Incidental Mutation 'R7206:Vps8'
| ID |
560659 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
045284-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R7206 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 21276171 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 235
(I235L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000093905
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096191
AA Change: I235L
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: I235L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000096192
AA Change: I237L
PolyPhen 2
Score 0.587 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: I237L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115397
AA Change: I237L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: I237L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117598
AA Change: I235L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: I235L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118923
AA Change: I237L
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: I237L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
99% (87/88) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 87 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl2 |
G |
A |
3: 59,932,662 (GRCm39) |
M392I |
probably benign |
Het |
| Aadacl4fm2 |
T |
A |
4: 144,285,211 (GRCm39) |
D142V |
probably damaging |
Het |
| Acr |
T |
C |
15: 89,458,374 (GRCm39) |
S352P |
probably benign |
Het |
| Adam6a |
T |
C |
12: 113,509,654 (GRCm39) |
C676R |
probably damaging |
Het |
| Adgra3 |
T |
C |
5: 50,164,238 (GRCm39) |
D247G |
probably damaging |
Het |
| Agxt2 |
A |
T |
15: 10,377,542 (GRCm39) |
E147D |
probably damaging |
Het |
| Atp2a1 |
T |
C |
7: 126,047,144 (GRCm39) |
T805A |
probably benign |
Het |
| Atp8b4 |
T |
C |
2: 126,300,212 (GRCm39) |
S106G |
probably damaging |
Het |
| Ccdc170 |
T |
A |
10: 4,464,120 (GRCm39) |
M87K |
possibly damaging |
Het |
| Ccnl2 |
T |
G |
4: 155,905,431 (GRCm39) |
V287G |
possibly damaging |
Het |
| Ccr6 |
A |
T |
17: 8,475,781 (GRCm39) |
M329L |
probably benign |
Het |
| Cflar |
G |
T |
1: 58,780,150 (GRCm39) |
M248I |
|
Het |
| Cib4 |
A |
T |
5: 30,703,110 (GRCm39) |
L5* |
probably null |
Het |
| Col27a1 |
A |
T |
4: 63,153,583 (GRCm39) |
Y645F |
probably benign |
Het |
| Cxcr2 |
A |
G |
1: 74,198,213 (GRCm39) |
T236A |
possibly damaging |
Het |
| Dnah12 |
G |
A |
14: 26,500,869 (GRCm39) |
|
probably null |
Het |
| Dnah7a |
A |
T |
1: 53,737,792 (GRCm39) |
L47* |
probably null |
Het |
| Dnajb6 |
A |
C |
5: 29,986,335 (GRCm39) |
K301T |
possibly damaging |
Het |
| Dpf2 |
T |
A |
19: 5,954,571 (GRCm39) |
I157F |
possibly damaging |
Het |
| Drd4 |
G |
A |
7: 140,872,032 (GRCm39) |
G28R |
probably damaging |
Het |
| Dus3l |
A |
T |
17: 57,074,807 (GRCm39) |
I310F |
probably damaging |
Het |
| Dusp29 |
A |
G |
14: 21,727,102 (GRCm39) |
V182A |
probably damaging |
Het |
| Eef1akmt3 |
A |
G |
10: 126,876,862 (GRCm39) |
L95P |
probably damaging |
Het |
| Fabp7 |
C |
T |
10: 57,661,087 (GRCm39) |
|
probably benign |
Het |
| Fam135a |
T |
C |
1: 24,069,354 (GRCm39) |
N505S |
probably benign |
Het |
| Fam216b |
C |
A |
14: 78,322,567 (GRCm39) |
D46Y |
probably damaging |
Het |
| Gata6 |
C |
T |
18: 11,054,850 (GRCm39) |
R260C |
probably damaging |
Het |
| Gm10800 |
A |
AC |
2: 98,497,378 (GRCm39) |
|
probably null |
Het |
| Golgb1 |
A |
G |
16: 36,734,111 (GRCm39) |
I1160M |
probably benign |
Het |
| Hjv |
A |
T |
3: 96,435,444 (GRCm39) |
D234V |
probably damaging |
Het |
| Kiss1 |
A |
G |
1: 133,255,063 (GRCm39) |
K26E |
probably benign |
Het |
| Knl1 |
T |
A |
2: 118,899,780 (GRCm39) |
F494I |
probably benign |
Het |
| Ktn1 |
T |
C |
14: 47,932,985 (GRCm39) |
L713S |
probably damaging |
Het |
| Loxhd1 |
A |
G |
18: 77,529,513 (GRCm39) |
D2052G |
probably damaging |
Het |
| Lpo |
A |
C |
11: 87,698,249 (GRCm39) |
L582R |
probably damaging |
Het |
| Map2k3 |
A |
G |
11: 60,834,406 (GRCm39) |
T125A |
|
Het |
| Matn3 |
T |
A |
12: 9,011,170 (GRCm39) |
N360K |
probably benign |
Het |
| Mlip |
A |
T |
9: 77,072,144 (GRCm39) |
V237E |
probably damaging |
Het |
| Mms22l |
T |
C |
4: 24,591,146 (GRCm39) |
V999A |
probably benign |
Het |
| Mn1 |
A |
G |
5: 111,568,378 (GRCm39) |
K783E |
possibly damaging |
Het |
| Myo1h |
A |
T |
5: 114,457,836 (GRCm39) |
K132* |
probably null |
Het |
| Nle1 |
A |
G |
11: 82,795,757 (GRCm39) |
V230A |
probably benign |
Het |
| Or1ak2 |
T |
A |
2: 36,827,784 (GRCm39) |
Y218N |
probably damaging |
Het |
| Or1e1b-ps1 |
A |
T |
11: 73,845,647 (GRCm39) |
I44F |
probably benign |
Het |
| Or4a68 |
T |
C |
2: 89,270,801 (GRCm39) |
|
probably benign |
Het |
| Or4f62 |
T |
G |
2: 111,986,804 (GRCm39) |
C169W |
probably damaging |
Het |
| Or51f23 |
T |
C |
7: 102,452,891 (GRCm39) |
S69P |
probably damaging |
Het |
| Or7e169 |
C |
T |
9: 19,757,856 (GRCm39) |
D20N |
probably damaging |
Het |
| Ormdl2 |
T |
A |
10: 128,656,284 (GRCm39) |
H7L |
possibly damaging |
Het |
| Pam |
A |
G |
1: 97,823,757 (GRCm39) |
S225P |
probably damaging |
Het |
| Pan2 |
C |
A |
10: 128,150,414 (GRCm39) |
Y719* |
probably null |
Het |
| Ppfia4 |
T |
C |
1: 134,255,127 (GRCm39) |
S243G |
probably benign |
Het |
| Ppig |
T |
G |
2: 69,571,910 (GRCm39) |
S210A |
unknown |
Het |
| Ppwd1 |
A |
T |
13: 104,350,106 (GRCm39) |
N426K |
probably damaging |
Het |
| Prxl2a |
T |
A |
14: 40,726,142 (GRCm39) |
M12L |
probably benign |
Het |
| Rnf10 |
T |
G |
5: 115,382,180 (GRCm39) |
D675A |
probably benign |
Het |
| Rrp12 |
A |
T |
19: 41,866,478 (GRCm39) |
L619H |
probably damaging |
Het |
| Rsph10b |
C |
T |
5: 143,898,010 (GRCm39) |
T497I |
possibly damaging |
Het |
| Scnm1 |
A |
T |
3: 95,041,205 (GRCm39) |
M1K |
probably null |
Het |
| Scp2 |
G |
T |
4: 107,931,638 (GRCm39) |
D332E |
probably benign |
Het |
| Senp3 |
T |
C |
11: 69,569,557 (GRCm39) |
I314V |
probably benign |
Het |
| Sfmbt1 |
T |
A |
14: 30,533,330 (GRCm39) |
|
probably null |
Het |
| Slc44a2 |
T |
C |
9: 21,258,103 (GRCm39) |
F451S |
probably damaging |
Het |
| Slfn1 |
A |
T |
11: 83,012,837 (GRCm39) |
M318L |
probably benign |
Het |
| Syne2 |
C |
T |
12: 76,051,531 (GRCm39) |
S4087L |
probably benign |
Het |
| Syt7 |
A |
G |
19: 10,395,337 (GRCm39) |
Y49C |
probably damaging |
Het |
| Tas2r134 |
T |
C |
2: 51,518,120 (GRCm39) |
Y200H |
probably benign |
Het |
| Tgfbr1 |
A |
T |
4: 47,402,941 (GRCm39) |
H315L |
probably damaging |
Het |
| Tmem184c |
A |
G |
8: 78,323,206 (GRCm39) |
V552A |
possibly damaging |
Het |
| Tnxb |
A |
G |
17: 34,923,075 (GRCm39) |
R2553G |
possibly damaging |
Het |
| Tomm40 |
C |
G |
7: 19,444,861 (GRCm39) |
R173S |
probably benign |
Het |
| Tonsl |
T |
C |
15: 76,517,851 (GRCm39) |
D650G |
probably damaging |
Het |
| Tpo |
G |
C |
12: 30,153,133 (GRCm39) |
S407W |
possibly damaging |
Het |
| Trank1 |
T |
C |
9: 111,174,583 (GRCm39) |
|
probably null |
Het |
| Trp53tg5 |
T |
C |
2: 164,313,378 (GRCm39) |
E99G |
probably damaging |
Het |
| Tubb2a |
C |
A |
13: 34,259,505 (GRCm39) |
S95I |
possibly damaging |
Het |
| Vav2 |
C |
A |
2: 27,226,731 (GRCm39) |
R114L |
probably benign |
Het |
| Vmn1r172 |
A |
T |
7: 23,359,582 (GRCm39) |
I156L |
possibly damaging |
Het |
| Vmn1r238 |
A |
G |
18: 3,122,623 (GRCm39) |
Y264H |
possibly damaging |
Het |
| Vmn2r26 |
T |
A |
6: 124,016,727 (GRCm39) |
M397K |
probably benign |
Het |
| Vmn2r73 |
T |
C |
7: 85,522,075 (GRCm39) |
N88S |
probably benign |
Het |
| Vps13a |
T |
C |
19: 16,731,662 (GRCm39) |
N150S |
probably damaging |
Het |
| Vps35 |
A |
T |
8: 86,014,350 (GRCm39) |
Y100N |
probably damaging |
Het |
| Yipf2 |
T |
A |
9: 21,501,657 (GRCm39) |
H157L |
probably damaging |
Het |
| Zfp354a |
A |
T |
11: 50,961,073 (GRCm39) |
H426L |
probably damaging |
Het |
| Zfp503 |
G |
T |
14: 22,035,553 (GRCm39) |
S454R |
possibly damaging |
Het |
| Zfp619 |
C |
T |
7: 39,184,824 (GRCm39) |
R285C |
probably benign |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0492:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- CAGTGCTCTAATGTGGTCTCAG -3'
(R):5'- CTGCTGCCAAACTGAGTTGG -3'
Sequencing Primer
(F):5'- CTCTAATGTGGTCTCAGTTGGTG -3'
(R):5'- GAAGCTGTATATGTTCATACCAGCCC -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation