Incidental Mutation 'R7203:Grm7'
ID 560775
Institutional Source Beutler Lab
Gene Symbol Grm7
Ensembl Gene ENSMUSG00000056755
Gene Name glutamate receptor, metabotropic 7
Synonyms 6330570A01Rik, Gpr1g, mGlu7a receptor, mGluR7, E130018M02Rik
MMRRC Submission 045281-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7203 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 110622542-111544191 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 111335530 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 647 (I647S)
Ref Sequence ENSEMBL: ENSMUSP00000133957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071076] [ENSMUST00000172951] [ENSMUST00000174018]
AlphaFold Q68ED2
Predicted Effect probably damaging
Transcript: ENSMUST00000071076
AA Change: I647S

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000064404
Gene: ENSMUSG00000056755
AA Change: I647S

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 3e-108 PFAM
Pfam:Peripla_BP_6 144 371 3e-11 PFAM
Pfam:NCD3G 519 569 1.2e-13 PFAM
Pfam:7tm_3 602 847 5.1e-59 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000172951
AA Change: I647S

PolyPhen 2 Score 0.939 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000133957
Gene: ENSMUSG00000056755
AA Change: I647S

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 484 1.7e-103 PFAM
Pfam:Peripla_BP_6 144 487 1e-12 PFAM
Pfam:NCD3G 519 569 1.2e-17 PFAM
Pfam:7tm_3 600 848 1.4e-87 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000174018
SMART Domains Protein: ENSMUSP00000134635
Gene: ENSMUSG00000056755

DomainStartEndE-ValueType
low complexity region 18 32 N/A INTRINSIC
Pfam:ANF_receptor 77 176 4.9e-20 PFAM
Meta Mutation Damage Score 0.8675 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (108/108)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
PHENOTYPE: Nullizygous mice exhibit epilepsy and deficits in fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to PTZ. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 108 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544G11Rik T C 6: 65,930,317 (GRCm39) V184A probably benign Het
Aars2 A G 17: 45,827,497 (GRCm39) Y513C probably damaging Het
Ackr2 G A 9: 121,738,033 (GRCm39) C136Y probably damaging Het
Aldh1l1 A G 6: 90,547,782 (GRCm39) K414R probably benign Het
Arl9 A G 5: 77,155,118 (GRCm39) Y83C possibly damaging Het
Atp10a G T 7: 58,436,221 (GRCm39) R337L probably benign Het
Atp6v1g3 A T 1: 138,215,538 (GRCm39) Q66L probably damaging Het
Atp7b A T 8: 22,487,351 (GRCm39) N1321K probably damaging Het
Axdnd1 A T 1: 156,209,959 (GRCm39) M437K probably damaging Het
Bap1 C A 14: 30,976,126 (GRCm39) P147Q probably damaging Het
Bicd1 C T 6: 149,414,403 (GRCm39) T372I possibly damaging Het
Brix1 T C 15: 10,483,378 (GRCm39) probably null Het
Btrc A G 19: 45,501,967 (GRCm39) probably null Het
C130050O18Rik A C 5: 139,400,129 (GRCm39) I61L probably benign Het
Cfap161 A G 7: 83,425,258 (GRCm39) S278P probably damaging Het
Cgnl1 T C 9: 71,631,815 (GRCm39) D512G possibly damaging Het
Chat T C 14: 32,141,014 (GRCm39) D461G probably damaging Het
Chl1 T A 6: 103,668,635 (GRCm39) V456D probably benign Het
Cib1 T C 7: 79,882,120 (GRCm39) T20A possibly damaging Het
Cubn T G 2: 13,355,814 (GRCm39) H1806P probably benign Het
Dapk1 T A 13: 60,844,149 (GRCm39) V56E possibly damaging Het
Dennd4a A G 9: 64,803,756 (GRCm39) N1032D probably benign Het
Dlg5 T A 14: 24,188,723 (GRCm39) E1756V probably damaging Het
Dnah1 T C 14: 30,996,339 (GRCm39) T2666A probably benign Het
Dnah11 A T 12: 118,009,257 (GRCm39) I2135N possibly damaging Het
Dnah6 T A 6: 73,150,528 (GRCm39) E745V probably benign Het
Dock8 A T 19: 25,158,927 (GRCm39) N1695I probably damaging Het
Esf1 C T 2: 140,006,139 (GRCm39) R336Q possibly damaging Het
