Incidental Mutation 'R7214:Nlrp1a'
| ID |
561330 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nlrp1a
|
| Ensembl Gene |
ENSMUSG00000069830 |
| Gene Name |
NLR family, pyrin domain containing 1A |
| Synonyms |
Nalp1 |
| MMRRC Submission |
045286-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.088)
|
| Stock # |
R7214 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
70983062-71035530 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 71014119 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 377
(C377Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000038186
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000048514]
[ENSMUST00000108518]
|
| AlphaFold |
Q2LKU9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000048514
AA Change: C377Y
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000038186
Gene: ENSMUSG00000069830
AA Change: C377Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
133 |
302 |
4.6e-41 |
PFAM |
|
low complexity region
|
482 |
494 |
N/A |
INTRINSIC |
|
LRR
|
632 |
659 |
4.53e-1 |
SMART |
|
LRR
|
742 |
769 |
3.04e-5 |
SMART |
|
low complexity region
|
856 |
870 |
N/A |
INTRINSIC |
|
Pfam:FIIND
|
921 |
1173 |
1.6e-102 |
PFAM |
|
Pfam:CARD
|
1209 |
1292 |
2.3e-20 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000108518
AA Change: C377Y
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000104158
Gene: ENSMUSG00000069830
AA Change: C377Y
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
11 |
N/A |
INTRINSIC |
|
Pfam:NACHT
|
133 |
302 |
1.1e-40 |
PFAM |
|
low complexity region
|
482 |
494 |
N/A |
INTRINSIC |
|
LRR
|
632 |
659 |
4.53e-1 |
SMART |
|
LRR
|
661 |
688 |
2.85e1 |
SMART |
|
LRR
|
689 |
716 |
3.04e-5 |
SMART |
|
Pfam:FIIND
|
819 |
1073 |
3e-136 |
PFAM |
|
Pfam:CARD
|
1091 |
1174 |
8.2e-20 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice heterozygous for an ENU-induced allele develop a multi-organ neutrophilic inflammatory disease. Homozygotes for the same ENU-induced allele develop a similar but lethal condition and exhibit neutrophilia, lymphopenia, splenomegaly, loss of peritoneal macrophages, and premature death. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrg5 |
C |
T |
8: 95,660,646 (GRCm39) |
T95I |
|
Het |
| Arap2 |
C |
T |
5: 62,906,681 (GRCm39) |
V113I |
probably benign |
Het |
| Atraid |
C |
T |
5: 31,209,590 (GRCm39) |
Q85* |
probably null |
Het |
| Bcdin3d |
T |
C |
15: 99,368,344 (GRCm39) |
D285G |
probably benign |
Het |
| Bmal1 |
T |
A |
7: 112,898,610 (GRCm39) |
I346K |
probably benign |
Het |
| Carmil3 |
T |
C |
14: 55,736,069 (GRCm39) |
W604R |
probably damaging |
Het |
| Ccl6 |
C |
T |
11: 83,480,582 (GRCm39) |
|
probably null |
Het |
| Cct4 |
C |
T |
11: 22,940,616 (GRCm39) |
|
probably benign |
Het |
| Cd2ap |
C |
T |
17: 43,156,285 (GRCm39) |
R84Q |
possibly damaging |
Het |
| Cdt1 |
T |
A |
8: 123,295,012 (GRCm39) |
|
probably null |
Het |
| Cln3 |
C |
T |
7: 126,181,942 (GRCm39) |
G40D |
probably damaging |
Het |
| Crlf3 |
T |
C |
11: 79,955,216 (GRCm39) |
S47G |
possibly damaging |
Het |
| Csrp3 |
T |
C |
7: 48,480,385 (GRCm39) |
K193R |
probably benign |
Het |
| Cxcl3 |
A |
C |
5: 90,934,219 (GRCm39) |
E33A |
probably damaging |
Het |
| Cyp11b1 |
T |
C |
15: 74,708,708 (GRCm39) |
D362G |
probably benign |
Het |
| Dnah2 |
T |
C |
11: 69,321,935 (GRCm39) |
D3795G |
probably damaging |
Het |
| Dnah3 |
G |
A |
7: 119,521,965 (GRCm39) |
A4076V |
probably damaging |
Het |
| Dnaja3 |
T |
A |
16: 4,519,046 (GRCm39) |
I380N |
possibly damaging |
Het |
| Dock10 |
T |
A |
1: 80,546,246 (GRCm39) |
H785L |
probably benign |
Het |
| Dop1b |
T |
G |
16: 93,607,023 (GRCm39) |
F2226V |
possibly damaging |
Het |
| Dscaml1 |
A |
T |
9: 45,581,437 (GRCm39) |
I419F |
probably benign |
Het |
| Dyrk4 |
T |
A |
6: 126,862,200 (GRCm39) |
I431F |
probably benign |
Het |
| Endog |
C |
T |
2: 30,062,902 (GRCm39) |
R181C |
probably damaging |
Het |
| Fam90a1a |
A |
T |
8: 22,453,641 (GRCm39) |
Y332F |
probably benign |
Het |
| Fastkd3 |
T |
C |
13: 68,737,499 (GRCm39) |
I588T |
probably benign |
Het |
| Galnt9 |
G |
A |
5: 110,737,694 (GRCm39) |
V217I |
probably benign |
Het |
| Gm973 |
A |
T |
1: 59,601,888 (GRCm39) |
R501* |
probably null |
Het |
| Gnptab |
C |
T |
10: 88,215,019 (GRCm39) |
|
probably benign |
Het |
| Gpn1 |
T |
C |
5: 31,660,761 (GRCm39) |
F184S |
probably damaging |
Het |
| Imp3 |
G |
T |
9: 56,845,007 (GRCm39) |
V73L |
probably benign |
Het |
| Ipo11 |
T |
C |
13: 107,032,365 (GRCm39) |
D259G |
probably null |
Het |
| Jag1 |
T |
C |
2: 136,948,802 (GRCm39) |
S142G |
probably benign |
Het |
| Klhl5 |
A |
T |
5: 65,289,098 (GRCm39) |
E120V |
probably benign |
Het |
| Lct |
C |
A |
1: 128,228,197 (GRCm39) |
V1099L |
probably benign |
Het |
| Lrba |
G |
C |
3: 86,235,633 (GRCm39) |
W912C |
probably damaging |
Het |
| Lss |
C |
T |
10: 76,383,305 (GRCm39) |
T535I |
probably damaging |
Het |
| Mcts2 |
T |
C |
2: 152,529,297 (GRCm39) |
I36T |
probably benign |
Het |
| Meikin |
T |
A |
11: 54,302,738 (GRCm39) |
N383K |
probably benign |
Het |
| Myo1g |
T |
C |
11: 6,461,055 (GRCm39) |
Y663C |
probably damaging |
Het |
| Nadk2 |
T |
A |
15: 9,108,342 (GRCm39) |
M419K |
probably damaging |
Het |
| Nbeal1 |
G |
C |
1: 60,276,310 (GRCm39) |
V684L |
probably benign |
Het |
| Nfat5 |
T |
C |
8: 108,020,515 (GRCm39) |
S20P |
probably damaging |
Het |
| Nlrp9a |
T |
C |
7: 26,250,463 (GRCm39) |
V76A |
probably damaging |
Het |
| Nrap |
C |
A |
19: 56,366,567 (GRCm39) |
A341S |
probably benign |
Het |
| Ntng2 |
T |
C |
2: 29,117,732 (GRCm39) |
S239G |
probably damaging |
Het |
| Nup188 |
T |
A |
2: 30,197,566 (GRCm39) |
C207S |
possibly damaging |
Het |
| Or10a4 |
T |
C |
7: 106,697,619 (GRCm39) |
*316R |
probably null |
Het |
| Or10ak7 |
T |
A |
4: 118,791,146 (GRCm39) |
I300F |
possibly damaging |
Het |
| Or1j17 |
T |
C |
2: 36,578,107 (GRCm39) |
I31T |
probably benign |
Het |
| Or2ag1 |
T |
C |
7: 106,473,474 (GRCm39) |
|
probably benign |
Het |
| Or5b118 |
T |
A |
19: 13,448,337 (GRCm39) |
M1K |
probably null |
Het |
| Or8c13 |
A |
C |
9: 38,091,318 (GRCm39) |
V267G |
probably damaging |
Het |
| Or8k31-ps1 |
C |
T |
2: 86,356,150 (GRCm39) |
V124I |
probably damaging |
Het |
| Pcdhgb2 |
C |
A |
18: 37,823,159 (GRCm39) |
A50E |
probably damaging |
Het |
| Pgap1 |
A |
T |
1: 54,582,220 (GRCm39) |
M209K |
possibly damaging |
Het |
| Plbd1 |
T |
A |
6: 136,589,829 (GRCm39) |
D463V |
probably damaging |
Het |
| Plcg2 |
T |
A |
8: 118,310,288 (GRCm39) |
I380N |
probably damaging |
Het |
| Pnpt1 |
T |
C |
11: 29,087,285 (GRCm39) |
W184R |
probably damaging |
Het |
| Pptc7 |
G |
A |
5: 122,451,840 (GRCm39) |
V202I |
probably benign |
Het |
| Prpf6 |
C |
T |
2: 181,282,389 (GRCm39) |
A510V |
probably damaging |
Het |
| Prr5l |
T |
C |
2: 101,559,777 (GRCm39) |
Y235C |
probably benign |
Het |
| Ptprk |
T |
C |
10: 28,450,905 (GRCm39) |
V1022A |
probably benign |
Het |
| Rbl2 |
T |
C |
8: 91,810,057 (GRCm39) |
|
probably null |
Het |
| Rmnd1 |
T |
C |
10: 4,360,753 (GRCm39) |
K348E |
probably benign |
Het |
| Rsf1 |
CGGCGGC |
CGGCGGCGGGGGCGGC |
7: 97,229,136 (GRCm39) |
|
probably benign |
Het |
| Sacs |
T |
A |
14: 61,429,241 (GRCm39) |
N433K |
probably benign |
Het |
| Scyl1 |
T |
C |
19: 5,810,057 (GRCm39) |
T590A |
probably benign |
Het |
| Sdhd |
A |
G |
9: 50,508,533 (GRCm39) |
V111A |
possibly damaging |
Het |
| Sec24b |
G |
T |
3: 129,827,509 (GRCm39) |
P330Q |
probably benign |
Het |
| Serpinb6d |
C |
T |
13: 33,848,128 (GRCm39) |
P31S |
probably damaging |
Het |
| Slc26a9 |
A |
T |
1: 131,687,211 (GRCm39) |
R457W |
probably damaging |
Het |
| Slc5a8 |
G |
A |
10: 88,755,364 (GRCm39) |
M490I |
probably benign |
Het |
| Slx4 |
A |
G |
16: 3,806,844 (GRCm39) |
I533T |
probably benign |
Het |
| Slx4ip |
T |
A |
2: 136,888,650 (GRCm39) |
F110L |
probably benign |
Het |
| Smchd1 |
T |
C |
17: 71,652,359 (GRCm39) |
R2000G |
probably benign |
Het |
| Snx8 |
T |
C |
5: 140,346,008 (GRCm39) |
E75G |
possibly damaging |
Het |
| Stab2 |
C |
A |
10: 86,735,705 (GRCm39) |
C1292F |
probably damaging |
Het |
| Swt1 |
A |
T |
1: 151,270,364 (GRCm39) |
M617K |
possibly damaging |
Het |
| Thoc2l |
A |
G |
5: 104,670,229 (GRCm39) |
T1584A |
probably benign |
Het |
| Tiam2 |
T |
A |
17: 3,568,687 (GRCm39) |
I1611N |
possibly damaging |
Het |
| Tmem63b |
T |
G |
17: 45,972,748 (GRCm39) |
N682T |
probably benign |
Het |
| Trio |
C |
T |
15: 27,871,273 (GRCm39) |
V674M |
probably damaging |
Het |
| Trpc3 |
G |
A |
3: 36,704,286 (GRCm39) |
T557M |
possibly damaging |
Het |
| Vac14 |
T |
G |
8: 111,397,674 (GRCm39) |
L463R |
probably damaging |
Het |
| Vmn2r43 |
C |
T |
7: 8,256,379 (GRCm39) |
|
probably null |
Het |
| Wdr49 |
A |
T |
3: 75,265,751 (GRCm39) |
Y232N |
possibly damaging |
Het |
| Wdr90 |
T |
C |
17: 26,064,367 (GRCm39) |
M1835V |
probably benign |
Het |
| Xpc |
T |
C |
6: 91,469,320 (GRCm39) |
E809G |
probably damaging |
Het |
| Zfhx3 |
A |
T |
8: 109,675,493 (GRCm39) |
Q2181L |
probably damaging |
Het |
| Zfp442 |
T |
C |
2: 150,251,201 (GRCm39) |
T234A |
probably benign |
Het |
| Zfp764 |
A |
T |
7: 127,004,450 (GRCm39) |
M227K |
probably benign |
Het |
| Zfp764l1 |
A |
G |
7: 126,990,695 (GRCm39) |
S431P |
probably benign |
Het |
| Zfp957 |
A |
G |
14: 79,450,750 (GRCm39) |
S350P |
unknown |
Het |
| Zscan29 |
T |
A |
2: 120,999,761 (GRCm39) |
K147* |
probably null |
Het |
|
| Other mutations in Nlrp1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00648:Nlrp1a
|
APN |
11 |
70,983,783 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00771:Nlrp1a
|
APN |
11 |
71,013,567 (GRCm39) |
nonsense |
probably null |
|
|
IGL01408:Nlrp1a
|
APN |
11 |
71,013,742 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01886:Nlrp1a
|
APN |
11 |
71,014,327 (GRCm39) |
missense |
probably benign |
|
|
IGL02221:Nlrp1a
|
APN |
11 |
71,013,944 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02291:Nlrp1a
|
APN |
11 |
71,013,415 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02375:Nlrp1a
|
APN |
11 |
71,004,339 (GRCm39) |
nonsense |
probably null |
|
|
IGL02408:Nlrp1a
|
APN |
11 |
71,013,456 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02516:Nlrp1a
|
APN |
11 |
71,005,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02583:Nlrp1a
|
APN |
11 |
71,014,227 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02622:Nlrp1a
|
APN |
11 |
71,013,826 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02642:Nlrp1a
|
APN |
11 |
71,014,358 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL02823:Nlrp1a
|
APN |
11 |
70,983,249 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02859:Nlrp1a
|
APN |
11 |
70,996,912 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
IGL02997:Nlrp1a
|
APN |
11 |
71,014,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03342:Nlrp1a
|
APN |
11 |
71,013,617 (GRCm39) |
missense |
probably benign |
0.19 |
|
Ants
|
UTSW |
