Incidental Mutation 'R7203:Dapk1'
| ID |
560816 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
045281-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7203 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 60844149 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 56
(V56E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076666
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000044083
AA Change: V56E
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: V56E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000077453
AA Change: V56E
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: V56E
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224789
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226059
AA Change: V56E
PolyPhen 2
Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
|
| Meta Mutation Damage Score |
0.3368 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
100% (108/108) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 108 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930544G11Rik |
T |
C |
6: 65,930,317 (GRCm39) |
V184A |
probably benign |
Het |
| Aars2 |
A |
G |
17: 45,827,497 (GRCm39) |
Y513C |
probably damaging |
Het |
| Ackr2 |
G |
A |
9: 121,738,033 (GRCm39) |
C136Y |
probably damaging |
Het |
| Aldh1l1 |
A |
G |
6: 90,547,782 (GRCm39) |
K414R |
probably benign |
Het |
| Arl9 |
A |
G |
5: 77,155,118 (GRCm39) |
Y83C |
possibly damaging |
Het |
| Atp10a |
G |
T |
7: 58,436,221 (GRCm39) |
R337L |
probably benign |
Het |
| Atp6v1g3 |
A |
T |
1: 138,215,538 (GRCm39) |
Q66L |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 22,487,351 (GRCm39) |
N1321K |
probably damaging |
Het |
| Axdnd1 |
A |
T |
1: 156,209,959 (GRCm39) |
M437K |
probably damaging |
Het |
| Bap1 |
C |
A |
14: 30,976,126 (GRCm39) |
P147Q |
probably damaging |
Het |
| Bicd1 |
C |
T |
6: 149,414,403 (GRCm39) |
T372I |
possibly damaging |
Het |
| Brix1 |
T |
C |
15: 10,483,378 (GRCm39) |
|
probably null |
Het |
| Btrc |
A |
G |
19: 45,501,967 (GRCm39) |
|
probably null |
Het |
| C130050O18Rik |
A |
C |
5: 139,400,129 (GRCm39) |
I61L |
probably benign |
Het |
| Cfap161 |
A |
G |
7: 83,425,258 (GRCm39) |
S278P |
probably damaging |
Het |
| Cgnl1 |
T |
C |
9: 71,631,815 (GRCm39) |
D512G |
possibly damaging |
Het |
| Chat |
T |
C |
14: 32,141,014 (GRCm39) |
D461G |
probably damaging |
Het |
| Chl1 |
T |
A |
6: 103,668,635 (GRCm39) |
V456D |
probably benign |
Het |
| Cib1 |
T |
C |
7: 79,882,120 (GRCm39) |
T20A |
possibly damaging |
Het |
| Cubn |
T |
G |
2: 13,355,814 (GRCm39) |
H1806P |
probably benign |
Het |
| Dennd4a |
A |
G |
9: 64,803,756 (GRCm39) |
N1032D |
probably benign |
Het |
| Dlg5 |
T |
A |
14: 24,188,723 (GRCm39) |
E1756V |
probably damaging |
Het |
| Dnah1 |
T |
C |
14: 30,996,339 (GRCm39) |
T2666A |
probably benign |
Het |
| Dnah11 |
A |
T |
12: 118,009,257 (GRCm39) |
I2135N |
possibly damaging |
Het |
| Dnah6 |
T |
A |
6: 73,150,528 (GRCm39) |
E745V |
probably benign |
Het |
| Dock8 |
A |
T |
19: 25,158,927 (GRCm39) |
N1695I |
probably damaging |
Het |
| Esf1 |
C |
T |
2: 140,006,139 (GRCm39) |
R336Q |
possibly damaging |
Het |
| Fam161a |
A |
G |
11: 22,971,664 (GRCm39) |
