|
probably null |
Het |
Crybg3 |
C |
A |
16: 59,379,253 (GRCm39) |
G667V |
probably benign |
Het |
Ctc1 |
A |
G |
11: 68,920,567 (GRCm39) |
D623G |
probably damaging |
Het |
Dennd1a |
A |
T |
2: 37,929,215 (GRCm39) |
H152Q |
probably damaging |
Het |
Dgke |
G |
A |
11: 88,932,306 (GRCm39) |
P495S |
probably damaging |
Het |
Dll3 |
A |
T |
7: 27,998,330 (GRCm39) |
C212S |
possibly damaging |
Het |
Dll4 |
A |
T |
2: 119,159,054 (GRCm39) |
S235C |
probably damaging |
Het |
Dnah12 |
G |
A |
14: 26,500,869 (GRCm39) |
|
probably null |
Het |
Dnah12 |
A |
T |
14: 26,503,442 (GRCm39) |
T1599S |
probably damaging |
Het |
Elavl1 |
G |
A |
8: 4,361,712 (GRCm39) |
T20M |
probably damaging |
Het |
Epha3 |
T |
C |
16: 63,472,695 (GRCm39) |
T397A |
probably benign |
Het |
Fanca |
A |
T |
8: 124,013,216 (GRCm39) |
I859N |
probably damaging |
Het |
Fzd1 |
A |
T |
5: 4,805,980 (GRCm39) |
V534D |
probably damaging |
Het |
Glmp |
A |
G |
3: 88,233,917 (GRCm39) |
Y258C |
probably damaging |
Het |
Gm9195 |
G |
A |
14: 72,711,626 (GRCm39) |
P329S |
probably damaging |
Het |
Gpt |
A |
G |
15: 76,583,199 (GRCm39) |
R379G |
probably benign |
Het |
Gsdmc2 |
T |
C |
15: 63,696,903 (GRCm39) |
T423A |
probably damaging |
Het |
Hemgn |
T |
C |
4: 46,397,054 (GRCm39) |
K61E |
possibly damaging |
Het |
Ikzf4 |
A |
T |
10: 128,479,759 (GRCm39) |
S56T |
possibly damaging |
Het |
Jak1 |
T |
C |
4: 101,032,332 (GRCm39) |
T425A |
probably benign |
Het |
Jsrp1 |
T |
C |
10: 80,646,319 (GRCm39) |
T80A |
probably benign |
Het |
Klra9 |
T |
A |
6: 130,165,643 (GRCm39) |
D124V |
possibly damaging |
Het |
Lama5 |
A |
T |
2: 179,843,970 (GRCm39) |
V397D |
probably damaging |
Het |
Lrp2 |
A |
G |
2: 69,302,877 (GRCm39) |
S2951P |
probably benign |
Het |
Map7d1 |
A |
G |
4: 126,149,808 (GRCm39) |
|
probably null |
Het |
Mcm6 |
A |
T |
1: 128,265,864 (GRCm39) |
C636S |
probably damaging |
Het |
Mia |
T |
C |
7: 26,880,358 (GRCm39) |
E39G |
possibly damaging |
Het |
Mpeg1 |
T |
A |
19: 12,440,258 (GRCm39) |
I572N |
probably damaging |
Het |
Muc21 |
AGCTGGATGCAGTGGTGGTCAGGGTGGGTGTAGAGCCTGAGCCAGTGCTGGATACAGTGGTGGTC |
AGCTGGATACAGTGGTGGTC |
17: 35,932,105 (GRCm39) |
|
probably benign |
Het |
Muc6 |
AGGCGCAGAAACCCTGGC |
AGGC |
7: 141,214,363 (GRCm39) |
|
probably null |
Het |
Mup5 |
A |
G |
4: 61,751,992 (GRCm39) |
Y86H |
probably damaging |
Het |
Nckap5 |
A |
T |
1: 125,954,104 (GRCm39) |
V816D |
probably benign |
Het |
Nfib |
T |
C |
4: 82,215,052 (GRCm39) |
|
probably null |
Het |
Nlrc5 |
T |
A |
8: 95,218,153 (GRCm39) |
V1056D |
possibly damaging |
Het |
Or7d9 |
A |
T |
9: 20,197,100 (GRCm39) |
Y43F |
probably benign |
Het |
Oxct1 |
T |
A |
15: 4,123,524 (GRCm39) |
L328Q |
probably damaging |
Het |
Pax5 |
T |
A |
4: 44,679,485 (GRCm39) |
I187F |
possibly damaging |
Het |
Pcdhb4 |
A |
T |
18: 37,442,292 (GRCm39) |
D534V |
probably damaging |
Het |
Pebp4 |
C |
T |
14: 70,085,046 (GRCm39) |
P35S |
probably benign |
Het |
Pkhd1l1 |
T |
A |
15: 44,386,949 (GRCm39) |
V1274E |
possibly damaging |
Het |
Plcz1 |
A |
T |
6: 139,956,150 (GRCm39) |
V373D |
probably benign |
Het |
Plxnb1 |
C |
T |
9: 108,929,243 (GRCm39) |
T33I |
probably damaging |
Het |
Prag1 |
T |
C |
8: 36,613,915 (GRCm39) |
C1156R |
probably benign |
Het |
Ptprc |
T |
A |
1: 138,045,600 (GRCm39) |
I87F |
probably benign |
Het |
Rbp4 |
G |
A |
19: 38,112,551 (GRCm39) |
T138I |
possibly damaging |
Het |
Semp2l2b |
A |
G |
10: 21,943,785 (GRCm39) |
L65P |
probably damaging |
Het |
Slc12a1 |
A |
T |
2: 125,042,542 (GRCm39) |
N733Y |
possibly damaging |
Het |
Slc27a3 |
A |
G |
3: 90,297,033 (GRCm39) |
V22A |
probably benign |
Het |
Tcaf1 |
T |
C |
6: 42,651,973 (GRCm39) |
|
probably null |
Het |
Tnc |
T |
C |
4: 63,889,392 (GRCm39) |
|
probably null |
Het |
Tspan31 |
A |
T |
10: 126,903,987 (GRCm39) |
*211R |
probably null |
Het |
Ttc17 |
A |
T |
2: 94,192,773 (GRCm39) |
V86D |
possibly damaging |
Het |
Ubr1 |
T |
A |
2: 120,734,558 (GRCm39) |
N1114I |
possibly damaging |
Het |
Ulk2 |
C |
T |
11: 61,674,457 (GRCm39) |
G850R |
probably benign |
Het |
Vmn1r13 |
T |
A |
6: 57,187,141 (GRCm39) |
I100N |
probably benign |
Het |
Zan |
T |
C |
5: 137,426,240 (GRCm39) |
D2512G |
unknown |
Het |
Zc3h14 |
A |
T |
12: 98,737,615 (GRCm39) |
N34I |
probably damaging |
Het |
Zcwpw1 |
T |
G |
5: 137,810,346 (GRCm39) |
L374R |
probably damaging |
Het |
Zfp747l1 |
A |
T |
7: 126,983,518 (GRCm39) |
I528K |
possibly damaging |
Het |
|
Other mutations in Nynrin |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01020:Nynrin
|
APN |
14 |
56,105,905 (GRCm39) |
missense |
probably benign |
0.38 |
IGL01131:Nynrin
|
APN |
14 |
56,110,142 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01357:Nynrin
|
APN |
14 |
56,107,874 (GRCm39) |
missense |
probably benign |
|
IGL01537:Nynrin
|
APN |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
IGL01583:Nynrin
|
APN |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01726:Nynrin
|
APN |
14 |
56,101,611 (GRCm39) |
missense |
probably benign |
|
IGL02161:Nynrin
|
APN |
14 |
56,101,441 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02167:Nynrin
|
APN |
14 |
56,100,792 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02247:Nynrin
|
APN |
14 |
56,109,167 (GRCm39) |
nonsense |
probably null |
|
IGL02302:Nynrin
|
APN |
14 |
56,105,962 (GRCm39) |
missense |
probably benign |
0.43 |
IGL02524:Nynrin
|
APN |
14 |
56,108,931 (GRCm39) |
missense |
possibly damaging |
0.73 |
IGL02600:Nynrin
|
APN |
14 |
56,101,449 (GRCm39) |
missense |
probably benign |
0.38 |
IGL02639:Nynrin
|
APN |
14 |
56,108,112 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02654:Nynrin
|
APN |
14 |
56,100,716 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02659:Nynrin
|
APN |
14 |
56,103,554 (GRCm39) |
unclassified |
probably benign |
|
IGL02736:Nynrin
|
APN |
14 |
56,108,366 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02949:Nynrin
|
APN |
14 |
56,109,837 (GRCm39) |
missense |
probably damaging |
0.99 |
PIT4458001:Nynrin
|
UTSW |
14 |
56,101,425 (GRCm39) |
missense |
probably benign |
0.39 |
R0017:Nynrin
|
UTSW |
14 |
56,109,852 (GRCm39) |