11 |
71,033,164 (GRCm39) |
missense |
probably benign |
0.01 |
|
dreary
|
UTSW |
11 |
71,004,466 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
picnic
|
UTSW |
11 |
71,013,573 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
seedless
|
UTSW |
11 |
71,014,378 (GRCm39) |
missense |
probably benign |
0.44 |
|
watermelon
|
UTSW |
11 |
71,013,531 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0022:Nlrp1a
|
UTSW |
11 |
71,014,207 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0345:Nlrp1a
|
UTSW |
11 |
71,014,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Nlrp1a
|
UTSW |
11 |
71,004,830 (GRCm39) |
intron |
probably benign |
|
|
R0364:Nlrp1a
|
UTSW |
11 |
71,004,830 (GRCm39) |
intron |
probably benign |
|
|
R0566:Nlrp1a
|
UTSW |
11 |
71,013,768 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1177:Nlrp1a
|
UTSW |
11 |
70,998,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1240:Nlrp1a
|
UTSW |
11 |
71,004,292 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1263:Nlrp1a
|
UTSW |
11 |
70,987,948 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1681:Nlrp1a
|
UTSW |
11 |
71,033,184 (GRCm39) |
missense |
unknown |
|
|
R1743:Nlrp1a
|
UTSW |
11 |
71,015,032 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1826:Nlrp1a
|
UTSW |
11 |
71,013,573 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1826:Nlrp1a
|
UTSW |
11 |
70,998,806 (GRCm39) |
intron |
probably benign |
|
|
R1981:Nlrp1a
|
UTSW |
11 |
70,989,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2083:Nlrp1a
|
UTSW |
11 |
71,015,046 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R2116:Nlrp1a
|
UTSW |
11 |
71,005,326 (GRCm39) |
nonsense |
probably null |
|
|
R2134:Nlrp1a
|
UTSW |
11 |
71,015,014 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2148:Nlrp1a
|
UTSW |
11 |
71,013,733 (GRCm39) |
nonsense |
probably null |
|
|
R2301:Nlrp1a
|
UTSW |
11 |
70,996,927 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3029:Nlrp1a
|
UTSW |
11 |
71,014,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3113:Nlrp1a
|
UTSW |
11 |
71,014,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3801:Nlrp1a
|
UTSW |
11 |
71,013,529 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3898:Nlrp1a
|
UTSW |
11 |
71,013,700 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4254:Nlrp1a
|
UTSW |
11 |
71,013,854 (GRCm39) |
nonsense |
probably null |
|
|
R4397:Nlrp1a
|
UTSW |
11 |
70,988,030 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4647:Nlrp1a
|
UTSW |
11 |
70,987,952 (GRCm39) |
splice site |
probably null |
|
|
R4740:Nlrp1a
|
UTSW |
11 |
71,004,466 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4965:Nlrp1a
|
UTSW |
11 |
70,983,141 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5009:Nlrp1a
|
UTSW |
11 |
71,013,531 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5103:Nlrp1a
|
UTSW |
11 |
70,990,352 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5355:Nlrp1a
|
UTSW |
11 |
71,015,077 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5577:Nlrp1a
|
UTSW |
11 |
70,990,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5892:Nlrp1a
|
UTSW |
11 |
70,990,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Nlrp1a
|
UTSW |
11 |
70,989,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5964:Nlrp1a
|
UTSW |
11 |
71,013,846 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6220:Nlrp1a
|
UTSW |
11 |
71,033,164 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6564:Nlrp1a
|
UTSW |
11 |
71,014,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6586:Nlrp1a
|
UTSW |
11 |
70,996,899 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6925:Nlrp1a
|
UTSW |
11 |
70,983,339 (GRCm39) |
missense |
probably null |
0.99 |
|
R7013:Nlrp1a
|
UTSW |
11 |
71,014,378 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7155:Nlrp1a
|
UTSW |
11 |
71,014,905 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7268:Nlrp1a
|
UTSW |
11 |
71,015,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7388:Nlrp1a
|
UTSW |
11 |
71,014,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7404:Nlrp1a
|
UTSW |
11 |
70,987,919 (GRCm39) |
nonsense |
probably null |
|
|
R7409:Nlrp1a
|
UTSW |
11 |
71,013,634 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7410:Nlrp1a
|
UTSW |
11 |
71,014,683 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7440:Nlrp1a
|
UTSW |
11 |
70,983,150 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7447:Nlrp1a
|
UTSW |
11 |
70,983,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7450:Nlrp1a
|
UTSW |
11 |
70,998,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7569:Nlrp1a
|
UTSW |
11 |
70,999,869 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7600:Nlrp1a
|
UTSW |
11 |
70,989,740 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7634:Nlrp1a
|
UTSW |
11 |
70,990,354 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7734:Nlrp1a
|
UTSW |
11 |
70,998,826 (GRCm39) |
missense |
unknown |
|
|
R7747:Nlrp1a
|
UTSW |
11 |
71,014,234 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8471:Nlrp1a
|
UTSW |
11 |
71,013,885 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8482:Nlrp1a
|
UTSW |
11 |
70,999,901 (GRCm39) |
splice site |
probably null |
|
|
R9008:Nlrp1a
|
UTSW |
11 |
71,014,735 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9028:Nlrp1a
|
UTSW |
11 |
71,013,819 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9441:Nlrp1a
|
UTSW |
11 |
71,013,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9516:Nlrp1a
|
UTSW |
11 |
70,998,488 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9701:Nlrp1a
|
UTSW |
11 |
70,987,946 (GRCm39) |
missense |
probably benign |
0.08 |
|
X0026:Nlrp1a
|
UTSW |
11 |
71,033,142 (GRCm39) |
missense |
probably benign |
0.18 |
|
Z1177:Nlrp1a
|
UTSW |
11 |
71,013,995 (GRCm39) |
missense |
probably benign |
0.27 |
|
Z1186:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1186:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1186:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1186:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1187:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1187:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1188:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1188:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1189:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1189:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1190:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1190:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1191:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1191:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
70,990,442 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
70,988,077 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1192:Nlrp1a
|
UTSW |
11 |
70,983,069 (GRCm39) |
missense |
probably benign |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
71,033,355 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Z1192:Nlrp1a
|
UTSW |
11 |
71,014,914 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TCCTCACTATCATCCAAGATGTAGG -3'
(R):5'- TCAAACTCAGCGCTCCTGAC -3'
Sequencing Primer
(F):5'- CATCCAAGATGTAGGACATTGCTGC -3'
(R):5'- CGCTCCTGACTCTGTGTGAAG -3'
|
| Posted On |
2019-06-26 |
Incidental Mutation