|
probably null |
Het |
| Fam89a |
T |
C |
8: 125,478,418 (GRCm39) |
E44G |
possibly damaging |
Het |
| Fndc3b |
A |
T |
3: 27,510,634 (GRCm39) |
D829E |
probably benign |
Het |
| Fxr1 |
C |
T |
3: 34,100,689 (GRCm39) |
T125I |
possibly damaging |
Het |
| Gfer |
T |
C |
17: 24,914,836 (GRCm39) |
D69G |
probably damaging |
Het |
| Gpatch2l |
T |
A |
12: 86,335,711 (GRCm39) |
S471T |
probably benign |
Het |
| Grm7 |
T |
G |
6: 111,335,530 (GRCm39) |
I647S |
possibly damaging |
Het |
| Gsn |
A |
G |
2: 35,188,807 (GRCm39) |
I447V |
probably benign |
Het |
| H2al2c |
C |
T |
Y: 2,599,234 (GRCm39) |
L46F |
possibly damaging |
Het |
| Hao2 |
A |
C |
3: 98,784,598 (GRCm39) |
|
probably null |
Het |
| Ifitm10 |
T |
C |
7: 141,882,305 (GRCm39) |
E155G |
probably benign |
Het |
| Igkv8-16 |
C |
A |
6: 70,363,794 (GRCm39) |
W76L |
probably benign |
Het |
| Igsf21 |
A |
T |
4: 139,834,648 (GRCm39) |
F75I |
possibly damaging |
Het |
| Ints14 |
T |
A |
9: 64,871,701 (GRCm39) |
M13K |
probably damaging |
Het |
| Ipmk |
A |
T |
10: 71,199,298 (GRCm39) |
D53V |
possibly damaging |
Het |
| Iqcn |
A |
T |
8: 71,169,597 (GRCm39) |
E1229V |
probably benign |
Het |
| Itga8 |
A |
G |
2: 12,234,906 (GRCm39) |
F451L |
possibly damaging |
Het |
| Jup |
A |
G |
11: 100,272,560 (GRCm39) |
F284S |
probably damaging |
Het |
| Kctd5 |
T |
C |
17: 24,292,209 (GRCm39) |
D65G |
probably benign |
Het |
| Klrc1 |
A |
T |
6: 129,654,184 (GRCm39) |
S148T |
probably benign |
Het |
| Kmt5b |
A |
G |
19: 3,864,147 (GRCm39) |
K404E |
probably damaging |
Het |
| Krt9 |
A |
C |
11: 100,081,617 (GRCm39) |
M304R |
probably damaging |
Het |
| Krtap5-1 |
A |
T |
7: 141,850,299 (GRCm39) |
S143T |
unknown |
Het |
| Kyat3 |
A |
G |
3: 142,426,162 (GRCm39) |
N68D |
probably damaging |
Het |
| Kynu |
A |
G |
2: 43,571,365 (GRCm39) |
D427G |
probably damaging |
Het |
| Leo1 |
A |
G |
9: 75,353,278 (GRCm39) |
|
probably null |
Het |
| Loxhd1 |
A |
G |
18: 77,501,892 (GRCm39) |
D1737G |
probably damaging |
Het |
| Lpo |
C |
A |
11: 87,700,077 (GRCm39) |
L521F |
possibly damaging |
Het |
| Lrrk1 |
A |
G |
7: 65,920,573 (GRCm39) |
S1477P |
probably damaging |
Het |
| Lrrtm1 |
C |
A |
6: 77,220,584 (GRCm39) |
L14M |
probably damaging |
Het |
| Ly75 |
G |
A |
2: 60,154,196 (GRCm39) |
R1084* |
probably null |
Het |
| Mcf2l |
A |
G |
8: 13,060,456 (GRCm39) |
D764G |
probably benign |
Het |
| Mmut |
A |
T |
17: 41,249,564 (GRCm39) |
M180L |
probably benign |
Het |
| Mrgprd |
A |
T |
7: 144,876,086 (GRCm39) |
D319V |
probably benign |
Het |
| Myom3 |
T |
C |
4: 135,522,490 (GRCm39) |
L897P |
possibly damaging |
Het |
| Ncapd2 |
A |
T |
6: 125,161,291 (GRCm39) |
M247K |
possibly damaging |
Het |
| Nlrp2 |
T |
C |
7: 5,320,533 (GRCm39) |
D868G |
probably damaging |
Het |
| Npy6r |
A |
G |
18: 44,408,999 (GRCm39) |
N140S |
probably damaging |
Het |
| Nsmce4a |
T |
C |
7: 130,141,602 (GRCm39) |
K196E |
probably benign |
Het |
| Nup88 |
T |
C |
11: 70,836,080 (GRCm39) |
K532R |
probably benign |
Het |
| Or6k4 |
T |
A |
1: 173,964,680 (GRCm39) |
Y123* |
probably null |
Het |
| Or8d6 |
T |
A |
9: 39,853,805 (GRCm39) |
V83E |
probably benign |
Het |
| Or8g29-ps1 |
A |
T |
9: 39,200,589 (GRCm39) |
I199N |
unknown |
Het |
| Pbxip1 |
A |
T |
3: 89,354,735 (GRCm39) |
D418V |
possibly damaging |
Het |
| Pde2a |
C |
A |
7: 101,159,151 (GRCm39) |
R761S |
possibly damaging |
Het |
| Phf10 |
A |
T |
17: 15,166,575 (GRCm39) |
C432S |
probably damaging |
Het |
| Pitpnm2 |
T |
C |
5: 124,259,522 (GRCm39) |
D1271G |
probably damaging |
Het |
| Plin1 |
A |
T |
7: 79,373,192 (GRCm39) |
L259Q |
probably damaging |
Het |
| Pmpca |
G |
C |
2: 26,285,046 (GRCm39) |
E424Q |
possibly damaging |
Het |
| Pou6f2 |
T |
A |
13: 18,414,379 (GRCm39) |
Q132L |
unknown |
Het |
| Ppa2 |
A |
T |
3: 133,036,199 (GRCm39) |
N118Y |
possibly damaging |
Het |
| Prickle2 |
T |
C |
6: 92,387,959 (GRCm39) |
E537G |
possibly damaging |
Het |
| Prl3d1 |
A |
G |
13: 27,282,684 (GRCm39) |
I141V |
possibly damaging |
Het |
| Prl8a1 |
A |
T |
13: 27,758,172 (GRCm39) |
V179D |
probably damaging |
Het |
| Prr14l |
A |
G |
5: 32,984,489 (GRCm39) |
F1669L |
probably benign |
Het |
| Prrg4 |
T |
A |
2: 104,669,787 (GRCm39) |
E110V |
possibly damaging |
Het |
| Rfx5 |
C |
A |
3: 94,866,187 (GRCm39) |
H495Q |
unknown |
Het |
| Rgl2 |
C |
T |
17: 34,152,403 (GRCm39) |
R367W |
probably damaging |
Het |
| Rpe65 |
A |
G |
3: 159,328,491 (GRCm39) |
Y433C |
probably damaging |
Het |
| Rpl35rt |
A |
T |
1: 156,193,657 (GRCm39) |
I4F |
probably damaging |
Het |
| Rtn4rl1 |
C |
T |
11: 75,156,576 (GRCm39) |
S336F |
possibly damaging |
Het |
| Scn2a |
A |
G |
2: 65,578,663 (GRCm39) |
D1446G |
probably benign |
Het |
| Sdk1 |
C |
A |
5: 142,031,931 (GRCm39) |
T1002K |
probably benign |
Het |
| Slc9b2 |
T |
C |
3: 135,036,422 (GRCm39) |
S409P |
probably benign |
Het |
| Sowahc |
A |
G |
10: 59,058,100 (GRCm39) |
T79A |
probably benign |
Het |
| Spata31h1 |
G |
A |
10: 82,129,248 (GRCm39) |
T1254I |
probably benign |
Het |
| Stk35 |
T |
A |
2: 129,643,513 (GRCm39) |
C166S |
probably benign |
Het |
| Tarbp2 |
A |
G |
15: 102,430,922 (GRCm39) |
H225R |
probably benign |
Het |
| Tdrd12 |
T |
A |
7: 35,188,648 (GRCm39) |
K530* |
probably null |
Het |
| Terf2ip |
A |
G |
8: 112,744,618 (GRCm39) |
I312V |
probably benign |
Het |
| Tgfb1 |
T |
C |
7: 25,391,964 (GRCm39) |
|
probably null |
Het |
| Thbs2 |
T |
C |
17: 14,891,720 (GRCm39) |
D939G |
probably damaging |
Het |
| Ube4b |
A |
T |
4: 149,483,067 (GRCm39) |
I67K |
probably benign |
Het |
| Ubn1 |
G |
T |
16: 4,895,080 (GRCm39) |
V709F |
possibly damaging |
Het |
| Ugt2b5 |
T |
C |
5: 87,276,258 (GRCm39) |
K339E |
possibly damaging |
Het |
| Vax2 |
T |
C |
6: 83,714,882 (GRCm39) |
S266P |
probably damaging |
Het |
| Vmn2r108 |
A |
G |
17: 20,683,038 (GRCm39) |
I722T |
probably benign |
Het |
| Vmn2r95 |
A |
G |
17: 18,661,577 (GRCm39) |
K441R |
probably benign |
Het |
| Wapl |
C |
A |
14: 34,458,648 (GRCm39) |
D903E |
probably benign |
Het |
| Wee1 |
T |
A |
7: 109,734,001 (GRCm39) |
V442D |
probably benign |
Het |
| Zan |
T |
C |
5: 137,432,358 (GRCm39) |
N2313S |
unknown |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCGTGTGTCCCCATGTTATG -3'
(R):5'- CAGTGCTTCTCTCAAGGATGGC -3'
Sequencing Primer
(F):5'- GTGTGTCCCCATGTTATGTCCTTG -3'
(R):5'- CTCTCAAGGATGGCTCAATTGG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation