Incidental Mutation 'R0593:Or10am5'
ID 56058
Institutional Source Beutler Lab
Gene Symbol Or10am5
Ensembl Gene ENSMUSG00000048067
Gene Name olfactory receptor family 10 subfamily AM member 5
Synonyms Olfr1349, MOR232-8, GA_x6K02T2QGBW-3245761-3244808
MMRRC Submission 038783-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R0593 (G1)
Quality Score 97
Status Validated
Chromosome 7
Chromosomal Location 6517198-6523354 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 6517808 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Tyrosine at position 207 (N207Y)
Ref Sequence ENSEMBL: ENSMUSP00000149880 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051982] [ENSMUST00000207043] [ENSMUST00000207075] [ENSMUST00000207820] [ENSMUST00000213504] [ENSMUST00000213656] [ENSMUST00000216447]
AlphaFold Q7TQV1
Predicted Effect probably benign
Transcript: ENSMUST00000051982
AA Change: N207Y

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000056639
Gene: ENSMUSG00000048067
AA Change: N207Y

DomainStartEndE-ValueType
Pfam:7tm_4 40 317 1.9e-47 PFAM
Pfam:7tm_1 50 299 3.3e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122705
Predicted Effect probably benign
Transcript: ENSMUST00000207043
Predicted Effect probably benign
Transcript: ENSMUST00000207075
Predicted Effect probably benign
Transcript: ENSMUST00000207820
AA Change: N207Y

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000213504
AA Change: N207Y

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000213656
AA Change: N207Y

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Predicted Effect probably benign
Transcript: ENSMUST00000216447
AA Change: N207Y

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 96.9%
  • 20x: 93.4%
Validation Efficiency 100% (39/39)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a T C 11: 109,958,925 (GRCm39) D733G probably damaging Het
Acmsd T C 1: 127,666,340 (GRCm39) probably benign Het
Adam34 T C 8: 44,104,724 (GRCm39) Y307C possibly damaging Het
Alox12e A G 11: 70,211,723 (GRCm39) probably benign Het
Ankrd50 C A 3: 38,537,156 (GRCm39) G29* probably null Het
Arhgap17 T C 7: 122,885,966 (GRCm39) probably benign Het
Asah1 A G 8: 41,802,619 (GRCm39) M141T probably benign Het
Atg2a GCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC GCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCCTTCC 19: 6,295,037 (GRCm39) probably benign Het
Bsn A T 9: 107,987,505 (GRCm39) I2749N unknown Het
Cds2 G A 2: 132,139,296 (GRCm39) probably benign Het
Ckmt2 A G 13: 92,001,757 (GRCm39) V384A probably damaging Het
Clock A G 5: 76,413,683 (GRCm39) S71P probably benign Het
Cops6 A G 5: 138,161,842 (GRCm39) T96A probably benign Het
Csnka2ip A T 16: 64,298,975 (GRCm39) V19D probably damaging Het
Dcaf17 T A 2: 70,917,744 (GRCm39) probably null Het
Dscam T C 16: 96,573,608 (GRCm39) K785E probably benign Het
Eif2d T A 1: 131,083,465 (GRCm39) probably benign Het
Gal3st2b T C 1: 93,868,549 (GRCm39) V258A probably benign Het
Gucy2c T C 6: 136,705,333 (GRCm39) N534S probably damaging Het
Hook1 C T 4: 95,887,023 (GRCm39) T210I possibly damaging Het
Ifi203 T C 1: 173,756,215 (GRCm39) probably benign Het
Irf7 T C 7: 140,844,975 (GRCm39) probably benign Het
Lrp2 C T 2: 69,297,350 (GRCm39) V3204I probably benign Het
Mtx2 A G 2: 74,699,780 (GRCm39) probably benign Het
Nelfcd G T 2: 174,265,223 (GRCm39) V248L probably benign Het
Oosp1 T C 19: 11,645,776 (GRCm39) S121G probably benign Het
Sec16b G C 1: 157,359,718 (GRCm39) G164R probably benign Het
Slc22a14 T A 9: 118,998,919 (GRCm39) D561V probably benign Het
Tet2 G A 3: 133,193,870 (GRCm39) T188I probably benign Het
Tex10 C T 4: 48,456,800 (GRCm39) R637Q probably benign Het
Trp53bp1 A G 2: 121,101,009 (GRCm39) V63A possibly damaging Het
Ube2d2a T G 18: 35,903,438 (GRCm39) probably benign Het
Vmn1r113 T A 7: 20,521,388 (GRCm39) V60E probably damaging Het
Other mutations in Or10am5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00917:Or10am5 APN 7 6,517,577 (GRCm39) missense probably damaging 1.00
IGL02350:Or10am5 APN 7 6,518,225 (GRCm39) missense probably damaging 1.00
IGL02357:Or10am5 APN 7 6,518,225 (GRCm39) missense probably damaging 1.00
IGL02955:Or10am5 APN 7 6,517,682 (GRCm39) missense probably damaging 1.00
R2311:Or10am5 UTSW 7 6,517,741 (GRCm39) missense probably benign
R2396:Or10am5 UTSW 7 6,517,784 (GRCm39) missense probably damaging 0.98
R3699:Or10am5 UTSW 7 6,517,993 (GRCm39) missense probably damaging 0.99
R4095:Or10am5 UTSW 7 6,518,252 (GRCm39) missense possibly damaging 0.94
R5009:Or10am5 UTSW 7 6,517,546 (GRCm39) missense probably damaging 0.99
R6818:Or10am5 UTSW 7 6,517,550 (GRCm39) missense probably damaging 0.99
R7248:Or10am5 UTSW 7 6,517,520 (GRCm39) missense probably damaging 1.00
R7697:Or10am5 UTSW 7 6,517,645 (GRCm39) missense probably damaging 1.00
R7848:Or10am5 UTSW 7 6,517,861 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GATGACCCCTGTTGTGCCATAGAAC -3'
(R):5'- GTGCTGTCCTGTGTCACATCTGAG -3'

Sequencing Primer
(F):5'- CTGTTGTGCCATAGAACAGAATTACC -3'
(R):5'- GTGTCACATCTGAGTGCTTCC -3'
Posted On 2013-07-11