Fam161a A G 11: 22,971,664 (GRCm39) probably null Het
Fam89a T C 8: 125,478,418 (GRCm39) E44G possibly damaging Het
Fndc3b A T 3: 27,510,634 (GRCm39) D829E probably benign Het
Fxr1 C T 3: 34,100,689 (GRCm39) T125I possibly damaging Het
Gfer T C 17: 24,914,836 (GRCm39) D69G probably damaging Het
Gpatch2l T A 12: 86,335,711 (GRCm39) S471T probably benign Het
Gsn A G 2: 35,188,807 (GRCm39) I447V probably benign Het
H2al2c C T Y: 2,599,234 (GRCm39) L46F possibly damaging Het
Hao2 A C 3: 98,784,598 (GRCm39) probably null Het
Ifitm10 T C 7: 141,882,305 (GRCm39) E155G probably benign Het
Igkv8-16 C A 6: 70,363,794 (GRCm39) W76L probably benign Het
Igsf21 A T 4: 139,834,648 (GRCm39) F75I possibly damaging Het
Ints14 T A 9: 64,871,701 (GRCm39) M13K probably damaging Het
Ipmk A T 10: 71,199,298 (GRCm39) D53V possibly damaging Het
Iqcn A T 8: 71,169,597 (GRCm39) E1229V probably benign Het
Itga8 A G 2: 12,234,906 (GRCm39) F451L possibly damaging Het
Jup A G 11: 100,272,560 (GRCm39) F284S probably damaging Het
Kctd5 T C 17: 24,292,209 (GRCm39) D65G probably benign Het
Klrc1 A T 6: 129,654,184 (GRCm39) S148T probably benign Het
Kmt5b A G 19: 3,864,147 (GRCm39) K404E probably damaging Het
Krt9 A C 11: 100,081,617 (GRCm39) M304R probably damaging Het
Krtap5-1 A T 7: 141,850,299 (GRCm39) S143T unknown Het
Kyat3 A G 3: 142,426,162 (GRCm39) N68D probably damaging Het
Kynu A G 2: 43,571,365 (GRCm39) D427G probably damaging Het
Leo1 A G 9: 75,353,278 (GRCm39) probably null Het
Loxhd1 A G 18: 77,501,892 (GRCm39) D1737G probably damaging Het
Lpo C A 11: 87,700,077 (GRCm39) L521F possibly damaging Het
Lrrk1 A G 7: 65,920,573 (GRCm39) S1477P probably damaging Het
Lrrtm1 C A 6: 77,220,584 (GRCm39) L14M probably damaging Het
Ly75 G A 2: 60,154,196 (GRCm39) R1084* probably null Het
Mcf2l A G 8: 13,060,456 (GRCm39) D764G probably benign Het
Mmut A T 17: 41,249,564 (GRCm39) M180L probably benign Het
Mrgprd A T 7: 144,876,086 (GRCm39) D319V probably benign Het
Myom3 T C 4: 135,522,490 (GRCm39) L897P possibly damaging Het
Ncapd2 A T 6: 125,161,291 (GRCm39) M247K possibly damaging Het
Nlrp2 T C 7: 5,320,533 (GRCm39) D868G probably damaging Het
Npy6r A G 18: 44,408,999 (GRCm39) N140S probably damaging Het
Nsmce4a T C 7: 130,141,602 (GRCm39) K196E probably benign Het
Nup88 T C 11: 70,836,080 (GRCm39) K532R probably benign Het
Or6k4 T A 1: 173,964,680 (GRCm39) Y123* probably null Het
Or8d6 T A 9: 39,853,805 (GRCm39) V83E probably benign Het
Or8g29-ps1 A T 9: 39,200,589 (GRCm39) I199N unknown Het
Pbxip1 A T 3: 89,354,735 (GRCm39) D418V possibly damaging Het
Pde2a C A 7: 101,159,151 (GRCm39) R761S possibly damaging Het
Phf10 A T 17: 15,166,575 (GRCm39) C432S probably damaging Het
Pitpnm2 T C 5: 124,259,522 (GRCm39) D1271G probably damaging Het
Plin1 A T 7: 79,373,192 (GRCm39) L259Q probably damaging Het
Pmpca G C 2: 26,285,046 (GRCm39) E424Q possibly damaging Het
Pou6f2 T A 13: 18,414,379 (GRCm39) Q132L unknown Het
Ppa2 A T 3: 133,036,199 (GRCm39) N118Y possibly damaging Het
Prickle2 T C 6: 92,387,959 (GRCm39) E537G possibly damaging Het
Prl3d1 A G 13: 27,282,684 (GRCm39) I141V possibly damaging Het
Prl8a1 A T 13: 27,758,172 (GRCm39) V179D probably damaging Het
Prr14l A G 5: 32,984,489 (GRCm39) F1669L probably benign Het
Prrg4 T A 2: 104,669,787 (GRCm39) E110V possibly damaging Het
Rfx5 C A 3: 94,866,187 (GRCm39) H495Q unknown Het
Rgl2 C T 17: 34,152,403 (GRCm39) R367W probably damaging Het
Rpe65 A G 3: 159,328,491 (GRCm39) Y433C probably damaging Het
Rpl35rt A T 1: 156,193,657 (GRCm39) I4F probably damaging Het
Rtn4rl1 C T 11: 75,156,576 (GRCm39) S336F possibly damaging Het
Scn2a A G 2: 65,578,663 (GRCm39) D1446G probably benign Het
Sdk1 C A 5: 142,031,931 (GRCm39) T1002K probably benign Het
Slc9b2 T C 3: 135,036,422 (GRCm39) S409P probably benign Het
Sowahc A G 10: 59,058,100 (GRCm39) T79A probably benign Het
Spata31h1 G A 10: 82,129,248 (GRCm39) T1254I probably benign Het
Stk35 T A 2: 129,643,513 (GRCm39) C166S probably benign Het
Tarbp2 A G 15: 102,430,922 (GRCm39) H225R probably benign Het
Tdrd12 T A 7: 35,188,648 (GRCm39) K530* probably null Het
Terf2ip A G 8: 112,744,618 (GRCm39) I312V probably benign Het
Tgfb1 T C 7: 25,391,964 (GRCm39) probably null Het
Thbs2 T C 17: 14,891,720 (GRCm39) D939G probably damaging Het
Ube4b A T 4: 149,483,067 (GRCm39) I67K probably benign Het
Ubn1 G T 16: 4,895,080 (GRCm39) V709F possibly damaging Het
Ugt2b5 T C 5: 87,276,258 (GRCm39) K339E possibly damaging Het
Vax2 T C 6: 83,714,882 (GRCm39) S266P probably damaging Het
Vmn2r108 A G 17: 20,683,038 (GRCm39) I722T probably benign Het
Vmn2r95 A G 17: 18,661,577 (GRCm39) K441R probably benign Het
Wapl C A 14: 34,458,648 (GRCm39) D903E probably benign Het
Wee1 T A 7: 109,734,001 (GRCm39) V442D probably benign Het
Zan T C 5: 137,432,358 (GRCm39) N2313S unknown Het
Other mutations in Grm7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01729:Grm7 APN 6 111,223,145 (GRCm39) missense probably benign 0.14
IGL02058:Grm7 APN 6 111,335,278 (GRCm39) missense probably damaging 1.00
IGL02650:Grm7 APN 6 111,335,919 (GRCm39) missense probably damaging 1.00
IGL02892:Grm7 APN 6 111,230,981 (GRCm39) missense probably damaging 0.99
IGL03074:Grm7 APN 6 111,472,604 (GRCm39) splice site probably null
IGL03185:Grm7 APN 6 110,623,183 (GRCm39) missense possibly damaging 0.84
Appropriated UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
Consumed UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
Devoured UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
Ravaged UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
shaky UTSW 6 111,472,752 (GRCm39) nonsense probably null
PIT4651001:Grm7 UTSW 6 110,623,050 (GRCm39) missense probably benign
R0539:Grm7 UTSW 6 111,336,055 (GRCm39) splice site probably benign
R0622:Grm7 UTSW 6 111,335,457 (GRCm39) missense probably damaging 1.00
R1356:Grm7 UTSW 6 111,335,985 (GRCm39) missense probably damaging 1.00
R1762:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1783:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1785:Grm7 UTSW 6 111,335,256 (GRCm39) missense probably damaging 1.00
R1816:Grm7 UTSW 6 111,472,752 (GRCm39) nonsense probably null
R1823:Grm7 UTSW 6 111,184,730 (GRCm39) missense probably benign 0.17
R1864:Grm7 UTSW 6 111,057,384 (GRCm39) missense probably benign 0.03
R1894:Grm7 UTSW 6 111,335,568 (GRCm39) missense probably benign
R1987:Grm7 UTSW 6 110,891,472 (GRCm39) missense probably damaging 1.00
R1993:Grm7 UTSW 6 111,184,769 (GRCm39) missense probably benign 0.13
R2138:Grm7 UTSW 6 110,623,098 (GRCm39) missense probably damaging 1.00
R2214:Grm7 UTSW 6 111,335,958 (GRCm39) missense probably damaging 1.00
R2289:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2296:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2339:Grm7 UTSW 6 111,472,642 (GRCm39) missense possibly damaging 0.64
R2847:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2849:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2879:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2884:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R2921:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R2923:Grm7 UTSW 6 111,472,866 (GRCm39) splice site probably null
R3014:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3015:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3703:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3713:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R3963:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4009:Grm7 UTSW 6 111,472,683 (GRCm39) missense probably damaging 1.00
R4091:Grm7 UTSW 6 110,891,301 (GRCm39) missense probably damaging 1.00
R4131:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4132:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4161:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 0.99
R4329:Grm7 UTSW 6 110,891,325 (GRCm39) missense probably damaging 1.00
R4357:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4359:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4379:Grm7 UTSW 6 111,223,335 (GRCm39) missense probably benign 0.05
R4379:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4380:Grm7 UTSW 6 110,623,309 (GRCm39) missense probably damaging 1.00
R4514:Grm7 UTSW 6 111,335,265 (GRCm39) missense possibly damaging 0.81
R4518:Grm7 UTSW 6 110,891,507 (GRCm39) splice site probably null
R4647:Grm7 UTSW 6 110,891,344 (GRCm39) nonsense probably null
R4714:Grm7 UTSW 6 111,057,383 (GRCm39) missense possibly damaging 0.52
R4775:Grm7 UTSW 6 110,891,332 (GRCm39) missense probably damaging 1.00
R4957:Grm7 UTSW 6 111,335,824 (GRCm39) missense probably damaging 1.00
R5056:Grm7 UTSW 6 111,057,404 (GRCm39) missense probably damaging 0.99
R5062:Grm7 UTSW 6 110,623,097 (GRCm39) missense probably damaging 1.00
R5256:Grm7 UTSW 6 111,335,182 (GRCm39) missense probably benign 0.01
R5431:Grm7 UTSW 6 111,335,387 (GRCm39) missense probably benign
R6026:Grm7 UTSW 6 111,478,500 (GRCm39) nonsense probably null
R6174:Grm7 UTSW 6 111,223,258 (GRCm39) missense probably benign
R6305:Grm7 UTSW 6 111,335,626 (GRCm39) missense probably damaging 1.00
R6318:Grm7 UTSW 6 111,335,836 (GRCm39) missense probably damaging 1.00
R6440:Grm7 UTSW 6 111,230,981 (GRCm39) missense probably damaging 1.00
R6519:Grm7 UTSW 6 111,184,713 (GRCm39) missense probably benign 0.00
R6531:Grm7 UTSW 6 111,335,386 (GRCm39) missense probably benign 0.29
R6888:Grm7 UTSW 6 111,335,314 (GRCm39) missense possibly damaging 0.79
R6949:Grm7 UTSW 6 111,472,690 (GRCm39) missense probably damaging 1.00
R6949:Grm7 UTSW 6 110,623,265 (GRCm39) missense probably benign 0.03
R6989:Grm7 UTSW 6 111,184,766 (GRCm39) missense probably damaging 1.00
R7076:Grm7 UTSW 6 111,335,113 (GRCm39) missense probably benign 0.04
R7208:Grm7 UTSW 6 111,335,530 (GRCm39) missense possibly damaging 0.94
R7217:Grm7 UTSW 6 111,335,785 (GRCm39) missense probably damaging 1.00
R7257:Grm7 UTSW 6 110,623,079 (GRCm39) missense probably damaging 1.00
R7297:Grm7 UTSW 6 110,622,974 (GRCm39) missense probably benign 0.16
R7470:Grm7 UTSW 6 111,478,476 (GRCm39) missense
R7567:Grm7 UTSW 6 111,335,722 (GRCm39) missense probably damaging 0.96
R7806:Grm7 UTSW 6 111,223,314 (GRCm39) nonsense probably null
R8018:Grm7 UTSW 6 111,184,737 (GRCm39) missense probably benign 0.01
R8076:Grm7 UTSW 6 111,543,000 (GRCm39) missense probably damaging 1.00
R8409:Grm7 UTSW 6 110,891,297 (GRCm39) missense probably benign 0.02
R8420:Grm7 UTSW 6 111,057,315 (GRCm39) missense probably benign
R8523:Grm7 UTSW 6 111,223,280 (GRCm39) missense possibly damaging 0.76
R8816:Grm7 UTSW 6 111,230,966 (GRCm39) missense possibly damaging 0.46
R8958:Grm7 UTSW 6 111,472,783 (GRCm39) missense probably damaging 0.96
R9135:Grm7 UTSW 6 111,472,729 (GRCm39) missense probably benign 0.39
R9207:Grm7 UTSW 6 111,335,874 (GRCm39) missense probably damaging 1.00
R9210:Grm7 UTSW 6 110,622,869 (GRCm39) missense probably benign 0.01
R9438:Grm7 UTSW 6 111,231,077 (GRCm39) missense possibly damaging 0.94
R9448:Grm7 UTSW 6 111,335,193 (GRCm39) missense probably benign 0.01
Z1176:Grm7 UTSW 6 111,335,451 (GRCm39) missense probably damaging 1.00
Z1176:Grm7 UTSW 6 111,335,110 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGGCTGTCAGAACATCCCAATC -3'
(R):5'- ACTGGAGGTAATTGCCAGTTG -3'

Sequencing Primer
(F):5'- TCAAACTGGAGTGGCACTC -3'
(R):5'- CTGGAGGTAATTGCCAGTTGTGATG -3'
Posted On 2019-06-26