missense |
probably damaging |
1.00 |
R0078:Nynrin
|
UTSW |
14 |
56,100,789 (GRCm39) |
missense |
probably damaging |
1.00 |
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
R0211:Nynrin
|
UTSW |
14 |
56,109,255 (GRCm39) |
missense |
probably benign |
0.08 |
R0413:Nynrin
|
UTSW |
14 |
56,109,648 (GRCm39) |
missense |
possibly damaging |
0.90 |
R0609:Nynrin
|
UTSW |
14 |
56,110,218 (GRCm39) |
missense |
probably damaging |
1.00 |
R0626:Nynrin
|
UTSW |
14 |
56,105,492 (GRCm39) |
missense |
probably damaging |
1.00 |
R1205:Nynrin
|
UTSW |
14 |
56,091,646 (GRCm39) |
intron |
probably benign |
|
R1222:Nynrin
|
UTSW |
14 |
56,100,998 (GRCm39) |
missense |
probably benign |
0.02 |
R1385:Nynrin
|
UTSW |
14 |
56,102,356 (GRCm39) |
missense |
probably benign |
0.00 |
R1820:Nynrin
|
UTSW |
14 |
56,107,835 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1829:Nynrin
|
UTSW |
14 |
56,110,404 (GRCm39) |
missense |
possibly damaging |
0.50 |
R1874:Nynrin
|
UTSW |
14 |
56,100,950 (GRCm39) |
missense |
probably benign |
0.04 |
R1927:Nynrin
|
UTSW |
14 |
56,101,049 (GRCm39) |
missense |
probably benign |
0.00 |
R2233:Nynrin
|
UTSW |
14 |
56,109,524 (GRCm39) |
missense |
possibly damaging |
0.83 |
R3018:Nynrin
|
UTSW |
14 |
56,100,867 (GRCm39) |
missense |
probably benign |
0.00 |
R3154:Nynrin
|
UTSW |
14 |
56,101,044 (GRCm39) |
missense |
possibly damaging |
0.46 |
R3853:Nynrin
|
UTSW |
14 |
56,101,562 (GRCm39) |
missense |
probably benign |
0.24 |
R4648:Nynrin
|
UTSW |
14 |
56,110,351 (GRCm39) |
nonsense |
probably null |
|
R4722:Nynrin
|
UTSW |
14 |
56,091,852 (GRCm39) |
missense |
probably damaging |
0.97 |
R4735:Nynrin
|
UTSW |
14 |
56,107,625 (GRCm39) |
missense |
probably benign |
0.03 |
R4736:Nynrin
|
UTSW |
14 |
56,101,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R4780:Nynrin
|
UTSW |
14 |
56,100,720 (GRCm39) |
missense |
probably damaging |
1.00 |
R4804:Nynrin
|
UTSW |
14 |
56,102,326 (GRCm39) |
missense |
probably benign |
|
R4816:Nynrin
|
UTSW |
14 |
56,109,458 (GRCm39) |
missense |
probably damaging |
1.00 |
R5307:Nynrin
|
UTSW |
14 |
56,101,263 (GRCm39) |
missense |
probably damaging |
1.00 |
R5372:Nynrin
|
UTSW |
14 |
56,105,948 (GRCm39) |
missense |
probably benign |
0.01 |
R5432:Nynrin
|
UTSW |
14 |
56,101,923 (GRCm39) |
missense |
possibly damaging |
0.80 |
R5800:Nynrin
|
UTSW |
14 |
56,108,088 (GRCm39) |
missense |
probably damaging |
1.00 |
R5825:Nynrin
|
UTSW |
14 |
56,101,683 (GRCm39) |
missense |
probably benign |
0.00 |
R6149:Nynrin
|
UTSW |
14 |
56,091,780 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6244:Nynrin
|
UTSW |
14 |
56,105,485 (GRCm39) |
missense |
probably damaging |
1.00 |
R6350:Nynrin
|
UTSW |
14 |
56,105,533 (GRCm39) |
missense |
probably benign |
0.19 |
R6379:Nynrin
|
UTSW |
14 |
56,107,848 (GRCm39) |
missense |
probably damaging |
1.00 |
R6437:Nynrin
|
UTSW |
14 |
56,109,227 (GRCm39) |
missense |
probably benign |
0.00 |
R6501:Nynrin
|
UTSW |
14 |
56,100,989 (GRCm39) |
missense |
probably benign |
|
R6702:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6703:Nynrin
|
UTSW |
14 |
56,101,935 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6907:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6908:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6928:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6934:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R6935:Nynrin
|
UTSW |
14 |
56,101,335 (GRCm39) |
missense |
probably benign |
0.20 |
R7197:Nynrin
|
UTSW |
14 |
56,109,380 (GRCm39) |
missense |
probably benign |
0.00 |
R7272:Nynrin
|
UTSW |
14 |
56,107,872 (GRCm39) |
missense |
probably damaging |
1.00 |
R7335:Nynrin
|
UTSW |
14 |
56,101,371 (GRCm39) |
missense |
probably benign |
|
R7361:Nynrin
|
UTSW |
14 |
56,107,857 (GRCm39) |
missense |
possibly damaging |
0.71 |
R7368:Nynrin
|
UTSW |
14 |
56,107,968 (GRCm39) |
missense |
probably damaging |
1.00 |
R7443:Nynrin
|
UTSW |
14 |
56,108,873 (GRCm39) |
missense |
probably benign |
0.18 |
R7584:Nynrin
|
UTSW |
14 |
56,109,041 (GRCm39) |
missense |
probably damaging |
1.00 |
R7677:Nynrin
|
UTSW |
14 |
56,107,693 (GRCm39) |
missense |
probably benign |
|
R7723:Nynrin
|
UTSW |
14 |
56,109,502 (GRCm39) |
missense |
possibly damaging |
0.87 |
R7776:Nynrin
|
UTSW |
14 |
56,103,420 (GRCm39) |
missense |
probably damaging |
1.00 |
R7787:Nynrin
|
UTSW |
14 |
56,107,980 (GRCm39) |
missense |
probably benign |
|
R7842:Nynrin
|
UTSW |
14 |
56,102,553 (GRCm39) |
missense |
probably damaging |
1.00 |
R7852:Nynrin
|
UTSW |
14 |
56,108,886 (GRCm39) |
missense |
probably damaging |
0.96 |
R8040:Nynrin
|
UTSW |
14 |
56,108,982 (GRCm39) |
missense |
probably benign |
0.01 |
R8159:Nynrin
|
UTSW |
14 |
56,102,517 (GRCm39) |
missense |
probably benign |
|
R8159:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R8258:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8259:Nynrin
|
UTSW |
14 |
56,100,815 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8343:Nynrin
|
UTSW |
14 |
56,101,248 (GRCm39) |
missense |
probably benign |
|
R8504:Nynrin
|
UTSW |
14 |
56,107,703 (GRCm39) |
missense |
probably benign |
0.01 |
R8671:Nynrin
|
UTSW |
14 |
56,107,899 (GRCm39) |
missense |
possibly damaging |
0.52 |
R8691:Nynrin
|
UTSW |
14 |
56,110,106 (GRCm39) |
missense |
probably damaging |
1.00 |
R8777:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
R8777-TAIL:Nynrin
|
UTSW |
14 |
56,109,120 (GRCm39) |
missense |
probably benign |
|
R9041:Nynrin
|
UTSW |
14 |
56,108,753 (GRCm39) |
missense |
possibly damaging |
0.83 |
R9346:Nynrin
|
UTSW |
14 |
56,100,495 (GRCm39) |
missense |
probably benign |
0.01 |
R9366:Nynrin
|
UTSW |
14 |
56,100,587 (GRCm39) |
missense |
probably damaging |
0.99 |
R9690:Nynrin
|
UTSW |
14 |
56,108,204 (GRCm39) |
missense |
probably benign |
0.00 |
RF007:Nynrin
|
UTSW |
14 |
56,103,658 (GRCm39) |
splice site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- TTTTAGGGCCTCCACCACAG -3'
(R):5'- ATCAGACTGCTAGGATAGACACAG -3'
Sequencing Primer
(F):5'- ACCGTTCCAGGTGCTGAC -3'
(R):5'- TAGACACAGCCCAGCTTGTCTG -3'
|
Posted On |
2019-06-26 |